Teorica Apoptosis 2011.ppt [Sólo lectura]
Transcript of Teorica Apoptosis 2011.ppt [Sólo lectura]
![Page 1: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/1.jpg)
APOPTOSISAPOPTOSIS
2011
![Page 2: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/2.jpg)
![Page 3: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/3.jpg)
![Page 4: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/4.jpg)
• 1842 VOGT DESCRIPCIÓN MORFOLÓGICA
• 1890 BOINET CÉLULAS MUEREN DURANTE EL TRANSCURSO NORMAL DE LA VIDA
• 1972 KERR APOPTOSIS
• 1980 HORNVITZ MUERTE CELULAR PROGRAMADA
![Page 5: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/5.jpg)
![Page 6: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/6.jpg)
![Page 7: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/7.jpg)
![Page 8: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/8.jpg)
![Page 9: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/9.jpg)
![Page 10: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/10.jpg)
![Page 11: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/11.jpg)
![Page 12: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/12.jpg)
![Page 13: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/13.jpg)
![Page 14: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/14.jpg)
![Page 15: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/15.jpg)
![Page 16: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/16.jpg)
![Page 17: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/17.jpg)
APOPTOSIS MUERTE CELULAR PROGRAMADA
• CONDENSACIÓN NUCLEAR Y CITOPLASMÁTICA
• ALTERACIONES EN LA ESTRUCTURA DE LA MEMBRANA
• VARIACIÓN EN LA COMPOSICIÓN DE LÍPIDOS. TRANSLOCACIÓN DE LA FOSFATIDILSERINA
• BURBUJEO O BLEBBING DE LA MEMBRANA CELULAR
• RÁPIDA DESTRUCCIÓN DEL GENOMA
• ACTIVACIÓN DE ENDONUCLEASAS QUE CLIVAN EL DNA GENÓMICO EN MÚLTIPLES FRAGMENTOS INTERNUCLEOSOMALES
• FRAGMENTACIÓN DE LA CÉLULA EN CUERPOS APOPTÓTICOS
• ELIMINACIÓN DE LOS FRAGMENTOS CELULARES POR CÉLULAS FAGOCÍTICAS
![Page 18: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/18.jpg)
NECROSISDAÑO IRREVERSIBLE Y MUERTE RÁPIDA
• DILATACIÓN O SWELLING DEL NÚCLEO
• DILATACIÓN DE ORGANELAS CITOPLASMÁTICAS
• RUPTURA DE LA MEMBRANA PLASMÁTICA
• DESINTEGRACIÓN CELULAR
• LIBERACIÓN DE MATERIAL CITOPLASMÁTICO
• RESPUESTA INFLAMATORIA
![Page 19: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/19.jpg)
Nature Immunology
4, 5, 2003
Nature Immunology
4, 5, 2003
![Page 20: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/20.jpg)
![Page 21: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/21.jpg)
![Page 22: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/22.jpg)
![Page 23: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/23.jpg)
![Page 24: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/24.jpg)
![Page 25: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/25.jpg)
![Page 26: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/26.jpg)
![Page 27: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/27.jpg)
![Page 28: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/28.jpg)
![Page 29: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/29.jpg)
![Page 30: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/30.jpg)
![Page 31: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/31.jpg)
![Page 32: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/32.jpg)
![Page 33: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/33.jpg)
![Page 34: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/34.jpg)
![Page 35: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/35.jpg)
![Page 36: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/36.jpg)
New cellsurfacemarkers
Cellphagocytosis
withoutinflammation
Alteredchromatinstructure
Second messengers
Gene transcriptionCa 2+
Activation ofCa 2+
Dependent enzymes
Endonuclease Calpain Transglutaminase(protease)
DNA degradationand chromatincondensation
Disruption ofcytoskeletonand cellshrinkage
Crosslinkingof cytoplasmicproteins
Ionizing radiationAnticancer drugs toxins
Fig-1 Common metabolic events in apoptosis
Withdrawal of trophic factors
GlucocorticoidsTumor necrosis factor (TNF)Transforming growth factor (TGF-)Apo- 1/Fas kgand
Positivestimuli
![Page 37: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/37.jpg)
![Page 38: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/38.jpg)
![Page 39: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/39.jpg)
Immunity, 1,
2000,
Immunity, 1,
2000,
![Page 40: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/40.jpg)
![Page 41: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/41.jpg)
![Page 42: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/42.jpg)
![Page 43: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/43.jpg)
![Page 44: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/44.jpg)
![Page 45: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/45.jpg)
![Page 46: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/46.jpg)
![Page 47: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/47.jpg)
![Page 48: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/48.jpg)
![Page 49: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/49.jpg)
![Page 50: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/50.jpg)
![Page 51: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/51.jpg)
![Page 52: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/52.jpg)
![Page 53: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/53.jpg)
![Page 54: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/54.jpg)
![Page 55: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/55.jpg)
![Page 56: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/56.jpg)
![Page 57: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/57.jpg)
![Page 58: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/58.jpg)
![Page 59: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/59.jpg)
![Page 60: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/60.jpg)
![Page 61: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/61.jpg)
![Page 62: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/62.jpg)
![Page 63: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/63.jpg)
![Page 64: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/64.jpg)
![Page 65: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/65.jpg)
![Page 66: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/66.jpg)
![Page 67: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/67.jpg)
![Page 68: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/68.jpg)
![Page 69: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/69.jpg)
![Page 70: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/70.jpg)
![Page 71: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/71.jpg)
![Page 72: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/72.jpg)
![Page 73: Teorica Apoptosis 2011.ppt [Sólo lectura]](https://reader035.fdocuments.ec/reader035/viewer/2022071620/62d224ae59c24d0a7f201a25/html5/thumbnails/73.jpg)