Hoja1TAREA N1: Efectos de los simpaticomimticos y simpaticolticos, sobre la FC y la PA. Droga DosisPresin arterial (mmHg) Frecuencia cardiaca (latidos/minuto) mg mlBasalCambioBasalCambioPentobarbital sdico 90013.846153 ---- ---- ---- ----Oclusin de la cartida 100125110180Asfixia 110135100135Epinefrina 0.0540.054100180110140Nicotina 90.18105115110120Etilefrina 1.440.144110200100110Terazosina 7.2360200115110150Epinefrina 0.090.9100105150190Propranolol 90.1810080150100Epinefrina 0.090.09808010090

Hoja2TAREA N 4: Efecto a dosis escalonada de Acetilcolina, matriz de datos.DrogaRoedorPeso (g)Dosis (mg)Presin arterial media (mmHg)frecuencia cardiaca (latidos/minuto) BasalCambioBasalCambioAcetilcolina 1ug/kg170000.007926011086271000.0071956510590370500.00705906510290472000.0072906511090572500.00725956510185670000.007956011090770000.007956211090870000.007906211090971000.00719061105901071000.0071936110188Acetilcolina 5ug/kg172500.03625893010926270000.035954011030371000.0355934211035471500.03575913511033572000.036933510533671000.0355953510533772000.036943010528872000.036953510028971000.03559030105281070000.035903010525Acetilcolina 10ug/kg 170000.07922410724270000.07952710427370000.07902510424471000.071902510625571000.071952510625671500.0715953010525772500.0715953010326871000.071902510323971000.0719026100251070000.07903010525Acetilcolina 10ug/kg170000.07922410724270000.07952710427370000.07902510424471000.071902510625571000.071952510625671500.0715953010525772500.0725953010326871000.071902510323971000.0719026100251070000.07932610525

Hoja3TAREA N 4: Efecto a dosis escalonada de Acetilcolina, matriz de datosDrogaRoedorPeso (g)Dosis (mg)Presin arterial media (mmHg)frecuencia cardiaca (latidos/minuto) BasalCambioBasalCambioAcetilcolina 20ug/kg172500.15922310920270000.14952510518371000.14902511018471500.14902210716572000.14952211020671000.14952210820772000.14952511120872000.14902510521971000.149025105171070000.14932510118Acetilcolina 50ug/kg170000.35912210714270000.35952010418370000.35932010418471000.36932010618571000.36932110615671500.36912010515772500.36912010315871000.36912010314971000.369021100141070000.35922110516Acetilcolina 100ugl/kg170000.70912311020271000.71931811012370500.71932110515472000.72932110215572500.73912111015670000.70912110116770000.70911811014870000.70901811014971000.719018110151071000.71901810515

Hoja4RoedorPeso (g)Dosis (mg)Presin arterialFrecuencia cardiacaDroga(mmHg)(latidos/minuto)

