Tratamiento Artroscopico de La Artrosis de Rodilla y Lesiones Condrales

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    TRATAMIENTOARTROSCOPICO DE LAARTROSIS DE RODILLA

    INTERNA KINESIOLOGIA UDLAMARA JOSE GONZALES

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    TRATAMIENTO ARTROSCOPICODE LA ARTOSIS DE RODILLA

    La Poblacin tiende a antene!"e#$"icaente cada %e& a" acti%a ' a!eali&a! acti%idade" a" deandante a

    edade" a" a%an&ada"

    A!t!o"co(ia a(a!ece coo )n (!ocediiento

    a" "i(le en (aciente *)e (o! edade" ocabio" de+ene!ati%o" eno!e" no "oncandidato" a )na a!t!o(la"tia,

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    -C).le" "on lo" ob/eti%o" de)na A!t!o"co(ia0

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    A!t!o"i" deRodilla

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    El t!ataiento de la a!t!o"i" de!odilla1

    Debe "e! eta(i2cado

    E3i"ti! !elacin con "$ntoa" ' "i+no"

    Se debe coen&a! con edida""i(le"1

    4a/a! de (e"o

    Modi2cacin de la Acti%idad Cal&ado ao!ti+)ado!

    5ine"iote!a(iaAaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $)uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ inpatient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    Lo" (aciente" *)e no (!e"ente )na!e"()e"ta #a%o!able al t!ataiento

    con"e!%ado!6 el t!ataiento*)i!)!+ico e" )na alte!nati%a cone/o!e" !e")ltado" en (aciente"

    ent!e 789 :8 a;o"

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    T!ataiento

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    Seleccin de (aciente 'c!ite!io (a!a )na A!t!o"co(ia

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    Tecnica *)i!)!+ica

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    El (!ocediiento b."icaenteincl)'e1

    El a"eo a!tic)la! (a!a dil)cin de laconcent!acin de en&ia" de+!adati%a" '!eocin de (!od)cto" i!!itante" de la

    de+ene!acin cond!al6 eni"cal o "ino%ial

    Reocin de c)e!(o" lib!e" int!a!tic)la!e"

    Meni"cectoia (a!cial

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    Meni"cectoia

    El (!oce"o (atol+ico de laa!t!o"i" en eta(a" ta!d$a" no"olo +ene!a la de"t!)ccin delca!t$la+o a!tic)la!6 "ino *)e

    a#ecta tabi>n la inte+!idadde eni"co" ' li+aento"

    C)al*)ie! (!ocediiento"ob!e el eni"co debe i!o!ientado a e/o!a! la"intoatolo+$a del (aciente

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    Un de"+a!!o en )n eni"co con cabio"

    de+ene!ati%o" e"ta a"ociado a cabio"e"t!)ct)!ale" (!ee3i"tente" en el ca!t$la+oa!tic)la! *)e ()eden !e(!e"enta! )naeta(a te(!ana de a!t!o"i"

    De(endiendo de c)anta #)ncionalidadeni"cal "e (ie!da con )n de"+a!!o o )na

    !e"eccin *)i!=!+ica6 la a!t!o"i" "e ()edeacele!a! a edida *)e a)enta la ca!+abioec.nica en el ca!t$la+o a!tic)la!

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    La !e"eccion de )na le"ion de c)e!(o(o"te!io! del eni"o inte!no di"in)'e endo" te!cio" la ca(acidad de ab"o!cion deca!+a

    Se debe e%ita! la !e"eccion del eni"co

    ?a"ta la (e!i#e!ia6 'a *)e elia laca(acidad del eni"co de "o(o!ta! ca!+a"

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    La e3t!)"in eni"cal e" ot!o ?alla&+o

    co=n en (aciente" a'o!e" ' e" aen)do ot!o "i+no de )na de+ene!acineni"cal ' a!t!o"i" (!ee3i"tente

    Una e3t!)"in eni"cal ()ede cont!ib)i! aa)enta! la e"t!ec?e& del e"(acioa!tic)la!

