Post on 11-Oct-2015
description
7/13/2019 Efecto Neuroquimico y Conductual de La Miotoxina III de Bothrops Asper Luego de Su Inyeccion en El Mesencefalo
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[E@YKXS@MFM MK CDS]F X@CF
S@S]KOF MK KS][M@DS MK RDSNXFMD
KIKC]D EK[XDV[O@CD P CDEM[C][FL MK LF
O@D]DZ@EF @@@ MK Hdtjrdps fspkr,
L[KND MK S[ @EPKCC@E KE KL
OKSKECIFLD MK XF]FS FM[L]FS
]ks`s sdokt`mf f cdes`mkrfc`e mk lf Cdo`s`e mkl Rrdnrfof mk Kstum`ds mkRdsnrfmd ke C`kec`fs H`dom`cfs pfrf dptfr pdr kl nrfmd mk Ofn`stkr Sc`ket`fkke C`kec`fs H`dom`cfs cde eifs`s ke Ifrofcdldnf
OFE[KL DXKFO[ED WKRKMF
C`umfm [e`vkrs`tfr`f Xdmr `nd Ifc`d, Cdstf X`cf
8220
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``
MKM@CF]DX@F
F o`s pfmrks Ofeukl y Jdrtkes`f.
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```
FNXFMKC@O@KE]DS
Mr. Hrued Ldodetk, Rj. M., `evkst`nfmdr @est`tutd Cldmdo`rd R`cfmd, [e`vkrs`mfm
mk Cdstf X`cf.
O Sc. Klv`rf Sflfs, OSc Gufe Cfrlds Hrkeks, H Sc Fmr`fef Sfhdrd, H Sc.
Femrkf Odenk, O`cjfkl Rfm`llf y dtrds `evkst`nfmdrks y fs`stketks mkl
Rrdnrfof mk @evkst`nfc`e ke Ekurdc`kec`fs.
O Sc. Cfrlds vde Ofrscjfll Our`lld, prdiksdr mk kstfmst`cf [e`vkrs`mfm Lft`ef
mk Cdstf X`cf.
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`v
Kstf ]ks`s jf s`md fckptfmf pdr lf Cdo`s`e mkl Rrdnrfof mk Kstum`ds mk
Rdsnrfmd ke C`kec`fs H`dom`cfs mk lf [e`vkrs`mfm mk Cdstf X`cf, cdod
rkqu`s`td pfrc`fl pfrf dptfr fl nrfmd mk Ofn`stkr Sc`ket`fk ke C`kec`fs
H`dom`cfs cde eifs`s ke Ifrofcdldnf.
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTRj. M. Hrued Ldodetk Y`nl`dtt`
Xkprksketfetk mk lf Mkcfef, S`stkof mk Kstum`ds mk Rdsnrfmd
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTRj. M. Gf`ok Idrefnukrf ]rfs
M`rkctdr mk ]ks`s
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTRj. M. Gds Ofrf Nut`rrkz Nut`rrkz
Fsksdr
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTO. Sc. Fmr`fef Surkz [rjfe
Fsksdrf
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTRj. M. Ckc`l`f Mfz Drk`rd
M`rkctdrf Rrdnrfof mk Rdsnrfmd ke C`kec`fs H`dom`cfs
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTOfeukl Drkfoued Wkpkmf
Cfem`mftd
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v
EM@CK NKEKXFL
MKM@CF]DX@F ................................................................................................... `
FNXFMKC@O@KE]DS ........................................................................................ ` `
EM@CK NKEKXFL ............................................................................................. v
XKS[OKE .......................................................................................................... x
L@S]F MK C[FMXDS ........................................................................................ x`
L@S]F MK I@N[XFS ........................................................................................ x`v
EM@CK MK FHXKY@F][XFS.......................................................................... xx`
CFR][LD @ ........................................................................................................ 6
6. @E]XDM[CC@E ............................................................................................ 6
CFR][LD @@ ....................................................................................................... >
8. OFXCD ]KX@CD ......................................................................................... >
8.6 Lds Nfenl`ds hfsflks .............................................................................. >
8.8 Ekurdquo`cf ke lds Nfenl`ds Hfsflks............................................... 68
8.3 S`stkof mdpfo`ern`cd ke kl S`stkof Ekrv`dsd Cketrfl ................... 6=
8.= Lf keikrokmfm mk Rfra`esde ................................................................ 6:
8.; Odmkld ke rftfs mk lks`e `etrfckrkhrfl cde 9-j`mrdx`mdpfo`ef ...... 8=
8.9 Kikctd cdemuctufl ke rftfs, `emuc`md pdr lks`e mk lf SEpc cde 9-
DJMF ............................................................................................................ 32
8.> Fct`v`mfm idsidl`pfsf F8........................................................................ 3=
8.: Kikctd ifrofcdln`cd mk lf o`dtdx`ef @@@ mk Hdtjrdps fspkr............. 3>
CFR][LD @@@ .................................................................................................... =6
3. OF]KX@FLKS P O]DMDS ........................................................................ =6
3.6 Kqu`pds `estruoketflks y oftkr`flks. ................................................. =6
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v`
3.8 Xkfct`vds y kstemfrks feflt`cds ....................................................... =8
3.3 Mkscr`pc`e nkekrfl mk lf `evkst`nfc`e ............................................. ==
3.= F`s lfo`ketd y pur` i`cfc`e mk lf o`dtdx`ef @@@ ..................................... ==
3.; Odm`i `cfc`e (flqu`lfc`e) mk lf o`dtdx`ef @@@ ...................................... =9
3.9 Sugktds mk fel`s`s ................................................................................ =>
3.> Ekurdc`runf k `eykcc`e `etrf pfrs cdopfctf................................... =:
3.: Okm`c `e mk lf cdemuctf ....................................................................... ;2
3.0 Sfcr`i `c `d mk lds fe`oflks ..................................................................... ;=
3.62 M`skcc`e mk lds tkg`mds ckrkhrflks ................................................... ;;
3.66 Fel `s `s j`stdln`cds ........................................................................... ;>
3.68 Fel `s `s ekurdquo`cds ...................................................................... ;>
3.63 Rr`okr kxpkr`oketd7 Kvflufc`e kxpldrftdr `f, f trks mds`s , mkl
kikctd mk lf O]-@@@, luknd mk su `eykcc`e ke lf SEpc .............................. 96
3.6= Sknuemd kxpkr`oketd7 Kvflufc`e kxpldrftdr`f mk lf kvdluc`e mkl
prdcksd mk lks`e ekurdefl mk lf o`dtdx`ef ke cuftrd odoketds
pdstdpkrftdr`ds ........................................................................................... 96
3.6; ]krckr kxpkr`oketd7 Cdopfrfc`e mkl kikctd pdr lks`e cde lf
o`dtdx `ef y cde lf o`dtdx`ef flqu`lfmf ke kl s`t`d cftflt`cd, f mds`s
cdestfetk...................................................................................................... 98
3.69 Fel`s`s kstfmst`cd mk lds rksultfmds ............................................... 93
CFR][LD @Y ................................................................................................... 9;
=. XKS[L]FMDS ............................................................................................. 9;
=.6 @oplkoketfc`e mk uef oktdmdldnf pdr JRLC/KM pfrf lf
mktkro`efc`e mk ekurdtrfeso`sdrks y sus oktfhdl`tds ke tkg`md
ckrkhrfl ........................................................................................................ 9;
=.6.6 Cdem`c`deks crdoftdnri`cfs. ............................................................... 9;
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v``
=.6.8 Cdem`c`deks mkl mktkctdr ....................................................................... 99
=.8 Xksultfmds mkl pr `okr kxpkr`oketd ..................................................... 9:
=.8.6 Mkscr`pc`e nkekrfl .............................................................................. 9:
=.8.8 Yfr`fc`e mkl pksd cdrpdrfl murfetk kl kxpkr`oketd ............................. 90
=.8.3 Cdemuctf mk n`rd ................................................................................... >2
=.8.= Cdemuctf mk pkr`tfx`s ........................................................................... >;
=.8.; Cdemuctf mk ldcdodc`e ....................................................................... :2
=.8.9 Cdemuctf mk kxpldrfc`e ...................................................................... :6
=.8.> Cdemuctf mk fc`cflfo`ketd ................................................................... :3
=.8.: Fel`s`s ekurdquo`cds ke kstr`fmd mdrsfl ............................................ :;
=.8 0 Fel`s`s ekurdquo`cds ke kstr`fmd vketrfl. .......................................... :>
=.8.62 Fel`s`s ekurdquo`cds ke skptd. ....................................................... :0
=.3 Xksul tfmds mkl sknuemd kxpkr`oketd ................................................. 02
=.3.6 Mkscr`pc`e nkekrfl .............................................................................. 02
=.3.8 Fel`s`s ekurdquo`cds ke kstr`fmd mdrsfl ............................................ 06
=.3.3 Fel`s`s ekurdquo`cds ke kstr`fmd vketrfl y skptd .............................. 0=
=.= Xksultfmds mkl tkrckr kxpkr`oketd. ..................................................... 0>
=.=.6 Mkscr`pc`e nkekrfl .............................................................................. 0>
=.=.8 Yfr`fc`e mkl pksd cdrpdrfl murfetk kl kxpkr`oketd ............................. 0:
=.=.3 Cdemuctf mk n`rd ..................................................................................622
=.=.= Cdemuctf mk pkr`tfx`s ..........................................................................62:
=.=.; Cdemuctf mk ldcdodc`e ......................................................................66:
=.=.9 Cdemuctf mk kxpldrfc`e .....................................................................682
=.=.> Cdemuctf mk fc`cflfo`ketd ..................................................................688
=.=.: Fel`s`s ekurdquo`cds ........................................................................68;
=.=.0 Fel`s`s j`stdln`cds .............................................................................632
CFR][LD Y .................................................................................................. 63>
;. M@SC[S@E MK XKS[L]FMDS P CDECL[S@DEKS ............................... 63>
;.6 Oktdmdldnf crdoftdnri`cf pdr JRLC/KM .............................................63>
;.8 Yfr`fc`e mkl pksd mk lds fe`oflks murfetk lds kxpkr`oketds................630
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v```
;.3 Odrtfl`mfm mk lds fe`oflks .....................................................................630
;.= Yfr`fc`e mkl kikctd mk lf o`dtdx`ef O]-@@@ eft`vf cde lf mds`s `eykctfmf
ke SEpc. .......................................................................................................6=6
;.; Kikctd mk lf O]-@@@ kl mf mk lf c`runf.....................................................6==
;.9 Kikctd mk lf O]-@@@ eft`vf y lf O]-@@@ flqu`lfmf sdhrk lfs cdemuctfs
kspdetekfs mk n`rd y pkr`tfx`s, kl pr`okr mf pdstdpkrftdr`d. ......................6=:
;.> Kikctd mk lf O]-@@@ eft`vf y lf O]-@@@ flqu`lfmf sdhrk lfs cdemuctfs
kspdetekfs mk n`rd y pkr`tfx`s, mkspus mkl pr`okr mf pdstdpkrftdr`d. .....6;>
;.: Kikctd mk lf O]-@@@ eft`vf y lf O]-@@@ flqu`lfmf sdhrk lfs cdemuctfs
kspdetekfs mk ldcdodc`e, kxpldrfc`e y fc`cflfo`ketd. ..........................698
;.0 Kikctd `emuc`md pdr fpdodri`ef ke lfs rftfs lks`defmfs cde lf O]-@@@
eft`vf y lf O]-@@@ flqu`lfmf, kl mf 82 pdstdpkrftdr`d. ....................................69:
;.62 Kikctd `emuc`md pdr feiktfo`ef ke lfs rftfs lks`defmfs cde lf O]-@@@
eft`vf y lf O]-@@@ flqu`lfmf, kl mf 88 pdstdpkrftdr`d. ....................................6>:
;.66 Cdopfrfc`e mkl kikctd pdr lks`e cde lf o`dtdx`ef (O]-@@@) eft`vf y
cde lf o`dtdx`ef (O]-@@@) flqu`lfmf ................................................................6:=
;.68 Cdeclus`deks ........................................................................................6:0
CFR][LD Y@ ................................................................................................. 60>
9. XKIKXKEC@FS H@HL@DNXI@CFS ........................................................... 60>
Cfptuld Y@@ .................................................................................................... 820
>. FEKZDS ..................................................................................................... 820
Fekxd @. Knrksds Jdsp`tflfr`ds mk lf Cfgf Cdstfrr`ckesk mkl Sknurd Sdc`fl
(CCSS), mk pfc`ketks m`fnedst`cfmds cde lf keikrokmfm mk Rfra`esde.
822; f 822>. .................................................................................................820
Fekxd @@. Rkro`sd mkl Cdo`t @est tuc`defl pfrf kl Cu`md y [sd mk Fe`oflks
(C@C[F) ........................................................................................................866
Fekxd @@@. M`fnrfofs mk lfs v`stfs mdrsfl (supkr`dr) y lftkrfl (`eikr`dr) mkl
crekd mk uef rftf ofcjd ^`stfr mk 802 n mk ofsf cdrpdrfl. Lfs v`stfs
oukstrfe lfs pds`c`deks mk lds puetds mk rkikrkec`f7 Hrknof, lf cfrf
pdstkr`dr mk lds `ec`s`vds y kl plfed mk lf lekf `etkrfurfl. ............................868
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`x
Fekxd @Y. M`fnrfofs pfrf lf uh`cfc`e kstkrkdtx`cf mk lf SEpc ke ue
ckrkhrd mk rftf ofcjd ^`stfr mk 802 n. Sk prksketf lds cdrtks cdrdefl ke
Hrknof - ;,32 oo1 sfn`tfl ke lftkrfl 6,02 oo y jdr`zdetfl ke hrknof :,62
oo. ...............................................................................................................863
Fekxd Y. Rrdckm`o`ketds mk t`ec`e mk cdrtks cdrdeflks mk ckrkhrd mk rftf
mk 8; o mk nrdsdr. ......................................................................................86=
Fekxd Y@. Cufmrds cde lds mftds em`v`muflks mk cdemuctf y mk
ekurdquo`cf pfrf lds trks kxpkr`oketds. ....................................................869
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x
XKS[OKE
Lf o`dtdx`ef O]-@@@ mk Hdtjrdps fspkr, uef idsidl`pfsf F8clfsk @@, iuk `eykctfmfkstkrkdtx`cf y ue`lftkrfloketk ke lf suhstfet`f e`nrf pfrs cdopfctf(SEpc) ke
rftfs ofcjd Sprfnuk Mfwlky fmultfs cde kl i`e mk cfrfctkr`zfr su kikctdsdhrk flnuefs cdemuctfs (odtdrfs y skes`t`vfs), tfetd kspdetekfs cdod`emuc`mfs ifrofcdln`cfoketk. Fmkos sk cfrfctkr`z su kikctd sdhrk lfekurdquo`cf ke kstr`fmd mdrsfl y vketrfl pdr JRLC cde mktkctdrklkctrdquo`cd. Sk kvflufrde mds`s mk lf O]-@@@ ketrk 2,6= y 6= n. Fmkos skcfrfctkr`z kl kikctd mk lf O]-@@@ flqu`lfmf cde p-HRH f lf mds`s mk 6,= n. Klmf mk lf c`runf sk o`m` ue fuoketd `opdrtfetk mk lds e`vklks mk mdpfo`ef,MDRFC y JYF ke kl jko`sikr`d `etkrvke`md. Kspdetekfoketk, ketrk kl mf uedy trks pdstdpkrftdr`ds sk o`m` ue n`rd `etkesd cdetrflftkrfl y uef pkr`tfx`s`ps`lftkrfl, pds`hlkoketk mkh`md fl fuoketd fs`otr`cd mk lds e`vklks mkmdpfo`ef ke kstr`fmd `ps`lftkrfl rkspkctd fl lfmd mk lf lks`e. Jfc`f kl mf 6:
pdstdpkrftdr`d lfs cdemuctfs fs`otr`cfs kspdetekfs t`kemke nrfmufloketk flf s`oktrf ld quk pds`hlkoketk ks `em`cft`vd mkl fvfeck lketd mk ue prdcksdekurdmknkekrft`vd. Cde lf O]-@@@ eft`vf y lf O]-@@@ flqu`lfmf (6,= n) sk dhtuvdlks`deks odmkrfmfs mk (8: 66) %, oh`td (-6 f 96%) y (8> 68) %, oh`td (-9f 9;) % rkspkct`vfoketk. Lf fpdodri`ef (2,;2 on/an, sc), `emuck ue n`rd y uefpkr`tfx`s `ps`lftkrflks y lf feiktfo`ef (6,2 on/an, `p) `emuck ue n`rd cdetrflftkrfly uef pkr`tfx`s `ps`lftkrfl. Sk prdpdek quk lds fe`oflks mksfrrdllfeokcfe`sods mk cdopkesfc`e ekurdquo`cf prks`ept`cds. Kl kikctd mk lf O]-@@@ flqu`lfmf ke kl s`t`d cftflt`cd RLF8cde p-HRH, ks skokgfetk fl okm`md pfrflf O]-@@@ eft`vf, mk kvdluc`e os lketf y mk okedr `etkes`mfm. Sk prdpdek quklds okcfe`sods mk lks`e mk lf O]-@@@ ke kl s`stkof e`nrd-kstr`ftfl, y lf
kxprks`e mk lfs cdemuctfs `emuc`mfs pdr lks`deks odmkrfmfs cde O]@@ sde keflnueds fspkctds m`ikrketks y ke dtrds skokgfetks f lds rkpdrtfmds ke lfl`tkrfturf pdr lks`e cde tdx`efs cls`cfs quk sk koplkfe ke lds odmkldsfe`oflks mk lf keikrokmfm mk Rfra`esde cdod lf 9-DJMF. Cde kstk kstum`d,sk fpdyf kl pdstulfmd quk lf cdemuctf mk pkr`tfx`s ks uef cdemuctf quk pkro`tkokm`r prdcksds ekurdln`cds m`ikrketks y mk uef ofekrf os skes`hlk quk lfcdemuctf mk n`rd.
