Web of Sciencelib.fjtcm.edu.cn/UserFiles/File/2011年福建中医药大学SCI文摘.pdf · TAT-SOD...

第 1 条，共 86 条标题: Effects of Intracellular Superoxide Removal at Acupoints with TAT-SOD on Obesity 作者: Guo, JK (Guo, Jingke); Chen, Y (Chen, Yue); Yuan, B (Yuan, Bin); Liu, ST (Liu, Shutao);

Rao, PF (Rao, Pingfan) 来源出版物 : FREE RADICAL BIOLOGY AND MEDICINE 卷 : 51 期 : 12 页 :

2185-2189 DOI: 10.1016/j.freeradbiomed.2011.09.036 出版年: DEC 15 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 26 摘要: TAT-SOD is a recombinant protein of superoxide dismutase fused with TAT peptide. By

pure accident, we discovered that topical application of TAT-SOD to acupoints could result in

acupuncture-like action. This study aimed to validate the accidental discovery by investigating the

effect on simple obesity of the topical application of TAT-SOD to acupoints in comparison with

acupuncture. 90 subjects were divided into 3 groups for 12-week treatments. Regular hospital

acupuncture treatment was given to Acupuncture Group 3 times a week. TAT-SOD Group were

instructed first to locate acupoints and apply 0.1 ml of 5000u SOD/ml TAT-SOD cream in an area

of 1 cm(2) to each of the same set of acupoints, which they then conducted at home three times

daily. Placebo Group applied the vehicle cream the same manner as TAT-SOD Group. Both

TAT-SOD and acupuncture treatments decreased adiposity with overall clinical effective rates of

60.0% and 76.7%, respectively. The placebo group showed no improvement. The results validate

that the enzymatic removal of the intracellular superoxide at acupoints could generate

acupuncture-like effects, and indicate a possibility of the new method as a simple substitute to

acupuncture and an insight of superoxide modulation along meridians for acupuncture mechanism.

(C) 2011 Elsevier Inc. All rights reserved. 入藏号: WOS:000297960000007 语种: English 文献类型: Article 作者关键词: Superoxide; TAT-SOD; Acupuncture; Meridian; Simple obesity; Free radicals

KeyWords Plus: APPETITE SUPPRESSION; PROTEIN; ACUPUNCTURE; DISMUTASE;

TRANSDUCTION; METAANALYSIS; CELLS 地址: [Guo, Jingke; Liu, Shutao; Rao, Pingfan] Fuzhou Univ, Inst Biotechnol, Fuzhou 350002,

Fujian, Peoples R China

[Chen, Yue; Yuan, Bin] Fujian Univ Tradit Chinese Med, Acupuncture Coll, Fuzhou, Fujian,

Peoples R China 通讯作者地址: Rao, PF (通讯作者),Fuzhou Univ, Inst Biotechnol, 523 Gongye Rd, Fuzhou

350002, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: ELSEVIER SCIENCE INC 出版商地址: 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA

Web of Science 分类: Biochemistry & Molecular Biology; Endocrinology & Metabolism 学科类别: Biochemistry & Molecular Biology; Endocrinology & Metabolism

IDS 号: 860PK

ISSN: 0891-5849

29 字符的来源出版物名称缩写: FREE RADICAL BIO MED

ISO 来源出版物缩写: Free Radic. Biol. Med. 来源出版物页码计数: 5 基金资助致谢: 基金资助机构授权号

National Basic Research Program of China 2010CB530605

National Natural Science Foundation of China 30973871

31071497

Fujian Science and Technology Bureau 2008Y0088

Education Council of Fujian Province of China JB09154

Fuzhou University, China 2010-XY-17

We Thank Du Jian and Dou Sidong of Fujian University of Tradional Chinese Medicine for

helpful discussions. This research was supported by National Basic Research Program of China

(Grant No. 2010CB530605); National Natural Science Foundation of China (Grant No. 30973871,

No. 31071497); Key Research Program of Fujian Science and Technology Bureau (Grant No.

2008Y0088); Education Council of Fujian Province of China (Grant No. JB09154); Science and

Technology Development Fund of Fuzhou University, China (Grant No. 2010-XY-17).

第 2 条，共 86 条标题: Anti-angiogenic effect of Spica prunellae extract in vivo and in vitro 作者: Lin, W (Lin, Wei); Zheng, LP (Zheng, Liangpu); Zhao, JY (Zhao, Jinyan); Zhuang, QC

(Zhuang, Qunchuan); Hong, ZF (Hong, Zhenfeng); Xu, W (Xu, Wei); Chen, YQ (Chen, Youqin);

Sferra, TJ (Sferra, Thomas J.); Peng, J (Peng, Jun) 来源出版物: AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY 卷: 5 期:

24 页: 2647-2654 DOI: 10.5897/AJPP11.266 出版年: DEC 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 35 摘要: Angiogenesis is a fundamental component of cancer growth and metastasis; therefore,

inhibition of angiogenesis has become a promising strategy for the discovery and development of

cancer chemotherapeutics. Recently, natural products have attracted significant interest as

therapeutic agents for cancer since they have relatively fewer side effects as compared to modern

chemotherapeutics and have long been used clinically to treat a variety of diseases, including

cancer. Spica prunellae is an important component in several traditional Chinese medicine (TCM)

formulations for cancer treatment. Recently, we reported that S. prunellae inhibits cancer cell

growth through the induction of mitochondrion-dependent apoptosis. However, the precise

mechanisms of its overall anti-cancer activity remain largely unknown. In the present study, we

investigated the anti-angiogenic effects of the ethanol extract of S. prunellae (EESP) in vitro on

human umbilical vein endothelial cells (HUVECs) and in vivo using the chick embryo

chorioallantoic membrane (CAM) assay. We found that EESP inhibited the proliferation of

HUVECs via blockade of cell cycle G1 to S progression. In addition, EESP inhibited the

migration and tube formation of HUVECs. Moreover, EESP treatment decreased VEGF-A

expression in HT-29 human colon carcinoma cells as well as the expression of VEGF-A and

VEGFR-2 in HUVECs. Furthermore, EESP exposure reduced the formation of blood vessels in

chick embryos. These results suggest that the inhibition of angiogenesis is one of the mechanisms

by which S. prunellae can mediate an anti-cancer effect. 入藏号: WOS:000299679300002 语种: English 文献类型: Article 作者关键词: Spica prunellae; angiogenesis; cancer treatment; herbal medicine

KeyWords Plus: ENDOTHELIAL GROWTH-FACTOR; TUMOR ANGIOGENESIS;

THERAPEUTIC IMPLICATIONS; COLORECTAL-CANCER; FACTOR EXPRESSION;

NATURAL-PRODUCTS; DRUG-RESISTANCE; METASTASIS; CARCINOMA; PROGNOSIS 地址: [Lin, Wei; Zheng, Liangpu; Zhao, Jinyan; Zhuang, Qunchuan; Hong, Zhenfeng; Peng, Jun]

Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China

[Zheng, Liangpu] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med Geriatr, Fuzhou

350108, Fujian, Peoples R China

[Xu, Wei] Fujian Univ Tradit Chinese Med, Dept Pharmacol, Fuzhou 350108, Fujian, Peoples R

China

[Chen, Youqin; Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Paediat, Oklahoma City,

OK 73190 USA

[Chen, Youqin; Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol,

Oklahoma City, OK 73190 USA 通讯作者地址: Peng, J (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, 1

Huatuo Rd, Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA

Web of Science 分类: Pharmacology & Pharmacy 学科类别: Pharmacology & Pharmacy

IDS 号: 884BG

ISSN: 1996-0816

29 字符的来源出版物名称缩写: AFR J PHARM PHARMACO

ISO 来源出版物缩写: Afr. J. Pharm. Pharmacol.

来源出版物页码计数: 8 基金资助致谢: 基金资助机构授权号

Natural Science Foundation of Fujian province of China 2009J01173

Research Foundation of Education Bureau of Fujian province of China JA10168


Developmental Fund of Chen Keji Integrative Medicine CKJ 2010019

This work was sponsored by the Natural Science Foundation of Fujian province of China

(2009J01173), the Research Foundation of Education Bureau of Fujian province of China

(JA10168), the National Natural Science Foundation of China (81073097) and the Developmental

Fund of Chen Keji Integrative Medicine (CKJ 2010019).

第 3 条，共 86 条标题: A comparative study on antioxidant activity of ten different parts of Nelumbo nucifera

Gaertn. 作者: Wu, YB (Wu, Yan-Bin); Zheng, LJ (Zheng, Li-Jun); Yi, J (Yi, Jun); Wu, JG (Wu, Jian-Guo);

Tan, CJ (Tan, Chun-Jiang); Chen, TQ (Chen, Ti-Qiang); Wu, JZ (Wu, Jin-Zhong); Wong, KH

(Wong, Ka-Hing) 来源出版物: AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY 卷: 5 期:

22 页: 2454-2461 DOI: 10.5897/AJPP11.352 出版年: DEC 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 27 摘要: The in vitro antioxidant activity of ten different parts of lotus (Nelumbo nucifera Gaertn.)

was evaluated and compared. Among the ten lotus extracts, the receptacle did not only possessed

the highest phenolic, flavonoid and proanthocyanidin contents, but its 2-picrylhydrazyl free

(DPPH) and 2, 2'-Azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging

activities, reducing power as well as total antioxidant activity were also comparable to, if not

better than those of the butylated hydroxytoluene (BHT) control (p < 0.05). Compared with the

BHT, all ten lotus extracts even exhibited significantly (p < 0.05) higher metal chelating activity.

Nevertheless, the hydroxyl radical scavenging ability of all ten lotus extracts was significantly (p

< 0.05) lower than that of the ascorbic acid control. In contrast to the metal chelating ability,

phenolic compounds in the ten lotus extracts would likely be responsible for their DPPH and

ABTS radical scavenging activities. 入藏号: WOS:000299677200005 语种: English 文献类型: Article 作者关键词: Louts (Nelumbo nucifera); total phenolic content; total flavonoid content; total

proanthocyanidin content; antioxidant activity

KeyWords Plus: IN-VITRO; LEAVES; FLAVONOIDS; EXTRACTS; STAMENS; MICE 地址: [Wu, Yan-Bin; Zheng, Li-Jun; Wu, Jian-Guo; Tan, Chun-Jiang; Wu, Jin-Zhong] Fujian Univ

Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China

[Yi, Jun] Fujian Inst Educ, Dept Chem & Life Sci, Fuzhou 350001, Fujian, Peoples R China

[Chen, Ti-Qiang] Fujian Acad Agr Sci, Inst Edible & Med Fungi, Fuzhou 350013, Peoples R

China

[Wong, Ka-Hing] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong

Kong, Peoples R China 通讯作者地址: Wu, JZ (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou

350108, Fujian, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA


IDS 号: 884AL

ISSN: 1996-0816


ISO 来源出版物缩写: Afr. J. Pharm. Pharmacol. 来源出版物页码计数: 8 基金资助致谢: 基金资助机构授权号

Fujian Provincial Universities for Haixi Development 5

Research Foundation of Health Bureau of Fujian Province of China wzzd0901

Developmental Fund of Chen Keji Integrative Medicine CKJ2010027

Natural Science Foundation of Fujian province of China 2011J01212

This work was conducted in Class III Laboratory of Traditional Chinese Medicine on

Pharmacognosy of State Administration of Traditional Chinese Medicine of People's Republic of

China and was financially supported by Key Project of Fujian Provincial Universities for Haixi

Development (Grant No. 5), the Research Foundation of Health Bureau of Fujian Province of

China (Grant No. wzzd0901), Developmental Fund of Chen Keji Integrative Medicine (Grant No.

CKJ2010027) as well as the Natural Science Foundation of Fujian province of China (Grant No.

2011J01212).

第 4 条，共 86 条标题: Comparing different physical factors on serum TNF-alpha levels, chondrocyte apoptosis,

caspase-3 and caspase-8 expression in osteoarthritis of the knee in rabbits 作者: Guo, H (Guo, Hua); Luo, QL (Luo, Qinglu); Zhang, JL (Zhang, Jinlong); Lin, HD (Lin,

Haidan); Xia, L (Xia, Lu); He, CQ (He, Chengqi) 来源出版物 : JOINT BONE SPINE 卷 : 78 期 : 6 页 : 604-610 DOI:

10.1016/j.jbspin.2011.01.009 出版年: DEC 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 35 摘要: Objective: To study the therapeutic effects that different physical factors may have on

rabbits with osteoarthritis of the knee.

Methods: A total of 64 rabbits were randomised and organised into eight groups, eight of which

were each assigned a different physical factor, in which the rabbits received one type of physical

therapy: millimetre waves for 20 min, pulsed electromagnetic fields, millimetre waves for 40 min,

ultrasound, low-level laser therapy or ultrashort wave diathermy. The two remaining groups, the

normal group and the model group, served as controls. The efficacy of the different treatments

were determined by observing the configuration and structure of the cartilaginous tissue by

haematoxylin and Eosin staining, measuring the serum tumour necrosis factor-alpha levels by

enzyme immunoassay, evaluating the expression levels of caspases-3 and -8 by

immunohistochemistry, and calculating the ratio of chondrocytes apoptosis by TdT-mediated

dUTP nick end labelling. The values obtained for each assessment of the eight groups were

analysed by a One-way ANOVA.

Results: By applying upmentioned physical treatments, the organisational configuration and

structure of cartilage cells from the knees of rabbits with osteoarthritis increased. These treatments

also decreased serum tumour necrosis factor-alpha levels, reduced the expression of caspase-3 and

caspase-8 and reduced chondrocyte apoptosis, resulting in an overall delay in osteoarthritis

development.

Conclusion: The application of pulsed electromagnetic fields, millimetre waves for 40 min,

ultrasound, or low-level laser therapy had significant effects in improving osteoarthritis; in

particular, treatment with pulsed electromagnetic fields or ultrasound yielded the greatest

therapeutic effect. (C) 2011 Societe francaise de rhumatologie. Published by Elsevier Masson

SAS. All rights reserved. 入藏号: WOS:000298148300015 语种: English 文献类型: Article 作者关键词: OA; TNF-alpha; Chondrocyte apoptosis; Caspase-3; Caspase-8

KeyWords Plus: MILLIMETER WAVES; BIOPHYSICAL STIMULATION; CARTILAGE;

THERAPY; INTERLEUKIN-1-BETA; PHONOPHORESIS; ULTRASOUND; RECEPTORS;

PATHWAY; DEATH 地址: [Guo, Hua; Luo, Qinglu; Zhang, Jinlong; Lin, Haidan; Xia, Lu; He, Chengqi] Sichuan Univ,

W China Hosp, Dept Rehabil Med, Chengdu 610041, Sichuan Provinc, Peoples R China

[He, Chengqi] Rehabil Key Lab Sichuan Prov, Chengdu, Peoples R China

[Luo, Qinglu] Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R China

通讯作者地址: He, CQ (通讯作者),Sichuan Univ, Huaxi Hosp, Chengdu 610041, Sichuan

Provinc, Peoples R China 电子邮件地址: [email protected] 出版商: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER 出版商地址: 23 RUE LINOIS, 75724 PARIS, FRANCE

Web of Science 分类: Rheumatology 学科类别: Rheumatology

IDS 号: 863FN

ISSN: 1297-319X

29 字符的来源出版物名称缩写: JOINT BONE SPINE

ISO 来源出版物缩写: Joint Bone Spine 来源出版物页码计数: 7 基金资助致谢: 基金资助机构授权号

National Natural Science Fund 30672215

We thank Yuqing Wang for the statistical and data analysis. We thank the National Natural Science

Fund (No. 30672215) for the financial support.