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    Cond!o(la"tia

    La !adio#!ec)encia ?a +anado (o()la!idadcoo ?e!!aienta a!t!o"co(ica

    S)" %enta/a" "on1

    9 @.cil de a(lica!

    94a/o co"to

    9 Ret!accin del

    col.+eno

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    E"t)dio" ?an deo"t!ado *)e la

    cond!o(la"tia )tili&ando !adio#!ec)enciaobtiene ")(e!2cie" li"a" *)e (e!anecene"table" (o! la!+o" (e!iodo" de tie(o

    Sin eba!+o6 la !adio#!ec)encia #)nciona at!a%>" del calo! ' ") de"%enta/a e"ta en*)e lo" cond!ocito" "on e3t!eadaente

    "en"ible" a la te(e!at)!a

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modernpractice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    Sino%ectoia ' !eocin deo"teo2to"

    En el ca"o" *)e la a!t!o"i"a%an&ada "e aco(a;e de"ino%iti" "i+ni2ca *)e(!o%oca!a de!!ae"

    !ec)!!ente"6 ' laSino%ectoia ()ede e"ta!indicada

    La !e"eccin de o"teo2to"en +ene!al no "on!ecoendado6 (o! el !ie"+ode (!o%oca! ?ea!t!o"i"

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modernpractice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modernpractice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    Re")ltado"

    8B a B de lo" (aciente conA!t!o"co(ia !e2e!en )na e/o!$a inicial

    B (!o+!e"a a )na a!t!o(la"tia total de!odilla a )n a;o

    77B (!e"enta )na di"in)cin cl$nica

    "i+ni2cati%a del dolo! a do" a;o" de"e+)iiento

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    22/90

    S(a?n et al E3aino lo" !e")ltado"de la A!t!o"co(ia en (aciente" con

    a!t!o"i" edial de !odilla

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    a"ociado" a al (!ono"tico""on1

    Tie(o de e%ol)cin de la a!t!o"i" a'o! aF7 e"e"

    Obe"idad

    O"teo2to" ediale" E"(acio a!tic)la! eno! a

    Tabaco

    P!e"encia de de#ecto cond!al tibial +!adoI ' nece"idad de )na Meni"cectoia totalo ")btotalAaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    No "e debie!a con"ide!a!)na A!t!o"co(ia

    Tienen (oca"(o"ibilidade" de "e!)n (!ocediiento

    e3ito"o

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    E"t)dio" Clinico"

    En el e"t)dio de @!ain+?a "ob!eindicacione" de Meni"cectoia en !odillaa!t!o"ica de"c!ibi1

    El :B de lo" ?ob!e" ent!e 8 ' H8 a;o""in "intoatolo+$a (!e"enta de"+a!!o"eni"cale" ' en (aciente" con a!t!o"i"!adio+!.2ca e"te (o!centa/e a)enta a

    FB Sin eba!+o 6 la !elacin ent!e da;oeni"cal ' a!t!o"i" e" co(le/a,

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    Una le"in eni"cal en )na !odilla "ana6 ()ede 6e%ent)alente 6 lle%a! al de"a!!ollo de la a!t!o"i"(o! (e!dida de la #)ncin eni"cal

    Una !odilla a!t!o"ica ()ede (!e"enta! )n de"+a!!oeni"cal *)e acele!a el (!oce"o de+ene!ati%o

    E"to ")+ie!e *)e el da;o eni"cal %i"ible

    en !e"onancia a+n>tica antecede a

    lo" cabio" %i"ible" del ca!t$la+o

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    Tecnica (!e#e!ida (o! ela)to!