Kstk kstum`d prdpdek ue eukvd odmkld pfrf kstum`fr lf neks`s y prdnrks`e mkkeikrokmfmks ekurdmknkekrft`vfs cde uef tdx`ef os pdtketk y okm`fetk mdsokcfe`sods mk lks`e (ued RLF8y dtrd mkscdedc`md), prdnrks`vds y lketds. Ed
sk mkscfrtf quk lf fcc`e mk lf O]-@@@ pukmf skr okm`fetk s`t`ds mk ue`e t`pd E.Kstk ks kl pr`okr kstum`d ke kl quk sk kstum`f lf `eius`e ue`lftkrfl ke SEpc mkuef o`dtdx`ef RLF8 ed ekurdtx`cf ke ckrkhrd. Kstk odmkld fe`ofl skprdpdek cdod uef eukvf y okgdr idrof mk kstum`fr prdcksds ekurdln`cds mklks`e ke SEpc, quk pdmrfe skr t`lks pfrf cdoprkemkr lds okcfe`sods mk ldskstfmds tkoprfeds mk lf keikrokmfm mk Rfra`esde ke lds juofeds.
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x`
L@S]F MK C[FMXDS
Cufmrd @7Cflkemfr`d mk cfmf uef mk lfs fct`v`mfmks quk sk rkfl`zfrde cde lds
fe`oflks..................................................................................................... ;2
Cufmrd @@7Knrksds jdsp`tflfr`ds pdr fd y kmfm mk tdmds lds jdsp`tflks mk lf
Cfgf Cdstfrr`ckesk mkl Sknurd Sdc`fl (CCSS). @eidrofc`e tdofmf mk lf
hfsk mk mftds mkl Mkpfrtfoketd mk Kstfmst`cfs mk Sflum mk lf CCSS y
cdoprkemk lds fds 822; f 822>............................................................ 820
Cufmrd @@@7 N`rds ektds (`ps` okeds cdetrf) murfetk 82 o`eutds pdr mf, pfrf
cfmf ued mk lds fe`oflks mk cuftrd nrupds mk trftfo`ketd cde m`ikrketks
mds`s mk lf o`dtdx`ef @@@, eft`vf7 hfgf7 2,6= n1 okm`f7 6,= n1 fltf7 6= n y
kl nrupd cdetrdl........................................................................................ 869
Cufmrd @Y7Murfc`e ke sknuemds mk lf cdemuctf mk pkr`tfx`s ektf (`ps` okeds
cdetrf) murfetk 82 o`eutds pdr mf, pfrf cfmf ued mk lds fe`oflks mk
cuftrd nrupds mk trftfo`ketd cde m`ikrketks mds`s mk lf o`dtdx`ef @@@, eft`vf7
hfgf7 2,6= n1 okm`f7 6,= n1 fltf7 6= n y kl nrupd cdetrdl..................... 86>
Cufmrd Y7 Eokrd mk crucks mk cufmrfetks v`rtuflks mkl cfopd fh`krtd,
murfetk 82 o`e, pfrf cfmf ued mk lds fe`oflks mk cuftrd nrupds mk
trftfo`ketd cde m`ikrketks mds`s mk lf o`dtdx`ef @@@, eft`vf7 hfgf7 2,6= n1
okm`f7 6,= n1 fltf7 6= n y kl nrupd cdetrdl............................................ 86:
Cufmrd Y@7Murfc`e mk lf cdemuctf mk kxpldrfc`e ke sknuemds, murfetk 82
o`eutds pdr mf, pfrf cfmf ued mk lds fe`oflks mk cuftrd nrupds mk
trftfo`ketd cde m`ikrketks mds`s mk lf o`dtdx`ef @@@, eft`vf7 hfgf7 2,6= n1
okm`f7 6,= n1 fltf7 6= n y kl nrupd cdetrdl............................................ 860
Cufmrd Y@@7 Murfc`e mk lf cdemuctf mk l`op`kzf ke sknuemds, murfetk 82
o`eutds pdr mf, pfrf cfmf ued mk lds fe`oflks mk cuftrd nrupds mk
trftfo`ketd cde m`ikrketks mds`s mk lf o`dtdx`ef @@@, eft`vf7 hfgf7 2,6= n1
okm`f7 6,= n1 fltf7 6= n y kl nrupd cdetrdl............................................ 882
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x``
Cufmrd Y@@@7Rdrcketfgks mk mkplkc`e ke kstr`fmd mdrsfl pfrf mdpfo`ef (MF) y
c`md 3,=-m`j`mrdx`ike`lfct`cd (MDRFC), c`md jdodvfel`cd (JYF),
skrdtde`ef (;-J]) y c`md ;-j`mrdx``emdlfct`cd (;-J@FF) y ke kstr`fmd
vketrfl y skptd pfmf MF y MDRFC1 pfrf cfmf ued mk lds fe`oflks mk lds
cuftrd nrupds mk trftfo`ketd cde m`ikrketks mds`s mk lf o`dtdx`ef @@@ eft`vf7
hfgf7 2,6= n1 okm`f7 6,= n1 fltf7 6= n y kl nrupd cdetrdl. ESM sk rki`krk
f quk kl cdopukstd ed iuk mktkctfmd ke flne jko`sikr`d. ..................... 886
Cufmrd @Z7Rdrcketfgks mk mkplkc`e ke kstr`fmd mdrsfl pfrf mdpfo`ef (MF) y
c`md 3,=-m`j`mrdx`ike`lfct`cd (MDRFC), c`md jdodvfel`cd (JYF),
skrdtde`ef (;-J]) y c`md ;-j`mrdx``emdlfct`cd (;-J@FF) y ke kstr`fmd
vketrfl y skptd pfmf MF y MDRFC, f mds`s cdestfetk mk o`dtdx`ef @@@ eft`vf
(6= n), pfrf cfmf ued mk lds fe`oflks mk cuftrd nrupds mk trftfo`ketd,
cde m`ikrketk t`kopd mk sfcr`i`c`d f pfrt`r mk lf `eykcc`e mk lf o`dtdx`ef
(6;, 92, 6:2 y 392 o`e). ........................................................................... 888
Cufmrd Z7 em`ck mk oktfhdl`sod ke kstr`fmd mdrsfl pfrf kl c`md 3,=-
m`j`mrdx`ike`lfct`cd (MDRFC) y kl c`md jdodvfel`cd (JYF) ke rklfc`e
cde kl ekurdtrfeso`sdr mdpfo`ef (MF), f mds`s cdestfetk mk o`dtdx`ef @@@
eft`vf (6= n), pfrf cfmf ued mk lds fe`oflks mk cuftrd nrupds mk
trftfo`ketd, cde m`ikrketk t`kopd mk sfcr`i`c`d f pfrt`r mk lf `eykcc`e mk lf
o`dtdx`ef (6;, 92, 6:2 y 392 o`e). ........................................................... 888
Cufmrd Z@7N`rds ektds (`ps` okeds cdetrf) murfetk 82 o`eutds pdr mf, pfrf
cfmf ued mk lds fe`oflks mk trks nrupds mk trftfo`ketd7 cdetrdl, tdx`ef
eft`vf 6,= n y tdx`ef flqu`lfmf 6,= n..................................................... 883
Cufmrd Z@@7 Murfc`e, ke sknuemds, mk lf cdemuctf mk pkr`tfx`s ektf (`ps`
okeds cdetrf) murfetk 82 o`eutds pdr mf, pfrf cfmf ued mk lds fe`oflks
mk trks nrupds mk trftfo`ketd7 cdetrdl, tdx`ef eft`vf 6,= n y tdx`ef
flqu`lfmf 6,= n........................................................................................ 88=
Cufmrd Z@@@7 Eokrd mk crucks mk cufmrfetks v`rtuflks mkl cfopd fh`krtd,
murfetk 82 o`e pfrf cfmf ued mk lds fe`oflks mk trks nrupds mk
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trftfo`ketd7 cdetrdl, tdx`ef eft`vf 6,= n y tdx`ef flqu`lfmf 6,= n.......... 88;
Cufmrd Z@Y7Murfc`e mk lf cdemuctf mk kxpldrfc`e ke sknuemds, murfetk 82
o`eutds pdr mf, pfrf cfmf ued mk lds fe`oflks mk trks nrupds mk
trftfo`ketd7 cdetrdl, tdx`ef eft`vf 6,= n y tdx`ef flqu`lfmf 6,= n.......... 889
Cufmrd ZY7 Murfc`e mk lf cdemuctf mk l`op`kzf ke sknuemds, murfetk 82
o`eutds pdr mf pfrf cfmf ued mk lds fe`oflks mk trks nrupds mk
trftfo`ketd7 cdetrdl, tdx`ef eft`vf 6,= n y tdx`ef flqu`lfmf 6,= n.......... 88>
Cufmrd ZY@7 Rdrcketfgks mk mkplkc`e ke kstr`fmd mdrsfl y vketrfl, pfrf
edrkp`ekir`ef (EK), skrdtde`ef (;-J]), mdpfo`ef (MF) y c`md 3,=-
m`j`mrdx`ike`lfct`cd (MDRFC) y c`md jdodvfel`cd (JYF) pfrf cfmf ued
mk lds fe`oflks mk trks nrupds mk trftfo`ketd7 cdetrdl, tdx`ef eft`vf 6,= ny tdx`ef flqu`lfmf 6,= n.......................................................................... 88:
Cufmrd ZY@@7em`ck mk oktfhdl`sod ke kstr`fmd mdrsfl y vketrfl pfrf kl c`md
3,=-m`j`mrdx`ike`lfct`cd (MDRFC) y kl c`md jdodvfel`cd (JYF) ke
rklfc`e cde kl ekurdtrfeso`sdr mdpfo`ef (MF), pfrf cfmf ued mk lds
fe`oflks mk trks nrupds mk trftfo`ketd7 cdetrdl, tdx`ef eft`vf 6,= n y
tdx`ef flqu`lfmf 6,= n. ............................................................................ 832
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L@S]F MK I@N[XFS
I`nurf 67M`fnrfof mk ue cdrtk sfn`tfl f 6,02 oo lftkrfl mk lf lekf okm`f mk
lds jko`sikr`ds, mk ue ckrkhrd mk rftf ^`stfr mk 802 n mk pksd cdrpdrfl.
Odm`i`cfmd mk Rfx`eds & ^ftsde, 600:....................................................... :
I`nurf 87M`fnrfof mk ued mk lds c`rcu`tds odtdrks mk lds nfenl`ds hfsflks ke
ue ckrkhrd juofed. ..................................................................................... 0
I`nurf 37Ksqukof mkl prdcksd h`ds`ett`cd mk mdpfo`ef f pfrt`r mk L--MDRF
................................................................................................................... 68
I`nurf =7Ksqukof mkl prdcksd h`ds`ett`cd mk skrdtde`ef (;-j`mdx`tr`ptfo`ef)
f pfrt`r mk L-tr`ptifed y ;-j`mrdx` L-tr`ptifed. (Odm`i`cfmd mk Ilrkz, 822:).
................................................................................................................... 6=
I`nurf ;7 Cdopfrfc`e mk ue c`rcu`td ekurfl ke lds nfenl`ds hfsflks ke ue
`em`v`mud sfed (F.) y ke ue `em`v`mud cde lf keikrokmfm mk Rfra`esde (H.).
