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    MSc. Dr. Lino Carmenate Milin

    FARMACOLOGA I

    (PG201)

    PRESENTACININTRODUCCIN

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    OBJETIVOS:

    I. Interpretar y criticar los conceptos y fundamentos

    bsicos de la FARMACOLOGA HUMANA comodisciplina cientfica.

    II. Interpretar y predecir los principales mecanismos

    fisiolgicos, clnicos, farmacolgicos,farmacocinticos y farmacodinmicos de losfrmacos con uso en el humano.

    III. Conocer e interpretar la situacin de farmacologa

    en HondurasIV. Aplicar conocimientos de FARMACOLOGA

    HUMANA en situaciones de investigacin y de

    prctica mdica.

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    REFERENCIAS BIBLIOGRFICAS:1. Goodman & Gilman's The pharmacological basis of therapeutics. 10th Edition

    (2001). Hardman JG, Limbird LE, Goodman Gilman A (Eds) McGraw-Hill,New York, USA.2. Farmacologa Humana, 3 Edicin (1998). Florez J (Eds).

    Masson SA, Barcelona, Espaa.3. Pharmacokinetics 2nd Edition Revised and Expanded. Gibaldi M, Perrier

    Donald (Eds), Marcel Dekker, Inc., New York, USA.

    4. El Manual Merck de diagnstico y tratamiento. Mark Beers y Robert Berkow.10 Edicin en espaol correspondiente a la 17 edicin de la obra original eningls. Ed. Harcoth. 1999.

    5. Azanza Perea, J. R. (2004). Farmacologa clnica para profesionales de lasalud. Pamplona: Eunate.

    6. Flrez, J. (2004). Farmacologa Humana. Barcelona: Masson.

    7. Rang, H.P. y Dale, M.M. (2000). Farmacologa. Madrid: Harcourt Brace deEspaa, S.A.

    8. Velasco, A. (2004). Farmacologa fundamental Madrid: McGraw-HillInteramericana.

    9. Velzquez y Lorenzo (2005). Farmacologa bsica y clnica. Madrid: EditorialMdica Panamericana.

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    REFERENCIAS BIBLIOGRFICAS:10. Domnech J, Martnez J, Pl JM. Biofarmacia y Farmacocintica Volumen I:

    Farmacocintica. 1 Edicin. Madrid: Editorial Sntesis, 1997 Weisman RS,

    Smith C, Goldfrank LR.11. Toxicokinetics. Applying pharmacokinetic principles to the poisoned patient.

    In: Hoffman RS, Goldfrank LR eds. Contemporary management in criticalcare. Critical Care Toxicology.New York: Churchill Livingstone, 1991 (vol1; no3): 21-42.

    12. Young-Jin S, Shannon M. Pharmacokinetics of Drugs in Overdose. ClinicalPharmacokinetics 1992; 23 (2): 93-105.

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    REFERENCIAS BIBLIOGRFICAS:Black J V, Stanley N P. Inverse Agonists Exposed. Nature 1995; 374: 214 15.

    Broach J R, Thorner J. High-throughput Screening for Drug Discovery. Nature1996; 384: 14 16.

    Colquhoun D. Binding, Gating, Affinity and Efficacy. Br J Pharmacol 1998; 125: 923 47.

    Gudermann T, Kalkbrenner F, Schulz C. Diversity and Selectivity of ReceptorG

    Protein Signalling. Ann Rev Pharmacol Toxicol 1996; 36: 429 59.

    Lefkowitz R J. G-proteins in Medicine. N Engl J Med 1995; 332: 186.

    Lerner M R. Tools for Investigating Functional Interactions between Ligands and G-protein Coupled Receptors. Trends Neurosci 1994; 17: 142 6.

    Libert F, Vassart G, Parmentier M. Current Developments in G-protein-coupledReceptors. Curr Opin Cell Biol 1991; 8: 218 23.