    Coo !e+la +ene!al "e debe "e!con"e!%ado! ' /)icio"o en la" !e"eccione"(a!a (!e"e!%a! al .3io la" e"t!)ct)!a"

    noble de la #)ncin a!tic)la!1 Ca!t$la+o 'Meni"co

    Toda e"t!)ct)!a ine"table debe "e!!e"ecada 'o !eodelada en ") /)"ta

    edida teniendo en c)enta *)e lo"(aciente" "olo )tili&a!an ")" !odilla en AD' ba/a deandaAaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    Cont!aindicao" #o!alente c)al*)ie!

    ti(o de (!ocediiento *)e ba"e ") >3itoen !e"()e"ta !e(a!ati%a" del (aciente6#)ndaentalente (o! lo" #acto!e" deedad ' (o! la "e%e!a alte!acin de la

    ?oeo"ta"i" a!tic)la! *)e liita"e!iaente ") !e"()e"ta !e+ene!ati%a (o!e/e(lo1 ic!o#!act)!a"6 eni"co!!e"i"6 etc

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modern

    practice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    No!alente (o! edad ' (!e"encia de

    #acto!e" de !ie"+o )tili&ao" t!ataientoanticoa+)lante (!o2l.ctico con 4PM en el(o"to(e!ato!io

    U"o de 5ine"iolo+$a (!eco& 6 con >n#a"i" en

    la o%ili&acin6 liitacin de la !e"()e"tainaato!ia"6 d!ena/e %eno"o ' lin#.tico6antencin t!o2"o )"c)la! ' el )"ot!an"ito!io de de"ca!+a en ladeab)lacion

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modernpractice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    Concl)"in

    La e%idencia e" cate+!ica en deo"t!a!*)e el t!ataiento a!t!o"co(ico no(!e"enta bene2cio" "ob!e el t!ataiento

    con"e!%ado! Sie(!e "e debe toa! c)enta *)e al

    oento de e%al)a! al (aciente *)e lo"(eo!e" !e")ltado" de )na A!t!o"co(ia en

    a!t!o"i" "e a"ocia a al alineaiento 6ine"tabilidade"6 a!t!o"i" a%an&ada" 6"intoatolo+$a c!nica6 ci!)+$a" (!e%ia"

    Aaron RK, Skolnick AH, Reinert Se,et al.Arthroscopic debridement for osteoarthritis of the knee.J Bone joint surg am 2!"##$%&!'(&.Bernstein j, )uaccht a perspecti*e on the stud+ of mosele+ et al $

    )uestioning the *alue of arthroscopic knee suger+ for osteoarthristis.cle*e clin j med.2&"-/$('(!'(0. Bin S1,ee SH,Kim 34,Kim th, lee dh results of arthroscopic medial meniscectom+ in

    patient 5ith grabe 1*osteoarthritis of the medial compartment.Arthroscop+ 2# 6ar,2(-&/"2!('#. Brian j.cole 67,6BA,and H.Ralph Schumacher, jr,67. 1n+ectable corticosteroids in modernpractice.J Am acad 8rthop surg 2"0&$&'(!. 3ook J, Kuroki k, kenter k, marberr+ k, bra5ner t, 9eiger t, ja+abalan :, bal Bs. Bipolar and monopolar radiofre)uenc+ treatment of osteoarthritic

    knee articular cartilage$ acute and temporal effects on caartillage compressi*e stiffnes, permeabilit+, cell s+nthesis, and e;tracellular matri; composition.J knee surg 2( apr" 0-2/$ %%'0#. 7a*id 7

    4addell, 67, and jack 6 bert 67.

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    LESIONES CONDRALES

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    ISTOLOGIA

    Ca!t$la+o ?ialino e" )na #o!ae"(eciali&ada de te/ido con/)nti%o

    Con"tit)ido" (o! eleento" cel)la!e"denoinado" CONDROCITOS *)e di"(onenen )na at!i& e3t!acel)la! d)!a de ti(o +el

    La" c>l)la" "e n)t!en ediante" di#)"in at!a%>" de la #a"e ac)o"a de la at!i& ' a

    (a!ti! de lo" ca(ila!e" de lo" te/ido" *)e!odean el ca!t$la+oAl#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+

    M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%etec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

    HH81(a+H9F Rec?t M6 bobic 6 4)!"tein D6 et al a+netic !e"onance ia+in+ o# a!tic)la! ca!tila+eClin o!t?o( !elat!e" F88H1"H9"H: ")((l S?elbo)!neKd6 Jai! "6 G!a' t O)tcoe o# )nt!eated t!a)atic a!tic)la! ca!tila+e de#ect" o# t?e 5nee1 a nat)!al ?i"to!' "t)d' J bone /oint ")!+ a F881(a+ 9: Zale"5e6 Da%id /6 dCa!tila+e and bone de%elo(ent,Ae!ican Acade' o# O!t?o(aedic S)!+eeon" In"t!)ctional co)!"e lect)!e" ol 76 (a+ 78:9 HH