第 5 条，共 86 条标题: Extraction of Lepidium apetalum Seed Oil Using Supercritical Carbon Dioxide and

Anti-Oxidant Activity of the Extracted Oil 作者: Xu, W (Xu, Wei); Chu, KD (Chu, Kedan); Li, H (Li, Huang); Chen, LD (Chen, Lidian);

Zhang, YQ (Zhang, Yuqin); Tang, XC (Tang, Xuchong) 来源出版物 : MOLECULES 卷 : 16 期 : 12 页 : 10029-10045 DOI:

10.3390/molecules161210029 出版年: DEC 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 30 摘要: The supercritical fluid extraction (SFE) of Lepidium apetalum seed oil and its anti-oxidant

activity were studied. The SFE process was optimized using response surface methodology (RSM)

with a central composite design (CCD). Independent variables, namely operating pressure,

temperature, time and flow rate were evaluated. The maximum extraction of Lepidium apetalum

seed oil by SFE-CO(2) (about 36.3%) was obtained when SFE-CO(2) extraction was carried out

under the optimal conditions of 30.0 MPa of pressure, 70 degrees C of temperature, 120 min of

extraction time and 25.95 L/h of flow rate. GC-MS analysis showed the presence of four fatty

acids in Lepidium apetalum seed oil, with a high content (91.0%) of unsaturated fatty acid. The

anti-oxidant activity of the oil was assessed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH)

radical-scavenging assay and 2,2'-azinobis(3-ethylbenzthiazoline-6-sulphonic acid) diammonium

salt (ABTS) test. Lepidium apetalum seed oil possessed a notable concentration-dependent

antioxidant activity, with IC(50) values of 1.00 and 3.75 mg/mL, respectively. 入藏号: WOS:000298411200019 语种: English 文献类型: Article 作者关键词: Lepidium apetalum; response surface methodology; supercritical fluid extraction;

GC-MS; anti-oxidant activity

KeyWords Plus: RESPONSE-SURFACE METHODOLOGY; FLUID EXTRACTION;

OPTIMIZATION; CAPACITY 地址: [Xu, Wei; Chu, Kedan; Li, Huang; Chen, Lidian; Zhang, Yuqin] Fujian Univ Tradit Chinese

Med, Coll Pharm, Fuzhou 350108, Peoples R China

[Tang, Xuchong] Hua Chiao Univ, Inst Chem Technol, Xiamen 361021, Peoples R China 通讯作者地址: Chen, LD (通讯作者),Fujian Univ Tradit Chinese Med, Coll Pharm, Fuzhou

350108, Peoples R China 电子邮件地址: [email protected] 出版商: MDPI AG 出版商地址: POSTFACH, CH-4005 BASEL, SWITZERLAND

Web of Science 分类: Chemistry, Organic 学科类别: Chemistry

IDS 号: 866UQ

ISSN: 1420-3049

29 字符的来源出版物名称缩写: MOLECULES

ISO 来源出版物缩写: Molecules 来源出版物页码计数: 17 基金资助致谢: 基金资助机构授权号

Key Project of Fujian Province Science-Technology Department 2009YZ0001-1-1

Fujian Province Science-Technology Plan projects 2010Y2004

Xiuping Chen of ICMS

The authors gratefully acknowledge the financial support by a Key Project of Fujian Province

Science-Technology Department (2009YZ0001-1-1) and Fujian Province Science-Technology

Plan projects (2010Y2004). At the same time they acknowledge the support of Xiuping Chen of

ICMS in the experiments.

第 6 条，共 86 条标题: Subtleties of biomineralisation revealed by manipulation of the eggshell membrane 作者: Li, N (Li, Nan); Niu, LN (Niu, Li-na); Qi, YP (Qi, Yi-pin); Yiu, CKY (Yiu, Cynthia K. Y.);

Ryou, H (Ryou, Heonjune); Arola, DD (Arola, Dwayne D.); Chen, JH (Chen, Ji-hua); Pashley, DH

(Pashley, David H.); Tay, FR (Tay, Franklin R.) 来源出版物 : BIOMATERIALS 卷 : 32 期 : 34 页 : 8743-8752 DOI:

10.1016/j.biomaterials.2011.08.007 出版年: DEC 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 35 摘要: Biocalcification of collagen matrices with calcium phosphate and biosilicification of diatom

frustules with amorphous silica are two discrete processes that have intrigued biologists and

materials scientists for decades. Recent advancements in the understanding of the mechanisms

involved in these two biomineralisation processes have resulted in the use of biomimetic strategies

to replicate these processes separately using polyanionic, polycationic or zwitterionic analogues of

extracellular matrix proteins to stabilise amorphous mineral precursor phases. To date, there is a

lack of a universal model that enables the subtleties of these two apparently dissimilar

biomineralisation processes to be studied together. Here, we utilise the eggshell membrane as a

universal model for differential biomimetic calcification and silicification. By manipulating the

eggshell membrane to render it permeable to stabilised mineral precursors, it is possible to

introduce nanostructured calcium phosphate or silica into eggshell membrane fibre cores or

mantles. We provide a model for infiltrating the two compartmental niches of a biopolymer

membrane with different intrafibre minerals to obtain materials with potentially improved

structure-property relationships. (C) 2011 Elsevier Ltd. All rights reserved. 入藏号: WOS:000296113500001 语种: English 文献类型: Article 作者关键词: Apatite; Biomineralisation; Silica; Membrane

KeyWords Plus: STABILIZED ORTHOSILICIC ACID; EXTRACELLULAR-MATRIX;

COLLAGEN; MINERALIZATION; BIOSILICIFICATION; MODEL; HEN 地址: [Pashley, David H.; Tay, Franklin R.] Georgia Hlth Sci Univ, Sch Grad Studies, Augusta,

GA 30912 USA

[Li, Nan] Fujian Univ Tradit Chinese Med, Coll Osteoped & Traumatol, Fuzhou, Peoples R China

[Niu, Li-na; Chen, Ji-hua] Fourth Mil Med Univ, Sch Stomatol, Dept Prosthodont, Xian 710032,

Peoples R China

[Qi, Yi-pin] Sun Yat Sen Univ, Guanghua Sch Stomatol, Guangzhou, Guangdong, Peoples R

China

[Yiu, Cynthia K. Y.] Univ Hong Kong, Prince Philip Dent Hosp, Hong Kong, Hong Kong, Peoples

R China

[Ryou, Heonjune; Arola, Dwayne D.] Univ Maryland Baltimore Cty, Dept Mech Engn, Baltimore,

MD 21228 USA 通讯作者地址: Tay, FR (通讯作者),Georgia Hlth Sci Univ, Sch Grad Studies, Augusta, GA

30912 USA 电子邮件地址: [email protected]; [email protected]

出版商: ELSEVIER SCI LTD 出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,

OXON, ENGLAND

Web of Science 分类: Engineering, Biomedical; Materials Science, Biomaterials 学科类别: Engineering; Materials Science

IDS 号: 836LP

ISSN: 0142-9612

29 字符的来源出版物名称缩写: BIOMATERIALS

ISO 来源出版物缩写: Biomaterials 来源出版物页码计数: 10 基金资助致谢: 基金资助机构授权号

NIDCR R21 DE019213

Georgia Health Sciences University

This work was supported by grant R21 DE019213 from NIDCR (Pl. Franklin Tay) and the PSRP

and ESA awards from the Georgia Health Sciences University. We thank R. Smith (Electron

Microscopy Core Unit, Georgia Health Sciences University, USA) for performing electron

diffractions, F. Chan (Electron Microscopy Unit, The University of Hong Kong, China) for

performing STEM-EDX and electron tomography and M. Burnside for secretarial support.

第 7 条，共 86 条标题: Antioxidative and anti-inflammatory properties of Chushizi oil from Fructus Broussonetiae 作者: Zhao, HF (Zhao, Hongfang); Huang, LZ (Huang, Linzhang); Qin, LP (Qin, Luping); Huang,

BK (Huang, Baokang) 来源出版物 : JOURNAL OF MEDICINAL PLANTS RESEARCH 卷 : 5 期 : 28 页 :

6407-6412 DOI: 10.5897/JMPR11.447 出版年: NOV 30 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 19 摘要: The fruit of Broussonetia papyrifera (L.) L'Herit. ex Vent. is a traditional Chinese medicine

with Chinese name Chushizi. It has been commonly used as an important tonic for the treatment

of age-related disorders. In this work, the antioxidant properties of the oil were investigated on

nitric oxide production in lipopolysaccharide (LPS), activated RAW264.7 cells along with the

1,1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide anion and hydroxyl radical scavenging

assays. The chemical composition of the oil was analyzed by Gas chromatography-mass

spectrometry (GC-MS). The oil mainly consists of 8, 11-octadecadienic acid (79.17%). It

possessed DPPH/superoxide anion/hydroxyl free radical scavenging and NO production inhibition

activities (IC50 58.00 +/- 0.37 mu g/ml). The results indicated that Chushizi oil was a powerful

antioxidant with versatile free radical-scavenging activity, which may have therapeutic potential in

associated with various inflammatory diseases. 入藏号: WOS:000298913200003 语种: English 文献类型: Article 作者关键词: Chushizi; Broussonetia papyrifera; anti-inflammatory; antioxidant

KeyWords Plus: FREE-RADICALS; LONICERA-JAPONICA; PAPYRIFERA 地址: [Zhao, Hongfang; Huang, Linzhang; Qin, Luping; Huang, Baokang] Mil Med Coll 2, Sch

Pharm, Shanghai 200433, Peoples R China

[Zhao, Hongfang; Huang, Linzhang] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou

350108, Peoples R China 通讯作者地址: Huang, BK (通讯作者),Mil Med Coll 2, Sch Pharm, Shanghai 200433, Peoples R

China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA

Web of Science 分类: Chemistry, Medicinal 学科类别: Pharmacology & Pharmacy

IDS 号: 873WE

ISSN: 1996-0875

29 字符的来源出版物名称缩写: J MED PLANTS RES

ISO 来源出版物缩写: J. Med. Plants Res. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构授权号


The work was supported by the National Natural Science Foundation of China (No. 30870236).

We thank Yanjie Wei and Liming Xue for the experiment assistances.

第 8 条，共 86 条标题: The genus Desmodium (Fabaceae)-traditional uses in Chinese medicine, phytochemistry

and pharmacology 作者: Ma, XQ (Ma, Xueqin); Zheng, CJ (Zheng, Chengjian); Hu, CL (Hu, Changling); Rahman,

K (Rahman, Khalid); Qin, LP (Qin, Luping) 来源出版物: JOURNAL OF ETHNOPHARMACOLOGY 卷: 138 期: 2 页: 314-332 DOI:

10.1016/j.jep.2011.09.053 出版年: NOV 18 2011 在 Web of Science 中的被引频次: 0

被引频次合计: 0 引用的参考文献数: 115 摘要: Ethnopharmacological relevance: Plants of the genus Desmodium (Fabaceae), such as

Desmodium styracifolium (Osbeck) Merr. and Desmodium gyrans (L f.) DC., have a long history

of medical use in Traditional Chinese Medicine to treat various ailments including rheumatism,

pyrexia, dysentery, wounds, cough, malaria, hepatitis, hemoptysis, etc. In the theory of Traditional

Chinese Medicine, most species have the effect of relieving internal heat or fever, neutralizing

toxins, inhibiting pain, invigorating blood circulation, suppressing cough and alleviating dyspnea.

Materials and methods: A bibliographic investigation was accomplished by analyzing secondary

sources including Chinese Herbal Classics, and worldwide accepted scientific databases (Pubmed.

Scopus and Web of Science, SciFinder) were scrutinized for the available information on the

ethnopharmacological uses in Chinese medicine, phytochemistry, pharmacology and toxicology of

Desmodium species.

Results: The genus Desmodium is a large member of the Papilionaceae (Fabaceae) family. It

contains about 350 plant species used for both feeding stuffs and herbal medicines, of which only

about 30 species have been phytochemically or pharmacologically investigated. Desmodium plant

extracts, as well as the active principles, have been experimentally studied for their

anti-inflammatory, cytotoxic, antidiabetic, antinephrolithic, antibacterial, and nootropic activities

in vitro or in vivo. And so far, a total of 212 compounds have been isolated from 15 Desmodium

species and characterized mainly as flavonoids and alkaloids, followed by terpenoids, steroids,

phenols, phenylpropanoids, glycosides and a number of volatile oils. The remaining unrevealed

species are recorded chiefly in Asia and Africa being used in empirical treatment for various

diseases.

Conclusions: Desmodium species have long been used in TCM to treat various ailments. Available

scientific references revealed that the traditional medical uses of some important Desmodium

species in TCM have been evaluated by modern pharmacological studies. As literature

demonstrated, flavonoids and alkaloids are perhaps responsible for most of the activities shown by

the plants of this genus. Further studies are still required to reveal the structure-activity

relationship of these active constituents. (C) 2011 Elsevier Ireland Ltd. All rights reserved. 入藏号: WOS:000298026400005 语种: English 文献类型: Review 作者关键词: Desmodium; Phytochemistry; Alkaloids; Flavonoids; Pharmacology; Toxicology

KeyWords Plus: PUSH-PULL TECHNOLOGY; AQUEOUS EXTRACT;

BETA-PHENETHYLAMINE; GANGETICUM EXTRACT; STRIGA-HERMONTHICA;

WESTERN KENYA; ROOT EXUDATE; ADSCENDENS; ISOFLAVANONES; UNCINATUM 地址: [Ma, Xueqin; Zheng, Chengjian; Hu, Changling; Qin, Luping] Mil Med Coll 2, Dept

Pharmacognosy, Sch Pharm, Shanghai 200433, Peoples R China

[Ma, Xueqin] NingXia Med Univ, Sch Pharm, Dept Pharmaceut Anal, Yinchuan 750004, Peoples

R China

[Hu, Changling] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108, Peoples R China

[Rahman, Khalid] Liverpool John Moores Univ, Fac Sci, Sch Biomol Sci, Liverpool L3 3AF,

Merseyside, England

通讯作者地址: Qin, LP (通讯作者),Mil Med Coll 2, Dept Pharmacognosy, Sch Pharm, 325

Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: ELSEVIER IRELAND LTD 出版商地址: ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO,

CLARE, 00000, IRELAND

Web of Science 分类: Plant Sciences; Chemistry, Medicinal; Integrative & Complementary

Medicine; Pharmacology & Pharmacy 学科类别: Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine

IDS 号: 861NN

ISSN: 0378-8741

29 字符的来源出版物名称缩写: J ETHNOPHARMACOL

ISO 来源出版物缩写: J. Ethnopharmacol. 来源出版物页码计数: 19

第 9 条，共 86 条标题: Anthraquinone compounds from Morinda officinalis inhibit osteoclastic bone resorption in

vitro 作者: Bao, LL (Bao, Leilei); Qin, LP (Qin, Luping); Liu, L (Liu, Lei); Wu, YB (Wu, Yanbin);

Han, T (Han, Ting); Xue, LM (Xue, Liming); Zhang, QY (Zhang, Qiaoyan) 来源出版物: CHEMICO-BIOLOGICAL INTERACTIONS 卷: 194 期: 2-3 页: 97-105 DOI:

10.1016/j.cbi.2011.08.013 出版年: NOV 15 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 31 摘要: The root of Morinda officinalis has been claimed to have a protective effect against bone

loss in sciatic neurectomized and ovariectomized osteoporotic rats, and this protective effect is

supposed to be attributed to anthraquinone compounds in the plant. In the present study, we

investigated the effects of three anthraquinones isolated from M. officinalis, including 1, 3,

8-trihydroxy-2-methoxy-anthraquinone (1), 2-hydroxy-1-methoxy-anthraquinone (2) and rubiadin

(3) on bone resorption activity in vitro and the mechanism on osteoclasts derived from rat bone

marrow cells. Compound 1, 2 and 3 decreased the formation of bone resorption pits, the number

of multinucleated osteoclasts, and the activity of tartrate resistant acid phosphates (TRAP) and

cathepsin K in the coculture system of osteoblasts and bone marrow cells in the presence of 1,

25-dihydroxyvitamine D(3) and dexamethasone. They also enhanced the apoptosis of osteoclasts

induced from bone marrow cells with M-CSF and RANKL In addition, Compound 1,2 and 3

improved the ratio of mRNA and protein expression of OPG and RANKL in osteoblasts,

interfered with the JNK and NF-kappa B signal pathway, and reduced the expression of calcitonin

receptor (CTR) and carbonic anhydrase/II (CA II) in osteoclasts induced from bone marrow cells

with M-CSF and RANKL These findings indicate that the anthraquinone compounds from M.

officinalis are potential inhibitors of bone resorption, and may also serve as evidence to explain

the mechanism of the inhibitory effects of some other reported anthraquinones on bone loss. (C)

2011 Elsevier Ireland Ltd. All rights reserved. 入藏号: WOS:000298459200002 语种: English 文献类型: Article 作者关键词: Morinda officinalis; Anthraquinone; Osteoclast; Bone resorption; Apoptosis

KeyWords Plus: GENE-EXPRESSION; KAPPA-B; RECEPTOR ACTIVATOR;

DIFFERENTIATION; RANKL; INDUCTION; APOPTOSIS; NFAT2 地址: [Bao, Leilei; Qin, Luping; Liu, Lei; Han, Ting; Xue, Liming; Zhang, Qiaoyan] Mil Med

Coll 2, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China

[Bao, Leilei] 411 Hosp PLA, Shanghai 200434, Peoples R China

[Liu, Lei; Wu, Yanbin] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108, Peoples R

China 通讯作者地址: Zhang, QY (通讯作者),Mil Med Coll 2, Sch Pharm, Dept Pharmacognosy, 325

Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected] 出版商: ELSEVIER IRELAND LTD 出版商地址: ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO,


Web of Science 分类 : Biochemistry & Molecular Biology; Pharmacology & Pharmacy;

Toxicology 学科类别: Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology

IDS 号: 867MT

ISSN: 0009-2797

29 字符的来源出版物名称缩写: CHEM-BIOL INTERACT

ISO 来源出版物缩写: Chem.-Biol. Interact. 来源出版物页码计数: 9 基金资助致谢: 基金资助机构授权号


This study was supported by the National Natural Science Foundation of China (NO. 90709023).

第 10 条，共 86 条标题 : DRUG-ASSOCIATED DIFFUSE ALVEOLAR HEMORRHAGE SYNDROMES:

REPORT OF TWO CASES AND 1ITERATURE REVIEW 作者: Xue, Q (Xue, Q.); Jiao, WK (Jiao, W-K); Wu, JH (Wu, J-H); Zhang, W (Zhang, W.); Fang,

GJ (Fang, G-J); Deng, XY (Deng, X-Y); Cheng, Y (Cheng, Y.)

来源出版物: RESPIROLOGY 卷: 16 特刊: SI 页: 323-323 增刊: 2 出版年: NOV 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 0 入藏号: WOS:000298547101386 语种: English 文献类型: Meeting Abstract 作者关键词: Hemorrhage; Diffuse; Pulmonary alveoli; Drug 地址: [Xue, Q.; Jiao, W-K; Wu, J-H; Zhang, W.; Fang, G-J; Deng, X-Y; Cheng, Y.] Fujian Med

Univ, Fujian Univ Chinese Med, Ningde Hosp, Dept Resp Dis,Teaching Hosp, Ningde, Peoples R

China 通讯作者地址: 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA

Web of Science 分类: Respiratory System 学科类别: Respiratory System

IDS 号: 868SZ

ISSN: 1323-7799

29 字符的来源出版物名称缩写: RESPIROLOGY

ISO 来源出版物缩写: Respirology 来源出版物页码计数: 1

第 11 条，共 86 条标题 : A (HNMR)-H-1-Based Metabonomics Study of Postmenopausal Osteoporosis and

Intervention Effects of Er-Xian Decoction in Ovariectomized Rats 作者: Xue, LM (Xue, Liming); Wang, Y (Wang, Yin); Liu, L (Liu, Lei); Zhao, L (Zhao, Lu); Han,

T (Han, Ting); Zhang, QY (Zhang, Qiaoyan); Qin, LP (Qin, Luping) 来源出版物: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 卷: 12 期: 11 页:

7635-7651 DOI: 10.3390/ijms12117635 出版年: NOV 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 39 摘要 : A metabonomics method using H-1 nuclear magnetic resonance spectroscopy

((HNMR)-H-1) was applied to obtain a systematic view of the development and progression of

postmenopausal osteoporosis. Using partial least squares discriminant analysis (PLS-DA), 26 and

34 characteristic resonances were found respectively in urine and plasma of ovariectomized rats

(Variable importance, VIP value >= 1.0), and the significant altered metabolites identified in the

plasma and urine were 10 and 9, respectively. Changes in these metabolites were related to the

pathways of lipid, energy and amino acid metabolism, some of which involved the oxidative

system. The described method was also used to analyze the therapeutic effects of Er-Xian

Decoction (EXD), a traditional Chinese medicine widely used in the clinical treatment of

osteoporosis in China. The results showed that EXD administration could provide satisfactory

effects on osteoporosis through partially regulating the perturbed pathways of lipid, energy and

amino acid metabolism and improving the anti-oxidative ability. 入藏号: WOS:000297696100025 语种: English 文献类型: Article 作者关键词: (HNMR)-H-1; metabonomics; ovariectomized rats; postmenopausal osteoporosis;

Er-Xian Decoction

KeyWords Plus: CHINESE HERBAL FORMULA; MENOPAUSAL SYMPTOMS;

LIPID-METABOLISM; BONE LOSS; IN-VITRO; ESTROGEN; TAURINE;

17-BETA-ESTRADIOL; PROGESTIN 地址: [Xue, Liming; Liu, Lei; Zhao, Lu; Han, Ting; Zhang, Qiaoyan; Qin, Luping] Mil Med Coll

2, Sch Pharm, Shanghai 200433, Peoples R China

[Wang, Yin] 455 Hosp CPLA, Dept Pharmaceut, Shanghai 200052, Peoples R China

[Liu, Lei; Zhao, Lu] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108, Peoples R

China 通讯作者地址: Zhang, QY (通讯作者),Mil Med Coll 2, Sch Pharm, 325 Guohe Rd, Shanghai

200433, Peoples R China 电子邮件地址 : [email protected]; [email protected]; [email protected];

[email protected]; [email protected]; [email protected]; [email protected] 出版商: MDPI AG 出版商地址: POSTFACH, CH-4005 BASEL, SWITZERLAND

Web of Science 分类: Chemistry, Multidisciplinary 学科类别: Chemistry

IDS 号: 857DS

ISSN: 1661-6596

29 字符的来源出版物名称缩写: INT J MOL SCI

ISO 来源出版物缩写: Int. J. Mol. Sci. 来源出版物页码计数: 17 基金资助致谢: 基金资助机构授权号


81173191

Key Program for Basic Research of Shanghai 09JC1417600

The work was supported by the National Natural Science Foundation of China (81073115,

81173191) and the Key Program for Basic Research of Shanghai (09JC1417600).

第 12 条，共 86 条标题 : Xiongshao Capsule ((sic)) Promotes Angiogenesis of HUVEC via Enhancing Cell

Proliferation and Up-regulating the Expression of bFGF and VEGF 作者: Lin, JM (Lin Jiu-mao); Zhao, JY (Zhao Jin-yan); Zhuang, QC (Zhuang Qun-chuan); Hong,

ZF (Hong Zhen-feng); Peng, J (Peng Jun) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 11 页 :

840-846 DOI: 10.1007/s11655-011-0895-8 出版年: NOV 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 22 摘要: Objective: To evaluate the angiogenic effect of the Xiongshao capsule ((sic)., XSC) in

human umbilical vein endothelial cells (HUVEC), and to investigate the possible molecular

mechanisms mediating its biological effect. Methods: Serum pharmacology was applied in this

study, in which different doses of XSC were administrated to rats orally and then XSC-containing

serum (XSC-S) was collected for the following in vitro experiments. The viability of HUVEC was

determined by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay.

Cell density was observed via phase-contrast microscopy. Fluorescence-activated cell sorting

analysis with propidium iodide staining was performed to determine cell cycle phase. Cell

migration was determined by wound-healing method. Capillary tube formation by HUVEC was

examined using ECMatrix gel-based assay. Vascular endothelial growth factor (VEGF) and basic

fibroblast growth factor (bFGF) expression levels were measured by reverse transcription

polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbant assay (ELISA) analyses.

Results: XSC-S dose-dependently stimulated proliferation of HUVEC by promoting the cell cycle

G1 to S progression. In addition, XSC-S treatment dramatically increased the migration and

capillary tube formation of HUVEC in a dose-dependent manner. Moreover, XSC-S enhanced the

expression of VEGF and bFGF at both mRNA and protein levels. Conclusion: XSC can promote

several features of angiogenesis in endothelial cells through up-regulating the expression of bFGF

and VEGF, suggesting that XSC may be a potential novel therapeutic agent for the treatment of

ischemic heart diseases. 入藏号: WOS:000296614000006 语种: English 文献类型: Article 作者关键词: Xiongshao capsule; Chinese medicine; angiogenesis; serum pharmacology

KeyWords Plus: FIBROBLAST-GROWTH-FACTOR; MEDICINE 地址: [Lin Jiu-mao; Zhao Jin-yan; Zhuang Qun-chuan; Hong Zhen-feng; Peng Jun] Fujian Univ

Tradit Chinese Med, Fujian Acad Integrat Med, Fuzhou 350108, Peoples R China

[Peng Jun] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med Geriatr, Fuzhou

350108, Peoples R China 通讯作者地址: Peng, J (通讯作者),Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med,

Fuzhou 350108, Peoples R China

电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA

Web of Science 分类: Integrative & Complementary Medicine 学科类别: Integrative & Complementary Medicine

IDS 号: 842QL

ISSN: 1672-0415

29 字符的来源出版物名称缩写: CHIN J INTEGR MED

ISO 来源出版物缩写: Chin. J. Integr. Med. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构授权号

CHEN Ke-ji Integrative Medicine CKJ 2008056

CKJ 2010019

Supported by the Developmental Fund of CHEN Ke-ji Integrative Medicine (No. CKJ 2008056

and CKJ 2010019)

第 13 条，共 86 条标题: Echocardiographic Abnormalities in a Cohort of Chinese Patients with Systemic Lupus

Erythematosus-A Retrospective Analysis of Eighty-Five Cases 作者: Yu, XH (Yu, Xuan-Hua); Li, YN (Li, Yi-Nong) 来源出版物: JOURNAL OF CLINICAL ULTRASOUND 卷: 39 期: 9 页: 519-526 DOI:

10.1002/jcu.20863 出版年: NOV-DEC 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 26 摘要: Objective. To investigate echocardiographic abnormalities in a cohort of Chinese patients

with systemic lupus erythematosus (SLE).

Methods. Eighty-five SLE patients who were hospitalized at our institution from January 2008 to

June 2009 were included. Their clinical manifestations, electrocardiogram, chest x-ray, CT scan,

and echocardiographic data were analyzed in relation to age, disease duration, and SLE disease

activity index (SLEDAI).

Results. Echocardiography showed abnormalities in 53 patients (62.35%), involving valves in

56.5% (n = 48), pericardium in 25.9%, left and right ventricle enlargement in 17.65% and 1.18%,

respectively, and auricle in 10.59% and 1.18% of the patients, respectively. The left ventricle

showed decreased compliance in 10.29%, impaired relaxation in 14.12%, and abnormal wall

motion in 42.35% of the patients. Interventricular septum thickness, left ventricular posterior wall

thickness, and isovolumic relaxation time were positively correlated with age (r = 0.42, 0.33, and

0.39, respectively, p < 0.01 for all variables), and disease duration (r = 0.22, 0.21, and 0.32,

respectively; p < 0.05). Left atrial and ventricular size were correlated with age (r = 0.32 and 0.41,

p > 0.01) and SLEDAI (p < 0.05).

Conclusions. Cardiac, especially valvular abnormalities are common in SLE patients and increase

with age and disease duration and activity. Inclusion of echocardiography in the clinical evaluation

of SLE patients could help identify an important subset of patients with cardiac abnormalities. (C)

2011 Wiley Periodicals, Inc. J Clin Ultrasound 39:519-526, 2011; Published online in Wiley

Online Library (wileyonlinelibrary.com). DOI: 10.1002/jcu.20863 入藏号: WOS:000296607700005 语种: English 文献类型: Article 作者关键词: systemic lupus erythematosus; cardiac involvement; echocardiography; retrospective

analysis

KeyWords Plus: CARDIAC INVOLVEMENT; DISEASE-ACTIVITY; ASSOCIATION;

DYSFUNCTION; HEART; PREVALENCE; ANTIBODIES; MORTALITY 地址: [Li, Yi-Nong] Fuzhou Gen Hosp, Dept Rheumatol, Fuzhou 350025, Peoples R China

[Yu, Xuan-Hua] Fujian Univ Tradit Chinese Med, Peoples Hosp, Dept Rheumatol, Fuzhou

350004, Peoples R China 通讯作者地址: Li, YN (通讯作者),Fuzhou Gen Hosp, Dept Rheumatol, 156 XierHuan Bei,

Fuzhou 350025, Peoples R China 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA

Web of Science 分类: Acoustics; Radiology, Nuclear Medicine & Medical Imaging 学科类别: Acoustics; Radiology, Nuclear Medicine & Medical Imaging

IDS 号: 842OB

ISSN: 0091-2751

29 字符的来源出版物名称缩写: J CLIN ULTRASOUND

ISO 来源出版物缩写: J. Clin. Ultrasound 来源出版物页码计数: 8

第 14 条，共 86 条标题: VEGF expression in mesenchymal stem cells promotes bone formation of tissue-engineered

bones 作者: Liu, BL (Liu, Boling); Li, XH (Li, Xihai); Liang, GQ (Liang, Guiqing); Liu, XX (Liu,

Xianxiang) 来源出版物 : MOLECULAR MEDICINE REPORTS 卷 : 4 期 : 6 页 : 1121-1126 DOI:

10.3892/mmr.2011.559 出版年: NOV-DEC 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 22

摘要: The purpose of this study was to investigate the in vivo vascularization and bone formation

activity of tissue-engineered bone constructed using bone marrow mesenchymal stem cells

(MSCs) transfected with vascular endothelial growth factor (VEGF). The expression of VEGF165

in rat bone marrow MSCs was confirmed using RT-PCR and immunohistochemistry. The MSCs

were cultured together with nano-hydroxyapatite/collagen (NHAC) to form tissue-engineered

bone. Untransfected MSCs were used as controls. The mice were sacrificed, and the bone

xenografts were analyzed using immunohistochemistry and quantified for the degree of

vascularization and new bone formation. Based on our results, expression of the VEGF165 gene

was detected using RT-PCR and immunohistochemistry following transfection and 4 weeks of

selection. The co-cultured NHAC- and VEGF-transfected MSCs had significantly higher alkaline

phosphatase (AP) activity compared to the controls (P<0.05). In the mice that received the

tissue-engineered bone xenografts, clumps of cartilage cells, irregular bone-like tissue and

microvessels were observed. The growth of these structures progressed with time. In the control

mice, however, only small amounts of bone-like and fibrotic tissue were observed. The differences

between the control and experimental groups were statistically significant (P<0.05). In conclusion,

VEGF165-transfected bone marrow MSCs promotes vascularization of tissue-engineered bone

and ectopic osteogenesis. 入藏号: WOS:000295389400013 语种: English 文献类型: Article 作者关键词 : vascular endothelial growth factor; bone marrow mesenchymal stem cells;

tissue-engineered bone; vascularization; ectopic osteogenesis

KeyWords Plus: ENDOTHELIAL GROWTH-FACTOR; GENE-THERAPY; IN-VITRO;

ANGIOGENESIS; DIFFERENTIATION; MATRIX; DELIVERY 地址: [Li, Xihai; Liu, Xianxiang] Fujian Univ Tradit Chinese Med, Acad Integrated Chinese &

Western Med, Fuzhou 350108, Fujian, Peoples R China

[Liu, Boling; Liang, Guiqing] Fuzhou Integrated Chinese & Western Med Hosp Fuji, Fuzhou

350007, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrated Chinese &

Western Med, 1 Huatuo Rd, Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE

Web of Science 分类: Oncology; Medicine, Research & Experimental 学科类别: Oncology; Research & Experimental Medicine

IDS 号: 826XR

ISSN: 1791-2997

29 字符的来源出版物名称缩写: MOL MED REP

ISO 来源出版物缩写: Mol. Med. Rep. 来源出版物页码计数: 6

基金资助致谢: 基金资助机构授权号

Fujian Key Laboratory of Integrative Medicine on Geriatrics 2008J1004-16

Development Fund of Chen Keji Integrated Chinese and Western Medicine CKJ2008003

This study was supported by the Open Fund of Fujian Key Laboratory of Integrative Medicine on

Geriatrics (no. 2008J1004-16) and the Development Fund of Chen Keji Integrated Chinese and

Western Medicine (no. CKJ2008003). The authors thank Dr Xia Bai from the Jiangsu Province

Blood Research Institute for providing the hVEGF165 full-length cDNA expression vector

pcDNA3.1-hVEGF165 and Professor Qingling Feng from the Tsinghua University for providing

the NHAC material.

第 15 条，共 86 条标题: Effect of Hedyotis Diffusa Willd extract on tumor angiogenesis 作者: Lin, JM (Lin, Jiumao); Wei, LH (Wei, Lihui); Xu, W (Xu, Wei); Hong, ZF (Hong,

Zhenfeng); Liu, XX (Liu, Xianxiang); Peng, J (Peng, Jun) 来源出版物 : MOLECULAR MEDICINE REPORTS 卷 : 4 期 : 6 页 : 1283-1288 DOI:

10.3892/mmr.2011.577 出版年: NOV-DEC 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 30 摘要 : Inhibition of tumor angiogenesis has become an attractive target of anticancer

chemotherapy. However, drug resistance and cytotoxicity against non-tumor associated

endothelial cells limit the long-term use and the therapeutic effectiveness of angiogenesis

inhibitors, thus increasing the necessity for the development of multi-target agents with minimal

side effects. Traditional Chinese medicine (TCM) formulas, which have relatively fewer side

effects and have been used clinically to treat various types of diseases, including cancer, for

thousands of years, are considered to be multicomponent and multi-target agents exerting their

therapeutic function in a more holistic way. Hedyotis Diffusa (EEHDW) has long been used as an

important component in several TCM formulas to treat various types of cancer. Although recently

we reported that EEHDW promotes cancer cell apoptosis via activation of the

mitochondrial-dependent pathway, the precise mechanism of its tunioricidalactivity still remains

to be clarified. In the present study, we investigated the angiogenic effects of the ethanol extract of

EEHDW. Cell cycle analysis was perfomed using flow cytometry. Cell viability was analyzed

using MTT assay. We found that EEHDW inhibited angiogenesis in vivo in chick embryo

chorioallantoic membrane (CAM). In addition, we observed that EEHDW dose- and

time-dependently inhibited the proliferation of human umbilical vein endothelial cells (HUVEC)

by blocking the cell cycle G1 to S progression. Moreover, EEHDW inhibited the migration and

tube formation of HUVECs. Furthermore, EEHDW treatment down-regulated the mRNA and

protein expression levels of VEGF-A in HT-29 human colon carcinoma cells and HUVECs. Our

findings suggest that inhibiting tumor angiogenesis is one of the mechanisms by which EEHDW is

involved in cancer therapy. 入藏号: WOS:000295389400039 语种: English 文献类型: Article 作者关键词: tumor angiogenesis; traditional Chinese medicine; multi-target agents; Hedyotis

Diffusa Willd

KeyWords Plus: ENDOTHELIAL GROWTH-FACTOR; THERAPEUTIC IMPLICATIONS;

FACTOR EXPRESSION; NATURAL-PRODUCTS; CANCER; METASTASIS; CARCINOMA;

VEGF; MECHANISMS; PROGNOSIS 地址: [Lin, Jiumao; Wei, Lihui; Hong, Zhenfeng; Peng, Jun] Fujian Univ Tradit Chinese Med,

Fujian Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China


China

[Liu, Xianxiang] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med Geriatr, Fuzhou

350108, Fujian, Peoples R China 通讯作者地址: Peng, J (通讯作者),Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med, 1

Huatuo Rd, Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE


IDS 号: 826XR

ISSN: 1791-2997


ISO 来源出版物缩写: Mol. Med. Rep. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构授权号

Natural Science Foundation of Fujian Province of China 2010J01195

Research Foundation of Education Bureau of Fujian Province of China JA10162



This study was sponsored by the Natural Science Foundation of Fujian Province of China

(2010J01195), the Research Foundation of Education Bureau of Fujian Province of China

(JA10162), the Developmental Fund of Chen Keji Integrative Medicine (CKJ 2010019) and the

National Natural Science Foundation of China (81073097).

第 16 条，共 86 条标题: Construction of lentiviral shRNA expression vector targeting phospholipase D2 (PLD2)

gene 作者: Lian, XF (Lian, Xue-Feng); Yu, CX (Yu, Chuan-Xing); He, XL (He, Xiao-Li); Lin, JJ (Lin,

Jun-Jin); Chen, YZ (Chen, Yi-Zhong); Zhu, L (Zhu, Ling) 来源出版物 : AFRICAN JOURNAL OF BIOTECHNOLOGY 卷 : 10 期 : 66 页 :

15044-15050 DOI: 10.5897/AJB11.137 出版年: OCT 26 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 14 摘要 : The aim of this research was to construct a lentiviral shRNA vectors targeting

phospholipase D2 (PLD2) gene, thus providing information for further study of the biological

functions of PLD2 and clinical treatments of leukemia. Specific siRNA targets with short hairpin

frame were designed using the siDESIGN software and synthesized according to cDNA sequence

of PLD2 (GenBank accession number: NM_002663). DNA oligo was cloned into lentiviral

expression vector, and then polymerase chain reaction (PCR) and sequencing analyses were

conducted to verify the constructs. The verified vectors were co-transfected into 293FT cells that

could produce lentiviral. shRNA lentiviruses from the selected constructs were propagated and

harvested with a virus packaging system, and the virus titers were determined by flow cytometry.

After the lentiviral packing with PLD2-shRNA2 transfecting 293FT cells, using fluorescence

microscope, we found the lentiviral interference vectors, which have GFP report genes expression

accompanied with the host genes in 293FT cells. The optimal interfering target was then selected,

while the titer of lentiviral packing PLD2-shRNA was 3.47 x 10(4) TU/ml and the virus was

successfully packaged. PCR and sequencing analyses revealed that lentiviral shRNA vectors of

three targeting PLD2 gene were successfully constructed. 入藏号: WOS:000298549800049 语种: English 文献类型: Article 作者关键词: RNA interference (RNAi); phospholipase D2 (PLD2); lentiviral vectors

KeyWords Plus: CELLS 地址: [Lian, Xue-Feng; He, Xiao-Li; Lin, Jun-Jin; Chen, Yi-Zhong; Zhu, Ling] Fujian Med Univ,

Dept Immunol, Fuzhou 350004, Fujian, Peoples R China

[Lian, Xue-Feng; He, Xiao-Li; Lin, Jun-Jin; Chen, Yi-Zhong; Zhu, Ling] Fujian Med Univ, Ctr

Neurosci, Fuzhou 350004, Fujian, Peoples R China

[Yu, Chuan-Xing] Internal Med Second Peoples Hosp Fujian Prov, Fuzhou 350003, Fujian,

Peoples R China 通讯作者地址: Zhu, L (通讯作者),Fujian Med Univ, Dept Immunol, Fuzhou 350004, Fujian,

Peoples R China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA

Web of Science 分类: Biotechnology & Applied Microbiology 学科类别: Biotechnology & Applied Microbiology

IDS 号: 868TX

ISSN: 1684-5315

29 字符的来源出版物名称缩写: AFR J BIOTECHNOL

ISO 来源出版物缩写: Afr. J. Biotechnol. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构授权号

Fujian Science and Technique Foundation 2009I0008

National Natural Science Foundation of Fujian 2010J01170

Fujian Medical University Professor Foundation JS06006

Project supported by Fujian Science and Technique Foundation, No 2009I0008; and supported by

National Natural Science Foundation of Fujian, No: 2010J01170; and supported by Fujian Medical

University Professor Foundation, No. JS06006.

第 17 条，共 86 条标题: Molecular Research on a Hypotensive Herb Formula and PPAR alpha Activation 作者: Chen, MM (Chen, Mei-mei); Lai, XM (Lai, Xin-mei); Li, C (Li, Chi); Yang, XM (Yang,

Xue-mei) 来源出版物: LATIN AMERICAN JOURNAL OF PHARMACY 卷: 30 期: 8 页: 1608-1613 出版年: OCT 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 25 摘要 : Surflex-dock method was explored to study interactions between Qingxuanjiangya

decoction (QXJYD in abbreviation, a famous hypotensive herb formula from Traditional Chinese

Medicine prescription) and Peroxisome proliferators activated receptor-alpha (PPAR alpha) for

detecting its pharmacological effects as well as to screen out PPAR alpha agonists. First, 28

compounds with values of PPAR alpha EC(50) from reported were introduced as a test set to

evaluate the docking accuracy according to the good validation between experimental values and

surflex-dock scores (correlation coefficient R = 0.866, RMSD = 1.169 angstrom, similarity =

0.804). And then, 739 molecules from QXJYD were docked to PPAR alpha by the validated way.

The result showed 200 compounds from QXJYD had activity with PPAR alpha and discovered

that a flavones compound (moralbanone, extracted from folium mori) with an excellent docking

score might be considered as a guide to design a new scaffold of PPAR alpha agonists in the

further study. 入藏号: WOS:000298869100024

语种: English 文献类型: Article 作者关键词: PPAR alpha Agonists; Qingxuanjiangya decoction; Surflex-dock

KeyWords Plus: RECEPTOR-ALPHA; PEROXISOME PROLIFERATORS;

PROTEIN-BINDING; ACID; IDENTIFICATION; STIMULATION; FLAVONO IDS;

DISCOVERY; AGONISTS; DOCKING 地址: [Chen, Mei-mei; Lai, Xin-mei; Yang, Xue-mei] Fujian Univ Tradit Chinese Med, Coll

Tradit Chinese Med, Fuzhou 350108, Fujian, Peoples R China

[Li, Chi] Tsinghua Univ, Dept Elect Engn, Beijing 100084, Peoples R China 通讯作者地址: Yang, XM (通讯作者),Fujian Univ Tradit Chinese Med, Coll Tradit Chinese Med,

Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES 出版商地址: DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA


IDS 号: 873GM

ISSN: 0326-2383

29 字符的来源出版物名称缩写: LAT AM J PHARM

ISO 来源出版物缩写: Lat. Am. J. Pharm. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构授权号

Foundation of Science & Technology Project of Fujian 2009Y0030

2009J05074

Fujian Provincial Health Department

YA-204

wzzsj0901

wz-zsj0902

Fujian Provincial Department of Education JA09130

The authors thanks American Tripos Company for offering us Sybylx1.1 program. This work is

supported in part by Foundation of Science & Technology Project of Fujian (2009Y0030 and

2009J05074), by Fujian Provincial Health Department Special Project (YA-204 and wzzsj0901

and wz-zsj0902), by Fujian Provincial Department of Education project (JA09130).

第 18 条，共 86 条标题: Solid-phase extraction-field-amplified sample injection coupled with CE-ESI-MS for online

pre-concentration and quantitative analysis of brain-gut peptides

作者: Ye, HZ (Ye, Hongzhi); Xia, SF (Xia, Shifei); Yu, LS (Yu, Lishuang); Xu, XQ (Xu, Xueqin);

Zheng, CS (Zheng, Chunsong); Xu, HF (Xu, Huifeng); Wang, LL (Wang, Lili); Liu, XX (Liu,

Xianxiang); Cai, ZW (Cai, Zongwei); Chen, GN (Chen, Guonan) 来源出版物 : ELECTROPHORESIS 卷 : 32 期 : 20 特刊 : SI 页 : 2823-2829 DOI:

10.1002/elps.201000591 出版年: OCT 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 44 摘要: In order to improve the sensitivity of CE-ESI-MS for the analysis of brain-gut peptides, a

solid-phase extraction combined with field-amplified sample injection was used for the

pre-concentration of the brain-gut peptides. Compared with the conventional pressure injection

method, the sensitivity in the detection of brain-gut peptides was improved more than 100-fold.

The possible factors affecting sample stacking, such as the sample matrix, the composition and the

length of the water column, the types and the volumes of eluent, have been investigated in detail.

Under the optimum conditions, the detectable concentration of brain-gut peptides was found to be

as low as 0.02 mu M. A linear response concentration for the detection was developed in the range

of 0.08-25 mu mol/L. A real sample of human cerebrospinal fluids, which was spiked with

brain-gut peptides, was also examined in order to evaluate the reliability of the proposed approach.

The recovery of the method was in a range from 69.2 to 85.4%. The method was found to be

reliable, accurate and potentially applicable for clinical drug analysis. 入藏号: WOS:000297424500008 语种: English 文献类型: Article 作者关键词: Brain-gut peptide; CE-ESI-MS; Cerebrospinal fluid; Field amplified; SPE

KeyWords Plus: ELECTROPHORESIS-MASS-SPECTROMETRY; PERFORMANCE

CAPILLARY-ELECTROPHORESIS; ELECTROSPRAY-IONIZATION;

ZONE-ELECTROPHORESIS; SENSITIVITY; STACKING; PROTEINS; OPTIMIZATION;

FLUORESCENCE; STRATEGIES 地址: [Ye, Hongzhi; Yu, Lishuang; Zheng, Chunsong; Wang, Lili; Liu, Xianxiang] Fujian Univ

Tradit Chinese Med, Acad Integrat Med, Fuzhou, Fujian, Peoples R China

[Xia, Shifei; Yu, Lishuang; Xu, Xueqin; Wang, Lili; Chen, Guonan] Fuzhou Univ, Minist Educ,

Fujian Prov Key Lab Anal & Detect Technol Food Sa, Key Lab Anal & Detect Food Safety,


[Xia, Shifei; Yu, Lishuang; Xu, Xueqin; Wang, Lili; Chen, Guonan] Fuzhou Univ, Dept Chem,


[Xu, Huifeng] Fujian Univ TCM, Fujian Key Lab Integrat Med Geriatr, Fuzhou, Peoples R China

[Cai, Zongwei] Hong Kong Baptist Univ, Dept Chem, Hong Kong, Hong Kong, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med,

Fuzhou, Fujian, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: WILEY-BLACKWELL

出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA

Web of Science 分类: Biochemical Research Methods; Chemistry, Analytical 学科类别: Biochemistry & Molecular Biology; Chemistry

IDS 号: 853KJ

ISSN: 0173-0835

29 字符的来源出版物名称缩写: ELECTROPHORESIS

ISO 来源出版物缩写: Electrophoresis 来源出版物页码计数: 7 基金资助致谢: 基金资助机构授权号

NSFC 20928005

Key Natural Sciences Foundation of Fujian Province, China

D0520001

2010Y0032

2009J01172

Fujian Province Key Foundation of Chinese Medicine wzzg0901

Key Foundation of Education Department of Fujian Province, China JK2009016

This project was financially supported by NSFC (20928005), the Key Natural Sciences Foundation

of Fujian Province, China (D0520001, 2010Y0032, 2009J01172), Fujian Province Key Foundation

of Chinese Medicine (wzzg0901), the Key Foundation of Education Department of Fujian

Province, China (JK2009016).

第 19 条，共 86 条标题 : Effect of Silver Colloid Concentration on Electroporation for Intracellular Surface

Enhanced Raman Scattering 作者: Yu, Y (Yu Yun); Lin, JQ (Lin Ju-Qiang); Huang, H (Huang Hao); Chen, YP (Chen

Yan-Ping); Feng, SY (Feng Shang-Yuan); Su, Y (Su Ying); Chen, JS (Chen Jie-Si); Chen, R (Chen

Rong) 来源出版物 : PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 卷 : 38 期 : 10 页 :

961-966 DOI: 10.3724/SP.J.1206.2011.00106 出版年: OCT 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 20 摘要: The effect of silver colloid concentration was explored for fastest delivery of silver

nanoparticles into living C666 cells (a human nasopharyngeal carcinoma cell line) for intracellular

surface enhanced raman scattering (SERS) by Electroporation. SERS spectra, the integrated SERS

intensity and the reproducibility of spectrum were compared in 6 electroporation experiments of

the same electric pulse parameters but different concentration of silver colloid. The silver

nanoparticle concentration is best under the condition of 500 mu l electroporation buffer

containing 50 mu l silver colloid using 875 V/cm, 1 ms rectangular electric pulses for

electroporation twice. Increasing the concentration of silver nanoparticle could improve the SERS

intensity while decrease the reproducibility of the spectrum. Moreover, the observed SERS bands

of living C666 cell were tentatively assigned. This work is promising for the practical application

of SERS technology, such as real time detection and analysis of the biochemical substance in

living cells. 入藏号: WOS:000296226100011 语种: Chinese 文献类型: Article 作者关键词: surface enhanced Raman scattering(SERS); electroporation; C666 cell; silver colloid

concentration

KeyWords Plus: LIVE CELLS; SPECTROSCOPY; NANOPARTICLES; TISSUES 地址: [Yu Yun; Lin Ju-Qiang; Feng Shang-Yuan; Chen Jie-Si; Chen Rong] Fujian Normal Univ,

Key Lab OptoElect Sci & Technol Med, Minist Educ, Fujian Prov Key Lab Photon Technol,


[Yu Yun; Huang Hao] Fujian Univ Tradit Chinese Med, Dept Integrat Med, Fuzhou 350108,

Peoples R China

[Chen Yan-Ping; Su Ying] Fujian Prov Tumor Hosp, Fuzhou 350001, Peoples R China 通讯作者地址: Chen, R (通讯作者),Fujian Normal Univ, Key Lab OptoElect Sci & Technol

Med, Minist Educ, Fujian Prov Key Lab Photon Technol, Fuzhou 350007, Peoples R China 电子邮件地址: [email protected] 出版商: CHINESE ACAD SCIENCES, INST BIOPHYSICS 出版商地址: 15 DATUN RD, CHAOYAND DISTRICT, BEIJING, 100101, PEOPLES R CHINA

Web of Science 分类: Biochemistry & Molecular Biology; Biophysics 学科类别: Biochemistry & Molecular Biology; Biophysics

IDS 号: 837TM

ISSN: 1000-3282

29 字符的来源出版物名称缩写: PROG BIOCHEM BIOPHYS

ISO 来源出版物缩写: Prog. Biochem. Biophys. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构授权号


60910106016

Science and Technology Project of Fujian Province 2008J0016

Science Foundation of Ministry of Health and United Fujian Provincial WKJ2008-2-046

This work was supported by grants from The National Natural Science Foundation of China

(60778046, 60910106016), The Science and Technology Project of Fujian Province (2008J0016,

2009J01276), and The Project of Science Foundation of Ministry of Health and United Fujian

Provincial Health and Education Project for Tackling the Key Research (WKJ2008-2-046).

第 20 条，共 86 条标题: CacyBP/SIP Protein Promotes Proliferation and G1/S Transition of Human Pancreatic

Cancer Cells 作者: Chen, X (Chen, Xiong); Mo, P (Mo, Ping); Li, XH (Li, Xiaohua); Zheng, PC (Zheng,

Peichan); Zhao, LN (Zhao, Lina); Xue, ZF (Xue, Zengfu); Ren, G (Ren, Gui); Han, GH (Han,

Guohong); Wang, X (Wang, Xin); Fan, DM (Fan, Daiming) 来源出版物 : MOLECULAR CARCINOGENESIS 卷 : 50 期 : 10 页 : 804-811 DOI:

10.1002/mc.20737 出版年: OCT 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 29 摘要: Calcyclin-binding protein or Siah-1-interacting protein (CacyBP/SIP), a component of the

ubiquitin-mediated proteolysis, could participate in beta-catenin degradation, which was found to

be related to the malignant phenotypes of pancreatic cancer previously. However, the role of

CacyBP/SIP itself in pancreatic cancer has not been investigated. In the present study, CacyBP/SIP

expression was assayed and manipulated to reveal the potential mechanism in pancreatic cancer

carcinogenesis. Here, we show that CacyBP/SIP is over-expressed in pancreatic cancer cells.

Down-regulation of CacyBP/SIP by small interference RNA (siRNA) severely suppresses the

proliferation and tumorigenesis in pancreatic cancer. G1/S transition arrest induced by inhibition

of CacyBP/SIP is at least partly mediated by down-regulation of Cyclin E and CDK2 as well as

up-regulation of p27 and Rb. Collectively, CacyBP/SIP as an enhancer of pancreatic cancer

malignance might develop into another possible therapeutic target. (C) 2011 Wiley-Liss, Inc. 入藏号: WOS:000294883800007 语种: English 文献类型: Article 作者关键词: CacyBP/SIP; proliferation; cell cycle; pancreatic cancer

KeyWords Plus: BINDING-PROTEIN; SIGNALING PATHWAY; CALCYCLIN; EXPRESSION;

PROSTATE; APOPTOSIS; RECEPTOR; DIFFERENTIATION; TARGET; GROWTH 地址: [Chen, Xiong; Mo, Ping; Li, Xiaohua; Zhao, Lina; Xue, Zengfu; Ren, Gui; Han, Guohong;

Wang, Xin; Fan, Daiming] Fourth Mil Med Univ, State Key Lab Canc Biol, Xian 710032,

Shaanxi, Peoples R China

[Chen, Xiong; Mo, Ping; Li, Xiaohua; Zhao, Lina; Xue, Zengfu; Ren, Gui; Han, Guohong; Wang,

Xin; Fan, Daiming] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian 710032, Shaanxi,

Peoples R China

[Zheng, Peichan] Peoples Hosp Fujian Prov, Dept Clin Lab, Fuzhou, Fujian, Peoples R China 通讯作者地址: Wang, X (通讯作者),Fourth Mil Med Univ, Key Lab Canc Biol, 17 Changle

Western Rd, Xian 710032, Shaanxi, Peoples R China 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA

Web of Science 分类: Biochemistry & Molecular Biology; Oncology 学科类别: Biochemistry & Molecular Biology; Oncology

IDS 号: 820CT

ISSN: 0899-1987

29 字符的来源出版物名称缩写: MOL CARCINOGEN

ISO 来源出版物缩写: Mol. Carcinog. 来源出版物页码计数: 8 基金资助致谢: 基金资助机构授权号



2010CB529306

We thank Taidong Qiao and Zheng Chen for excellent experimental assistant and Yongzhan Nie

for constructive advice. This study was supported by the National Natural Science Foundation of

China (No. 30871143) and the National Basic Research Program of China (No.2010CB529300

and No.2010CB529306).

第 21 条，共 86 条标题: Effects of Herba Epimedii and Fructus Ligustri lucidi on the Transcription Factors in

Hypothalamus of Aged Rats 作者: Cai, J (Cai Jing); Zheng, T (Zheng Teng); Zhang, L (Zhang Lei); Tian, Y (Tian Yun); Yang,

MH (Yang Min-he); Du, J (Du Jian) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 10 页 :

758-763 DOI: 10.1007/s11655-011-0636-z 出版年: OCT 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 19 摘要: Objective: To comparatively analyze the difference in the expression of 54 transcription

factors in the hypothalamus using protein chips following the medication of Chinese drugs for

Shen ((sic))-tonification, Herba Epimedii, and Fructus Ligustri lucidi (FL) to aged rats. Methods:

Wistar rats, aged 15 months of SPF grade, were randomized into three groups, three males and

three females in each group. They were medicated with Herba Epimedii decoction (HED, 0.14

g/kg), Fructus Ligustri lucidi decoction (FLD, 0.12 g/kg), and distilled water, respectively, twice a

day for 15 days. The rats were sacrificed at the morning of the 16th day 1 h after medication, and

their hypothalamus was taken and made into homogenate under an ice-bath for detecting the

expression of transcription factors with chip technique. Results: The expressions of signal

transduction and transcription activation factor-6 (Stat-6) and androgen receptor (AR) were

up-regulated, and those of pre-B transcription factor1 (Pbx-1), stat-1 and AP-2 were

down-regulated in both HED and FLD treated groups, but these changes occurred mainly in

female rats in the former while mainly in males in the latter. Conclusions: Chinese drugs for

Shen-tonification could impact the expression of transcription factors in the hypothalamus of aged

rats, dominantly on the neuro-endocrine factors responsible for the growth and development. The

effects of drugs for tonifying Shen-yang and for tonifying Shen-yin are different, which is

probably one of the pharmacological mechanisms of the Shen-tonifying drugs. 入藏号: WOS:000295548600007 语种: English 文献类型: Article 作者关键词: Herba Epimedii; Fructus Ligustri lucidi; transcription factor; aged rat; hypothalamus

KeyWords Plus: EXPRESSION; PBX1; CELLS 地址: [Cai Jing; Tian Yun; Du Jian] Fujian Univ Tradit Chinese Med, Fujian Inst Integrat Chinese

& Western Med, Fuzhou 350108, Peoples R China

[Zhang Lei; Yang Min-he] Fujian Normal Univ, Fuzhou 350108, Peoples R China

[Zheng Teng] Fujian Entry Exit Inspect & Quarantine Bur PR Chi, Fuzhou 350001, Peoples R

China 通讯作者地址: Cai, J (通讯作者),Fujian Univ Tradit Chinese Med, Fujian Inst Integrat Chinese

& Western Med, Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA


IDS 号: 829BC

ISSN: 1672-0415




CHEN Ke-ji Development Fund of Integrative Medicine CKJ2010025

Supported by the National Natural Science Foundation of China (No. 30672729), CHEN Ke-ji

Development Fund of Integrative Medicine (No. CKJ2010025)

第 22 条，共 86 条标题: Relationship of carotid intima-media thickness and duration of vegetarian diet in Chinese

male vegetarians 作者: Yang, SY (Yang, Shu-Yu); Zhang, HJ (Zhang, Hui-Jie); Sun, SY (Sun, Su-Yun); Wang, LY

(Wang, Li-Ying); Yan, B (Yan, Bing); Liu, CQ (Liu, Chang-Qin); Zhang, W (Zhang, Wei); Li, XJ

(Li, Xue-Jun) 来源出版物 : NUTRITION & METABOLISM 卷 : 8 文献号 : 63 DOI:

10.1186/1743-7075-8-63 出版年: SEP 19 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 34 摘要: Objective: Many studies have shown that vegetarian diet has beneficial effects on the

prevention of cardiovascular diseases. However, the effect of vegetarian diet on carotid

intima-media thickness (IMT), as well as the association between IMT and duration of vegetarian

diet, are still unclear. The present study aims to investigate the influence of duration of vegetarian

diet on cardiovascular risk factors, and more importantly on IMT among Chinese vegetarians.

Methods: One hundred and seventy-one Chinese male vegetarians were screened for metabolic

profile, cardiovascular risk and carotid IMT. They were compared with 129 age-matched

omnivores recruited from a community-based health project. The effects of confounding factors

were adjusted by stepwise logistic regression analysis.

Results: Compared to the omnivores, the vegetarians had lower BMI, weight, systolic blood

pressure and diastolic blood pressure. Also, the levels of triglyceride, total cholesterol,

HDL-Cholesterol, LDL-Cholesterol, ApoA1, ApoB, uric acid, albumin and g-glutamyltransferase

were significantly reduced in vegetarians. Omnivores had significantly higher fasting blood

glucose than that of vegetarians. However, there were no differences in fasting insulin, C-reactive

protein and HOMA-IR between the two groups. IMT was thinner in the vegetarian group than in

the omnivore group (0.59 +/- 0.16 vs. 0.63 +/- 0.10 cm, P < 0.05). The vegetarians were divided

according to duration of vegetarian diet (< 6 years, 6 to <= 11 years, > 11 years), those in tertile 1

(< 6 years) and tertile 2 (6 to <= 11 years) had shown thinner IMT as compared to the omnivores,

and tertile 3 had shown no reduction.

Conclusion: A decrease in multiple cardiovascular risk factors such as BMI, blood pressure and

lipid profile was associated with vegetarian diet. Moreover, taking a low-calorie, low-protein, or

vegetarian diet might have great beneficial effects on IMT through improved lipid profile, and the

beneficial effects appeared to be correlated with the duration of vegetarian diet. 入藏号: WOS:000295594900001 语种: English 文献类型: Article 作者关键词: vegetarian diet; IMT; duration of vegetarian diet

KeyWords Plus: CARDIOVASCULAR RISK PROFILE; C-REACTIVE PROTEIN;

NUTRITION TRANSITION; METABOLIC SYNDROME; MORTALITY; DISEASE;

MARKERS; ATHEROSCLEROSIS; INFLAMMATION; OMNIVORES 地址: [Yang, Shu-Yu] Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med, Fuzhou

350108, Peoples R China

[Yang, Shu-Yu; Zhang, Hui-Jie; Sun, Su-Yun; Wang, Li-Ying; Yan, Bing; Liu, Chang-Qin; Zhang,

Wei; Li, Xue-Jun] Xiamen Univ, Affiliated Hosp 1, Dept Diabet, Xiamen Diabet Inst, Xiamen

361003, Peoples R China 通讯作者地址: Yang, SY (通讯作者),Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med,

1 Hua Tuo Rd, Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: BIOMED CENTRAL LTD 出版商地址: 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND

Web of Science 分类: Nutrition & Dietetics 学科类别: Nutrition & Dietetics

IDS 号: 829PA

ISSN: 1743-7075

29 字符的来源出版物名称缩写: NUTR METAB

ISO 来源出版物缩写: Nutr. Metab. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构授权号

Natural Science Foundation of China 81000320

Natural Science Foundation of Fujian Province and Xiamen 2009D016

3502Z20104026

Youth Foundation of Fujian Provincial Health Department 2010-2-86

We are grateful to the consideration and cooperation of all the participants of the study. The

authors would like to acknowledge Prof. Xiao-Ying Li from Rui-jin Hospital Affiliated to

Shanghai Jiaotong University, for his advices in the present project. This study is supported by the

grants from the Natural Science Foundation of China (NO. 81000320), the Natural Science

Foundation of Fujian Province and Xiamen (NO. 2009D016 and 3502Z20104026) and the Youth

Foundation of Fujian Provincial Health Department (NO.2010-2-86).

第 23 条，共 86 条标题: Synthesis and photobiological study of a novel chlorin photosensitizer BCPD-18MA for

photodynamic therapy 作者: Zhang, JL (Zhang, Jialiang); Deng, L (Deng, Li); Yao, JZ (Yao, Jianzhong); Gu, P (Gu,

Peng); Yang, F (Yang, Feng); Wang, XX (Wang, Xiuxin); Liu, W (Liu, Wei); Zhang, YY (Zhang,

Yingying); Ke, XF (Ke, Xingfa); Jing, XL (Jing, Xiaolong); Chen, JM (Chen, Jianming) 来源出版物 : BIOORGANIC & MEDICINAL CHEMISTRY 卷 : 19 期 : 18 页 :

5520-5528 DOI: 10.1016/j.bmc.2011.07.041 出版年: SEP 15 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 35 摘要 : This paper reports synthesis and photobiological properties of a novel chlorin

photosensitizer BCPD-18MA. Cytotoxicity, cellular uptake, subcellular location, biodistribution,

photodynamic therapy (PDT) efficiency, cell apoptosis as well as histological analysis of the

liposomal-delivered BCPD-18MA (L-BCPD-18MA) was studied using mammary

adenocarcinoma MDA-MB-231 cells and Lewis lung carcinoma (LLC) implanted in C57BL/6

mice as experimental models. The results showed that L-BCPD-18 was incorporated rapidly into

MDA-MB-231 cells and localized partially in mitochondria. L-BCPD-18 induced cell apoptosis

by PDT. In addition, biodistribution of L-BCPD-18MA in LLC-bearing mice demonstrated a fast

clearance rate of the drug and good skin-related tumor selectivity. Finally, entrapment of

BCPD-18 into liposomes resulted in a dramatic impairment of dark toxicity and a notable

improvement of PDT antitumor efficacy in vitro. Compared with liposomal-delivered BPDMA

(L-BPDMA), L-BCPD-18MA exhibited low dark toxicity and high PDT efficiency on

MDA-MB-231 cells. The photodynamic efficacy of L-BCPD-18MA on LLC-bearing mice is

comparable to that of L-BPDMA, implying that L-BCPD-18MA is a potential antitumor candidate

for PDT. (C) 2011 Elsevier Ltd. All rights reserved. 入藏号: WOS:000294711100024 语种: English 文献类型: Article 作者关键词: Cancer; Photodynamic therapy; Liposome; Chlorin; Photosensitizer; Apoptosis;

Synthesis

KeyWords Plus: BASIC PRINCIPLES; MECHANISMS; APOPTOSIS; TUMORS; DIFFUSION;

INDUCTION; LIPOSOMES; DELIVERY; CELLS 地址: [Zhang, Jialiang; Deng, Li; Yao, Jianzhong; Gu, Peng; Yang, Feng; Wang, Xiuxin; Liu, Wei;

Zhang, Yingying; Ke, Xingfa; Jing, Xiaolong; Chen, Jianming] Mil Med Coll 2, Sch Pharm,

Shanghai 200433, Peoples R China

[Zhang, Jialiang; Ke, Xingfa; Jing, Xiaolong] Fujian Univ Tradit Chinese Med, Dept Pharm,

Fujian 350108, Peoples R China 通讯作者地址: Chen, JM (通讯作者),Mil Med Coll 2, Sch Pharm, Shanghai 200433, Peoples R

China 电子邮件地址: [email protected]; [email protected] 出版商: PERGAMON-ELSEVIER SCIENCE LTD 出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,

ENGLAND

Web of Science 分类: Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,

Organic

学科类别: Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry

IDS 号: 817XO

ISSN: 0968-0896

29 字符的来源出版物名称缩写: BIOORGAN MED CHEM

ISO 来源出版物缩写: Bioorg. Med. Chem. 来源出版物页码计数: 9 基金资助致谢: 基金资助机构授权号

Nation Natural Science Foundation of China 30371737

Foundation of China 2009ZXJ09003-028

This research was supported by the Nation Natural Science Foundation of China (Grant No.

30371737) and the National Science & Technology Major Project 'Major New Drug Creation

Program' Foundation of China (Grant No. 2009ZXJ09003-028).

第 24 条，共 86 条标题 : Synthesis and Biological Activities of Novel Danshensu Amide Derivatives as

Anti-Myocardial Ischemia Agents 作者: Wang, TF (Wang, Tingfang); Shu, JJ (Shu, Jingjing); Zheng, LP (Zheng, Liping); Xiong, LY

(Xiong, Liyan); Wang, J (Wang, Jing); Jin, L (Jin, Lei); Wu, QY (Wu, Qiuye); Zou, H (Zou, Hao);

Zhang, C (Zhang, Chuan) 来源出版物: LATIN AMERICAN JOURNAL OF PHARMACY 卷: 30 期: 7 页: 1355-1359 出版年: SEP 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 21 摘要: A series of novel danshensu amide derivatives were synthesized, and the protective effects

of all the compounds on rat myocardial cell lines H9C2 by hypoxia were investigated. The results

showed that all the seven compounds could significantly increased cell viability compared with

hypoxia group. Among these compounds,

3-(3,4-dimethoxyphenyl)-2-hydroxy-N-propylpropanamide (6) exhibited good activities, with cell

viability reached 94.2 % compared to the normal. The novel danshensu amide derivatives,

possessing an additional lipophilic alkyl chain showed a good lipophilicity. 入藏号: WOS:000298220700016 语种: English 文献类型: Article 作者关键词: Anti-myocardial ischemia activities; Danshensu amide derivatives; Lipophilicity;

Synthesis

KeyWords Plus: SALVIA-MILTIORRHIZA; AQUEOUS EXTRACT; DYSFUNCTION;

ARTERY 地址: [Wang, Tingfang; Shu, Jingjing; Zheng, Liping; Xiong, Liyan; Wang, Jing; Jin, Lei; Zou,

Hao; Zhang, Chuan] Mil Med Coll 2, New Drug Res Ctr, Sch Pharm, Shanghai 200433, Peoples R

China

[Wang, Tingfang; Shu, Jingjing; Zheng, Liping] Fujian Univ Tradit Chinese Med, Sch Pharm,

Fuzhou 350108, Fujian, Peoples R China

[Wu, Qiuye] Mil Med Coll 2, Dept Organ Chem, Sch Pharm, Shanghai 200433, Peoples R China 通讯作者地址: Zou, H (通讯作者),Mil Med Coll 2, New Drug Res Ctr, Sch Pharm, Guohe Rd

325, Shanghai 200433, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES 出版商地址: DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA


IDS 号: 864EV

ISSN: 0326-2383

29 字符的来源出版物名称缩写: LAT AM J PHARM

ISO 来源出版物缩写: Lat. Am. J. Pharm. 来源出版物页码计数: 5 基金资助致谢: 基金资助机构授权号

Science and Technology Commission of Shanghai 08DZ1970802


2009CB521907

This study was supported by the Science and Technology Commission of Shanghai special

purpose for modernization of traditional Chinese medicine in 2008 (No. 08DZ1970802) and

National Basic Research Program of China (No. 2006CB504100 and 2009CB521907).

