Efecto Del 02 y Reoxigenación

7/21/2019 Efecto Del 02 y Reoxigenación

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EFECTO DEL 02 YREOXIGENACIÓN

Jaime Humberto Soto Lugo R2RO



O!ge" e"#a"$eme"t ratio OER

%ro&or$i'" a(iti)a (e* 02 La &ro&or$i'" (e (o+i+ a(mi"i+tra(a ba,o

$o"(i$io"e+ #i&'i$a+ a aerea(a+ &ara

*ograr mi+mo e-e$to bio*'gi$o 2./1./ &ara r ! r



3o(i4$a(ore+ (e* OER

5. Fa+e (e* $i$*o 6i")er+o ara(io+e"+ibi*i(a(78

3a!or e" G5 ! me"or e" S

2. E"erg9a (e ra(ia$i'" A me"or e"erg9a ma!or OER: e$e&to

me"or a 5 G!

1. Ti&o (e ra(ia$i'"8 De"+i(a( A me"or (e"+i(a( ma!or OER

;. Co"$e"tra$i'" 02



2. E"erg9a (e ra(ia$i'"



1. Ti&o (e ra(ia$i'"8 De"+i(a(



3e$a"i+mo (e a$$i'" (e* 02

Ra(i$a*e+ *ibre+82<1 (e* e-e$to(e R

=i(a (e 50/+

Di>metro ;mi$ra+

Forma$i'" (e&er'i(o8

Irre)er+ib*e



3e$a"i+mo (e a$$i'" (e* 02

Hi&'te+i+ (e 4,a$i'" (e* 02



Co"$e"tra$i'" <e-e$to

I(ea* 2/? (e02 610mmHg7

Te"+i'" 02

te,i(o+ %rome(io 20

;0 mm Hg

Ra"go5 500mm Hg.



Co"$e"tra$i'"<e-e$to

6A7 C9r$u*o+ &O2 5.@ mm Hg

Cua(ra(o+ b$o8

&O2 0.2/ mmHg Cua(ra(o "go8

&O2 0.0@/ mmHg

67 Tri>"gu*o+&O2 o- 0.00@/mm Hg



Hi&oia

Agu(a

• O$*u+i'")a+$u*ari"termite"te

I"terme(ia

• CB*u*a+uie+$e"te+$*o"ogB"i$

a+ "ora(io+e"+ib*e+

Cr'"i$a

• Di+ta"$ia$e*)a+oma!or @0mi$ra+



Hi&oia $r'"i$a



Hi&oia agu(a )+ $r'"i$a



Hi&oia ! Hb



Cur)a+ (e +u&er)i)e"$ia e" tumore+.

CB*u*a+ $o" (i-ere"te+gra(o+ (e Hi&oia



TB$"i$a+ &ara me(i$i'" (e #i&oia

E&&e"(or- Corre*a$i'" $o" $o"tro*

tumora* ! agre+i)i(a((e tumor

Nitroimi(ao*e+6&imo"i(ao*78 IH

Di+ti"$i'" e"tre te,i(o)iab*e ! "e$r'ti$o

Di+ti"$i'" e"tre #i&oia$r<ag

Co"$e"tra$i'" $e*u*ar

(e 02



TB$"i$a+ &ara me(i$i'" (e #i&oia8

Nitroimi(ao*e+.



TB$"i$a+ &ara me(i$i'" (e #i&oia

3ar$a(ore+ e"('ge"o+ (e #i&oia8a"#i(ra+a IX 6CA7 -a$tor i"(u$ib*e &or#i&oia 6HIF7

Regu*a(o+ &or -a$tore+ a(em>+ (e 02 E"+a!o $ometa DNA Com&ara$i'" DS e" te,i(o 'i$o )+

#i&'i$o



REOXIGENACIÓN



Reoige"a$i'"

CB*u*a+ #i&'i$a+(e oige"a"&o+terior a u"a

(o+i+ (e ra(ia$i'" Dire$tame"te

&ro&or$io"a* a*tiem&o

Fra$$io"amie"to(e RT



Se$ue"$i

a e" e*tiem&o



Se$ue"$ia e" tiem&o (e a$uer(o a ti&o (etumor

Cir$u*o b$o8Car$i"omamamario rat'"

Tri>"gu*o "go8

Sar$oma rata Tri>"$u*o b$o8

O+teo+ar$omarat'"

Cir$u*o "go8Fibro+ar$omarat'"

Rombo8Fibro+ar$oma

rat'"

i (



3e$a"i+mo+ (ereoige"a$i'"



Im&orta"$ia (e *a Reoige"a$i'" e" RT

I i ( *



Im&orta"$ia (e *areoige"a$i'" Fra$$io"amie"to (e (o+i+

Tiem&o (e reoige"a$i'" e+&e$94$o (e$a(a ti&o tumora*

%rome(io 2 a 1 (9a+ CB*u*a+ ue "o re+&o"(e" a Rt

$o")e"$io"a*8 reoige"a$i'" i"a(e$ua(a

La ma!or9a (e *o+ tumore+ "o re+&o"(er9a"a 0 G! e" 10 - +i" 02 Agre+i)i(a( tumora*8 Re+&ue+ta !

%ro"'+ti$o



Hi&oia ! uimiorre+i+te"$ia

F*u,o +a"gu9"eo Di-u+i'" &H Ra(i$a*e+ *ibre+ %ro*i-era$i'" (i+mi"ui(a



Hi&oia ! &rogre+i'"5. I"e+tabi*i(a( ge"'mi$a

Ru&tura (e $romo+oma+ ! -u+i'" (e$romo+oma+ (ob*e+ e" regio"e+ -r>gi*e+6HSR7

Am&*i4$a$i'"8 E"(o"u$*ea+a 6&H o&timo ./7 I"#ibi$i'" (e 3*#5: 3+H2: a"( 3+H Aume"to e" i"e+tabi*i(a( &or re&eti$i'" (e

(i"u$*e'ti(o+ Aume"to e" a$ti)i(a( (e Ra( /58

(i+mi"u$i'" (e re$ombi"a$i'" #om'*oga



Hi&oia ! &rogre+i'"5. I"e+tabi*i(a( ge"'mi$a

Se*e$$i'" (e $B*u*a+ $o" (e-e$to+ e"a&o&to+i+8 b$* 2: &/1



Hi&oia ! &rogre+i'"5. Fa$tore+ tra"+$ri&$io"a*e+

F a $ t o r

t r a " + $ r i & $ i ' " • H I F 5 a * - a : C R E : A % 0 5 : N F 0 : A T F : X % 0 5

G e "

• 0 3 e t a b o * i + m o a " a e r o b i o

• 0 A " g i o g B " e + i + • 0 R e m o ( e * a $ i ' " • 0 % r o * i - e r a $ i ' " • 0 R e g u * a $ i ' "

t r a " + $ r i & $ i o " a *



Hi&oia ! &rogre+i'"1. Aume"to e" &ote"$ia* meta+t>+i$o

No i"i$ia &ero +i &romue)e e* &ote"$ia*meta+t>+i$o

A$umu*a$i'" (e muta$io"e+8 I"(e&e"(e"$ia a -a$tore+ (e $re$imie"to Degra(a$i'" (e matri etra$e*u*ar %ro(u$$i'" (e -a$tore+ a"giogB"i$o+



Hi&oia e" tumore+ (e #uma"o+



La #i&oia e+ u" i"(i$a(or (e agre+i)i(a(tumora* e" &a$ie"te+ $o" CaCu



&02 me(ia8 @./ mmHg meta+t>+i$o+ )+20 mm Hg "o

met+6& 0.017 Su&er)i)e"$ia *ibre

(e e"-erme(a( a 5Kme+e+8 @0? &02

50 mm Hg )+ 1/?M50 mm Hg 6& 0.057

E+tu(io+ e" #uma"o+



E+tu(io+ e" #uma"o+.Co"$*u+io"e+ La #i&oia e" u" tumor e+t> re*a$io"a(a

$o" +u agre+i)i(a( ! &or *o ta"to8 Re+&ue+ta a* tratamie"to %rogre+i'" meta+t>+i$a Sobre)i(a g*oba* ! *ibre (e e"-erme(a(

Efecto Del 02 y Reoxigenación

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