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    E"to le con2e!e )na d)!e&a ' e3ibilidad (oco?abit)ale"

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    S)" Di#e!encia" e"t.n dada" (o!1

    9 Mat!i& cel)la!9@ib!a" de Col.+eno"9 @ib!a" de Ela"tina

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    Ca!tila+o ialino

    Se (!e"enta en anillo" t!a*)eal6 la na!i&6la!in+e6 ")(e!2cie" a!tic)la!e"

    Cond!ocito" "e enc)ent!an (o! deba/o del(e!icond!io

    Zona a" (!o#)nda del ca!t$la+o 6 la"la+)na" tienen )na con2+)!acin?ei"#>!ica o an+)la!

    Cito(la"a (!e"enta )na ba/a den"idad6contienen +ota" de l$(ido ' cantidade"%a!iable" de +l)c+eno

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%etec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

    HH81(a+H9F Rec?t M6 bobic 6 4)!"tein D6 et al a+netic !e"onance ia+in+ o# a!tic)la! ca!tila+eClin o!t?o( !elat!e" F88H1"H9"H: ")((l S?elbo)!neKd6 Jai! "6 G!a' t O)tcoe o# )nt!eated t!a)atic a!tic)la! ca!tila+e de#ect" o# t?e 5nee1 a nat)!al ?i"to!' "t)d' J bone /oint ")!+ a F881(a+ 9: Zale"5e6 Da%id /6 dCa!tila+e and bone de%elo(ent,Ae!ican Acade' o# O!t?o(aedic S)!+eeon" In"t!)ctional co)!"e lect)!e" ol 76 (a+ 78:9 HH

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    Mat!i& Ca!tila+ino"a

    E" de colo! a&)l +!i".ceo ' (a!cialentet!a"l)cida

    Col.+eno *)e (!edoina e" ti(o II6 *)e #o!a

    2b!a" d>bile" con e"t!iacin t!an"%e!"al La" 2b!a" de la &ona ")(e!2cial e"t.n

    o!ientada" (a!alelaente ' la a" (!o#)nda"?acia adent!o en #o!a de col)na"%e!ticale"

    La o!ientacin de la" 2b!a" "on ada(tada"(a!a !e"i"ti! la ten"in a la *)e e"t.n ")/eta"

    no!alente

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    Dent!o de la at!i& e3i"ten )na ca(")la(e!icel)la!6 *)e !odea a la" la+)na"

    E"ta #o!ada (o! 2b!a" )' 2na" deca!acte!$"tica" "iila!e" a la laina ba"al

    De"e(e;a )n (a(el i(o!tante en la

    (!oteccin de lo" cond!ocito" de a*)ello"ca!t$la+o" "oetido" a co(!e"in oten"in ec.nica

    La at!i& (o"ee a'o! concent!acin de

    (!oteo+licano"

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    Ca!tila+o A!tic)la!

    E" )n ti(o de ca!t$la+o ?ialino6 *)e c)b!ete!inacione" O"ea" de la a!tic)lacione""ino%iale"

    E" a%a"c)la! ' dene!%ado6 el 8B98B de") (e"o e" a+)a

    Con"tit)ido (o! col.+eno ti(o II6 (o"ee

    (oca ela"tina ' )n co(onente eno! de+lico(!ote$na" ' l$(ido"

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

    Se o!+ani&a en c)at!o

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    Se o!+ani&a en c)at!oca(a" 1

    9 S)(e!2cial S

    F9 T!an"icion T

    9 Medial M79 Calci2cada C

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    Ca(a S)(e!2cial

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    En e"ta ca(a lo" cond!ocito" "ec!etan )naat!i& con alta concent!acion de cola+eno' ba/a concent!acion de (!oteo+licano"

