Sociedad Hondureña de Epilepsia

Capítulo de la ILAE

Dra. Claudia AmadorDr Marco Tulio Medina

Dra. Sofia Dubon

The Flag of Honduras

Honduran Epilepsy Society

1. Dr. Claudia Amador * President

2. Dr. Heike Hesse Vice President

3. Prof. Marco T. Medina Past President

4. Dr. Reyna Duron Secretariat

5. Dr. Lazaro Molina Treasurer

HONDURAS

Is a Central America Country with a Population of 8 millions

Health Care Three Health Systems in

Honduras:1. Ministry of Health 2. Social Security for

state workers and others

3. Private Hospitals

Neurological Care

• There was one neurologist per 325,000 inhabitants in 1998

• Neurological diseases account for approx. 20% of the medical consultations in hospitals

Formación de Neurólogos y Epileptólogos WFN

Epidemiología (Medina et al Epilepsia 2003, 2005)

TREATMENT

Status Epilepticus

Proyecto Demostrativo en Honduras: Brecha de Tratamiento

Community Intervention (Medina et al 2010, submitted)

Significant reduction of Epilepsy due to NCC (36% versus 13.9%)

Neuroepidemiology Studies

The Salama Epilepsy StudyETIOLOGY OF EPILEPSY (n=90)

Neurocysticercosis 37%

Cryptogenic (occult) 30%

Idiopathic 8%

Perinatal brain damage 8 %Head trauma 3%CNS malformations 2%Vascular 2%

Other neuroinfections 2%Other causes* 8%

Other causes: inespecific calcified lesions, alcohol toxicity, inespectific intraventricular cyst, multifactorial.

Government involvement

Epilepsy Surgery Program in Honduras

Disease JME CAE

Phenotype

Myoclonic, grand mal epilepsy, 1/3 with absences

Pyknoleptic (2-200/day) absences of

childhood

Pathology Microdysgenesis-Displaced and dystopic cells

Normal

Gene Myoclonin/EFHC1

GABRB3

Transgenic mice

KO mice replicate pathology and susceptibility

KO mice replicate epilepsy

Epilepsy GenesEpilepsy genes found in Honduras

Suzuki et al.Nature Genetics, 2004

Tanaka M, Olsen RW, Medina MT, et al Am J Hum Genet. 2008 Jun;82(6):1249-61.

Medina MT et al. Neurology 2008

Group of Patients

• Epilepsy (FUNDACION HONDURENA DE EPILEPSIA)

Publicaciones (Books and Journals

Latin American Epilepsy Academy (Academia Latino Americana de Epilepsia ALADE) Founded in Sao Paulo Feb. 27th, 2007