BasalEfectoBasalEfecto

122510090170190022300105921651920323001031001751880423210895170195

Epinefrina 1nmol/kg52709590175193

626510090170193

726010096170190

827010596165190

925510595170187

1024511090175188

1250101125170220

2250105128180200

3255105123165205

4240105125170205

Epinefrina 3 nmol/kg5255110125170200

6255107130170210

7255108123170220

8245110123165220

9245100125180225

10245100130180220

Hoja5TAREA N 3: Efecto a dosis escalonada de Epinefrina, matriz de datos.DrogaRoedorPeso (g)Peso (kg)Dosis (mg)Presin arterial (mmHg)Frecuencia cardiaca (latidos/minuto)BasalEfectoBasalEfectoEpinefrina 1 nmol/kg12250.2250.00004121009017019022300.2300.00004211059216519232300.2300.000042110310017518842320.2320.00004251089517019552700.2700.0000495959017519362650.2650.00004851009017019372600.2600.00004761009617019082700.2700.00004951059616519092550.2550.000046710595170187102450.2450.000044911090175188Epinefrina 3 nmol/kg12500.2500.000137410112517022022500.2500.000137410512818020032550.2550.000140210512316520542400.2400.000131910512517020552550.2550.000140211012517020062550.2550.000140210713017021072550.2550.000140210812317022082450.2450.000134711012316522092450.2450.0001347100125180225102450.2450.0001347100130180220Epinefrina 6 nmol/kg12500.2500.000274810014017524022350.2350.000258310514518024532350.2350.000258310215018024342400.2400.000263810513518024552450.2450.000269310314018224062380.2380.000261610814017024072480.2480.000272610714518124082500.2500.000274810114017524092500.2500.0002748101145180250102500.2500.0002748101150175243Epinefrina 12 nmol/kg12510.2510.000551810315517025022500.2500.000549610816017325532500.2500.000549611016017725542480.2480.000545211016017025552480.2480.000545211015817025162500.2500.000549610115817025172500.2500.000549610115517025182500.2500.000549610015517725092440.2440.0005364100168177250102430.2430.0005342100168171250Epinefrina 24 nmol/kg12250.2250.000989310016017025022300.2300.001011310517016526032300.2300.001011310317017525542320.2320.001020110816517025552700.2700.00118729516517526562650.2650.001165210017017026572600.2600.001143210016517026582700.2700.001187210517016526592550.2550.0011212105170170265102450.2450.0010772110170175255Epinefrina 48 nmol/kg12500.2500.002198410017517026522350.2350.002066510517518026532350.2350.002066510217518026042400.2400.002110510518018026052450.2450.002154510318018026062380.2380.002092910818318126072480.2480.002180910718318125882500.2500.002198410118217825892500.2500.0021984101178178258102500.2500.0021984101180178257Epinefrina 96 nmol/kg12510.2510.004414510318017026022500.2500.004396910818016526032500.2500.004396911018017526042480.2480.004361711018017026552480.2480.004361711018517526562500.2500.004396910118517026572500.2500.004396910118517026582500.2500.004396910018816527092440.2440.0042914100188170270102430.2430.0042738100189175270

Hoja7TAREA N2: Efectos sistmicos de los parasimpaticomimticos y los parasimpaticolticos en Conejo, matriz de recoleccin de datos.

FrmacoDosisDosisBasalEfectos(mg)(ml)

Ojo: 5 mmOjo: 2 mmSecreciones: 5 mlSecreciones: 0 mlFrecuencia cardiaca: Disminuy ++.Frecuencia cardiaca: Normal.Frecuencia respiratoria: Aument +++.Frecuencia respiratoria: Normal.Mucosas (brillo de las escleras):Mucosas (brillo de las escleras): Normal.Aument ++.Fasciculaciones: (-).Fasciculaciones: (++).Pilocarpina150.375Lacrimacin: (-).Lacrimacin: (+++).Defecacin: Normal.Defecacin: Aumento (++).Convulsiones: (-)Convulsiones: (-)Temblores: (-)Temblores: (++)Excitacin: (-)Excitacin: (++)Sedacin: (-).Sedacin: (-).Muerte: (-).Muerte: (-).

Ojo: 2 mmOjo: 9 mmSecreciones: 5 mlSecreciones: 0 mlFrecuencia cardiaca: Disminuy ++.Frecuencia cardiaca: Aumenta +++.Frecuencia respiratoria: Aument +++.Frecuencia respiratoria: Disminuye ++.Mucosas (brillo de las escleras):Mucosas (brillo de las escleras):Aument ++.Disminuy ++.Atropina510Fasciculaciones: (++).Fasciculaciones: (-).Lacrimacin: (+++).Lacrimacin: (-).

Defecacin: Aumento (++).Defecacin: Normal.Convulsiones: (-)Convulsiones: (-)Temblores: (++)Temblores: (-)Excitacin: (++)Excitacin: (-)Sedacin: (-).Sedacin: (++).Muerte: (-).Muerte: (-).

Tarea 3Epinefrina 1nmol/kgEpinefrina 3nmol/kgEpinefrina 6nmol/kgEpinefrina 12nmol/kgEpinefrina 24nmol/kgEpinefrina 48nmol/kgEpinefrina 96nmol/kg901251401551601751809212814516017017518010012315016017017518095125135160165180180901251401581651801859013014015817018318596123145155165183185961231401551701821889512514516817017818890130150168170180189Media93.4125.7143159.7167.5179.1184SD3.32264954522.57099202644.5825756954.58366665453.35410196623.04795013083.5213633723