    La ca!acte!i"tica e"t!)ct)!al de e"ta ca(ae" *)e dete!inan )na alta #)e!&a ten"il '!e"i"tencia a la co(!e"ion ")(e!io! a la"ca(a" (!o#)nda"

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    Ca(a T!an"icion

    Po"ee a'o! +!o"o! *)e la ca(a ")(e!2cial Lo" cond!ocito" ado(tan )na o!#olo+$a

    e"(i!oidal

    S)" c>l)la" (o"een a'o! den"idad deo!+anelo"6 !ecit.c)lo endo(la"atico 'a(a!ato de Gol+i

    Sinteti&an at!i& con 2b!a" col.+eno" de

    a'o! di.et!o con alta concent!acin de(!oteo+licano ' eno! de concent!acinde a+)a ' col.+enoAl#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+

    M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    Ca(a Medial

    lo" cond!ocito" e"#e!oide" )bicado"(e!(endic)la! a la ")(e!2cie a!tic)la!

    (o"ee 2b!a" de cola+eno" de +!an

    diaet!o La concent!acion a" alta de

    (!oteo+licano" ' la a" ba/a de a+)a

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    Ca(a Calci2cado

    E" )na &ona de ca!t$la+o calci2cado *)e"e(a!a la &ona !adial del ?)e"o ")bcond!al

    Contienen )' (oco !et$c)loendo(la"atico ' a(a!ato de Gol+i

    La" c>l)la" a(a!ecen co(letaente!odeando el ca!t$la+o calci2cado6 lo *)e")+ie!e )na ba/a acti%idad etablica

    E"t)dio" ")+ie!en *)e (od!$a /)+a! )n !olen el de"a!!ollo ' (!o+!e"in de lao"teoa!t!iti"Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+

    M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    Ca!tila+o A!tic)la! No!al

    La #)ncin de e"te ca!t$la+o e" 1

    Minii&a! el e"t!>" "ob!e el ?)e"o ")bcond!al

    Di"t!ib)cin de ca!+a" en la a!tic)lacinDi"in)'e el coe2ciente de #!iccin de la"

    ")(e!2cie" a!tic)la!e"

    La inte!accin con el li*)ido "ino%ial(!o(o!ciona )n e3celente ecani"o del)b!icacin

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

    E i t d i d

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    E3i"ten do" ecani"o" del)b!icacion 1

    9 @l)id @il 1 ca(a de )ido "ino%ial eno!a F ) 6 de +!an %i"co"idad

    F9 L)b!icacion @!onte!a1 AP6 (!ote$na deacido ?ial)!onico de alta a2nidad (o! la")(e!2cie a!tic)la!6 *)e #)nciona coo )ni(o!tante l)b!icante li$t!o#e con la")(e!2cie a!tic)la!

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    Lo" 2laento" de col.+eno antienen lacon2+)!acin del te/ido ' la !e"i"tencia ala" #)e!&a" ten"ile"

    Lo" (!oteo+licano" (!o(o!cionan )n +el?id!atado ' 2!e *)e ab"o!be la" #)e!&a"de co(!e"in ' ade." ()eden at!a(a! eino%ili&a! )n +!an %ol)en de a+)a

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

    -C i t l

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    -Co "e !e"i"ten la"#)e!&a" co(!e"i%a"0

    c)ando "e e/e!ce )na #)e!&a co(!e"i%a6 ela+)a "e ale/a de la" !e+ione" con ca!+ael>ct!ica de lo" (!oteo+licano" Entonce" 6

    la ca!+a" ne+ati%a" de lo" +!)(o" ca!bo3ilo' ")l#ato "e a(!o3ian ' la #)e!&a de!e()l"in de la" i"a" (e!iten !e"i"ti!la co(!e"in

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

    M i d di i i d

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    Mecani"o de di"i(acin deene!+$a

    El li*)ido inte!"ticial )'e lentaente (o!la e3i"tencia de (e*)e;o" (o!o" en ele"(acio inte!olec)la! 6 con ello ba/a la