第 25 条，共 86 条标题: Scientific research at Fujian Academy of Integrative Medicine: Current status and future

directions 作者: Liu, XX (Liu Xian-xiang); Wu, JZ (Wu Jin-zhong); Lin, YP (Lin Yan-ping); Cao, ZY (Cao

Zhi-yun); Peng, J (Peng Jun); Cai, J (Cai Jing); Tan, CJ (Tan Chun-jiang); Liao, LM (Liao

Lian-ming); Du, J (Du Jian) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 9 页 :

643-649 DOI: 10.1007/s11655-011-0840-x 出版年: SEP 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0

引用的参考文献数: 88 入藏号: WOS:000294820500001 语种: English 文献类型: Editorial Material

KeyWords Plus: MESENCHYMAL STEM-CELLS; TOUGU XIAOTONG GRANULE; KNEE

OSTEOARTHRITIS; COMPUTATIONAL PHARMACOLOGY;

CAPILLARY-ELECTROPHORESIS; INDUCED DIFFERENTIATION; APOPTOSIS;

PATHWAY; PROLIFERATION; CHONDROCYTES 地址: [Liu Xian-xiang; Wu Jin-zhong; Lin Yan-ping; Cao Zhi-yun; Peng Jun; Cai Jing; Tan

Chun-jiang; Liao Lian-ming; Du Jian] Fujian Acad Integrat Med, Fuzhou 350108, Peoples R

China 通讯作者地址: Du, J (通讯作者),Fujian Acad Integrat Med, Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA


IDS 号: 819JF

ISSN: 1672-0415


ISO 来源出版物缩写: Chin. J. Integr. Med. 来源出版物页码计数: 7

第 26 条，共 86 条标题: Pien Tze Huang (c parts per thousand double dagger a >>"c (TM) Euro)-induced apoptosis

in human colon cancer HT-29 cells is associated with regulation of the Bcl-2 family and activation

of caspase 3 作者: Lin, JM (Lin Jiu-mao); Wei, LH (Wei Li-hui); Chen, YQ (Chen You-qin); Liu, XX (Liu

Xian-xiang); Hong, ZF (Hong Zhen-feng); Sferra, TJ (Sferra, Thomas J.); Peng, J (Peng Jun) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 9 页 :

685-690 DOI: 10.1007/s11655-011-0846-4 出版年: SEP 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 23 摘要: To investigate the cellular effects of Pien Tze Huang (c parts per thousand double dagger a

>>"c (TM) Euro, PZH) in the HT-29 human colon carcinoma cell line.

The viability of HT-29 cells was determined by MTT assay. A fluorescence-activated cell sorting

(FACS) analysis with annexin-V/propidium iodide (PI) and JC-1 staining were performed to

determine cell apoptosis and the loss of mitochondrial membrane potential, respectively.

Activation of caspase 3 was evaluated by a colorimetric assay. The mRNA expression levels of

Bcl-2 and Bax were measured by reverse transcription polymerase chain reaction (RT-PCR).

PZH, in a dose- and timedependent manner, reduced viability and induced apoptosis of HT-29

cells. Moreover, PZH treatment resulted in the collapse of the mitochondrial membrane potential,

activation of caspase 3, and an increase in the Bax/Bcl-2 ratio.

PZH inhibits the growth of HT-29 cells by inducing cancer cell apoptosis via regulation of the

Bcl-2 family and activation of caspase 3, which may, in part, explain its anticancer activity. 入藏号: WOS:000294820500008 语种: English 文献类型: Article 作者关键词: Pien Tze Huang; Chinese medicine; colon cancer; apoptosis; HT-29 cells

KeyWords Plus: CHANNEL-FORMING ACTIVITY; CYTOCHROME-C; MITOCHONDRIA;

BAX; RELEASE; PROTEINS; CYTOSOL; SWITCH; DEATH 地址: Fujian Acad Integrat Med, Fuzhou 350108, Peoples R China

[Lin Jiu-mao; Wei Li-hui; Liu Xian-xiang; Hong Zhen-feng; Peng Jun] Fujian Acad Integrat Med,


[Lin Jiu-mao; Liu Xian-xiang] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med

Geriatr, Fuzhou 350108, Peoples R China

[Chen You-qin; Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK

73190 USA

[Chen You-qin; Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol,

Oklahoma City, OK 73190 USA

[Peng Jun] Zhangzhou Pien Tze Huang Pharmaceut Co Ltd, Postdoctor Workstn, Zhangzhou

363000, Fujian, Peoples R China 通讯作者地址: Peng, J (通讯作者),Fujian Acad Integrat Med, Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA


IDS 号: 819JF

ISSN: 1672-0415




Developmental Fund of CHEN Ke-ji Integrative Medicine CKJ 2011001


Supported by the National Natural Science Foundation of China (No. 81073097), the

Developmental Fund of CHEN Ke-ji Integrative Medicine (No. CKJ 2011001), and the Natural

Science Foundation of Fujian Province of China (No. 2010J01195)

第 27 条，共 86 条标题: Fuzheng Yiliu Granule (ae parts per thousand ae aeSc pound similar to currency signe cent

uc(2)') inhibits the growth of hepatocellular cancer by regulating immune function and inducing

apoptosis in vivo and in vitro 作者: Cao, ZY (Cao Zhi-yun); Chen, XZ (Chen Xu-zheng); Liao, LM (Liao Lian-ming); Peng, J

(Peng Jun); Hu, HX (Hu Hai-xia); Liu, ZZ (Liu Zhi-zhen); Du, J (Du Jian) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 9 页 :

691-697 DOI: 10.1007/s11655-011-0847-3 出版年: SEP 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 25 摘要: To study the inhibitory effect of Fuzheng Yiliu Granule (ae parts per thousand ae aeSc

pound similar to currency signe cent uc(2)', FYG) on hepatocellular cancer (HCC) and investigate

the mechanism mediating its bioactivity.

H22 tumor-bearing ICR mice were treated with FYG [3.6 g/(kg center dot d)] for 5 days. Tumor

volume and tumor weight, percentages of CD3(+), CD4(+), CD8(+), and natural killer (NK) cells

in peripheral blood, tumor apoptosis and serum levels of interleukin-2 (IL-2), and tumor necrosis

factor-alpha (TNF-alpha) were evaluated. FYG-containing serum was prepared from SD rats

treated for 7 days [high dose 3.6 g/(kg center dot d); middle dose 1.8 g/(kg center dot d); low dose

0.9 g/(kg center dot d)]. Cell cycle, cell viability, and apoptosis were evaluated after HepG2 cell

line was cultured in FYG-containing serum for 48 h. The levels of IL-2 and TNF-alpha in

FYG-containing serum were also determined.

FYG produced a potent antitumor effect (P < 0.01) and induced marked apoptosis of the tumor

tissue (P < 0.05). Mice treated with FYG had higher percentages of CD3(+) and CD4(+) (P <

0.05), and more NK cells (P < 0.01) in the peripheral blood than those in the animals treated with

normal saline. Mice receiving FYG had the highest serum levels of IL-2 and TNF-alpha (P <

0.01). High-dose FYG-containing serum significantly decreased HepG2 cell viability, inhibited

cell proliferation (P < 0.05), and induced apoptosis (P < 0.01). In addition, the levels of IL-2 and

TNF-alpha of high-dose-containing serum were higher than the blank serum (P < 0.01).

FYG could inhibit HCC growth by regulating immune function and inducing apoptosis of tumor

cells in vivo and in vitro. 入藏号: WOS:000294820500009 语种: English 文献类型: Article 作者关键词: Fuzheng Yiliu Granule; hepatocellular cancer; immune function; apoptosis

KeyWords Plus: GANODERMA-LUCIDUM; TUMOR-METASTASIS; CARCINOMA;

LIGAND; INTERFERON; MECHANISMS 地址: [Cao Zhi-yun; Chen Xu-zheng; Liao Lian-ming; Peng Jun; Hu Hai-xia; Liu Zhi-zhen; Du

Jian] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Peoples R China 通讯作者地址: Du, J (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou

350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA


IDS 号: 819JF

ISSN: 1672-0415



CHEN Ke-ji Integrative Medicine Development Fund CKJ2010020

Ministry of Science and Technology of the People's Republic of China 2008DFA32200

Department of Education of Fujian Province JA09136

Supported by CHEN Ke-ji Integrative Medicine Development Fund (No. CKJ2010020);

International Science Joint Project of the Ministry of Science and Technology of the People's

Republic of China (No. 2008DFA32200); Project of Department of Education of Fujian Province

(No. JA09136)

第 28 条，共 86 条标题: Potential synergistic and multitarget effect of herbal pair Chuanxiong Rhizome-Paeonia

Albifora Pall on osteoarthritis disease: A computational pharmacology approach 作者: Ye, HZ (Ye Hong-zhi); Zheng, CS (Zheng Chun-song); Xu, XJ (Xu Xiao-jie); Wu, MX (Wu

Ming-xia); Liu, XX (Liu Xian-xiang) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 9 页 :

698-703 DOI: 10.1007/s11655-011-0853-5 出版年: SEP 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 20 摘要: To study the polypharmacological mechanism of herbal pair Chuanxiong Rhizome-Paeonia

Albifora Pall (HP CXR-PAP) on the treatment for osteoarthritis (OA).

Chemical space was used to discuss the similarities and differences between the molecule sets of

HP CXR-PAP and drugs. Docking protocol was used to study the interaction between HP

CXR-PAP and OA target enzymes. The similarities and differences of HP CXR-PAP and drugs in

target spaces were elucidated by network features.

The plots between the molecule sets of HP CXR-PAP and drugs in chemical space had the

majority in the same region, and compounds from HP CXR-PAP covered a much larger additional

region of space than drug molecules, which denoted the diverse structural properties in the

molecule set of HP CXR-PAP. The molecules in HP CXR-PAP had the properties of promiscuous

drugs and combination drug, and both HP CXR-PAP ligand-target interaction network and drug

ligand-target interaction network were similar in the interaction profiles and network features,

which revealed the effects of multicomponent and multitarget.

The clue of potential synergism was obtained in curing OA disease by Chinese medicine, which

revealed the advantages of Chinese medicine for targeting osteoarthritis disease. 入藏号: WOS:000294820500010 语种: English 文献类型: Article 作者关键词: herbal pair Chuanxiong Rhizome-Paeonia Albifora Pall; chemical space; virtual

screening; target space; computational pharmacology; osteoarthritis

KeyWords Plus: TOUGU XIAOTONG GRANULE; INFLAMMATION; NETWORKS 地址: [Ye Hong-zhi; Zheng Chun-song; Wu Ming-xia; Liu Xian-xiang] Fujian Univ Tradit

Chinese Med, Fujian Acad Integrat Med, Fuzhou 350108, Peoples R China

[Xu Xiao-jie] Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

[Liu Xian-xiang] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med Geriatr, Fuzhou

350108, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med,

Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA


IDS 号: 819JF

ISSN: 1672-0415




CHEN Ke-ji Integrative Medicine Development Foundation CKJ2010032

Emphasis Foundation of Fujian Provincial Department of Science and 2010Y0029

Supported by the National Natural Science Foundation of China (No. 81072826), CHEN Ke-ji

Integrative Medicine Development Foundation (No. CKJ2010032), and Emphasis Foundation of

Fujian Provincial Department of Science and Technology (No. 2010Y0029)

第 29 条，共 86 条标题: Millimeter wave treatment inhibits the mitochondrion-dependent apoptosis pathway in

chondrocytes 作者: Wu, GW (Wu, Guangwen); Sferra, T (Sferra, Thomas); Chen, XZ (Chen, Xuzheng); Chen,

YQ (Chen, Youqin); Wu, MX (Wu, Mingxia); Xu, HF (Xu, Huifeng); Peng, J (Peng, Jun); Liu,

XX (Liu, Xianxiang) 来源出版物 : MOLECULAR MEDICINE REPORTS 卷 : 4 期 : 5 页 : 1001-1006 DOI:

10.3892/mmr.2011.522 出版年: SEP-OCT 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 25 摘要: Millimeter wave (MW) is an electromagnetic wave with a wavelength between 1 and 10

mm and a frequency of 30-300 GHz that causes multiple biological effects, both locally and

globally. MW has been widely used in clinical medicine. Although our previous work

demonstrated that MW is capable of inhibiting sodium nitroprussiate (SNP)-induced apoptosis in

chondrocytes, the precise mechanism of the anti-apoptotic activity remains to be elucidated. The

purpose of this study was to investigate the effects of MW in SNP-induced apoptotic

chondrocytes. Sprague Dawley rat chondrocytes were isolated and cultured, and the cells were

counted. Cell viability was evaluated using MTT assay. Cells were then treated with SNP and

MW, and flow cytometry was used to detect apoptosis. Our results showed that MW treatment

inhibited a SNP-induced mitochondrion-dependent pathway of apoptosis. MW treatment inhibited

the loss of plasma membrane asymmetry (externalization of phosphatidylserine), collapse of

mitochondrial membrane potential, and activation of caspase-9 and caspase-3. Taken together, the

results indicate that MW inhibits the mitochondrion-dependent pathway of apoptosis in

chondrocytes and this may, in part, explain its clinical effect in the treatment of osteoarthritis. 入藏号: WOS:000293435300034 语种: English 文献类型: Article 作者关键词: chondrocyte; millimeter wave; apoptosis; mitochondria

KeyWords Plus: NO-INDUCED APOPTOSIS; CYTOCHROME-C; GENE-EXPRESSION;

RELEASE; MEMBRANE; DEATH; CELLS; BCL-2; BAX; OLIGOMERIZATION

地址: [Wu, Guangwen; Chen, Xuzheng; Wu, Mingxia; Peng, Jun; Liu, Xianxiang] Fujian Univ

Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Peoples R China

[Xu, Huifeng] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med Geriatr, Fuzhou


[Sferra, Thomas; Chen, Youqin] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK

73190 USA 通讯作者地址: Peng, J (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, 1

Huatuo Rd, Fuzhou 350108, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE


IDS 号: 801JQ

ISSN: 1791-2997




Fujian Province Small Creations and Projects

This work was supported by the Developmental Fund of Chen Keji Integrative Medicine

(CKJ2010023) and 2008 Fujian Province Small Creations and Projects (no.1).

第 30 条，共 86 条标题: Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in

MG-63 osteosarcoma cells 作者: Liang, WN (Liang, Wenna); Li, XH (Li, Xihai); Li, CD (Li, Candong); Liao, LM (Liao,

Lianming); Gao, BZ (Gao, Bizheng); Gan, HJ (Gan, Huijuan); Yang, ZY (Yang, Zhaoyang); Liao,

LH (Liao, Linghong); Chen, XZ (Chen, Xuzheng) 来源出版物 : MOLECULAR MEDICINE REPORTS 卷 : 4 期 : 5 页 : 1017-1023 DOI:

10.3892/mmr.2011.533 出版年: SEP-OCT 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 29 摘要: Quercetin (a natural polyphenolic compound) is a polyphenolic flavonoid compound found

in a variety of plants. It has been demonstrated to exert cytostatic activity against a variety of

human cancer cell lines, including the human osteosarcoma cell line, MG-63. However, its effects

on osteosarcoma cell apoptosis are still undefined. The present study was undertaken to examine

the effect of quercetin on cell viability, apoptosis and mitochondrial membrane potential, and to

determine the molecular mechanism of quercetininduced apoptosis by investigating the expression

of Bcl-2 family proteins (Bcl-2, Bax), cytochrome C, caspase-9 and caspase-3 in MG-63 cells. We

found that quercetin suppressed the viability of MG-63 cells in a dose- and time- dependent

manner. Furthermore, we observed that quercetin induced the loss of mitochondrial membrane

potential, upregulated the expression of the proapoptotic proteins, Bax and cytochrome C, and

activated caspase-9 and caspase-3, and downregulated the expression of antiapoptotic protein,

Bcl-2. These data suggest that quercetin may induce apoptosis via the mitochondrial-dependent

pathway in MG-63 cells. 入藏号: WOS:000293435300036 语种: English 文献类型: Article 作者关键词: osteosarcoma; apoptosis; quercetin; mitochondria

KeyWords Plus: CANCER PREVENTION; BCL-2 FAMILY; DEATH; BAX; INHIBITION;

MECHANISMS; PROTEINS; THERAPY; MTDNA 地址 : [Liang, Wenna; Li, Candong; Gao, Bizheng; Gan, Huijuan; Yang, Zhaoyang; Liao,

Linghong] Fujian Univ Tradit Chinese Med, Res Base TCM Syndrome, Fuzhou 350108, Fujian,

Peoples R China

[Li, Xihai; Liao, Lianming; Chen, Xuzheng] Fujian Univ Tradit Chinese Med, Acad Integrat Med,

Fuzhou 350108, Fujian, Peoples R China 通讯作者地址: Li, CD (通讯作者),Fujian Univ Tradit Chinese Med, Res Base TCM Syndrome, 1

Huatuo Rd, Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE


IDS 号: 801JQ

ISSN: 1791-2997




This study was supported by the National Natural Science Foundation of China (Grant no.