................................................................................................................... 88
I`nurf 97Crdoftdnrfof pdr JRLC/[Y f 8:2 eo mk lf pur`i`cfc`e fm`c`defl mk
lf o`dtdx`ef @@@. ........................................................................................... =;
I`nurf >7Iroulf pfrf kl clculd mkl em`ck mk fs`oktrf f pfrt`r mk lf cdemuctfmk n`rd pfrf ue fe`ofl `. N `ps` ? eokrd tdtfl mk n`rds `ps`lftkrflks y N
tdtfl ? eokrd mk n`rds tdtflks (n`rds `ps` + n`rds cdetrflftkrflks). ............ ;8
I`nurf :7M`fnrfof mk uef v`stf vketrfl mk ue ckrkhrd mk rftf quk oukstrf lfs
lekfs mk cdrtk pfrf lf m`skcc`e mk lds tkg`mds quk sk koplkfrde pfrf lds
kstum`ds ekurdquo`cds k j`stdln`cds. ..................................................... ;;
I`nurf 07M`fnrfof mk ue cdrtk cdrdefl, cfrf pdstkr`dr mk ue ckrkhrd mk uef
rftf ^`stfr ofcjd mk 802 n f 6,22 oo pdstkr`dr mkl puetd hrknof, quk
oukstrf lfs rkn`deks quk sk fefl`zfrde pdr JRLC. ................................... ;9
I`nurf 627Iroulf pfrf kl clculd mkl pdrcketfgk mk mkplkc`e rklft`vd ketrk kl
jko`sikr`d lks`defmd y kl ed lks`defmd, pfrf ue ekurdtrfeso`sdr d pfrf ue
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oktfhdl`td ke ue tkg`md mktkro`efmd. ......................................................... ;0
I`nurf 667Iroulf pfrf kl clculd mkl em`ck mk oktfhdl`sod @O e,o pfrf
uef rftf, ke ue tkg`md mktkro`efmd, mdemk e ? ekurdtrfeso`sdr y o su
rkspkct`vd oktfhdl`td. ................................................................................ 92
I`nurf 687Kgkopld mk uef skpfrfc`e crdoftdnri`cf pfrf ue pftre feflt`cd
cdopukstd mk EK, MJHF (kstemfr `etkred), MF, MDRFC, ;-J], J@FF y
JYF f lf cdecketrfc`e mk 682 en mk cfmf fefl`td pdr oL ke JClD=2,;E,
okm`md hfgd lfs cdem`c`deks mk lf oktdmdldnf mksfrrdllfmf. ................... 99
I`nurf 63 @etkes`mfm prdokm`d mk lf skfl mkl mktkctdr klkctrdquo`cd, pfrf
cfmf ued mk lds fefl`tds cdetrf kl pdtkec`fl fpl`cfmd fl klkctrdmd mk
trfhfgd. ....................................................................................................... 9>
I`nurf 6=7 Rrdokm`d pdr nrupd mk lf m`ikrkec`f mkl pksd cdrpdrfl ketrk kl mf 88
pdstdpkrftdr`d y kl mf prkdpkrftdr`d, pfrf lds m`ikrketks nrupds mk
trftfo`ketd7 cdetrdl, mds`s 2,6= n1 mds`s 6,= n1 mds`s 6= n mk o`dtdx`ef
@@@ eft`vf. .................................................................................................... >2
I`nurf 6;7 Rrdokm`d pdr nrupd mkl n`rd ektd murfetk 82 o`e pdr mf, ke
m`ikrketks nrupds mk trftfo`ketd7 cdetrdl1 mds`s 2,6= n1 mds`s 6,= n1 y
mds`s 6= n mk o`dtdx`ef @@@ eft`vf. Kl vfldr mk ckrd ke kl kgk mk lfs
drmkefmfs `em`cf lf s`oktrf cdemuctufl. ................................................... >6
I`nurf 697Rrdokm`d pdr nrupd mkl em`ck mk fs`oktrf mk lf cdemuctf mk n`rd
(@F), murfetk 82 o`e pdr mf, ke m`ikrketks nrupds mk trftfo`ketd7 cdetrdl1
mds`s 2,6= n1 mds`s 6,= n1 y mds`s 6= n mk o`dtdx`ef @@@ eft`vf. Lf lekf
rdgf ke kl vfldr mk ;2 `em`cf lf s`oktrf cdemuctufl. .................................. >3
I`nurf 6>7 Rrdokm`d pdr nrupd mkl t`kopd ektd mk pkr`tfx`s murfetk 82 o`e pdr
mf, ke m`ikrketks nrupds mk trftfo`ketd7 cdetrdl1 mds`s 2,6= n1 mds`s 6,=
n1 y mds`s 6= n mk o`dtdx`ef @@@ eft`vf. Kl vfldr mk ckrd ke kl kgk mk lfs
drmkefmfs `em`cf lf s`oktrf cdemuctufl. ................................................... >9
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I`nurf 6:7 Rrdokm`d pdr nrupd mkl em`ck mk fs`oktrf mk lf cdemuctf mk
pkr`tfx`s (@F),murfetk 82 o`e pdr mf, ke m`ikrketks nrupds mk trftfo`ketd7
cdetrdl1 mds`s 2,6= n1 mds`s 6,= n1 y mds`s 6= n mk o`dtdx`ef @@@ eft`vf.
Lf lekf rdgf ke kl vfldr mk ;2 `em`cf lf s`oktrf cdemuctufl. ..................... >0
I`nurf 607 Rrdokm`d pdr nrupd mk lf cdemuctf mk ldcdodc`e cdod kl eokrd
mk crucks mk cufmrfetks v`rtuflks mkl cfopd fh`krtd, murfetk 82 o`eutds
pdr mf, ke m`ikrketks nrupds mk trftfo`ketd7 cdetrdl1 mds`s 2,6= n1 mds`s
6,= n1 y mds`s 6= n mk o`dtdx`ef @@@ eft`vf. ............................................. :2
I`nurf 827 Rrdokm`d pdr nrupd mkl t`kopd tdtfl mk kxpldrfc`e murfetk 82
o`eutds pdr mf, ke m`ikrketks nrupds mk trftfo`ketd7 cdetrdl1 mds`s 2,6= n1
mds`s 6,= n1 y mds`s 6= n mk o`dtdx`ef @@@ eft`vf. .................................... :8
I`nurf 867 Rrdokm`d pdr nrupd mkl t`kopd tdtfl ke fc`cflfo`ketd murfetk 82
o`eutds pdr mf, ke m`ikrketks nrupds mk trftfo`ketd7 cdetrdl1 mds`s 2,6= n1
mds`s 6,= n1 y mds`s 6= n mk o`dtdx`ef @@@ eft`vf. .................................... :=
I`nurf 887 Rdrcketfgk mk mkplkc`e prdokm`d ke kstr`fmd mdrsfl, pfrf mdpfo`ef
(MF), c`md 3,=-m`j`mrdx`ike`lfct`cd (MDRFC), c`md jdodvfel`cd (JYF),
skrdtde`ef (;-J]) y c`md ;-j`mrdx` 3-`emdlfct`cd (;-J@FF) pfrf lds cuftrd
nrupds mk trftfo`ketd cde m`ikrketks mds`s mk lf o`dtdx`ef @@@, eft`vf7
cdetrdl ? 6 L sdluc`e sfl`ef1 mds`s hfgf ? 2,6= n O]-@@@1 mds`s okm`f 6,=
n O]-@@@ y mds`s fltf 6= n O]-@@@. ............................................................ :9
I`nurf 837 Rdrcketfgk mk mkplkc`e prdokm`d ke kstr`fmd vketrfl, pfrf
mdpfo`ef (MF) y c`md j`mrdx`ike`lfct`cd (MDRFC) pfrf lds cuftrd nrupds
mk trftfo`ketd cde m`ikrketks mds`s mk lf o`dtdx`ef @@@, eft`vf7 cdetrdl ? 6 L
sdluc`e sfl`ef1 mds`s hfgf ? 2,6= n O]-@@@1 mds`s okm`f 6,= n O]-@@@ y
mds`s fltf 6= n O]-@@@. .............................................................................. ::
I`nurf 8=7 Rdrcketfgk mk mkplkc`e prdokm`d ke skptd, pfrf mdpfo`ef (MF) y
c`md j`mrdx`ike`lfct`cd (MDRFC), pfrf lds cuftrd nrupds mk trftfo`ketd
cde m`ikrketks mds`s mk lf o`dtdx`ef @@@, eft`vf7 cdetrdl ? 6 L sdluc`e
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sfl`ef1 mds`s hfgf ? 2,6= n O]-@@@1 mds`s okm`f 6,= n O]-@@@ y mds`s fltf 6=
n O]-@@@. ................................................................................................... :0
I`nurf 8;7 Rrdokm`d pdr nrupd mkl pdrcketfgk mk mkplkc`e ke kstr`fmd mdrsfl,
pfrf mdpfo`ef, skrdtde`ef y oktfhdl`tds f mds`s cdestfetk mk tdx`ef O]-@@@7 6= n/L, pfrf cfmf ued mk lds fe`oflks `evdlucrfmds ke kl kstum`d.
Mdpfo`ef (MF), c`md 3,=-m`j`mrdx`ike`lfct`cd (MDRFC), c`md
jdodvfel`cd (JYF), skrdtde`ef (;-J]) y c`md ;-j`mrdx` 3-`emdlfct`cd (;-
J@FF). ........................................................................................................ 08
I`nurf 897 Rrdokm`d pdr nrupd mkl em`ck mk Oktfhdl`sod ke kstr`fmd mdrsfl,
pfrf lf trfesidrofc`e mk MF ke cfmf ued mk sus oktfhdl`tds MDRFC y
JYF rkspkctd f su ekurdtrfeso`sdr pfmrk, y oktfhdl`tds f mds`s cdestfetkmk tdx`ef O]-@@@7 6= n/L. Mdpfo`ef (MF), c`md 3,=-m`j`mrdx`ike`lfct`cd
(MDRFC), c`md jdodvfel`cd (JYF). ....................................................... 0=
I`nurf 8>7 Rdrcketfgk mk mkplkc`e ke kstr`fmd vketrfl pfrf mdpfo`ef (MF) y
c`md j`mrdx`ike`lfct`cd (MDRFC) f mds`s cdestfetk mk tdx`ef O]-@@@7 6=
n/L. ......................................................................................................... 0;
I`nurf 8:7 Rrdokm`d pdr nrupd mkl em`ck mk Oktfhdl`sod ke kstr`fmd vketrfl,
pfrf lf trfesidrofc`e mk MF ke su oktfhdl`td MDRFC, f mds`s cdestfetk
mk tdx`ef O]-@@@7 6= n/L. Mdpfo`ef (MF), c`md 3,=-m`j`mrdx`ike`lfct`cd
(MDRFC). ................................................................................................... 09
I`nurf 807 Rrdokm`d pdr nrupd mk lf m`ikrkec`f mkl pksd cdrpdrfl ketrk kl mf
fetkr`dr fl sfcr`i`c`d y kl mf prkdpkrftdr`d, pfrf lds m`ikrketks nrupds mk
trftfo`ketd7 cdetrdl, o`dtdx`ef O]-@@@ eft`vf 6,= n (tdx`ef) y o`dtdx`ef O]-
@@@ flqu`lfmf 6,= n/L (flqu`lfmf). .............................................................. 00
I`nurf 327 Rrdokm`d pdr nrupd mkl n`rd ektd murfetk 82 o`e pdr mf, ke
m`ikrketks nrupds mk trftfo`ketd7 cdetrdl, o`dtdx`ef O]-@@@ eft`vf 6,= n
(tdx`ef) y o`dtdx`ef O]-@@@ flqu`lfmf 6,= n/L (flqu`lfmf). Kl vfldr mk ckrd
ke kl kgk mk lfs drmkefmfs `em`cf lf s`oktrf cdemuctufl. ........................ 622
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I`nurf 367Rrdokm`d pdr nrupd mkl em`ck mk fs`oktrf mk lf cdemuctf mk n`rd
(@F), murfetk 82 o`e pdr mf, ke m`ikrketks nrupds mk trftfo`ketd7 cdetrdl1
o`dtdx`ef O]-@@@ eft`vf 6,= n (tdx`ef) y o`dtdx`ef O]-@@@ flqu`lfmf 6,= n
(flqu`lfmf). Lf lekf rdgf ke kl vfldr mk ;2 `em`cf lf s`oktrf cdemuctufl. 623
I`nurf 387 Rrdokm`d pdr nrupd mkl n`rd tdtfl (`ps`lftkrfl + cdetrflftkrfl) murfetk
82 o`e pdr mf, ke m`ikrketks nrupds mk trftfo`ketd7 cdetrdl1 o`dtdx`ef O]-
@@@ eft`vf 6,= n (tdx`ef) y o`dtdx`ef O]-@@@ flqu`lfmf 6,= n (flqu`lfmf). . 62>
I`nurf 337 Rrdokm`d pdr nrupd mkl t`kopd ektd mk pkr`tfx`s murfetk 82 o`e pdr
mf, ke m`ikrketks nrupds mk trftfo`ketd7 cdetrdl, o`dtdx`ef O]-@@@ eft`vf 6,=
n (tdx`ef) y o`dtdx`ef O]-@@@ flqu`lfmf 6,= n (flqu`lfmf). Kl vfldr mk ckrd
ke kl kgk mk lfs drmkefmfs `em`cf lf s`oktrf cdemuctufl. ........................ 620
I`nurf 3=7 Rrdokm`d pdr nrupd mkl em`ck mk fs`oktrf mk lf cdemuctf mk
pkr`tfx`s (@F), murfetk 82 o`e pdr mf, ke m`ikrketks nrupds mk trftfo`ketd7
cdetrdl, o`dtdx`ef O]-@@@ eft`vf 6,= n (tdx`ef) y o`dtdx`ef O]-@@@ flqu`lfmf
6,= n (flqu`lfmf). Lf lekf rdgf ke kl vfldr mk ;2 `em`cf lf s`oktrf
cdemuctufl................................................................................................ 668
I`nurf 3;7 Rrdokm`d pdr nrupd mkl t`kopd tdtfl mk pkr`tfx`s murfetk 82 o`e pdr
mf, ke m`ikrketks nrupds mk trftfo`ketd7 cdetrdl1 o`dtdx`ef O]-@@@ eft`vf 6,=
n (tdx`ef) y o`dtdx`ef O]-@@@ flqu`lfmf 6,= n (flqu`lfmf). ...................... 669
I`nurf 397 Rrdokm`d pdr nrupd mk lf cdemuctf mk ldcdodc`e cdod kl eokrd
tdtfl mk crucks mk cufmrfetks v`rtuflks mkl cfopd fh`krtd, murfetk 82
o`eutds pdr mf, ke m`ikrketks nrupds mk trftfo`ketd7 cdetrdl, o`dtdx`ef
O]-@@@ eft`vf 6,= n (tdx`ef) y o`dtdx`ef O]-@@@ flqu`lfmf 6,= n (flqu`lfmf).