    (e!eabilidad de la at!i& ti")la! '+!acia" a e"to no e3i"te )na e3ce"i%ade#o!acin del te/ido ' "e c!ea lainte!accin de #!iccin ent!e )ido" ' la

    at!i&

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    -lo" (!oteo+licano" in)'enen el en%e/eciiento0

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    E"t)dio" co(a!a!on c)lti%o" decond!ocito" de aniale" %ie/o" ' /%ene"

    ()diendo ob"e!%a! *)e lo" cond!ocito"%ie/o" "ec!etan (!oteo+licano" de eno!taa;o ' con cadena" cond!oitin ")l#atoa" co!ta"

    "e ?a (!o()e"to *)e al "e! de eno!taa;o el (!oteo+licano 6le (e!ite!etene! )na cantidad eno! de a+)a6 lo*)e di"in)'e ") ca(acidad (a!a !e"i"ti!#)e!&a" co(!e"i%a"

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    V con ello la at!i& "e!ia a" %)lne!able a(e*)e;a" ca!+a" de (e"o6 (!od)ciendo!eaccione" inaato!ia" *)e "e!ia la ca)"a

    de la "intoatolo+$a dolo!o"a de la a!t!iti"6de/ando coo (o"ibilidad *)e la(!e%alencia de la o"teoa!t!iti" en anciano"e"te !elacionada con cabio" en la at!i&

    ca!tila+ino"a

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    El ca!t$la+o ?ialino )e"t!a )na ca(acidad)' liitada de !e(a!acin

    S)" c>l)la" de(enden de la di#)"in den)t!iente" ' o3i+eno en di"tancia"con"ide!able" a t!a%>" de la at!i&

    C)ando di"in)'e el )/o de "an+!eal!ededo! del ca!t$la+o6 ")" c>l)la" ()edeno!i! ' el ca!t$la+o e" in%adido (o! %a"o""an+)$neo" ' c>l)la" #a+ocita!ia" ient!a"

    *)e la at!i& e" !eab"o!bida ' ")"tit)ida(o! te/ido cicat!i&al

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

    Le"ione" del ca!tila+o

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    Le"ione" del ca!tila+oa!tic)la!

    El ca!t$la+o ?ialino (o"ee )na !elacinin/)!ia9!e"()e"ta )' e"t!ec?a

    La a+nit)d ' el +!ado de le"in del

    ca!t$la+o de(ende!. del ecani"o '+!ado de !e"()e"ta !e(a!ati%a

    La !e"()e"ta !e(a!ati%a *)e el ca!t$la+o e"ca(a& de da! e" in")2ciente ' de al

    (!ono"tico en +ene!al

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

    De ac)e!do con la a+nit)d del da;o

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    De ac)e!do con la a+nit)d del da;o+ene!ado en el ca!tila+o ?ialino e3iten

    +!)(o" de le"ion1

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

    Le"ion a+)da "in di"!)(cion

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    Le"ion a+)da "in di"!)(cionde te/ido %i"ible

    Le"in con a'o! ca(acidad de e/o!$a

    T!a)ati"o cont)"o ce!!ado coo )nt!a)a de ca!+a !e(etiti%a6 ind)ce

    cabio" "i+ni2cati%o" en la ?i"tolo+$a6bio*)$ica ' ca!acte!$"tica" e"t!)ct)!ale"de la at!i&

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

    Una de la" (!ie!a" alte!acione"

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    (ob"e!%ada" en e"te ti(o de le"ion

    co!!e"(onde 1

    9 (e!dida de (!oteo+licano" o di"!)(cinde ") o!+ani&acin

    F9di"in)cion en la concent!acin de

    (!oteo+licano"6 alte!ando la" (!o(iedade"2"ca"

    9(e"o o ca!+a ")(!a2"iolo+ica "ob!e 'adebilitada" (!ote$na" e"t!)ct)!ale"

    79cabio" del edio abiente *)e !odeaal cond!ocito

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

    Di"!)(cion ecanica del

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    Di"!)(cion ecanica delca!tila+o

    No e3i"te )na edida e3acta de laa+nit)d de la #)e!&a *)e el ca!t$la+o e"ca(a& de "o(o!ta! ante de ")#!i! da;oe"t!)ct)!al ac!o"c(ico

    Sin eba!+o el liite c!itico de inte+!idade"t!)ct)!al de lo" cond!ocito" e"e*)i%alente a F89F M(a"

    Un e"t!>" ")(e!io! a e"ta edida +ene!a!a)e!te ' 2")!a del cond!ocito

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    S) etiolo+$a ()ede e"ta! en le"ione" *)e

    (enet!an la a!tic)lacin6 (!od)ciendolace!acin o ab!a"in del ca!t$la+o

    La !e"()e"ta ti")la! a e"te da;o "eenc)ent!a ca!acte!i&ado (o! )n te/ido

    a%a"c)la!6 no e3i"te la +ene!acin de )n#eneno de inaacin cl."ico

    Po! tanto el cond!ocito "on lo" !e"(on"able"

    de todo el (!oce"o de !e(a!acin

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation o#in/)!ied o! de+ene!ated a!tic)la! ca!tila+e, Ae!ican acade' o# o!t?o(aedic ")!+eon"n7 /)l'a+)"t6HH76 (a+6 HF9F8HH7 4)c5alte! Jan5in J A!tic)la! ca!tila+ePa!t II de+ene!ation and o"tea!t?!o"i"6 !e(ai! !e+ene!ation and t!an"(lantationJ4one and /oint ")+e!'6 HH Ha6 (a+ :F9:F Da%id 2+)!oa6 d6 Ra#ael cal%o 6 d6 ale3%ai"an6 d6 an+od' 6 GKi"?6 & 5a!(ati O"tec?ond!al (l)+"1 a)to+eno)" o"teoc?ond!al o"aic(la"t' #o! t?e t!eatent o# #ocal c?ond!al and o"teoc?ond!al de#ect"Io(e!ati%e Tec?ni*)e in O!t?o(aedic"6 %ol6 n)be!76octobe!HH6 (a+ F9FF/)n95'o6S)?6 (?det al ba"ic "cience o# a!tic)la! ca!tila+e in/)!' and !e(ai!, O(e!ati%e

    tec?ni*)e in "(o!t" edicine %ol6n)be! F6 (a+ 9:6 ab!il HH Kinne! 46 ca(ito R6 "(ecto! M Re+ene!ation o# a!tic)la! ca!tila+ead% bioc?e en+ biotec?nolF88H71(a+ H9F Menc?e 6 Da%id "6 d a+"ne""6 T?oa" /!6 d et al T?e t!eatent o# i"olated a!tic)la! ca!tila+e le"ion" in t?e 'o)n+ indi%id)al, Ae!ican Acade'o# O!t?o(aedic S)!+eon" In"t!)ctional Co)!"e lect)!e"ol76 (a+6 89 HH OD!i"coll S T?e ?ealin+ and !e+ene!ation o# a!tic)la! ca!tila+e J bone /oint ")!+ a

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    Le"in O"teocond!al

    En e"te ca"o el t!a)ati"o e" de tala+nit)d *)e incl)'e le"in del ?)e"o")bcond!al o #!act)!a o"teocond!al

    E"ta le"in !e(a!a dando o!i+en a te/ido

    2b!oca!tila+ino"o con (!o(iedade" )'di"tinta" al ca!t$la+o ?ialino a!tic)la!no!al

    La !e"ta)!acin de la (laca ")bcond!altoa #o!a a (a!ti! de la" :9 "eana"

    Al#o!d /6 cole b/ ca!tila+e !e"to!ation6 (a!t1 ba"ic "cience6 ?i"to!ial (e!"(ecti%e6 (atient e%al)ation6 and t!eatent o(tion" a / "(o!t" ed F88 (a+ FH98: 4!ittbe!+M6inal"5i C E%al)tion o# ca!tila+e in/)!ie" and !e(ai! J bone /oint ")!+ a F881(a+9:H 4)c5alte! /6 d o %an c6 (?6 and !atcliQe Ant?on'6 (?d,!e"to!ation