Gabapentin
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Reactions 1485, p21 - 25 Jan 2014 S Gabapentin Choreoathetosis in an elderly patient: case report A 74-year-old woman developed choreoathetosis while receiving gabapentin for painful tonic spasms (PTS) associated with neuromyelitis optica spectrum disorder [NMOSD; route not stated]. The woman was diagnosed with NMOSD and initially treated with methylprednisolone. Due to the development of PTS, she began receiving carbamazepine. Her PTS improved, but she developed thrombocytopenia. Two days after switching from carbamazepine to gabapentin 400 mg/day, she developed choreoathetotic movement in her left arm. The dosage of gabapentin was increased to 600 mg/day, but the woman’s PTS and choreoathetosis did not improve. Her serum trough concentration of gabapentin was 4.08 mg/mL. Gabapentin was discontinued. Two days later, her serum concentration of gabapentin decreased to 0.23 mg/dL and her choreoathetosis disappeared. Author comment: "Gabapentin enhances gamma aminobutyric acid (GABA) synthesis and inhibits GABA degradation. . . [T]he choreoathetosis emerged after taking gabapentin and was accompanied by PTS. We suggest that modification of the GABA receptor activity and the cervical gray matter lesion had a role in the development of choreoathetosis." Sugeno N, et al. Choreoathetosis in a patient with neuromyelitis optica spectrum disorder. Neurology and Clinical Neuroscience 1: 154-156, No. 4, Jul 2013. Available from: URL: http://dx.doi.org/10.1111/ncn3.36 - Japan 803098399 1 Reactions 25 Jan 2014 No. 1485 0114-9954/14/1485-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved
Transcript of Gabapentin
Reactions 1485, p21 - 25 Jan 2014
SGabapentin
Choreoathetosis in an elderly patient: case reportA 74-year-old woman developed choreoathetosis while
receiving gabapentin for painful tonic spasms (PTS) associatedwith neuromyelitis optica spectrum disorder [NMOSD; routenot stated].
The woman was diagnosed with NMOSD and initiallytreated with methylprednisolone. Due to the development ofPTS, she began receiving carbamazepine. Her PTS improved,but she developed thrombocytopenia. Two days afterswitching from carbamazepine to gabapentin 400 mg/day, shedeveloped choreoathetotic movement in her left arm.
The dosage of gabapentin was increased to 600 mg/day, butthe woman’s PTS and choreoathetosis did not improve. Herserum trough concentration of gabapentin was 4.08 mg/mL.Gabapentin was discontinued. Two days later, her serumconcentration of gabapentin decreased to 0.23 mg/dL and herchoreoathetosis disappeared.
Author comment: "Gabapentin enhances gammaaminobutyric acid (GABA) synthesis and inhibits GABAdegradation. . . [T]he choreoathetosis emerged after takinggabapentin and was accompanied by PTS. We suggest thatmodification of the GABA receptor activity and the cervicalgray matter lesion had a role in the development ofchoreoathetosis."Sugeno N, et al. Choreoathetosis in a patient with neuromyelitis optica spectrumdisorder. Neurology and Clinical Neuroscience 1: 154-156, No. 4, Jul 2013.Available from: URL: http://dx.doi.org/10.1111/ncn3.36 - Japan 803098399
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Reactions 25 Jan 2014 No. 14850114-9954/14/1485-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved
