Download - Bee Propolis Presentation

  • 7/30/2019 Bee Propolis Presentation


    Bee Propolis:

    Ancient Cure for Todays Ailments

    By: Dana Catalfamo

  • 7/30/2019 Bee Propolis Presentation



    Essentially the glue in bee hives.

    Made of plant resin.

    Preserves warmth in hive and keeps out microbes.

    Has various antimicrobial properties. Used for healing and part of apitherapy.

    Interesting uses including violin varnish.

    Used since the Ancient Greeks and Romansdiscovered it.

  • 7/30/2019 Bee Propolis Presentation


    Propolis in the Hive

    (Kulincevica & Gacica, 1991)

  • 7/30/2019 Bee Propolis Presentation


    Major Components

    Caffeic acid phenethyl ether or CAPE.






  • 7/30/2019 Bee Propolis Presentation


    Properties of Propolis in General

    Stimulates antibody production.

    Inhibits viral entry into CD4 lymphocytes, especiallyagainst HIV-1.

    Increases effectiveness of antiviral drugs such as thereverse transcriptase inhibitor, zidovudine.

    Treats opportunistic infections that plague AIDSpatients.

    Decreases lymphocyte proliferation when exposed to

    mitogens such as ConA. Increases production of IFN- and activates


  • 7/30/2019 Bee Propolis Presentation


    Interesting Properties of CAPE

    Inhibits Nuclear Transcription Factor KappaB or NF-B, which drives T-cell proliferation and effectorfunctions.

    Anti-inflammatory activity.

    Treats arthritis and inflammatory bowel disease, orIBD.

    Inhibits IL-2 which also drives T-cell proliferation.

  • 7/30/2019 Bee Propolis Presentation


    Different Geographical Samples of


    Not much of a difference in the effectiveness

    of propolis from different regions. Most common one studied is from Brazil and

    also from Bulgaria.

  • 7/30/2019 Bee Propolis Presentation


    Increased Antibody Production

    Propolis was shown to increase antibody

    production in rats immunized with bovine

    serum albumin, BSA.

    Acted as adjuvant.

    Enhanced the activity of macrophages.

  • 7/30/2019 Bee Propolis Presentation


    Increased Antibody Production

    (Sforcin, Orsi, & Bankova, 2005)

  • 7/30/2019 Bee Propolis Presentation


    Inhibition of NF-B

    CAPE inhibited NF-B binding to macrophages and

    decreased cytokine production.

    Tumor necrosis factor alpha, TNF-, which stimulates

    macrophages to kill tumor cells was used to see if NF-B would bind.

    Anti-inflammatory activity.

    Macrophages underwent apoptosis in patients withIBD leading to healing of the injuries to the colon.

  • 7/30/2019 Bee Propolis Presentation


    Inhibition of NF-B

    (Fitzpatrick, Wang, & Le, 2001)

  • 7/30/2019 Bee Propolis Presentation


    CAPE Induces Apoptosis in

    Macrophages in Patients with IBD

    (Fitzpatrick, Wang, & Le, 2001)

  • 7/30/2019 Bee Propolis Presentation


    CAPE Reduces Injury to the Colon

    (Fitzpatrick, Wang, & Le, 2001)

  • 7/30/2019 Bee Propolis Presentation


    Inhibition of IL-2

    CAPE inhibited IL-2 leading to anti-

    inflammatory activity.

    T-cell proliferation was inhibited in sampleswith Con-A, a mitogen, added.

  • 7/30/2019 Bee Propolis Presentation


    Anti-viral Activity

    Viral entry of HIV-1 was inhibited in CD4


    Effectiveness of the reverse transcriptaseinhibitor, zidovudine, was increased.

    Virus was kept from proliferating.


  • 7/30/2019 Bee Propolis Presentation


    Propolis Decreased Viral Expression

    in CD4 Cells

    (Gekker, Hu, Spivak, Lokensgard, & Peterson, 2005)

  • 7/30/2019 Bee Propolis Presentation


    Propolis Increases Effectiveness of

    Anti-viral Drugs

    (Gekker et. al, 2005)

  • 7/30/2019 Bee Propolis Presentation


    Treatment for AIDS Patients

    Propolis treats opportunistic fungal infections

    such as thrush and leukoplakia.