................................................................................................................. 660
I`nurf 3>7 Rrdokm`d pdr nrupd mkl t`kopd tdtfl mk kxpldrfc`e murfetk 82
o`eutds pdr mf, ke m`ikrketks nrupds mk trftfo`ketd7 cdetrdl, o`dtdx`ef
O]-@@@ eft`vf 6,= n (tdx`ef) y o`dtdx`ef O]-@@@ flqu`lfmf 6,= n/L
(flqu`lfmf). ............................................................................................... 686
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I`nurf 3:7 Rrdokm`d pdr nrupd mkl t`kopd tdtfl ke fc`cflfo`ketd murfetk 82
o`eutds pdr mf, ke m`ikrketks nrupds mk trftfo`ketd7 cdetrdl, o`dtdx`ef
O]-@@@ eft`vf 6,= n (tdx`ef) y o`dtdx`ef O]-@@@ flqu`lfmf 6,= n/L
(flqu`lfmf). ............................................................................................... 683
I`nurf 307 Rrdokm`d pdr nrupd mkl pdrcketfgk mk mkplkc`e pfrf cfmf
oktfhdl`td, ke lds m`ikrketks nrupds mk trftfo`ketd7 cdetrdl, o`dtdx`ef O]-
@@@ 6,= n/L y o`dtdx`ef O]-@@@ flqu`lfmf 6,= n/L ke kstr`fmd mdrsfl.... 68;
I`nurf =27 Rrdokm`d pdr nrupd mkl pdrcketfgk mk mkplkc`e pfrf cfmf
oktfhdl`td, ke lds m`ikrketks nrupds mk trftfo`ketd7 cdetrdl, o`dtdx`ef O]-
@@@ 6,= n/L y o`dtdx`ef O]-@@@ flqu`lfmf 6,= n/L ke kstr`fmd vketrfl... 68>
I`nurf =67 Rrdokm`d pdr nrupd mkl em`ck mk oktfhdl`sod pfrf MDRFC y JYF,ke lds m`ikrketks nrupds mk trftfo`ketd7 cdetrdl, o`dtdx`ef O]-@@@ 6,= n/L
y o`dtdx`ef O]-@@@ flqu`lfmf 6,= n/L, tfetd ke kstr`fmd vketrfl cdod
mdrsfl. Lf lekf rdgf ke kl vfldr mk em`ck mk oktfhdl`sod ? 622,
rkprksketf kl vfldr mk `nufl fct`v`mfm oktfhl`cf ke lds jko`sikr`ds....... 680
I`nurf =87 Idtdnrfif mk uef oukstrf mk ckrkhrd mk rftf prkskrvfmf ke
idrofl`ef cde fodrt`nufmdr mk idsiftds, cdldcfmf ke kl o`crtdod........ 636
I`nurf =37 O`crdidtdnrfif mk ue cdrtk cdrdefl mk ue ckrkhrd mk rftf cde lks`e
ke SEpc cde O]@@ eft`vf, quk oukstrf lf lekf mk lf c`cftr`z. Lf t`ec`e
koplkfmf ks cde jkoftdx`l`ef / kds`ef (fuoketd =2Z).......................... 638
I`nurf ==7 O`crdidtdnrfif mk ue cdrtk cdrdefl mk ue ckrkhrd mk rftf cde lks`e
ke SEpc cde O]@@, quk oukstrf lf lekf mk lf c`cftr`z y kl s`t`d mk llknfmf mk
lf ceulf gustd ke SEpc. Lf t`ec`e koplkfmf ks cde jkoftdx`l`ef / kds`ef
(Fuoketd =22Z).Xkprdmuc`md cde pkro`sd mk Sfhdrd, 822:................ 633
I`nurf =;7 Cdrtk cdrdefl f Hrknof -;.92 oo, `etkrfurfl 3,=2 oo (odm`i`cfmd
mk Rfx`eds & ^ftsde, 600:), ke kl quk sk oukstrfe lds rksultfmds mk lf
llknfmf mk lfs ceulfs............................................................................. 63=
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I`nurf =97 Cdrtk cdrdefl f Hrknof -9,2= oo, `etkrfurfl 8,09 oo (odm`i`cfmd
mk Rfx`eds & ^ftsde, 600:), ke kl quk sk oukstrfe lds rksultfmds mk lf
llknfmf mk lfs ceulfs............................................................................. 63;
I`nurf =>7 M`fnrfofs mk lfs v`stfs mdrsfl (supkr`dr) y lftkrfl (`eikr`dr) mkl
crekd mk uef rftf ofcjd ^`stfr mk 802 n mk ofsf cdrpdrfl................. 868
I`nurf =:7 M`fnrfofs pfrf lf uh`cfc`e kstkrkdtx`cf mk lf SEpc (ke cdldr rdgd)
ke ue ckrkhrd mk rftf ofcjd ^`stfr mk 802 n.F. cdrtk cdrdefl ke Hrknof -
;,32 oo1 H. cdrtk sfn`tfl ke lftkrfl 6,02 oo y C. cdrtk jdr`zdetfl ke
hrknof :,62 oo.................................................................................... 863
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EM@CK MK FHXKY@F][XFS
Fch7 eclkd fccuohkes
FORc7 fmkedseodedidsiftd ccl`cd
p-HRH7 hrdourd mk pfrf-hrdodikefc`ldCDOR]7 cftkcdl D-okt`ltrfesikrfsf
CRu7 cfumfmd y putfoke
MF7 mdpfo`ef
MDRFC7 c`md 3,=-m`j`mrdx`ike`lfct`cd
KEA7 keckifl`ef
NFHF7 c`md nfof-fo`edhutr`cd
NL[7 nlutfoftd
NRL7 nldhd pl`md lftkrfl
NRo7 nldhd pl`md okm`fl
;-J@FF7 c`md ;-j`mrdx` 3-`emdlfct`cd
JRLC7 crdoftdnrfif lqu`mf mk fltf ki`c`kec`f
;-J]7 skrdtde`ef d ;-j`mrdx`tr`ptfo`ef
JYF7 c`md jdodvfel`cd
OFD7 odedfo`ed dx`mfsf
3-O]7 3-oktdx`t`rfo`ef
O]-@@@7 o`dtdx`ef @@@ mk Hdtjrdps fspkr
EK7 edrkp`ekir`ef
ES]7 eclkd suhtflo`cd
9-DJMF7 9-j`mrdx`mdpfo`ef
RLF87 idsidl`pfsf F8
SEC7 s`stkof ekrv`dsd cketrfl
SEpc7 pfrs cdopfctf mk lf suhstfec`f e`nrfSEpr7 pfrs rkt`culftf mk lf suhstfec`f e`nrf
SR7 sustfec`f R
YFpc/YLd tlfod vketrdfetkr`dr pfrvdcklulfr y vketrdlftkrfl drfl`s.
YR7 nldhd pl`md vketrfl
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CFR][LD @
6. @E]XDM[CC@E
Lf o`dtdx`ef @@@ (O]-@@@), ks uef mk cuftrd o`dtdx`efs quk sk jfe f`slfmd y
pur`i`cfmd mkl vkeked mk lf skrp`ketk Hdtjrdps fspkr cdedc`mf cdod ]krc`dpkld
(Nut`rrkz & Ldodetk, 600;). Kstf o`dtdx`ef, ke pfrt`culfr jf s`md f`slfmf,
pur`i`cfmf, skcukec`fmf y cfrfctkr`zfmf kstructurfloketk cdod uef idsidl`pfsf F8
(RLF8), hs`cf y mk lf clfsk @@F (Af`skr kt fl., 6002). Sk jfe rkfl`zfmd oucjds
kstum`ds sdhrk sus kikctds ifrofcdln`cds ke l`pdsdofs, osculd nfstrdceko`d
mk rfte (Hultre kt fl., 6003f), nlhulds rdgds y dtrfs clulfs mk dr`nke fe`ofl
(Hultre kt fl., 6003h).
Yfr`ds `evkst`nfmdrks jfe kstum`fmd kl kikctd mk m`ikrketks idsidl`pfsfs F8, fl
`eykctfrlfs `etrfckrkhrfloketk. Rdr kgkopld sk jfe kstum`fmd uefs f`slfmfs mkl
vkeked mk lf skrp`ketk Dxyurfeus scutkllftus scutkllftus, y dtrfs f`slfmfs mkl
vkeked mk fhkgfs (Nfemdlid kt fl., 6009), fmkos mk idsidl`pfsfs F8pfecrkt`cfs
(Mdrfemku kt fl., 600:). Ke kstf o`sof m`rkcc`e, ke Cdstf X`cf, sk cuketf cde
kstum`ds p`ldtd, ed puhl`cfmds, mk Nut`rrkz, G. O. cde lfs o`dtdx`efs mk Hdtjrdps
fspkr tfoh`e ke ckrkhrd. Kspkci`cfoketk, ke lds trfhfgds cde O]-@@@, sk jf
okm`md ue kikctd ifrofcdln`cd ke rftdeks, cfrfctkr`zfmd pdr cdevuls`deks y
pdstkr`droketk lf oukrtk f uef mds`s mk 6 n ke ue vdluoke mk = L. Ks
`opdrtfetk mkstfcfr quk tdmds kstds kstum`ds prksketfe ke cdoe quk lf
`eykcc`e mk lfs idsidl`pfsfs F8 ks ke lds vketrculds ckrkhrflks, pdr ld quk kl
kikctd ifrofcdln`cd rkpdrtfmd ed ks prdmuctd mk uef fcc`e ldcfl`zfmf ke uef
sdlf rkn`e ckrkhrfl. Sk cdes`mkrf rklkvfetk kstum`fr f prdiuem`mfm lf cdemuctfdhskrvfmf ke lds rftdeks lks`defmds cde lf O]-@@@, mkh`md f quk kstd pukmk
fpdrtfr ue ofydr cdedc`o`ketd mk lf fcc`e mk kstf tdx`ef ke tkg`md ckrkhrfl.
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Kl `etkrs nkekrfl ke kstum`fr lf fcc`e mk idsidl`pfsfs F8ke ckrkhrd, sk mkhk f
quk stfs fmkos, sde cdopukstds kemnkeds ke juofeds y f quk lf
kst`oulfc`e mk idsidl`pfsfs F8, sk crkk quk ks `opdrtfetk ke lds prdcksds mk
`eilfofc`e fsdc`fmf f mksrmkeks ekurdln`cds (Ifrddqu` kt fl., 600>). Lfsidsidl`pfsfs F8cdetr`huyke ke lf pftdneks`s mk c`krtds mksrmkeks ekurdln`cds,
cdod kl Rfra`esde, ftfcfemd lfs okohrfefs cklulfrks y l`hkrfemd okm`fmdrks
l`pm`cds prd`eilfoftdr`ds (Ifrddqu` kt fl, 600>1 ]k`sofee kt fl, 8223). Rdr
kgkopld, Al`vkey` kt fl, (600:) mkoukstrfe quk lds rftdeks quk ed kxprksfe uef
RLF8 t`pd @Y prksketfe rks`stkec`f f lf tdx`c`mfm cde 6-okt`l-=-ike`l-6,8,3,9-
tktrfj`mrdp`r`m`ef (OR]R), uef ekurdtdx`ef mdpfo`ern`cf koplkfmf ke lf
nkekrfc`e mk ue odmkld fe`ofl mk lf keikrokmfm mk Rfra`esde (Hluo kt fl.,8226). Fmkos sk jfe okm`md e`vklks klkvfmds mk fct v`mfm RLF8ke mksrmkeks
ekurdln`cds fsdc`fmds cde `eilfofc`e y kstrs dx`mft`vd, pdr ld quk sk kstum`f
cde i`eks tkrfput`cds, lf fcc`e mk `ej`h`mdrks ed kspkci`cds mk RLF8 cdod
qu`efcr`ef, jkpfr`ef, nfenl`s`mds y v tfo`ef K (Ifrddqu` kt fl., 6000). Dtrds
`evkst`nfmdrks jfe mkodstrfmd ue kikctd prdtkctdr mk lf qu`efcr`ef (`ej`h`mdr mk lf
fct`v`mfm RLF8) sdhrk lf ekurdtdx`c`mfm `emuc`mf pdr 9-j`mrdx`mdpfo`ef (9-DJMF)
y OR]R ke rdkmdrks (]fr`q kt fl., 8226). Lf 9-DJMF y kl OR]R sde mds mk lfs
ekurdtdx`efs s`ett`cfs os ut`l`zfmfs pfrf odmklfr lf keikrokmfm mk Rfra`esde
ke m`vkrsfs kspkc`ks mk fe`oflks (Hktfrhkt kt fl, 82281 Mfwsde kt fl, 82281 Mfukr
& Rrzkmhdrsa`, 82231 Kohdrm, 822=). ]foh`e sk jfe okm`md e`vklks fltds mk
RLF8ke suhstfec`f e`nrf mk pfc`ketks cde keikrokmfm mk Rfra`esde cdopfrfmds
cde `em`v`muds sfeds (Xdss kt fl., 8226). Ke rftfs lks`defmfs cde 9-DJMF sk jfe
mktkro`efmd e`vklks ofydrks mk `ecdrpdrfc`e mk c`md frfqu`me`cd ofrcfmd ke
lf pds`c`e se-8 mk idsift`m`l`eds`tdl y idsift`m`lcdl`ef, ke lfs okohrfefs ekurflks
mk nfenl`ds hfsflks y rkn`deks odtdrfs mkl crtkx, ke kl jko`sikr`d `ps`lftkrflrkspkctd mk lf lks`e. Kstk kikctd pdmrf `em`cfr uef ofydr fct`v`mfm RLF8ke kl
jko`sikr`d lks`defmd (Jfyfafwf kt fl., 600:). ]dmf kstf kv`mkec`f pfrkck sunkr`r
ue kikctd edc`vd mk lf fcc`e mk idsidl`pfsfs F8 ke mksrmkeks ekurdln`cds,
kspkci`cfoketk cdod ke lf keikrokmfm mk Rfra`esde.
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Cde kstk prdykctd mk `evkst`nfc`e sk prktkemk fpdrtfr ue cdedc`o`ketd prkl`o`efr
sdhrk kl kikctd ifrofcdln`cd f e`vkl mkl s`stkof ekrv`dsd cketrfl (SEC) mk lf
o`dtdx`ef O]-@@@ mk Hdtjrdps fspkr, ut`l`zfemd ue odmkld fe`ofl mk lks`e ckrkhrflue`lftkrfl, ouy ut`l`zfmd pfrf kstum`fr lf keikrokmfm mk Rfra`esde ([enkrstkmt,
60>61 Scjwfrt`en & Justde, 6009f1 Hktfrhkt kt fl, 82281 Mkuokes kt fl, 82281
Mfukr & Rrzkmhdrsa`, 82231 Jfrr`sde & LfJdstk, 8229). Fmkos sk prktkemk
fopl`fr kl pkri`l ifrofcdln`cd mk kstf tdx`ef, ke v`stf mk quk ed jf s`md kstum`fmf
ke ekurdefs cketrflks, ld cufl kvketufloketk pdmrf pkro`t`r lf cfrfctkr`zfc`e mk
lds prdcksds mk mknkekrfc`e y rknkekrfc`e ekurdefl, quk suhyfcke ke
keikrokmfmks ekurdmknkekrft`vfs cdod kl odrhus Rfra`esde.
Kstf `evkst`nfc`e rkqu`krk mk lf `oplkoketfc`e mk uef tce`cf mk fel`s`s pfrf
lf mktkro`efc`e quo`cf mk ekurdtrfeso`sdrks ke tkg md keckil`cd. Kstk t`pd mk
oktdmdldnf, fmfptfmf f dtrfs oftr`cks cdod sfenrk u dr`ef, kvketufloketk
pkro`t`r prdykctfr kl skrv`c`d mk lf [e`vkrs`mfm mk Cdstf X`cf jfc`f lf pdhlfc`e
efc`defl. Rdr kgkopld, okm`fetk lf cdlfhdrfc`e cde jdsp`tflks efc`deflks, quk
jfstf kl odoketd ed ut`l`zfe kstk t`pd mk tce`cfs crdoftdnri`cfs, pfrf
kstfhlkckr ue m`fnest`cd mk c krtfs keikrokmfmks mkl s`stkof ekrv`dsd. ]fl cfsd
pukmk skr kl m`fnest`cd y trftfo`ketd mk keikrokmfmks rklfc`defmfs cde
cdemuctfs fedroflks (k.n.cdemuctfs fnrks`vfs, mi`c`t mk ftkec`e) ke lfs quk ks
`opdrtfetk kl ode`tdrkd mk lds e`vklks mk skrdtde`ef, mdpfo`ef y mk edrfmrkefl`ef
ke sfenrk, m`so`euykemd fs kvketuflks kikctds fmvkrsds pdr okm`cfc`deks
`efprdp`fmfs.
Fmkos cde kstk prdykctd sk kstfhlkc`krde veculds mk `evkst`nfc`e ketrk kl@est`tutd Cldmdo`rd R`cfmd y kl Rrdnrfof mk @evkst`nfc`e ke Ekurdc`kec`fs
cdet`eufemd lekfs mk `evkst`nfc`e prdp`fs mk fohds cketrds y fprdvkcjfemd
rkcursds prdp`ds mk lf rkn`e cketrdfokr`cfef.