30772697).

第 31 条，共 86 条标题: A review of chemistry and bioactivities of a medicinal spice: Foeniculum vulgare 作者: He, WP (He, Weiping); Huang, BK (Huang, Baokang) 来源出版物 : JOURNAL OF MEDICINAL PLANTS RESEARCH 卷 : 5 期 : 16 页 :

3595-3600 出版年: AUG 18 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 51 摘要: Foeniculum vulgare Mill. with common name fennel, is a very popular spice as well as an

important traditional Chinese medicine. The plant is native to Southern Europe and Mediterranean

region. It has two important subspecies of Capillaceum and Piperitum. It mainly contains essential

oil, fatty acids and phenolic compounds, etc. The most intense odor compounds of fennel are

trans-anethole, estragole and fenchone. Fennel has many biological activities due to its volatile

and nonvolatile compounds, and it has been used in traditional Chinese medicine for treating

various conditions, particularly rheumatism, cold pain and stomach disorder. It is also used as a

spice for its aromatic fruit. This review covers progresses on the chemistry, pharmacology and

nutraceutical value of fennel, and aims to lay the foundation for further study and utilization of

fennel. 入藏号: WOS:000297463900004 语种: English 文献类型: Review 作者关键词: Chemistry; bioactivity; Foeniculum vulgare

KeyWords Plus: ESSENTIAL OIL COMPOSITION; STORED-PRODUCT INSECTS;

ACARICIDAL ACTIVITY; TYROPHAGUS-PUTRESCENTIAE; ANTIOXIDANT

ACTIVITIES; CHEMICAL-COMPOSITION; LARVICIDAL ACTIVITY; VOLATILE OIL;

SEED OILS; FENNEL 地址: [He, Weiping; Huang, Baokang] Mil Med Coll 2, Sch Pharm, Shanghai 200433, Peoples R

China

[He, Weiping] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350108, Peoples R China 通讯作者地址: He, WP (通讯作者),Mil Med Coll 2, Sch Pharm, Shanghai 200433, Peoples R

China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA


IDS 号: 853ZJ

ISSN: 1996-0875


ISO 来源出版物缩写: J. Med. Plants Res. 来源出版物页码计数: 6

第 32 条，共 86 条标题: Tetramethylpyrazine (TMP) promotes chondrocyte proliferation via pushing the progression

of cell cycle 作者: Li, XH (Li, Xihai); Peng, J (Peng, Jun); Xu, YF (Xu, Yanfang); Wu, MX (Wu, Mingxia);

Ye, HZ (Ye, Hongzhi); Zheng, CS (Zheng, Chunsong); Wu, GW (Wu, Guangwen); Xu, HF (Xu,

Huifeng); Chen, XZ (Chen, Xuzheng); Liu, XX (Liu, Xianxiang) 来源出版物 : JOURNAL OF MEDICINAL PLANTS RESEARCH 卷 : 5 期 : 16 页 :

3896-3903 出版年: AUG 18 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 27 摘要: Tetramethylpyrazine (TMP) is the major bioactive constituent of Rhizoma Chuanxiong

which has long been used as an important component in several Chinese medicine formulations

for the clinical treatment of osteoarthritis. However, the molecular mechanism of the therapeutic

effect of TMP remains unclear. In the present study, we investigated the cellular effects of TMP in

cultured primary chondrocytes. Chondrocytes isolated from the knee articular cartilage of SD rats

were cultured and identified using toluidine blue staining. The second generation of chondrocytes

was treated with or without TMP. We found that TMP treatment could promote chondrocyte

proliferation via pushing the progression of cell cycle. Furthermore, using RT-PCR and Western

blotting analyses we observed that the mRNA and protein levels of Cyclin D1 and CDK4 were

significantly enhanced after TMP treatment, whereas those of p21 were significantly decreased.

Our study suggests that promoting the proliferation of chondrocytes is one of the mechanisms by

which TMP treats osteoarthritis. 入藏号: WOS:000297463900050 语种: English 文献类型: Article 作者关键词: Tetramethylpyrazine; chondrocyte; osteoarthritis; cell cycle

KeyWords Plus: MESENCHYMAL STEM-CELLS; CHONDROGENIC DIFFERENTIATION;

ARTICULAR CHONDROCYTES; ENDOTHELIAL-CELLS; MODULATION; EXPRESSION;

DEGRADATION; TRANSITION; CARTILAGE; DAMAGE 地址: [Li, Xihai; Peng, Jun; Ye, Hongzhi; Zheng, Chunsong; Wu, Guangwen; Xu, Huifeng; Chen,

Xuzheng; Liu, Xianxiang] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108,

Peoples R China

[Li, Xihai] Fujian Key Lab Integrat Med Geriatr, Fuzhou 350108, Peoples R China

[Xu, Yanfang] Fujian Med Univ, Affiliated Hosp 1, Fuzhou 350005, Peoples R China

[Wu, Mingxia] Fujian Univ Tradit Chinese Med, Hosp 2, Dept Acupuncture & Moxibust, Fuzhou

350003, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou

350108, Peoples R China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA


IDS 号: 853ZJ

ISSN: 1996-0875



Foundation of Fujian Provincial Administration of Science and Technology 2009Y0029


This work was supported by the Project supported by the Major Project Foundation of Fujian

Provincial Administration of Science and Technology (No. 2009Y0029), the National Natural

Science Foundation of China (No. 81072826).

第 33 条，共 86 条标题: Volatile components of fruits of Ligustrum lucidum Ait. stimulate proliferation and

differentiation of rat calvarial osteoblasts 作者: Wu, YB (Wu, Yan-Bin); Lin, XH (Lin, Xiong-Hao); Wu, JG (Wu, Jian-Guo); Yi, J (Yi, Jun);

Zheng, YZ (Zheng, Yan-Zhi); Wu, JZ (Wu, Jin-Zhong) 来源出版物: AFRICAN JOURNAL OF BIOTECHNOLOGY 卷: 10 期: 43 页: 8662-8668 出版年: AUG 10 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 30 摘要: The fruits of Ligustrum lucidum Ait., (FLL), which contain rich volatile components, are

commonly used as tonic for kidney and liver in the traditional Chinese medicine prescriptions.

This study aimed to investigate the effects of volatile components of FLL on the proliferation and

differentiation of rat calvarial osteoblasts by the MTT method and measuring the activity of

alkaline phosphatase (ALP). Results showed that volatile components (1 to 100 mu g/mL) of FLL

significantly (p<0.01) stimulated the proliferation and increased the ALP activity of rat calvarial

osteoblasts which indicated that volatile components of FLL played an important role in

osteoblastic bone formation just as non-volatile components in FLL. Such finding accredited the

FLL as a potential candidate that might be useful in bone engineering and in treating bone defects

including osteoporosis. The volatile components were analyzed by GC-MS. A total of 67

compounds were identified and the main components included (Z,Z)-9,12-octadecadienoic acid

(33.47%), n-hexadecanoic acid (15.02%), (E)-9-octadecenoic acid (9.03%), alpha-cadinol

(6.51%), 4-hexyl-2,5-dihydro-2,5-dioxo-3-furanacetic acid (4.93%) and (E)-8-octadecenoic acid

methyl ester (2.69%). 入藏号: WOS:000294679900018 语种: English 文献类型: Article 作者关键词: Ligustrum lucidum; volatile components; rat calvarial osteoblasts

KeyWords Plus: POLYUNSATURATED FATTY-ACIDS; OVARIECTOMIZED RATS;

IN-VITRO; BONE; OSTEOPOROSIS; EXTRACT; SUPPLEMENTATION; OSTEOCLASTS;

EXPRESSION; OILS 地址: [Wu, Yan-Bin; Lin, Xiong-Hao; Wu, Jian-Guo; Zheng, Yan-Zhi; Wu, Jin-Zhong] Fujian

Univ Tradit Chinese Med, Fuzhou 350108, Fujian, Peoples R China

[Yi, Jun] Fujian Inst Educ, Dept Chem & Life Sci, Fuzhou 350001, Fujian, Peoples R China 通讯作者地址: Wu, JZ (通讯作者),Fujian Univ Tradit Chinese Med, Fuzhou 350108, Fujian,

Peoples R China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA

Web of Science 分类: Biotechnology & Applied Microbiology 学科类别: Biotechnology & Applied Microbiology

IDS 号: 817NF

ISSN: 1684-5315

29 字符的来源出版物名称缩写: AFR J BIOTECHNOL

ISO 来源出版物缩写: Afr. J. Biotechnol. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构授权号

Fujian Provincial Universities for Haixi Development

Department of Education Fujian Province JA10181

Fujian Key Laboratory of Integrative Medicine on Geriatrics (Fujian University

of TCM) 2008J1004-42

Natural Science Foundation of Fujian province 2011J01214

This work was conducted in Class III Laboratory of Traditional Chinese Medicine on

Pharmacognosy of State Administration of Traditional Chinese Medicine of People's Republic of

China and was financially supported by Key Project of Fujian Provincial Universities for Haixi

Development (Grant No. 5), Fund of Department of Education Fujian Province (Grant No.

JA10181), Open Fund of Fujian Key Laboratory of Integrative Medicine on Geriatrics (Fujian

University of TCM) (Grant No. 2008J1004-42) as well as Research supported by the Natural

Science Foundation of Fujian province (No. 2011J01214).

第 34 条，共 86 条标题 : Determination of Fulvestrant in Rat Plasma by LC-MS-MS: Application to a

Pharmacokinetic Study 作者: Liu, ZY (Liu, Zhongyang); Gu, GZ (Gu, Guangzhi); Xia, HM (Xia, Huimin); Liu, Q (Liu,

Qiang); Pang, ZQ (Pang, Zhiqing); Jiang, XG (Jiang, Xinguo); Chen, J (Chen, Jun) 来源出版物 : CHROMATOGRAPHIA 卷 : 74 期 : 3-4 页 : 227-234 DOI:

10.1007/s10337-011-2071-x 出版年: AUG 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 7 摘要 : A reversed-phase liquid chromatography coupled to tandem mass spectrometry

(LC-MS-MS) method was developed and validated for the determination of fulvestrant in rat

plasma. Sample preparation involved a liquid-liquid extraction using 1.0 mL of

n-hexane-isopropanol (90:10, v/v) to extract the analyte from 0.1 mL of rat plasma. The analytes

were separated on a phenyl-based column using the mobile phase consisting of methanol/water

containing 5 mM ammonium acetate at the flow rate of 0.3 mL min(-1). The analytes were

monitored by tandem mass spectrometry under electrospray negative ionization mode. Linear

calibration curves were generated over the fulvestrant concentration ranges of 0.05-10.0 ng

mL(-1) in rat plasma. The accuracy and within-and between-day precisions were within the

generally accepted criteria for bioanalytical methods (<15%). This developed and validated assay

method was successfully employed to characterize the plasma concentration-time profile of

fulvestrant after its intramuscular administration in rats at a dose of 10 mg kg(-1). 入藏号: WOS:000294068100006 语种: English 文献类型: Article 作者关键词: LC-MS-MS; Fulvestrant; Pharmacokinetics

KeyWords Plus: BREAST-CANCER; ENDOCRINE THERAPY; WOMEN 地址: [Liu, Zhongyang; Gu, Guangzhi; Xia, Huimin; Pang, Zhiqing; Jiang, Xinguo; Chen, Jun]

Fudan Univ, Dept Pharmaceut, Sch Pharm, Shanghai 201203, Peoples R China

[Liu, Qiang] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350108, Peoples R China 通讯作者地址: Chen, J (通讯作者),Fudan Univ, Dept Pharmaceut, Sch Pharm, Shanghai 201203,

Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER HEIDELBERG 出版商地址: TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY


IDS 号: 809PB

ISSN: 0009-5893

29 字符的来源出版物名称缩写: CHROMATOGRAPHIA

ISO 来源出版物缩写: Chromatographia 来源出版物页码计数: 8 基金资助致谢: 基金资助机构授权号

National Key Basic Research Program of the People's Republic of China 2007CB935800

National Science and Technology Major Project 2009ZX09310-006

This work was partly financially supported by a project of the "National Key Basic Research

Program of the People's Republic of China" (no. 2007CB935800) and a project of the "National

Science and Technology Major Project" (no. 2009ZX09310-006).

第 35 条，共 86 条标题: Analysis of thrombin-antithrombin complex contents in plasma and hematoma fluid of

hypertensive intracerebral hemorrhage patients after clot removal 作者: Wu, CH (Wu, C. -H.); Yang, RL (Yang, R. -L.); Huang, SY (Huang, S. -Y.); Li, HZ (Li, H.

-Z.); Wang, KY (Wang, K. -Y.); Yang, DH (Yang, D. -H.); Yan, XH (Yan, X. -H.); Xue, XH (Xue,

X. -H.); Wu, SY (Wu, S. -Y.); Wang, JM (Wang, J. -M.); Lin, JS (Lin, J. -S.); Liao, LM (Liao, L.

-M.); Chen, LD (Chen, L. -D.) 来源出版物: EUROPEAN JOURNAL OF NEUROLOGY 卷: 18 期: 8 页: 1060-1066 DOI:

10.1111/j.1468-1331.2010.03336.x 出版年: AUG 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 21 摘要: Background and purpose: Animal experiments indicate that the cerebral thrombin is

associated with secondary brain damage after intracerebral hemorrhage (ICH). This study was

aimed to investigate the concentrations of thrombin-antithrombin complex (TAT) in hematoma

fluid and plasma of the patients with ICH after surgery and analyze the correlation between TAT

complex levels and severity of ICH.

Methods: Sixty patients with ICH were enrolled. Craniotomy for removal of intracranial blood

clot was performed within 24 h after ICH. Hematoma fluid and plasma were collected on

postoperative days 1, 2, and 4. The plasma obtained from healthy subjects and cerebrospinal fluid

from patients without cerebrovascular diseases served as controls, respectively. Enzyme-linked

immunosorbent assay was used to determine the concentrations of TAT complex in the patients

and controls.

Results: TAT complex concentrations in both postoperative plasma and hematoma fluid of patients

with ICH were significantly higher than those of the controls (P < 0.01). In patients with ICH,

hematoma fluid had a higher TAT complex level than plasma (P < 0.01). The preoperative

hemorrhage volume and postoperative TAT complex levels in plasma and hematoma fluid

correlated positively with National Institutes of Health stroke scale and negatively with Glasgow

coma score (P < 0.01).

Conclusion: This study indicates that TAT complex levels of plasma and hematoma fluid correlate

positively with the severity of ICH. Determination of the plasma TAT complex concentration is

helpful for the evaluation of the severity of post-ICH brain injury. 入藏号: WOS:000292699900014 语种: English 文献类型: Article 作者关键词: antithrombin III-protease complex; cerebral hematoma fluid; glasgow coma scale;

national institutes of health stroke scale; plasma

KeyWords Plus: EDEMA DEVELOPMENT; BRAIN EDEMA; STROKE; MODEL;

MECHANISMS 地址: [Wu, C. -H.; Yang, R. -L.; Xue, X. -H.; Wu, S. -Y.; Wang, J. -M.; Lin, J. -S.; Liao, L. -M.;

Chen, L. -D.] Fujian Univ Tradit Chinese Med, Affiliated Clin Coll 2, Dept Neurol, Fuzhou


[Huang, S. -Y.; Wang, K. -Y.; Yan, X. -H.] Fujian Prov Hosp, Dept Neurosurg, Fuzhou, Peoples R

China

[Li, H. -Z.; Yang, D. -H.] Fujian Univ Tradit Chinese Med, Affiliated Clin Coll 2, Dept Neurosurg,

Fuzhou 350003, Peoples R China 通讯作者地址: Wu, CH (通讯作者),Fujian Univ Tradit Chinese Med, Affiliated Clin Coll 2, Dept

Neurol, Fuzhou 350003, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA

Web of Science 分类: Clinical Neurology; Neurosciences 学科类别: Neurosciences & Neurology

IDS 号: 791WR

ISSN: 1351-5101

29 字符的来源出版物名称缩写: EUR J NEUROL

ISO 来源出版物缩写: Eur. J. Neurol. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构授权号

Fujian Provincial Department of Health WZY0622

Fujian Provincial Natural Science Fund 2006J0106

This work was supported by the Scientific Research Fund of Fujian Provincial Department of

Health (No. WZY0622) and Fujian Provincial Natural Science Fund (No. 2006J0106). We thank

Shanghai Institute of Immunology (China) for providing research equipment and Dr. Tom

Lonsdale (Australia), and Dr. Jie Liu for their assistance during the drafting of the manuscript.

