plegable biolog­a

Click here to load reader

download plegable biolog­a

of 20

  • date post

  • Category


  • view

  • download


Embed Size (px)

Transcript of plegable biolog­a

Presentacin de PowerPoint

Protein synthesis: process and regulation.By: Natalia Zapata Lpez Medicine student III semester


RNA: The unknotted strand of life

that opposite of what was believed, the single stand of the RNA doesn't have knots on its structure but has a tendency to take geometric configurations .

They foundcomputer-generated RNA structure tied in a trefoil knot

The reason this facilitates the synthesis of proteins and achieve a faithful reproduction of the genomic information

opinionWith this new information the science can take advantage of the simple shape of the RNA strand, making it an easy molecular target to change genomic information and also changing its own translation in specific proteins, making with it effective treatments for illness based in damages in the protein synthesis. Also can be useful to understand better the molecular structure and the different process of the cell.

In a role reversal, RNAs proofread themselves

The synthesis of proteins needs a special control to prevent the cell of making bad translation, and therefore creating a mutation that can affect the cell or even worst the organism.

For this process the cell has special enzymes, capable of detect the mistakes in the encode and create a reaction to destroy or fix the damage. the enzyme that helps in this process is the CCA-adding enzyme

CCA-adding enzymecapable of duplicate de mistake for making it more visible for the regulation mechanism

also they revealed that the enzyme cant distinguish between the difference of a normal or a mutant gene

The recognition process of the good from yhe ad translations is done by the strand of RNA, which apparently has its own system of regulation.

the RNA finds the mistake and make the cell know that there is the problem, then the enzyme arrives and duplicates the mistake adding the nucleotide CCA the RNA finds the mistake and make the cell know that there is the problem, then the enzyme arrives and duplicates the mistake adding the nucleotide CCA

Opnion The auto regulation system allow the science and the scientist to understand more the process of mutations, its regulation and the proliferation of bad information that can generate a pathology. With more knowledge about this topics they can find more answers for different unanswered questions that can helps to deal with different illness or mortal diseases that have their origin in the bad translation of proteins associated to changes in the genomic material, and also replicates this model to use it in new technologies in favor of the human well been

Medical importance.

The RNA and all it cell cycle needs to be completely studies for the science, specially for the medicine and all the botanic careers , because thank to it is that how we can understand different processes that have relation with the cell, the synthesis of proteins and de well function of the organism,

If we can detect how everything normally Works it would be easier to understand the problems that are interrupting this process, how is been interrupted and a possible solution to this issue.

Thanks to this, the medicine can now redirect the focus and look for new alternatives to cure or treat different disease that have their main problem in the translation or the synthesis of the proteins that act directly or indirectly on the different systems

They also can start to replicate a mechanic or robotic structure that can do the same process with the same technique and precision and with this try to replicate the cell model and start to use it for investigation or other applications.


Martnez Snchez Lina mara, biologa molecular 2 Ed Medelln upb facultad de medicina 2006 Www.sciencedaily.comClaus-D. Kuhn, JeremyE. Wilusz, Yuxuan Zheng, PeterA. Beal, Leemor Joshua-Tor.On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme.Cell, Cristian Micheletti, Marco Di Stefano, and Henri Orland.Absence of knots in known RNA structures.PNAS, February 2, 2015