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Cde kstf `evkst`nfc`e sk pumd mktkro`efr quk lf o`dtdx`ef @@@ mk Hdtjrdps fspkr
ks uef tdx`ef ouy prdoktkmdrf pfrf kl kstum`d mk keikrokmfmks ekurdln`cfs
(cdod kl Rfra`esde) yf quk pkro`tk kstum`fr, ke odmklds fe`oflks, lf neks`s mk
kstf pftdldnf okm`fetk mds okcfe`sods7 ued mkpkem`ketk mk lf fct`v`mfm RLF8ydtrd `emkpkem`ketk (Ldodetk & Nut`rrkz, 60:01 Mfz kt fl., 600;) y ouy
pds`hlkoketk m`ikrketks f lds mkscr`tds pfrf dtrfs tdx`efs trfm`c`deflks cdod 9-
DJMF y OR]R, ketrk dtrfs. Kstk trfhfgd ks lf pr`okr vkz quk sk kstum`f ke
ekurdefs cketrflks, uef o`dtdx`ef ed ekurdtx`cf (Lfohkfu kt fl, 60061 E`cdlfs kt
fl, 600>) y quk lf o`sof prksketf ue kikctd mk lks`e `opdrtfetk. Ke SEpc, lf
fcc`e tx`cf mk lf O]-@@@ okm`fetk kl okcfe`sod ed kez`ot`cd, ed ks uef fcc`e
lkvk cdod sk jf mkscr`td ke kstum`ds ke clulfs ousculfrks mk ofoikrds (Hultrekt fl, 6003f & 6003h), s`ed uef fcc`e mk ofne`tum skokgfetk fl okm`md pdr lf
fcc`e idsidl`pfsf F8.
Kl dhgkt`vd nkekrfl mk kstf tks`s ks cfrfctkr`zfr lds kikctds ekurdquo`cds y
cdemuctuflks, mkspus mk lf `eykcc`e `etrfckrkhrfl mk lf O]-@@@, kspkci`cfoketk
ke lf sustfec`f e`nrf pfrs cdopfctf mk rftfs fmultfs. Lds dhgkt`vds kspkci`cds
sde lds s`nu`ketks7
Kstfemfr`zfr uef oktdmdldnf pdr JRLC/KM pfrf lf mktkro`efc`e mk
edrkp`ekir`ef, mdpfo`ef, skrdtde`ef y flnueds oktfhdl`tds ke tkg`md ckrkhrfl mk
rftf.
Kstfhlkckr lfs mds`s mk trfhfgd mk lf O]-@@@ okm`fetk ue kscrut`e`d mk su kikctd
ifrofcdln`cd (cdemuctufl y ekurdquo`cd) trfs su `eykcc`e ke lf pfrs
cdopfctfmk lf sustfec`f e`nrf ke trks mds`s7 2,6=1 6,= y 6= n cde cdetrdlks mk
sdluc`e sfl`ef (EfCl 2,0 %). Kvflufr pdr ekurdquo`cf, f mds`s cdestfetk, lf kvdluc`e mkl prdcksd mk lks`e
ekurdefl mk lf o`dtdx`ef O]-@@@ f lds 6;, 92, 6:2 y 392 o`eutds pdstkr`drks f su
`eykcc`e.
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Cdopfrfr, f uef mds`s prkmki`e`mf, lds kikctds cdemuctuflks y ekurdquo`cds
pdr `eykcc`e mk lf O]-@@@, cde lds prdmuc`mds pdr lf `eykcc`e mk lf o`sof
tdx`ef pkrd flqu`lfmf ke kl s`t`d cftflt`cd RLF8, ld cufl kl`o`ef su fct`v`mfm
kez`ot`cf cdedc`mf.
Xkfl`zfr fel`s`s j`stdln`cds pfrf cdrrdhdrfr j`stdln`cfoketk lf rkn`e
ckrkhrfl (sustfec`f e`nrf) mdemk llknf lf ceulf cde lf quk sk `eykct lf
o`dtdx`ef @@@.
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CFR][LD @@
8. OFXCD ]KX@CD
8.6 Lds Nfenl`ds hfsflks
Lfs rkn`deks mkl ckrkhrd quk sk vfe f kstum`fr ke kstk prdykctd mk `evkst`nfc`e
idrofe pfrtk mk lds nfenl`ds hfsflks, pdr kstd ks `opdrtfetk prksketfr fspkctds
tkr`cds sdhrk su iuec`e y ldcfl`zfc`e.
Lds nfenl`ds hfsflks sde ue cdeguetd mk kstructurfs mkl kecifld quk odmulfe mkidrof `em`rkctf, guetd cde dtrfs kstructurfs ckrkhrflks, fspkctds rklfc`defmds cde
kl odv`o`ketd cdrpdrfl vdluetfr`d, ketrk dtrfs iuec`deks, ed tdmfs h`ke mki`e`mfs
(Ilrkz, 822:). Sk uh`cfe pr ec`pfloketk lftkrflks y flrkmkmdr mkl tlfod,
dcupfemd nrfe pfrtk mk lfs rkn`deks os prdiuemfs mk fohds jko`sikr`ds
ckrkhrflks. Kllds prdvkke kl l`nfoke i`s`dln`cd cruc`fl ketrk lf `mkf mk odv`o`ketd
y lf kxprks`e odtdrf mk kstf `mkf. Kstfs kstructurfs kgkrcke su `eilukec`f sdhrk
lfs rkn`deks odtdrfs mk lf cdrtkzf ckrkhrfl fetks quk lds cdofemds odtdrks skfe
kev`fmds fl tflld y lf omulf ksp`efl. Ke dtrfs pflfhrfs, lf fct`v`mfm ekurdefl mkl
s`stkof odtdr mksckemketk sk cdrrklfc`def tkopdrfloketk cde kl fctd odtdr
fctufl, ke cfoh`d lf ofydrf mk lf fct`v`mfm ekurdefl mk lds nfenl`ds hfsflks
dcurrk fetks quk kl odv`o`ketd `e`c`k. Lfs lks`deks ke lf iuec`e mkl s`stkof
odtdr mksckemketk y lf omulf ksp`efl cfusfe ke kl pfc`ketk pfrks`s d pfrl`s`s,
o`ketrfs quk lfs lks`deks ke lds nfenl`ds hfsflks cfusfe m`sturh`ds ke lf
`e`c`fc`e d cksk mkl kvketd odtdr (Afemkl kt fl., 8222 y A`enslky, 8222).
Lds nfenl`ds hfsflks kste idrofmds pdr kl eclkd cfumfmd (mkl lfte7 cdlf) y kl
eclkd putfoke (mkl lfte7 c`ruklf), kl eclkd fccuohkes (mkl lfte7 `ecl`efmd), kl
nldhd pl`md (mkl lfte7 ksikrf pl`mf), kl eclkd suhtflo`cd (edohrfmd fs pdr su
uh`cfc`e cfumfl fl tlfod) y lf sustfec`f e`nrf (edohrfmd fs pdr lf cdldrfc`e
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dscurf quk prksketf kstk tkg`md). Lf uh`cfc`e fefto`cf mk kstds eclkds ke ue
ckrkhrd mk rftf ^`stfr, sk pukmk fprkc`fr ke ue cdrtk sfn`tfl (vkr I`nurf 6).
I`nurf 67M`fnrfof mk ue cdrtk sfn`tfl f 6,02 oo lftkrfl mk lf lekf okm`f mk lds jko`sikr`ds, mkue ckrkhrd mk rftf ^`stfr mk 802 n mk pksd cdrpdrfl. Odm`i`cfmd mk Rfx`eds & ^ftsde, 600:.Kl m`fnrfof oukstrf, ke ue plfed, lf uh`cfc`e mk lfs m`ikrketks kstructurfs quk cdeidrofe ldsnfenl`ds hfsflks y kl tlfod. Ke kl m`fnrfof sk mkstfcf7 ke vkrmk kl kstr`fmd mdrsfl (CRu7cfumfmd y putfoke), ke fofr`lld kl kstr`fmd vketrfl (Fch7 eclkd fccuohkes) ke odrfmd kl pl`mdvketrfl (YR), ke fefrfegfmd kl tlfod, ke cfi dscurd kl eclkd suhtflo`cd, ke fzul lf pfrsrkt`culfmf mk lf sustfec`f e`nrf y ke rdgd lf pfrs cdopfctf mk lf sustfec`f e`nrf.
Kl eclkd cfumfmd y kl putfoke (fohds tfoh`e mkedo`efmds ekdkstr`fmd d
kstr`fmd mdrsfl) sde lfs kstructurfs mk lds nfenl`ds hfsflks quk rkc`hke lf ofydr
cfet`mfm mk fikrkec`fs. Kstfs mds kstructurfs guetdcde kl eclkd fccuohkes sk
mkedo`efe kstr`fmd. Kl eclkd fccuohkes (tfoh`e mkedo`efmd kstr`fmd vketrfl)sk ldcfl`zf vketrfl f lf cfhkzf mkl cfumfmd. Kl nldhd pl`md, quk idrof pfrtk mkl
m`kecifld, sk m`v`mk ke ue sknoketd kxtkred y ued `etkred. Kl eclkd suhtflo`cd
sk uh`cf vketrfl fl tlfod ke kl puetd mk ue`e mk stk lt`od cde kl okskecifld.
Lf sustfec`f e`nrf sk kecuketrf ke kl okskecifld y sk m`v`mk ke mds kstructurfs7
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lf pfrtk pl`mf vketrfl (tfoh`e cdedc`mf cdod pfrs rkt`culftf d zdef rkt`culfmf) y
lf pfrtk p`noketfmf mdrsfl (tfoh`e cdedc`mf cdod pfrs cdopfctf d zdef
cdopfctf). Lf zdef cdopfctf cdet`kek cukrpds (sdofs) ekurdeflks
mdpfo`ern`cds, cde lf ofydr cfet`mfm mk mdpfo`ef mk tdmd kl ckrkhrd. Kstdscukrpds fmkos cdet`keke ekurdoklfe`ef, quk ks ue p`noketd rkspdesfhlk mk lf
cdldrfc`e eknrf cfrfctkrst`cf mk lf rkn`e, y quk sk dhskrvf ke ckrkhrds irkscds
mk cfmvkrks juofeds(Afemkl kt fl., 8222 y A`enslky, 8222).
Lds nfenl`ds hfsflks sk kecuketrfe ouy `etkrcdekctfmds y iuec`defe cdod ue
puketk ketrk kl tklkecifld y kl m`kecifld. Ke lf I`nurf 8, sk `lustrfe lfs
pr`ec`pflks vfs mk cdoue`cfc`e ketrk lds nfenl`ds hfsflks y dtrfs kstructurfskeckil`cfs.
I`nurf 87M`fnrfof mk ued mk lds c`rcu`tds odtdrks mk lds nfenl`ds hfsflks ke ue ckrkhrd juofed.
Lfs ilkcjfs `em`cfe lf m`rkcc`e mk lf trfeso`s`e ekurdefl. Lf ilkcjf ke rdgd skflf lf vfmdpfo`ern`cf enrd-kstr`ftfl. ES]7 eclkd suhtflo`cd, SEpc7 sustfec`f e`nrf pfrs cdopfctf,SEpr7 sustfec`f e`nrf pfrs rkt`culftf. Odm`i`cfmd mk Afemkl kt fl. (8222).
SEpr
Crtkx
]lfod
ES]
SEpc
Kstr`fmd
Rl`md Kxtkred
Rl`md @etkred
Fl trdecdkeckil`cd yomulf ksp`efl
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Cfs` tdmfs lfs cdekx`deks fikrketks mk lds nfenl`ds hfsflks llknfe fl ekdkstr`fmd.
stk rkc`hk fikrkec`fs pr`ec`pfloketk mk lf cdrtkzf ckrkhrfl y mk lds eclkds
`etrflfo`efrks mkl tlfod. Cfmf rkf mkl crtkx prdykctf f ue eclkd m`st etd mkl
kstr`fmd y cfmf eclkd mk kstds lt`ods pfrt`c`pf ke uef iuec`e cdemuctuflkspkci`cf. Rdr kgkopld, kl putfoke kst `opl`cfmd iuemfoketfloketk ke kl
cdetrdl odtdr y kl cfumfmd pfrt`c`pf ke kl cdetrdl mk lds odv`o`ketds dculfrks y ke
mktkro`efmfs iuec`deks cdne`t`vfs y kl kstr`fmd vketrfl kst rklfc`defmd cde dtrfs
rkfs cdrt`cflks quk okm`fe lds kikctds mk lf kodc`e sdhrk lf cdemuctf. Kl
eclkd suhtflo`cd rkc`hk tfoh`e fikrkec`fs mk lf cdrtkzf ckrkhrfl. Lfs
ekurdefs mk m`st`etfs rkn`deks mkl cfumfmd y mkl putfoke kevfe prdykcc`deks f
zdefs kspkci`cfs mkl nldhd pl`md y lf sustfec`f e`nrf. Fe os, lf drnfe`zfc`eks tdpdnri`cf mk tfl odmd quk zdefs kspkci`cfs mk lf cdrtkzf fctfe f trfvs mkl
kstr`fmd ke zdefs kspkci`cfs mkl nldhd pl`md y lf sustfec`f e`nrf. Kl eclkd
suhtflo`cd rkc`hk `eidrofc`e mkl sknoketd kxtkred mkl nldhd pl`md y kevf
prdykcc`deks drnfe`zfmfs tdpdnri`cfoketk, f fohds sknoketds mkl nldhd pl`md
y f lf zdef rkt`culfmf mk lf sustfec`f e`nrf. ]foh`e rkc`hk fikrkec`fsm`rkctfs
drnfe`zfmfs tdpdnri`cfoketk mksmk lf cdrtkzf odtdrf pr`ofr`f y prkodtdrf,
prdpdrc`defemd f lf cdrtkzf odtdrf dtrd okm`d pfrf cdetrdlfr lfs sfl`mfs mk lds
nfenl`ds hfsflks (Afemkl kt fl., 82221 A`enslky, 8222).
Ketrk kstfs rutfs mk `etkrcdoue`cfc`e, uef ks lf mk ofydr rklkvfec`f pfrf kl
mksfrrdlld mk kstf `evkst`nfc`e7 lf vf e`nrd-kstr`ftfl. Kl ekdkstr`fmd rkc`hk lf
prdykcc`e mdpfo`ern`cf os `opdrtfetk mksmk lf zdef cdopfctf mk lf
sustfec`f e`nrf (vkr ke lf I`nurf 8, lf vf quk sk rksfltf cde uef ilkcjf mk cdldr
rdgd). Lf prm`mf prdnrks`vf mk kstf prdykcc`emdpfo`ern`cf ks cfrfctkrst`cf
mk lf keikrokmfm mk Rfra`esde. Oucjfs mk lfs ekurdefs mdpfo`ern`cfs mk lfpfrs cdopfctf tfoh`e prdmucke cdlkc`stdqu`e`ef (CCA) y ue ppt`md ekurdfct`vd,
pdr ld quk ue mfd ke kstf rkn`e `evdlucrf tfoh`e lf prm`mf mk kstfs skflks.
Fmkos mkl ekdkstr`fmd, kstfs ekurdefs mdpfo`ern`cfs sk prdykctfe fl
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cdoplkgd fo`nmfld`mk, kl eclkd fccuohkes y lf cdrtkzf prkirdetfl (Afemkl kt fl.,
8222 y A`enslky, 8222).