    Kept infections from coming back andalleviated symptoms.

    Increased the immune response.

  • 7/30/2019 Bee Propolis Presentation


    Increased Production of IFN-

    Propolis increased IFN- production leading tothe antigen being presented on cells and theimmune response starting to clear it faster.

    Mitogen infected cells did not showproliferation that would normally happen.

    Kept mitogen from working.

  • 7/30/2019 Bee Propolis Presentation


    Propolis Inhibits Mitogen Activity

  • 7/30/2019 Bee Propolis Presentation



    No recommended dose.

    Capsules, liquid, lozenges, tablets, creams,

    gels, toothpastes, mouth rinses, and cough


    Well tolerated unless a person is allergic to a

    component of propolis.

    If allergic, hives result.

  • 7/30/2019 Bee Propolis Presentation



    Propolis is an effective anti-inflammatoryagent.

    Can be used to help AIDS patients.

    Controls inflammatory diseases.

    Increases effectiveness of immune system.

    Mechanisms are not known yet.


    Ancient cure for todays ailments.

  • 7/30/2019 Bee Propolis Presentation


    Works Cited Devillers, J., & Pham-Delegue, M. (2002). Honey Bees: Estimating the

    Environmental Impact of Chemicals. New York: Taylor & Francis Inc.

    Ellis, H. (2004). Sweetness & Light. New York: Harmony Books.

    Fitzpatrick, L.R., Wang, J., & Le, T. (2001 December). Caffeic acid phenethyl ester,

    an inhibitor of nuclear factor-KB, attenuates bacterial peptidoglycan poly-

    saccharide-induced colitis in rats. The Journal of Pharmacology and

    Experimental Therapeutics, (299(3), 915-920. Retrieved October 23, 2005,

    from PubMed database, On the World Wide Web: http://www.ncbi.nlm.nih.


    Gekker, G., Hu, S., Spivak, M., Lokensgard, J.R., & Peterson, P.K. (2005, May).

    Anti-HIV-1 activity of propolis in CD4+ lymphocyte and microglial cellcultures. Journal of Ethnopharmacology, 102(1), 158-163.Retrieved September 2, 2005, from ScienceDirect database, On the World Wide Web:

    Hubbell, S. (1988). A Book of Bees and How to Keep Them. New York:

    Random House Inc. James, J.S. (1987, July 31). Bee Propolis for Thrush, Fungus or Leukoplakia?

    AIDS Treatment News, 1(37), Retrieved September 19, 2005, from the

    World Wide Web:

    Kulinevia, J. & Gaia, R. (1991). Propolis. Retrieved November 14, 2005,

    from the World Wide Web:

    Marquez, N., Sancho, R., Macho, A., Calzado, M.A., Fiebich, B.L., & Munoz, E.

    (2003, November 14). Caffeic acid phenethyl ester inhibits t-cell activation

    by targeting both nuclear factor of activated t-cells and NF-KB transcription

    factors. Journal of Pharmacology and Experimental Therapeutics Fast

    Forward, 308(3), 993-1001. Retrieved October 23, 2005, from PubMed

    database, On the World Wide Web: Parham, P. (2005). The Immune System. New York: Garland Science.

    Propolis. (2005). Retrieved September 19, 2005, from the World Wide Web:

    Sa-Nunes, A., Faccioli, L.H., & Sforcin, J.M. (2003). Propolis: lymphocyte

    proliferation and IFN- production. Journal of Ethnopharmacology, 87, 93-

    97. Retrieved October 19, 2005, from ScienceDirect database, On the World

    Wide Web:

    Sforcin, J.M., Orsi, R.O., & Bankova, V. (2005, April). Effects of propolis, some

    isolated compounds and its source plant on antibody production. Journal of

    Ethnopharmacology, 98(3), 301-305. Retrieved September 19, 2005, from ScienceDirect database, On the World Wide Web: