Acenocoumarol
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Reactions 1463, p5 - 3 Aug 2013 S Acenocoumarol DRESS syndrome in an elderly patient: case report An 85-year-old man developed DRESS syndrome while receiving acenocoumarol for thromboembolism prophylaxis. The man was started on acenocoumarol [route and dosage not stated] for prevention of venous thromboembolism due to atrial fibrillation. He presented at an emergency department 6 weeks later, experiencing syncope and exertional dyspnoea. A maculopapular rash was noted on his limbs and trunk, in addition to purple blisters and lesions on the distal region of his legs. Blood tests showed the following values: creatinine 1.95 mg/dL, urea 61 mg/dL, GGT 142 UI/L, and eosinophilia of 14.20%. The man was suspected to have experienced an adverse reaction to acenocoumarol, and the drug was withdrawn. He was admitted to hospital, and given systemic corticosteroids, antihistamines, fluid therapy, enoxaparin sodium and local wound healing. His skin lesions resolved, and he made a good clinical recovery. His abnormal laboratory values were normalising 1 month later. His clinical manifestations had completely resolved 45 days later. Skin patch tests were negative to dabigatran and warfarin, and he was subsequently commenced on dabigatran for thromboembolism prophylaxis. Author comment: "We report the case of an 85-year-old man with [a] diagnosis of DRESS syndrome induced by acenocoumarol". Pinero-Saavedra M, et al. DRESS syndrome induced by acenocoumarol with tolerance to warfarin and dabigatran: A case report. Blood Coagulation and Fibrinolysis 24: 576-578, No. 5, 2013. Available from: URL: http:// dx.doi.org/10.1097/MBC.0b013e32835facc8 - Spain 803090672 1 Reactions 3 Aug 2013 No. 1463 0114-9954/13/1463-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Transcript of Acenocoumarol
Reactions 1463, p5 - 3 Aug 2013
SAcenocoumarol
DRESS syndrome in an elderly patient: case reportAn 85-year-old man developed DRESS syndrome while
receiving acenocoumarol for thromboembolism prophylaxis.The man was started on acenocoumarol [route and dosage
not stated] for prevention of venous thromboembolism due toatrial fibrillation. He presented at an emergency department6 weeks later, experiencing syncope and exertional dyspnoea.A maculopapular rash was noted on his limbs and trunk, inaddition to purple blisters and lesions on the distal region ofhis legs. Blood tests showed the following values: creatinine1.95 mg/dL, urea 61 mg/dL, GGT 142 UI/L, and eosinophilia of14.20%. The man was suspected to have experienced anadverse reaction to acenocoumarol, and the drug waswithdrawn. He was admitted to hospital, and given systemiccorticosteroids, antihistamines, fluid therapy, enoxaparinsodium and local wound healing. His skin lesions resolved,and he made a good clinical recovery. His abnormal laboratoryvalues were normalising 1 month later. His clinicalmanifestations had completely resolved 45 days later. Skinpatch tests were negative to dabigatran and warfarin, and hewas subsequently commenced on dabigatran forthromboembolism prophylaxis.
Author comment: "We report the case of an 85-year-oldman with [a] diagnosis of DRESS syndrome induced byacenocoumarol".Pinero-Saavedra M, et al. DRESS syndrome induced by acenocoumarol withtolerance to warfarin and dabigatran: A case report. Blood Coagulation andFibrinolysis 24: 576-578, No. 5, 2013. Available from: URL: http://dx.doi.org/10.1097/MBC.0b013e32835facc8 - Spain 803090672
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Reactions 3 Aug 2013 No. 14630114-9954/13/1463-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