Lf vf kikrketk pr`ec`pfl mk lds nfenl`ds hfsflks surnk mkl sknoketd `etkred mklnldhd pl`md y mk lf zdef rkt`culfmf mk lf sustfec`f e`nrf. Kstfs vfs tkro`efe ke
vfr`ds eclkds mkl tlfod, quk f su vkz prdykctfe sdhrk vfr`fs rkfs cdrt`cflks7
prkirdetfl, prkodtdrf y kl rkf odtdrf suplkoketfr`f. Okm`fetk kstfs
prdykcc`deks, lds nfenl`ds hfsflks `eiluyke sdhrk dtrds s`stkofs mksckemketks,
tflks cdod lds s`stkofs cdrt`cdksp`eflks y cdrt`cdhulhfr (Afemkl kt fl., 82221
A`enslky, 8222).
Yfr`fs keikrokmfmks ekurdln`cfs sk jfe rklfc`defmd cde lks`deks kspkci`cfs mk
lds nfenl`ds hfsflks. Ke nkekrfl, kl mfd mk lds nfenl`ds hfsflks prdmuck
keikrokmfmks cfrfctkr`zfmfs pdr mksrmkeks ke kl odv`o`ketd cdrpdrfl d
m`squ`eks`fs. Lfs m`squ`eks`fs sde keikrokmfmks ke lfs quk sk prksketfe
prm`mfs mkl cdetrdl vdluetfr`d mkl odv`o`ketd y lf rknulfc`e mkl o`sod. Jfy mds
t`pds mk m`squ`eks`fs (A`enslky, 8222)7
Lfs j`pkrqu`eks`fs7 quk rksultfe ke lf kxprks`e mk odv`o`ketds `evdluetfr`ds
kspdetekds. Rdr kgkopld, ke lf keikrokmfm mk Juet`entde mdemk sk
prksketf uef prm`mf prdnrks`vf mk lds eclkds cfumfmd y putfoke, fs cdod
prm`mf mk ekurdefs cdrt`cflks y sk cfrfctkr`zf fmkos pdr cufmrds mk
mkokec`f, y fltkrfc`deks mk lf pkrsdefl`mfm (Ofrt`e, 6000).
Lfs j`pdqu`eks`fs7 quk rksultfe ke odv`o`ketds kspdetekds kscfsds y
kelketkc`o`ketd mkl odv`o`ketd vdluetfr`d. [e kgkopld mk j`pdqu`eks`f sk mfke lf keikrokmfm mk Rfra`esde (Ofrt`e, 6000).
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8.8 Ekurdquo`cf ke lds Nfenl`ds Hfsflks
Ketrk lds ekurdtrfeso`sdrks f e`vkl mk lds nfenl`ds hfsflks sk kecuketrfe lfs
fo`efs h`dne`cfs quk sde7 lfs cftkcdlfo`efs y lf skrdtde`ef (Afemkl kt fl.,
8222). ]dmds lds ekurdtrfeso`sdrks cftkcdlfo`ern`cds7 mdpfo`ef, edrfmrkefl`ef
y fmrkefl`ef1 sk s`etkt`zfe f pfrt`r mkl fo`edc`md t`rds`ef (]yr) ke lf o`sof rutf
h`ds`ett`cf. Ke kstf rutf sk jfe `mket`i`cfmd c`ecd kez`ofs pr`ec`pflks7 lf t rds`ef
j`mrdx`lfsf (]J), lf L-fo`edc`md frdot`cd mkscfrhdx`lfsf (FFM), lf mdpfo`ef -
j`mrdx`lfsf (MFJ), lf ptkr`m`ef rkmuctfsf (RtX) y lf ike`lktfedlfo`ef E-
okt`ltrfesikrfsf (EO]).
Lf pr`okrf kez`of, lf t`rds`ef j`mrdx`lfsf (]J), ifc`l`tf lf dx`mfc`e mk lf t`rds`ef
(]yr, L-=-j`mrdx`ike`lflfe`ef) ke L-3,=-m`j`mrdx`ike`lflfe`ef (L-MDRF). Ke kstk
pfsd `etkrv`kek cdod cdifctdr uef ptkr`m`ef rkmuc`mf (Rt-8J), quk sk rknkekrf f
pfrt`r mk lf ptkr`m`ef (Rt), pdr fcc`e mk dtrf kez`of7 lf ptkr`m`ef rkmuctfsf (RtX).
Lf L-MDRF ks h`dmkscfrhdx`lfmf pdr lf fcc`e mk lf kez`of L-fo`edc`md
frdot`cd mkscfrhdx`lfsf (LFFM) pfrf nkekrfr mdpfo`ef (3,=-
m`j`mrdx`ike`lkt`lfo`ef) cde lf cdeskcuketk prm`mf mk lf qu`rfl`mfm ke kl prdmuctd
(vkr i`nurf 3).
I`nurf 37Ksqukof mkl prdcksd h`ds`ett`cd mk mdpfo`ef f pfrt`r mk L--MDRF
Lf tkrckrf kez`of, lf mdpfo`ef -j`mrdx`lfsf (MFJ) ifc`l`tf lf prdmucc`e mk
edrfmrkefl`ef d 3,=-m`j`mrdx`ike`lktfedlfo`ef. Lf edrfmrkefl`ef prksketk ke
JD
JD
EJ8
mdpfo`efL-MDRF
JDEJ3+
D
D-JD LF FM
+ CD8
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kstr`fmd t`kek su dr`nke pr`ec`pfloketk ke prdykcc`deks quk prdv`keke mkl ldcus
cdkrulkus. Kstfs prdykcc`deks pfsfe vketrdokm`fl f lf pfrs cdopfctf
(E`kuwkejuys, 60:;).
I`efloketk lf kez`of ike`lktfedlfo`ef E-okt`ltrfesikrfsf (EO]), ifc`l`tf lf
h`dtrfesidrofc`e mk lf edrfmrkefl`ef ke fmrkefl`ef d 3,=-m`j`mrdx`-E-
okt`like`lktfedlfo`ef. Kstk prdcksd dcurrk ke lf omulf fmrkefl. Lf kez`of EO]
ed sk s`etkt`zf ke s`stkof ekrv`dsd cketrfl, fuequk flnuefs ekurdefs keckil`cfs
ut`l`zfe fmrkefl`ef cdod ekurdtrfeso`sdr (Eklsde & Cdx, 8222).
Ed tdmfs lfs ekurdefs ckrkhrflks quk l`hkrfe cftkcdlfo`efs, kxprksfe lfs c`ecdkez`ofs. Rdr kgkopld, lfs ekurdefs quk l`hkrfe edrfmrkefl`ef ed kxprksfe lf
EO] y lfs quk l`hkrfe mdpfo`ef ed kxprksfe lf EO] e` lf MFJ.
Lfs pr`ec`pflks kez`ofs `evdlucrfmfs ke kl oktfhdl`sod mk lfs cftkcdlfo`efs f
e`vkl mk tdmd kl drnfe`sod y tfoh`e mkl kecifld sde lfs OFD
(odedfo`eddx`mfsfs) y lfs CDO] (cftkcdl-D-okt`ltrfesikrfsfs) (Ilrkz, 822:).
Lfs OFD sde kez`ofs dx`mft`vfs o`tdcdemr`flks quk fctf ke lf cfmkef lftkrfl.
Su fct`v`mfm sk cketrf ke lf irfcc`e c`tdplfsot`cf mk lfs odedfo`efs ed
prdtkn`mfs ke kl `etkr dr mk lfs vksculfs. Lf CDO] ks uef kez`of mk lf irfcc`e
sdluhlk c`tdplfsot`cf k `eclusd pukmk kstfr fsdc`fmf f lf okohrfef cklulfr
pdsts`ept`cf, pkrd ed sk kecuketrf l`nfmf pfrt`culfroketk f lfs ekurdefs
cftkcdlfo`ern`cfs (Ilrkz, 822:).
Ke kl cfsd kspkci`cd mk lf mdpfo`ef, stf ks oktfhdl`zfmf pdr lf OFD y luknd lf
FMJ (flmkjmd mksj`mrdnkefsf) f c`md 3,=-m`j`mrdx`ike`lfct`cd (MDRFC), ke lftkro`efc`e s`ept`cf. Lf mdpfo`ef l hkrfmf ks trfesidrofmf pdr lf CDO] f 3-
oktdx`t`rfo`ef (3-O]), lf cufl ks pdstkr`droketk oktfhdl`zfmf pdr lf OFD y luknd
lf FMJ ke c`md 3-oktdx`-=-j`mrdx`ike`lfct`cd, tfoh`e cdedc`md cdod c`md
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jdodvfel`cd (JYF). Kl MDRFC f su vkz ks oktfhdl`zfmd pdr lf CDO] tfoh`e f
JYF.
Lf skrdtde`ef (;-j`mrdx`tr`ptfo`ef) sk h`ds`etkt`zf ke ue prdcksd quk `e`c`f cde lfj`mrdx`lfc`e mk L-tr`ptifed f ;-j`mrdx`tr`ptifed pdr fcc`e mk lf kez`of tr`ptifed
j`mrdx`lfsf (^J) y luknd lf mkscfrhdx`lfc`e mk stk lt`od cde fcc`e mk lf LFFM
(vkr i`nurf =).
I`nurf =7 Ksqukof mkl prdcksd h`ds`ett`cd mk skrdtde`ef (;-j`mdx`tr`ptfo`ef) f pfrt`r mk L-tr`ptifed y ;-j`mrdx` L-tr`ptifed. (Odm`i`cfmd mk Ilrkz, 822:).
Rdr su pfrtk lf skrdtde`ef ks oktfhdl`zfmf pr`ec`pfloketk pdr lf OFD y luknd pdr
lf FMJ ke c`md ;-j`mrdx` 3-`emdlfct`cd (;-J@FF). Lf skrdtde`ef prksketk ke kl
kstr`fmd t`kek su dr`nke pr`ec`pfloketk ke prdykcc`deks quk prdv`keke mkl eclkd
mkl Xfi. Kstfs prdykcc`deks pfsfe mdrsdokm`fl f lf pfrs cdopfctf
(E`kuwkejuys, 60:;).
8.3 S`stkof mdpfo`ern`cd ke kl S`stkof Ekrv`dsd Cketrfl
Kl s`stkof mdpfo`ern`cd ke kl s`stkof ekrv`dsd cketrfl (SEC), kst cdest`tu`md
pdr vfr`ds klkoketds mk prdykcc`e, cuyfs i`hrfs sde mk lden`tum vfr`fhlk7 lfrnfs,
cdrtfs y ultrfcdrtfs (Ilrkz, 822:)7
EJ
D
EJ3+
D-
L-tr`ptifed
RtX
RtRt (8J)
+ J8D
^J
+ D8 EJ
D
EJ3+
D-
JD
;-j`mrdx` L-tr`ptifed skrdtde`ef
EJ
EJ8JD
- CD8
LFFM
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f) Kl s`stkof e`nrdstr`fmd7 su dr nke kst ldcfl`zfmd ke lf SEpc y ke okedr
nrfmd ke lf idrofc`e rkt`culfmf okskeckil`cf y prdykctf prdiusfoketk fl
cfumfmd y putfoke mdemk idrof uef rkm mkesf mk tkro`efc`deks.
h) S`stkof oksdloh`cd7 efck pr`ec`pfloketk ke kl rkf tknoketfl vketrfl y skm`str`huyk pdr kl s`stkof loh`cd cde kxckpc`e mkl j`pdcfopd, eclkd
fccuohkes, tuhrculd dliftdr`d, eclkd cketrfl mk lf fonmflf, skptuo
lftkrfl y eclkd `etkrst`c`fl mk lf kstrf tkro`efl.
c) S`stkof oksdcdrt`cfl7 f m`ikrkec`f mk ld quk dcurrk ke lds rdkmdrks, kstk
s`stkof sk kecuketrf ouy mksfrrdllfmd ke lf kspkc`k juofef. Mksmk lf
SEpc y rkf tknoketfl vketrfl prdykctf jfstf lfs cdrtkzfs odtdrfs,
prkodtdrfs y suplkoketfr`fs y f lfs cdrtkzfs pfr`ktfl, tkopdrfl y c`enulfrpdstkr`dr, ks mkc`r, jfstf lfs pr`ec`pflks rkfs skesdr`odtdrfs y mk
fsdc`fc`e. Fmkos, y fl `nufl quk ke lds rdkmdrks, lfs tkro`efc`deks
mdpfo`ern`cfs sk kxt`kemke f lfs cdrtkzfs prkirdetfl, c`enulfr fetkr`dr,
`esulfr, p`r`idrok, pkr`rr`efl y ketdrr`efl y, os prdhfhlkoketk, f lf cdrtkzf
v`sufl.
m) Yfs cdrtfs7 sde lf tuhkrdj`pdi`sfr`f, quk efck ke kl j`pdtlfod vketrfl
tuhkrdhfsfl k `ekrvf lf ko`ekec`f okm`f y kl lhuld `etkrokm`d mk lf
j`pi`s`s, y lf `eckrtdj`pdtflo`cf, quk cdekctf kl j`pdtlfod mdrsfl y
pdstkr`dr cde lds eclkds lftkrflks skptflks. ]foh`e kx`stke pkqukfs
vfs ke kl eclkd odtdr mdrsfl mkl vfnd, kl eclkd mkl trfctd sdl`tfr`d y lf
sustfec`f nr`s pkr`fcukmuctfl.
k) Yfs ultrfcdrtfs7 sk kecuketrfe ke lf cfpf euclkfr `etkref mk lf rkt`ef,
cdod clulfs fofcr`efs, y ke lfs ekurdefs pkr`nldokrulfrks mkl hulhd
dliftdr`d.
Lds s`stkofs mdpfo`ern`cds ckrkhrflks kste et`ofoketk rklfc`defmds cde
prdcksds ke lds quk kl odv`o`ketd y lf kgkcuc`e mk tfrkfs cdest`tuyke ue
klkoketd clfvk. Ke pr okr lunfr, kl s`stkof e`nrdkstr`fmd ks kskec`fl ke lf
kspkc`k juofef pfrf quk kl odv`o`ketd skf rkfl`zfmd mk idrof frode`dsf y
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dhkmkzcf f lfs rmkeks vdluetfr`fs mkl `em`v`mud mk fcukrmd cde pftrdeks odtdrks
h`ke kstfhlkc`mds. Ke kstf fcc`e pfrt`c`pfe prdhfhlkoketk mk idrof cdeguetf lf
fct`vfc`e mk rkckptdrks M6 y M8. Kl s`stkof oksdloh`cd `etkrv`kek
fhuemfetkoketk ke tdmds fqukllds prdcksds ke quk lf odt`vfc`e idrof pfrtkkskec`fl mk lf cdemuctf, skf stf i`s`dln`cf pfrf ftkemkr lfs ekcks`mfmks
klkoketflks mkl `em`v`mud y mk lf kspkc`k d pftdln`cf crkfmf pdr lf
j`pkrkst`oulfc`e mkl s`stkof, k.n.ifrofcdmkpkemkec`f (Ilrkz, 822:).