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    REFERENCIAS BIBLIOGRFICAS:

    Mangelsdorf D J, Thummel C, Beato M et al. The Nuclear Receptor Superfamily:

    The Second Decade. Cell 1995; 83: 835 9.

    Rang H P, Dale M M, Ritter J M. Pharmacology. Edinburgh: Churchill-Livingstone,1995.

    Wilson S, Bergsma D J, Chambers J K et al. Orphan G protein - coupled

    Receptors: The Next Generation of Drug Targets? Br J Pharmacol 1998; 125:1387 92.

    Golan D.E., Tashjian A.H. Jr., Armstrong E.J., Galanter J.M., Armstrong A.W.,Arnaout R.A. y Rose H.S. Principles of Pharmacology, Lippincott Williams &Wilkins, 2005.

    Hernndez M.A. y Rathinavelu A. "Basic Pharmacology", CRC Taylor & Francis,2006.

    H.P. Rang, M.M Dale. Farmacologa 5 ed. Ed: Elsevier Espaa, 2004.

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    REFERENCIAS BIBLIOGRFICAS:Silverman R. B. The Organic Chemistry of Drug Design and Drug Action, 2nd

    Edition, Elsevier, 2004.

    Walsh C.T. y Schwartz-Bloom D.S. Levine Pharmacology: Drug Actions andReactions , 7th Ed., Taylor and Francis, 2005.

    LeskA. M. Introduction to Bioinformatics, 2th Ed., Oxford University Press, 2005.

    Claverie J. M. y Notredame C. Bioinformatics for dummies, Wiley, New York,2003.

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    REFERENCIAS BIBLIOGRFICAS:World Health Organization. WHO Drug Information.

    http://www.who.int/druginformation

    World Health Organization. Biologicals information.http://www.who.int/biologicals/en/

    World Health Organization. WHO Expert Committee on Biological Standardization.

    Fifty-sixth Report. Geneva, 2007.http://www.who.int/biologicals/expert_committee/Full%20Text%20TRS941.pdf

    http://www.revistadelaofil.org/

    http://www.who.int/druginformationhttp://www.who.int/biologicals/en/http://www.who.int/biologicals/expert_committee/Full%20Text%20TRS941.pdfhttp://www.revistadelaofil.org/http://www.revistadelaofil.org/http://www.who.int/biologicals/expert_committee/Full%20Text%20TRS941.pdfhttp://www.who.int/biologicals/en/http://www.who.int/druginformation
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    REFERENCIAS BIBLIOGRFICAS:Farmacovigilancia (FV):

    Flix RH and Smith, AG. Skin disorders. In textbook of Adverse Drugs Reactions

    (uth edn). Davies, DM. Ed., pp. 491-534. Oxford University Press, New York, 1991.

    Moore D. Drug-induced cutaneus photosensitivity. Drug Safety 2002; 25:345-372.Svensson CK, Cowen EW and Gaspari AA. Cutaneus drug reactions. PharmacolRev 2000; 53:357-379.

    Tokura Y. Quinolone photoallergy: Photosentivity dermatitis induced by systemicadministration of photohaptenic drugs. J Dermatol Sci1998;18:1-10.

    Kochevar IE. Phototoxicity og non steroidal inflammatory drugs. Coincidence orspecific mechanism? Arch Dermatol 1989;125:824-826.

    Beasley S, and Araujo OE. Drug induced photosensitivity: a clinical review. J Pharm.

    Technology 1996;12:52-57.

    Consejo General de Colegios Oficiales de Farmacuticos. Lista de principiosactivos que provocan reaccin de fotosensibilidad, disponible en:http://www.portalfarma.com/home.nsf.

    Consejo General de Colegios Oficiales de Farmacuticos. Catlogo deMedicamentos de la Coleccin Consejo Plus, 2006.

    http://www.portalfarma.com/home.nsfhttp://www.portalfarma.com/home.nsf