Receptores
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Transcript of Receptores
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RECEPTORESCarol Andrea Casallas Vanegas
Farmacología Clínica
Noviembre 2011
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CONCEPTOS GENERALES
Fijación Inespecífica
Receptor Farmacológico
Receptores: macromoléculas de carácter proteico (lípidos, CHO)
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CONCEPTOS GENERALES
Receptores percibir estimulo y activar reacciones
Membrana Celular, Citoplasma, Núcleo
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CONCEPTOS GENERALES Afinidad
Especificidad
Eficacia
Potencia
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CONCEPTOS GENERALES
Receptores Transductores: receptor –
efector Vía de transducción Segundos mensajeros amplificación
Mecanismo de acción de los fármacos Alterado la concentración de
los ligandos endógenos: Aines, NE, IRS
Alteración Canales Iónicos
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EFECTOS
Adenil Ciclasa
α β γ
AMPcGMPc
5’GMP
5’AMP
PKA
Enzimas EfectorasCanales Iónicos
Transcripción Genética Diferenciación Proliferación
Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188
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RC PROTEINA G
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RC PROTEINA G
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Calcio AMPc PKA GEFs
PKG PDES
SEGUNDOS MENSAJEROS
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CANALES IONICOS
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CANALES IONICOS
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Tirosin Kinasas Factor de Crecimiento Epidemrico Janus Tirosin Kinasa Factores de Crecimeinto (SerinaTreonina
kinasa) Interferon Factor de necrosis Tumural (JAK STAT) Peptidos Natriureticos
TRANSMEMBRANA ENZIMAS
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RTK
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JAK STAT
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PEPTIDO NATRIURETICO
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NUCLEAR
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RECEPTORES
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GRACIAS!!!!
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