Lf mdpfo`ef, mk idrof s`o`lfr quk lfs dtrfs cftkcdlfo`efs, sk kecuketrf
ofydroketk flofckefmf ke nreulds d vksculfs mk lfs clulfs ekurdeflks. Ke
lfs ekurdefs, lds nreulds sk cdecketrfe prkikrketkoketk ke lfs vfr`cds`mfmksquk kx`stke f ld lfrnd mk lds fxdeks. Lf okohrfef mk kstds nreulds t kek ue
pdmkrdsd s`stkof mk trfespdrtk quk rkqu`krk mk F]R y On+8, okm`fetk kl cufl
nkekrf ue nrfm`ketk mk prdtdeks m`r`n`md jfc`f kl `etkr`dr vks`culfr. Kl trfespdrtk
jfc`f kl `etkr`dr vks`culfr, mk lf mdpfo`ef s`etkt`zfmf, sk rkfl`zf okm`fetk
`etkrcfoh`d cde prdtdeks. Lf mdpfo`ef, uef vkz ke kl `etkr`dr, sk ofet`kek
prkikrketkoketk ke su idrof `de`zfmf, pdr ld quk ed pukmk m`iuem`r jfc`f kl
kxtkr`dr f trfvs mk lf okohrfef vks`culfr. Lf l`hkrfc`e mk mdpfo`ef jfc`f lf
tkro`efc`e s`ept`cf sk prdmuck pdr ue prdcksd mk kxdc`tds`s okm`fmf pdr lf
fct`vfc`e mk cfeflks mk Cf+8 (Ilrkz, 822:1 Afemkl kt fl, 82221 A`enslky, 82221
Eklsde & Cdx, 8222).
Sk jfe mkscr`td c`ecd t`pds mk rkckptdrks mdpfo`ern`cds mkedo`efmds7 M6, M8,
M3, M= y M;. Kstf clfs`i`cfc`e sk jf hfsfmd ke su m`ikrketk s`stkof mk
trfesmucc`e mk skfl (t`pd mk prdtkef N), su m`ikrketk fi`e`mfm ifrofcdln`cf
(tfetd f fnde`stfs sklkct`vds cdod fetfnde`stfs sklkct`vds), fs cdod pdr klcrdodsdof quk cdet`kek kl nke quk kxprksf cfmf rkckptdr (Hrdmy kt kl, 600:1
Ilrkz, 822:). Lf kstructurf odlkculfr mk lds rkckptdrks mdpfo`ern`cds ks mk
rkckptdrks fcdplfmds f prdtkef N kst`oulfmdrfs (M6y M;) d `ej`h`mdrfs (M8, M3y
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M=) cde uef kstructurf mk s`ktk sknoketds trfesokohrfef (Hrdmy kt fl, 600:1
Ilrkz, 822:).
Lds rkckptdrks M6 mk ldcfl`zfc`e fhuemfetk ke ekdkstr`fmd, sk fsdc`fe cde lffct`vfc`e mk lf fmke`l`lc`clfsf. Su kxc`tfc`e prdmuck ue fuoketd mkl FORc. Sk
ldcfl`zfe ke m`vkrsds eclkds y rkfs mkl SEC mdemk pfrt`c`pfe ke kl cdetrdl mk lf
fct`v`mfm odtdrf pdr kl s`stkof kxtrfp`rfo`mfl. ]foh`e sk ldcfl`zfe ke lf
nlemulf pfrft`rd`mks cuyf kst`oulfc`e prdmuck l`hkrfc`e mk lf jdrodef
(Akhfh`fe, 600;1 Ilrkz, 822:).
Lds rkckptdrks M8, mk ldcfl`zfc`e fhuemfetk ke ekdstr`fmd, sk fsdc`fe cde lf`ej`h`c`e mk lf fmke`l`lc`clfsf, lf suprks`e mk cdrr`ketks mk Cf+8y lf fct`vfc`e mk
lfs cdrr`ketks mk A+. Sk kecuketrfe m`str`hu`mds ke kl SEC7 ke lf j`pi`s`s fetkr`dr
y ke lds eclkds cfumfmd y putfoke. Lds rkckptdrks M8sk jfe `opl`cfmd ke lf
i`s`dpftdldnf mk lf ksqu`zdirke`f y mk lf keikrokmfm mk Rfra`esde (Hrdmy kt kl,
600:1 Ilrkz, 822:).
Lds rkckptdrks M3, kste fsdc`fmds cde lf fmke`l`lc`clfsf tfoh`e mk idrof
`ej`h`tdr`f y prksketfe s`o`l`tum cde lds rkckptdrks M8. Su ldcfl`zfc`e prkikrketk
ke kl SEC sk c`rcuescr`hk f lds `sldtks mk Cfllkgf y kl eclkd fccuohkes. Ed sk
cdedck lf fcc`e kspkci`cf mk kstds rkckptdrks M3. Rrksketfe uef fi`e`mfm pdr lf
mdpfo`ef 82 vkcks supkr`dr f su jdoldnd M8 (Ilrkz, 822:). Lds rkckptdrks M=
sk ldcfl`zfe prkikrketkoketk ke rkfs cdrt`cflks, f m`ikrkec`f mk lf ldcfl`zfc`e
kstr`ftfl mk su jdoldnd kl rkckptdr M8. Lf cldzfp`ef prksketf ofydr fi`e`mfm pdr
lds rkckptdrks mdpfo`ern`cds M=, quk lds rkckptdrks M8 (Ilrkz, 822:). Lds
rkckptdrks M; sde ouy kscfsds y sk ldcfl`zfe ke j`pdtlfod, j`pdcfopd y kleclkd pfrfifsc`culfr mkl tlfod. Lds rkckptdrks M;sk fsdc`fe cde lf fct`vfc`e
mk lf fmke`l lc`clfsf. Rrksketfe ofydr fi`e`mfm pdr lf mdpfo`ef pkrd tdmfvf sde
`em`st`enu`hlks ifrofcdln`cfoketk mk lds rkckptdrks M6(Ilrkz, 822:).
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Ke kl s`stkof ekrv`dsd pkr`ir`cd, sk kecuketrfe tfoh`e rkckptdrks
mdpfo`ern`cds. F e`vkl pkr`ir`cd sk m`st enuke mds t`pds mk rkckptdrks quk
cdrrkspdemke f lfs ifo`l`fs M6 y M8. Lds rkckptdrks M8 sk ldcfl`zfe, ke hukef
pfrtk, ke tkro`efc`deks s`opt`cfs pdstnfenl`defrks mk flnueds rnfeds7 fpfrftdcfrm`dvfsculfr (i`hrfs s`opt`cfs mkl cdrfze, vfsds rkeflks y oksketr`cds),
okohrfef e`ct`tfetk, hfzd y cdemuctd mkikrketk. Su fct`vfc`e prdmuck `ej`h`c`e
mk lf l`hkrfc`e mk edrfmrkefl`ef y pdr ld tfetd rkmucc`e mk lf fct`v`mfm s`opt`cf.
Lds rkckptdrks mk lf ifo`l`f M6sk kecuketrfe fsdc`fmds f lfs i`hrfs ousculfrks
l`sfs mk flnueds vfsds (k.n. rkeflks), f lfs clulfs yuxtfnldokrulfrks y f lds
thulds rkeflks (Hrdmy kt kl, 600:1 Ilrkz, 822:).
8.= Lf keikrokmfm mk Rfra`esde
Lf keikrokmfm mk Rfra`esde (KR) mkscr`tf pdr pr`okrf vkz ke 6:6> pdr kl Mr.
Gfoks Rfra`esde (Hrdmy kt fl., 600:1 A`enslky, 8222) ks ue mksdrmke
ekurdmknkekrft`vd mk lds nfenl`ds hfsflks (Afemkl, 8222), mk cfusf mkscdedc`mf
fe. Cle`cfoketk sk ofekgf su s`etdoftdldnf1 pkrd fe ks `opds`hlk mktkekr su
prdnrks`e d rkstfurfr lf prm`mf mk iuec`deks (]duldusk & Sull`vfe. 822:).
Lf keikrokmfm mk Rfra`esde fikctf f os mk ue o`lle mk pkrsdefs ke lds KK[[
(Lfen & Ldzfed, 600:f). Ke ksk pfs sk jf mktkro`efmd quk lf KR fikctf
fprdx`ofmfoketk fl 6% mk lf pdhlfc`e ofydr mk ;; fds (Mkuokes kt fl., 8228),
y cde uef prkvflkec`f mkl 8% ke lf pdhlfc`e ofydr mk 9; fds (Ofrt`e, 6000), ld
quk lf cdev`krtk ke kl sknuemd mksdrmke ekurdmknkekrft`vd os cdoe mkspus
mkl Flzjk`okr (Ofrt e, 6000). Lf KR sk kecuketrf rklfc`defmf cde lf kmfm fmultf,ckrcf mkl 99% mk lds pfc`ketks sk kecuketrfe ketrk lds ;; y lds 90 fds (Hrdmy,
kt. fl., 600:). Mftds os rkc`ketks ke Kurdpf dcc`mketfl jfe kv`mkec`fmd tfoh`e
ue `opfctd sdc`fl y kcdeo`cd `opdrtfetk mk kstf keikrokmfm. Sk rkpdrtf quk
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fikctf ketrk kl 2,; y kl 6% mk lf pdhlfc`e ketrk lds 9; y 90 fds k `ecrkoketf
ketrk ue 6 y ue 3% mk lf pdhlfc`e ofydr mk :2 fds (]duldusk & Sull`vfe, 822:).
Ke Cdstf X`cf ed kx`stke, jfstf fjdrf, mftds mk `ec`mkec`f, e` prkvflkec`f mk kstfkeikrokmfm ke lf pdhlfc`e efc`defl. Ld fetkr`dr sk pukmk cdeclu`r luknd mk
rkfl`zfr uef `evkst`nfc`e ke edv`kohrk mk 822:, ke flnuefs `est`tuc`deks
phl`cfs. Sk `evkst`n ke lf di`c`ef mk lf Drnfe`zfc`e Rfefokr`cfef mk lf Sflum
(DRS) ke Cdstf X`cf, kl Mkpfrtfoketd mk Y`n`lfec`f mk lf Sflum mkl O`e`stkr`d mk
Sflum, kl @est`tutd Efc`defl mk Kstfmst`cfs y Ckesd (@EKC), y kl Mkpfrtfoketd mk
Kstfmst`cfs mk Sflum mk lf Cfgf Cdstfrr`ckesk mkl Sknurd Sdc`fl (CCSS). Ke kl
s`stkof phl`cd mk sflum cdstfrr`ckesk, lfs keikrokmfmks ekurdln`cfs cre`cfsed sk kecuketrfe `eclu`mfs ketrk lfs keikrokmfmks quk mkhke skr rkpdrtfmfs fl
O`e`stkr`d Sflum. Ketrk lfs keikrokmfmks rkpdrtfhlks sk kecuketrfe lfs
cfrm`dvfsculfrks y kl ceckr.
Ke kl Mkpfrtfoketd mk Kstfmst`cfs mk Sflum mk lf CCSS, sk llkvf ue rkn`strd mkl
eokrd mk knrksds pdr fd mk tdmds lds Jdsp`tflks mkl Sknurd Sdc`fl mkl pfs.
Kstds rkn`strds sk kecuketrfe clfs`i`cfmds pdr Jdsp`tfl y pdr kmfm mkl pfc`ketk. F
pfrt`r mk kstds mftds mk knrksds ketrk lds fds 822; y 822> (vkr Fekxd @), sk
cflcul quk kl >9% mk lds pfc`ketks knrksfmds y quk iukrde m`fnedst`cfmds cde
KR, sde ofydrks mk 9; fds. Kstds mftds pkro`tke kxtrfpdlfr uef ofydr
`ec`mkec`f mk kstf keikrokmfm ke lf pdhlfc`e fmultf ofydr ke eukstrd pfs.
Dtrd mftd quk sk pukmk kxtrfkr mkl rkpdrtk feufl mk knrksds, ks quk ke prdokm`d
pdr fd knrksfe 9; pfc`ketks m`fnedst`cfmds cde KR. Kstds 9; pfc`ketks ke lf
pdhlfc`e efc`defl (kst`ofmf ke =.;=0.023 jfh`tfetks, fl 26 mk gul`d mk 822: pdr kl@EKC) rkprksketfe ue 2,226=%. Mkh`md f quk kl eokrd mk knrksds sdld cuhrk
lds pfc`ketks ftkem`mds ke lds skrv`c`ds mk okm`c`ef `etkref y kokrnkec`fs,
fmkos quk kst rkstr`en`md fl s`stkof mk sknur`mfm sdc`fl phl`cd, ed ks pds`hlk
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cdeclu`r quk kstk 2,226=% rkprksketk lf `ec`mkec`f mk lf KR ke kl pfs. Lf
`ec`mkec`f rkfl pdmrf skr ofydr.
Lf keikrokmfm mk Rfra`esde d pfrl`s`s fn`tfetk sk cfrfctkr`zf pdr trks setdofspr`ec`pflks7 hrfm`qu`eks`f (lket`tum fedrofl mk odv`o`ketds), r`n`mkz d fqu`eks`f
(r`n`mkz ousculfr y m`i`cultfm ke `e`c`fr kl odv`o`ketd) y trkodr (tkohldr ke rkpdsd
mk = f > Jz quk m`so`euyk murfetk lf rkfl`zfc`e mk odv`o`ketds vdluetfr`ds).
Kstk trkodr sk prksketf ke ue nrfe pdrcketfgk mk lds pfc`ketks quk pfmkcke kstf
keikrokmfm k `e`c`f ke uef kxtrko`mfm (pr`ec`pfloketk supkr`drks7 ofeds y
mkmds) y luknd sk kxt`kemk f lfs dtrfs. Dtrds setdofs sde lf `ecfpfc`mfm pfrf
ofetkekr lf pdsturf edrofl quk rksultf ke ue femfr frrfstrfemd lds p`ks y keirkcuketks cfmfs y m`siuec`deks cdne`t`vfs (prdhlkofs ke kl pkesfo`ketd, lf
okodr`f y kl lkenufgk) quk fuoketfe prdnrks`vfoketk (Lfen & Ldzfed, 600:f &
600:h).
Lf kv`mkec`f ekurdpftdln`cf os cdes`stketk ke lds pfc`ketks cde lf keikrokmfm
mk Rfra`esde, ks lf prm`mf mk lfs ekurdefs p`noketfmfs mk lf pfrs cdopfctf mk
lf sustfec`f e`nrf. Lf prm`mf mk kstfs clulfs sk fcdopff mk uef m`so`euc`e
mk dtrfs clulfs p`noketfmfs mkl s`stkof ekrv`dsd cketrfl, ke kl ldcus cdkrulkusy
ke kl eclkd odtdr mdrsfl mkl vfnd. Dtrf cfrfctkrst`cf ekurdpftdln`cf m`st`et`vf
ks lf fpfr`c`e mk `eclus`deks c`tdplfsot`cfs fedroflks mkedo`efmfs cukrpds mk
Lkwy quk sk prksketfe ke lfs ekurdefs mk lf sustfec`f e`nrf quk cdet`keke
oklfe`ef (Ofrte, 6000).
Ke lf mcfmf mk 60;2 sk rkfl`z ue mkscuhr`o`ketd ouy `opdrtfetk pfrf lf
cdoprkes`e mk kstf keikrokmfm. Sk kecdetr quk lds pfc`ketks cde Rfra`esdeprksketfhfe uef rkmucc`e skvkrf mkl ekurdtrfeso`sdr mdpfo`ef. Kstf cfrkec`f
sk mkhf f lf mknkekrfc`e mk lfs ekurdefs mdpfo`ern`cfs mk lf sustfec`f e`nrf
quk prdykctfe fl kstr`fmd (Afemkl, 8222). Kl Rfra`esde iuk lf pr`okrf keikrokmfm
cuyf s`etdoftdldnf sk fsdc` cde lf prm`mf mk ue ekurdtrfeso`sdr kspkci`cd.
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Lf `opdrtfec`f mk kstk mkscuhr`o`ketd pkro`t` `etrdmuc`r kl trftfo`ketd
ifrofcdln`cd cde L-MDRF, fe v`nketk (Ilrkz, 822:). Kstk jfllfznd fmkos
pkro`t` mkodstrfr quk lds trfstdreds mkl s`stkof ekrv`dsd pukmke fikctfr f
ekurdefs kspkci`cfs, y f prdcksds odlkculfrks kspkci cds. Os fe, sk pusd mkofe`i`kstd quk lf fmo`e`strfc`e mk ue ekurdtrfeso`sdr d mk su prkcursdr pukmke
koplkfrsk cdod tkrfp`f ifrofcdln`cf, cdod suckmk ke lf fctufl`mfm ke c`krtds
trfstdreds ps`qu`tr`cds (Afemkl, 8222).
Kl pr`ec`pfl c`rcu`td ekurfl quk sk fikctf ke lf KR sk mkscr`hk f cdet`eufc`e. Ke
ue drnfe`sod sfed, lf mdpfo`ef prdmuc`mf ke lfs clulfs mk lf pfrs cdopfctf,
kst`oulf d ifc`l`tf lfs ekurdefs os fhuemfetks ke kstr`fmd7 lfs ekurdefsksp`edsfs mk tfofd okm`fed okm`uo sp`ey ekurdes pdr su fcc`e okm`fetk
rkckptdrks mkl t`pd M6. Lfs kikrkec`fs NFHFrn`cfs mk lfs ksp`edsfs tfoh`e
rkc`hke tkro`eflks mk prdykcc`deks cdrt`cflks nlutfoftrn`cfs, fs cdod dtrfs
prdykcc`deks kxtreskcfs7 skrdtde`ern`cfs y fmkeds`ern`cfs k `etreskcfs7
cdl`ern`cfs y sdoftdstft`ern`cfs (Cjfsk kt fl., 600:). Fprdx`ofmfoketk kl 8%
mk lfs clulfs mkl kstr`fmd, lfs `etkrekurdefs ed ksp`edsfs n`nfetks, sde
cdl`ern`cfs y prdvkke uef `ekrvfc`e kxtkes`vf ke kstr`fmd, pr`ec`pfloketk sdhrk
lfs ekurdefs NFHFrn`cfs ksp`edsfs okm`fefs. Kstfs fikrkec`fs odmulfe lf
fct`v`mfm mk lfs ekurdefs okm`fefs ksp`edsfs. [e mkshflfeck ke kstr`fmd ketrk
lf l`hkrfc`e mk fckt`lcdl`ef y mdpfo`ef mk lds fxdeks quk sk dr`n`efe ke lf
suhstfet`f e`nrf pfrs cdopfctf, ks ld quk jf s`md iukrtkoketk `opl`cfmd cde lf
keikrokmfm mk Rfra`esde (L`e kt fl., 822=).
Ke ue `em`v`mud cde Rfra`esde, kstf ifc`l`tfc`e sdhrk kl kstr`fmd sk p`krmk ke os
mk ue :2% (Hrdmy kt. fl., 600:). Mkh`md f kstd lt`od, sk rkmuck lf fcc`e`ej`h`mdrf NFHFrn`cf mkl kstr`fmd sdhrk lfs ekurdefs mkl nldhd pl`md okm`fl y
sdhrk lf sustfec`f e`nrf rkt culfmf, cdod sk dhskrvf ke lf i`nurf ;. Rdr tfetd, kstf
m`so`euc`e mk lf skfl `ej`h`tdr`f sdhrk lfs ekurdefs mkl nldhd pl`md okm`fl y
sdhrk lf sustfec`f e`nrf rkt`culfmf prdmucke ue fuoketd mk lf tfsf mk m`spfrd mkl
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cdoplkgd nldhd pl`md sustfec`f e`nrf rkt`culfmf (cdoplkgd tfoh`e `ej`h`tdr`d).
Ke ue `em`v`mud sfed, kstk cdoplkgd `ej`hk kl tlfod vketrd-lftkrfl, y ke ued
keikrod, fl kecdetrfrsk kl cdoplkgd nldhd pl`md okm`fl - sustfec`f e`nrf
rkt`culfmf pdcd `ej`h`md, fuoketf su tfsf mk m`spfrd `ej`h`tdr`f y kl tlfod vketrd-lftkrfl ks `ej`h`md ke nrfe okm`mf. Cdod rksultfmd, ke ue `em`v`mud cde
Rfra`esde, lf vf tlfod cdrt`cfl ed iuec`def edrofloketk, ld quk prdmuck
j`pdqu`eks`f (Afemkl, 82221 vkr i`nurf ;).
I`nurf ;7Cdopfrfc`e mk ue c`rcu`td ekurfl ke lds nfenl`ds hfsflks ke ue `em`v`mud sfed (F.) y keue `em`v`mud cde lf keikrokmfm mk Rfra`esde (H.).M67 rkckptdrks mdpfo`ern`cds t`pd 6, M87 rkckptdrks mdpfo`ern`cds t`pd 8, NL[7 nlutfoftd, MF7mdpfo`ef1 SR7 sustfec`f R1 KEA7 keckifl`ef1 NFHF7 c`md nfof-fo`edhutr`cd1 NRL7 nldhd pl`mdlftkrfl1 SEpc7 sustfec`f e`nrf pfrs cdopfctf1 ES]7 eclkd suhtflo`cd1 NRo7 nldhd pl`md okm`fl1SEpr7 sustfec`f e`nrf pfrs rkt`culftf1 YFpc/YLd7 ]lfod vketrdfetkr`dr pfrvdcklulfr y vketrdlftkrfldrfl`s. Fmfptfmd mk A`enslky, 8222.
NFHF
+ +
+
SEpcNRL
ES]
NRo / SEpr
]knoketd Yfpc / YLd
Cdrtkzf ckrkhrfl
NL[ NL[ NL[
NL[
MF
MF
MF
SR SRKEA
NFHF
NFHF
NFHFNFHF
NFHF
kstr`fmd
M6
M8
+
++++
+
+
-
-
-
-
-
SEpcNRL
ES]
NRo / SEpr
]knoketd Yfpc / YLd
Cdrtkzf ckrkhrfl
NL[ NL[ NL[
NL[
MF
MF
MF
SR SRKEA
NFHF
NFHF
NFHFNFHF
kstr`fmd
+
++++
- -
-
-
-
-
- - -
+
F. H.
+
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Fmkos mk ld fetkr`dr, lf vf mdpfo`ern`cf nkekrf `em`rkctfoketk uef `ej`h`c`e
sdhrk lfs ekurdefs ksp`edsfs mk keckifl`ef mkl kstr`fmd fctufemd sdhrk
rkckptdrks mkl t`pd M8. Ke ue `em`v`mud cde Rfra`esde, kstf `ej`h`c`e kst
m`so`eu`mf, ld quk nkekrf ue fuoketd ke lf l`hkrfc`e mkl ekurdtrfeso`sdr NFHFtfoh`e `ej`h`tdr`d, quk fctf sdhrk kl nldhd pl`md lftkrfl. Ke ue `em`v`mud sfed, kl
kstr`fmd `ej`hk lf fcc`e mkl nldhd pl`md lftkrfl y ke ued keikrod kstf `ej`h`c`e
kst fuoketfmf y cdeskcuketkoketk mkcrkck lf tfsf mk m`spfrd mkl nldhd pl`md
lftkrfl sdhrk kl eclkd suhtflo`cd. Rdr lt`od, ke ue `em`v`mud keikrod kl eclkd
suhtflo`cd prksketf `ecrkoketfmf su tfsf mk m`spfrd kst`oulfetk sdhrk kl
cdoplkgd7 nldhd pl`md okm`fl - sustfec`f e`nrf rkt culfmf. Rdr tfetd, kstk
fuoketd mk lf kst`oulfc`e, `ecrkoketf lf tfsf mk m`spfrd `ej`h`tdr`f mkl cdoplkgdnldhd pl`md sustfec`f e`nrf rkt`culfmf sdhrk kl tlfod vketrd-lftkrfl. Cde kstd
lt`od, tfoh`e pdr kstf dtrf vf sk prdmuck uef `ej`h`c`e mk lf vf tlfod
cdrt`cfl, quk cdod sk mkscr`h` fetkr`droketk, sk trfmuck ke j`pdqu`eks`f (Afemkl,
82221 vkr i`nurf ;).
[ef jkrrfo`ketf v`tfl pfrf kstum`fr kl iuec`defo`ketd edrofl mk m`vkrsfs
kstructurfs ckrkhrflks cdod lds nfenl`ds hfsflks, fs cdod kl dr`nke y lf
kvdluc`e mk keikrokmfmks ekurdmknkekrft`vfs cdod kl Rfra`esde, ks okm`fetk
odmklds fe`oflks. [ed mk lds odmklds fe`oflks os ut`l`zfmds pfrf kl kstum`d
mkl Rfra`esde ks kl odmkld mk lks`e mk lf vf e`nrdkstr`ftfl cde m`ikrketks tdx`efs
(^ddmruii & Edeekofe, 600=1 Hktfrhkt kt fl, 82281 Mfwsde kt fl, 82281 Mfukr &
Rrzkmhdrsa`, 82231 Kohdrm, 822=) cdod pdr kgkopld lf lks`e ke rftfs mk kstf vf
cde lf ekurdtdx`ef cftkcdlfo`ern`cf7 9-j`mrdx`mdpfo`ef (9-DJMF) (Scjwfrt`en &
Justde, 6009f & 6009h1 Idrefnukrf & Scjwfrt`en, 60001 Gfcasde-Lkw`s &
L`hkrftdrk, 82221 S`emju kt fl, 8229).
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8.; Odmkld ke rftfs mk lks`e `etrfckrkhrfl cde 9-j`mrdx`mdpfo`ef
Lds odmklds ke rftfs mk lf keikrokmfm mk Rfra`esde, quk `evdlucrfe lf lks`e cde
ekurdtdx`efs mk lf vf mdpfo`ern`cf e`nrdkstr`ftfl, jfe s`md ouy kstum`fmds
(^ddmruii & Edeekofe, 600=1 Gfcasde-Lkw`s & L`hkrftdrk, 82221 Hktfrhkt kt fl.,
82281 Mfukr & Rrfkmhdrsa`, 82231 S`emju kt fl, 822;). Kx`stke vfr`fc`deks ketrk
lds odmklds skne7 lf tdx`ef koplkfmf (Ade`ts`dt`s kt fl, 600:1 Sfwfourf kt fl,
82261 S`emju kt fl, 822;1 Zu kt fl, 822;)1 lf rkn`e kspkci`cf mk lf vf e`nrd-
kstr`ftfl quk sk lks`dek (Mkuokes kt fl., 82281 S`emju kt fl, 8229), kl nrfmd mk
lks`e (Jkit` kt fl, 60:21 Idrefnukrf kt fl, 60031 Scjwfrt`en & Justde, 6009f) y s`
lf lks`e ks ue`lftkrfl (ued mk lds jko`sikr`ds ckrkhrflks) (Scjwfrt`en & Justde,
6009f1 Mkuokes kt fl., 8228) d h`lftkrfl (So`tj kt fl, 8228).
Rdr kgkopld, lfs rkn`deks mk lf vf e`nrd-kstr`ftfl quk sk jfe lks`defmd ke
odmklds cde 9-j`mrdx`mdpfo`ef (9-DJMF) cdoprkemke (Mkuokes kt fl., 8228)7
f) Lf rkn`e okm`fl mkl prdskecifld. Kstk t`pd mk lks`e prdmuck uef
m`so`euc`e mdpfo`ern`cf kxtkes`vf.
h) Lf pfrs cdopfctf mk lf sustfec`f e`nrf, ld quk prdmuck uef m`so`euc`e
mdpfo`ern`cf os kspkci`cf y odmkrfmf.
c) Suh-rkn`deks mkl cdoplkgd cfumfmd putfoke quk prdmuck m`so`euc`deks
mdpfo`ern`cfs kspkci`cfs y okedrks quk lfs mkscr`tfs pfrf lf lks`e mkl
puetd h), fetkr`dr.
Kstds odmklds mk lks`e cde 9-DJMF jfe s`md ouy t`lks pfrf fuoketfr kl
cdedc`o`ketd mk lf i`s`dldnf mk lds nfenl`ds hfsflks y mk su i`s`dpftdldnf cdod
ke lf keikrokmfm mk Rfra`esde. Fmkos, sk jfe koplkfmd ke kl mksfrrdlld mk
eukvfs kstrftkn`fs tkrfput`cfs, f sfhkr, kl mksfrrdlld mk eukvds irofcds y lf
7/13/2019 Efecto Neuroquimico y Conductual de La Miotoxina III de Bothrops Asper Luego de Su Inyeccion en El Mesencefalo
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`oplkoketfc`e mk fprdx`ofc`deks qu`rrn`cfs cdod trfsplfetks mk tkg`md ekurfl
sfed (^ddmruii & Edeekofe, 600=).
Skne Scjwfrt`en & Justde (6009f), kl odmkld cde ofydr sklkct`v`mfm y cdemkplkc`deks mk mdpfo`ef os cdetrdlfmfs, ks kl mk lf lks`e mk lf sustfec`f e`nrf
pfrs cdopfctf (SEpc) cde 9-DJMF. Lf ekurdtdx`ef 9-DJMF ks kl pr`okr
cdopukstd quo`cd mkscuh`krtd quk prksketf kikctd ekurdtx`cd kspkci`cd sdhrk
lfs vfs cftkcdlfo`ern`cfs ([enkrstkmt, 609:).
Kstf tdx`ef pukmk skr trfespdrtfmf fl `etkr`dr mk lds cukrpds cklulfrks
mdpfo`ern`cds pdr kl trfespdrtfmdr mk mdpfo`ef. Lf 9-DJMF prdmuck lfmkstrucc`e mk lfs tkro`eflks ekrv`dsfs. Sk jfe prdpukstd mds okcfe`sods
`emkpkem`ketks pfrf kxpl`cfr lf ekurdtdx`c`mfm mk lf 9-DJMF. [ed mk kllds ks lf
`emucc`e mk kstrs dx`mft`vd pdr lf nkekrfc`e mk pkrx`md mk j`mrnked y
rfm`cflks j`mrdx`ld mkr`vfmds. Kl dtrd okcfe`sod sk hfsf pr`ec`pfloketk ke su
pdtketk kikctd `ej`h`mdr mk kez`ofs rksp`rftdr`fs o`tdcdemr`flks. Mkh`md fl mi`c`t
oktfhl`cd `emuc`md, lfs ekurdefs fikctfmfs oukrke (Hluo kt fl, 82261 Mkuokes
kt fl., 8228). Ke kstk odmkld, lf lks`e ed kst rkstr`en`mf f lf pfrs cdopfctf,
tfoh`e sk jfe rkpdrtfmd lks`deks, fuequk pfrc`flks, mk lfs clulfs
mdpfo`ern`cfs mkl rkf vketrfl tknoketfl. Lf sklkct`v`mfm mk lf lks`e cde 9-
DJMF tfoh`e sk pukmk vkr fikctfmf pdr lf cfpturf mk lf tdx`ef pdr trfespdrtfmdr
prks`ept`cd mk edrkp`ekir`ef. Kstd lt`od sk pukmk kv`tfr cde lf fmo`e`strfc`e
s`sto`cf, prkv`d f lf lks`e, mk mks`prfo`ef