第 36 条，共 86 条标题: Lipoprotein-associated phospholipase A2 gene V279F polymorphisms and coronary heart

disease: a meta-analysis 作者 : Zheng, GH (Zheng, Guo-Hua); Chen, HY (Chen, Hai-Ying); Xiong, SQ (Xiong,

Shang-Quan); Chu, JF (Chu, Jian-Feng) 来源出版物 : MOLECULAR BIOLOGY REPORTS 卷 : 38 期 : 6 页 : 4089-4099 DOI:

10.1007/s11033-010-0529-9 出版年: AUG 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 41 摘要: Lipoprotein-associated phospholipase A2 (LP-PLA2) may play an important role in the

pathophysiology of coronary heart disease (CHD). The polymorphism of LP-PLA2 gene caused

LP-PLA2 enzyme activity depressing or lost. But there is not a definite conclusion for the

association of between the LP-PLA2 gene polymorphism and CHD risk. To assess the relationship

between LP-PLA2 gene V279F polymorphism and CHD, a comprehensive Meta-analysis was

performed. All the case-control studies evaluating the association of between the LP-PLA2 gene

V279F polymorphism and CHD risk were identified. Seven case-control studies involving 3,614

patients with CHD and 4,334 controls were included. The crude odds ratios (ORs) of

meta-analysis under the different gene model were not significant. But in the stratified analysis by

study size, ethnicity, cases definition, and source of controls under the additive model, the

association was evident in ethnicity for Japanese group (OR = 1.38, 95%CI = 1.22-1.56), cases

definition for MI (OR = 1.22, 95%CI = 1.01-1.49), source of controls for the based-hospital (OR =

1.42, 95%CI = 1.24-1.59). These data suggested that the V279F polymorphism in LP-PLA2 gene

may contribute to CHD development. But there is necessary that more well-designed large studies

are required for the validation of this association. 入藏号: WOS:000291656800058 语种: English 文献类型: Article 作者关键词: Lipoprotein-associated phospholipase A2 (LP-PLA2); Coronary heart disease;

Genetic polymorphism; Meta-analysis

KeyWords Plus: ACTIVATING-FACTOR-ACETYLHYDROLASE; ARTERY-DISEASE;

RISK-FACTOR; CARDIOVASCULAR HEALTH; MYOCARDIAL-INFARCTION;

PAF-ACETYLHYDROLASE; LUDWIGSHAFEN RISK; MISSENSE MUTATION;

ATHEROSCLEROSIS; INFLAMMATION 地址: [Xiong, Shang-Quan] Peoples Hosp Fujian Prov, Fuzhou, Peoples R China

[Zheng, Guo-Hua] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China

通讯作者地址: Zheng, GH (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, Ctr

Evidence Based Med, 1 Huatuo Rd, Fuzhou, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS

Web of Science 分类: Biochemistry & Molecular Biology 学科类别: Biochemistry & Molecular Biology

IDS 号: 777WW

ISSN: 0301-4851

29 字符的来源出版物名称缩写: MOL BIOL REP

ISO 来源出版物缩写: Mol. Biol. Rep. 来源出版物页码计数: 11 基金资助致谢: 基金资助机构授权号

natural science foundation of Fujian province 2009J01163

foundation of Chen Ke-Ji Academician CKJ2009002

Funding was provided by the natural science foundation of Fujian province (no. 2009J01163.

Fujian Provincial department of Science & Technology, Fujian, China) and the foundation of Chen

Ke-Ji Academician (no. CKJ2009002. Academy of Integrative Medicine, Fujian, China).

第 37 条，共 86 条标题 : Inhibition of tumor angiogenesis by Scutellaria barbata D. Don via suppressing

proliferation, migration and tube formation of endothelial cells and downregulation of the

expression of VEGF-A in cancer cells 作者: Wei, LH (Wei, Lihui); Lin, JM (Lin, Jiumao); Xu, W (Xu, Wei); Hong, ZF (Hong,

Zhenfeng); Liu, XX (Liu, Xianxiang); Peng, J (Peng, Jun) 来源出版物 : JOURNAL OF MEDICINAL PLANTS RESEARCH 卷 : 5 期 : 14 页 :

3260-3268 出版年: JUL 18 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 30 摘要: Scutellaria barbata D. Don is a medicinal herb that has long been clinically used in China to

treat various types of cancer. Extracts of S. barbata D. Don have been shown to inhibit the growth

of many cancer cells. Previously, we reported that S. barbata D. Don promotes cancer cell

apoptosis via activation of the mitochondrion-dependent pathway. To further elucidate the precise

mechanism of its tumorcidal activity, we investigated the effects of ethanol extract of S. barbata D.

Don (EESB) on tumor angiogenesis. We found that EESB inhibited angiogenesis in vivo in chick

embryo chorioallantoic membrane (CAM). In addition, we observed that EESB dose and

time-dependently inhibited the proliferation of human umbilical vein endothelial cells (HUVEC)

via blocking the cell cycle G1 to S progression. Moreover, EESB inhibited the migration and tube

formation of HUVECs. Furthermore, EESB treatment down-regulated the mRNA and protein

expression levels of VEGF-A in both HT-29 human colon carcinoma cells and HUVECs. Our

findings suggest that inhibiting tumor angiogenesis is one of the mechanisms by which S. barbata

D. Don treats cancer. 入藏号: WOS:000299749400045 语种: English 文献类型: Article 作者关键词: Tumor angiogenesis; traditional Chinese medicine; multi-target agents; Scutellaria

barbata D. Don

KeyWords Plus: GROWTH-FACTOR EXPRESSION; THERAPEUTIC IMPLICATIONS;

NATURAL-PRODUCTS; CARCINOMA; PATHWAY; METASTASIS; MECHANISMS;

APOPTOSIS 地址: [Wei, Lihui; Lin, Jiumao; Hong, Zhenfeng; Peng, Jun] Fujian Univ Tradit Chinese Med,

Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China


China

[Liu, Xianxiang] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med Geriatr, Fuzhou

350108, Fujian, Peoples R China 通讯作者地址: Peng, J (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, 1



IDS 号: 885AG

ISSN: 1996-0875







This work was sponsored by the Developmental Fund of Chen Keji Integrative Medicine (CKJ

2010019), the National Natural Science Foundation of China (81073097), the Natural Science

Foundation of Fujian Province of China (2010J01195), and the Research Foundation of Education

Bureau of Fujian Province of China (JA10162).

第 38 条，共 86 条标题: Oleanolic acid inhibits hypertrophic scarring in the rabbit ear model 作者: Wei, YJ (Wei, Y. -J.); Yan, XQ (Yan, X. -Q.); Ma, L (Ma, L.); Wu, JG (Wu, J. -G.); Zhang, H

(Zhang, H.); Qin, LP (Qin, L. -P.) 来源出版物 : CLINICAL AND EXPERIMENTAL DERMATOLOGY 卷 : 36 期 : 5 页 :

528-533 DOI: 10.1111/j.1365-2230.2010.04012.x 出版年: JUL 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 16 摘要: Background. Hypertrophic scarring, a common proliferative disorder of dermal fibroblasts,

results from an overproduction of collagen and excessive deposition of extracellular matrix.

Although treatment with surgical excision or steroid hormones can modify the symptoms,

numerous treatment-related complications have been described.

Aim. To investigate the effects of oleanolic acid (OA). a naturally occurring triterpenoid, on

hypertrophic scarring in a rabbit ear model.

Methods. A rabbit ear model of hypertrophic scarring was used, with wounds produced with a

biopsy punch. Oleanolic acid (2.5%, 5% and 10%) was applied once daily to the scars for 22 days.

On postoperative day 28, the scars were excised, and the tissue used for histological examination

and assays of the levels of collagens I and III matrix metalloproteinase (MMP)-1 and transforming

growth factor (TGF)-beta(1). The scar elevation index (SEI) was also determined.

Results. Treatment with different concentrations of oleanolic acid (OA) for 22 days significantly

inhibited hypertrophic scarring in rabbit ear tissue. Levels of TGF-beta(1). collagen I and collagen

III were significantly decreased and levels of MMP-1 significantly increased in the scar tissue.

SEI was also significantly reduced. Histological findings showed significant amelioration of the

scar tissue.

Conclusions. OA suppresses hypertrophic scarring in the rabbit ear model and may be an effective

cure for human hypertrophic scarring. 入藏号: WOS:000292659600016 语种: English 文献类型: Article

KeyWords Plus: POLYGONUM-CUSPIDATUM; EXPRESSION; POLYDATIN; SCARS; LIFE 地址: [Wei, Y. -J.; Wu, J. -G.; Zhang, H.; Qin, L. -P.] Mil Med Coll 2, Sch Pharm, Dept

Pharmacognosy, Shanghai, Peoples R China

[Wei, Y. -J.] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou, Peoples R China

[Yan, X. -Q.] Mil Med Coll 2, Changhai Hosp, Dept Anaesthesiol, Shanghai, Peoples R China

[Ma, L.] Capital Med Univ, Sch Tradit Chinese Med, Beijing, Peoples R China

通讯作者地址: Zhang, H (通讯作者),325 Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA

Web of Science 分类: Dermatology 学科类别: Dermatology

IDS 号: 791IT

ISSN: 0307-6938

29 字符的来源出版物名称缩写: CLIN EXP DERMATOL

ISO 来源出版物缩写: Clin. Exp. Dermatol. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构授权号

Shanghai Committee of Science and Technology 08JC1405700

This work was supported by a grant from the Key Programs for Basic Research of Shanghai

Committee of Science and Technology (Grant no. 08JC1405700).

第 39 条，共 86 条标题: BMP2 promotes chondrocyte proliferation via the Wnt/beta-catenin signaling pathway 作者: Li, XH (Li, Xihai); Peng, J (Peng, Jun); Wu, MX (Wu, Mingxia); Ye, HZ (Ye, Hongzhi);

Zheng, CS (Zheng, Chunsong); Wu, GW (Wu, Guangwen); Xu, HF (Xu, Huifeng); Chen, XZ

(Chen, Xuzheng); Liu, XX (Liu, Xianxiang) 来源出版物 : MOLECULAR MEDICINE REPORTS 卷 : 4 期 : 4 页 : 621-626 DOI:

10.3892/mmr.2011.474 出版年: JUL-AUG 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 23 摘要: Bone morphogenetic protein 2 (BMP2), a member of the transforming growth factor-beta

(TGF-beta) superfamily, plays a key role in the induction of the differentiation of mesenchymal

cells into chondrocytes to form cartilage tissue. However, it is not clear whether BMP2 regulates

the proliferation of chondrocytes. In the present study, the effect of BMP2 on the proliferation of

chondrocytes and its underlying mechanism was investigated. Chondrocytes isolated from the

knee of SD rats were cultured and identified using toluidine blue staining. The second generation

chondrocytes were collected and stimulated with or without BMP2 for 48 h. Cell viability was

analyzed using the MTT assay. mRNA and protein expression levels of beta-catenin, GSK-3 beta,

Dvl1 and Cyclin D1 were detected using real-time RT-PCR and Western blotting, respectively.

The cell cycle distribution of the chondrocytes was analyzed by flow cytometry. BMP2

stimulation was found to significantly increase cell viability. In addition, following BMP2

treatment, beta-catenin, Cyclin D1 and Dvl1 expression was significantly increased, whereas

GSK-3 beta expression was significantly decreased. Moreover, the percentage proportion of

chondrocytes in the G0/G1 phase was significantly decreased, whereas that in the S phase was

significantly increased. The results indicate that BMP2 promotes chondrocyte proliferation via the

Wnt/beta-catenin signaling pathway. 入藏号: WOS:000291525900007 语种: English 文献类型: Article 作者关键词: bone morphogenetic protein 2; chondrocyte; cell cycle; osteoarthritis

KeyWords Plus: ARTICULAR CHONDROCYTES; OSTEOARTHRITIS; EXPRESSION;

CARTILAGE; DIFFERENTIATION; DEGENERATION; CULTURES; MATRIX 地址: [Li, Xihai; Peng, Jun; Wu, Mingxia; Ye, Hongzhi; Zheng, Chunsong; Wu, Guangwen; Liu,

Xianxiang] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Peoples R

China

[Xu, Huifeng; Chen, Xuzheng] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med

Geriatr, Fuzhou 350108, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, 1

Huatuo, Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE


IDS 号: 776HU

ISSN: 1791-2997



Keji Chen Development Foundation for Integrated Traditional and Western

Medicine CKJ2008003

2008 Fujian Province Small Creations and Projects

This study was supported by a grant from the Keji Chen Development Foundation for Integrated

Traditional and Western Medicine (no. CKJ2008003) and the 2008 Fujian Province Small

Creations and Projects (no. 1).

第 40 条，共 86 条

标题: Effects and mechanisms of actions of Chinese herbal medicines for asthma 作者: Hong, ML (Hong Min-li); Song, Y (Song Ying); Li, XM (Li Xiu-min) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 7 页 :

483-491 DOI: 10.1007/s11655-011-0780-5 出版年: JUL 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 41 摘要: Asthma is a chronic inflammatory disorder of airways that affects approximately 300

million adults and children worldwide. Most therapy currently uses bronchodilators and

corticosteroids. Systemic side effects from chronic use of these drugs are concern. Chinese

medicine (CM) has a long history of human use in China and other Asian countries and well

received by the patients. But as one component of Western integrative medicine (WIM), it is

required that CM use is supported by scientific evidence. On the other hand, there are also

suggestions that Western standardized medicine should consider personalized practice. In recent

years there have been an increasing studies to narrow the gap between CM, the personalized

medicine and Western medicine, evidence based medicine. This communication reviews several

CM studies published in the English language in details by reviewing the effects and mechanisms

of actions on asthma from clinic and experimental studies.

Chinese herbal medicines exhibit broad actions on multiple asthma pathologic mechanisms. These

mechanisms may involve antiinflammatory and immunomodulatory effects, inhibiting airway

remodeling and normalization of hypothalamus, pituitary and adrenal (HPA)-axis disturbances.

However, the mechanisms of actions of Chinese herbal medicines for asthma are not fully

understood. More controlled clinical studies are warranted and some anti-asthma CM may be

proved to be effective when used as monotherapy or complementary asthma therapies. 入藏号: WOS:000292305400001 语种: English 文献类型: Article 作者关键词: asthma; complementary and alternative medicine; Chinese medicine; Chinese herbal

medicine; mechanism of action

KeyWords Plus: KAPPA-B PATHWAY; ALLERGIC-ASTHMA; AIRWAY INFLAMMATION;

INHALED CORTICOSTEROIDS; INTERFERON-GAMMA; IN-VITRO; INHIBITION;

MODEL; INTERVENTION; CHILDREN 地址: [Hong Min-li; Song Ying; Li Xiu-min] Mt Sinai Sch Med, Ctr Chinese Med Allergy &

Asthma, Jaffe Food Allergy Inst, Pediat Dept,Div Allergy & Immunol, New York, NY 10029 USA

[Hong Min-li] Fujian Univ Tradit Chinese Med, Resp Dept, Zhangzhou Tradit Chinese Med Hosp,

Affiliated Hosp, Zhangzhou 363000, Peoples R China 通讯作者地址: Li, XM (通讯作者),Mt Sinai Sch Med, Ctr Chinese Med Allergy & Asthma, Jaffe

Food Allergy Inst, Pediat Dept,Div Allergy & Immunol, New York, NY 10029 USA 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA


IDS 号: 786KA

ISSN: 1672-0415



NIH/NCCAM center P01 AT002647-01 01

This work was partially supported by NIH/NCCAM center grants # P01 AT002647-01 01 "Center

for Chinese Herbal Therapy (CHT) for Asthma" to Dr. LI Xiu-min. We thank Drs. Hugh Sampson,

Ming Chun Wen, Kayer Kattan, Juan Wisnivesky, Tengfei Zhang, Kamal Srivastava, Sangita Patil,

Nan Yan, Joseph Goldfarb, Sylvan Wallenstein and Brian Schofield for their critical contribution to

ASHMI studies.

第 41 条，共 86 条标题: Mesenchymal-stem-cell-based experimental and clinical trials: current status and open

questions 作者: Wang, J (Wang, Jin); Liao, LM (Liao, Lianming); Tan, JM (Tan, Jianming) 来源出版物 : EXPERT OPINION ON BIOLOGICAL THERAPY 卷 : 11 期 : 7 页 :

893-909 DOI: 10.1517/14712598.2011.574119 出版年: JUL 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 174 摘要: Introduction: Mesenchymal stem cells (MSCs) possess remarkable self-renewal ability and

are able to differentiate into various cell lineages. MSCs can also enhance tissue repair and

angiogenesis through a paracrine mechanism. It has been recognized that these cells hold great

promise for tissue regeneration and treatment of immune-related diseases.

Areas covered: This review aims at discussing the mechanisms of MSC-mediated

immunomodulation and tissue repair and the related clinical trials, with special emphasis on

factors that influence the efficiency of MSC-based therapy, including the source of MSCs, cell

passage, cell dose, timing and route of administration.

Expert opinion: MSCs may facilitate tissue repair through cell replacement and/or improving the

microenvironment by releasing growth factors. Some of these factors also mediate the

immunomodulatory effects of MSCs. It is important to establish global guidelines, protocols and

standards for production and clinical trials of MSCs, so that MSCs can become a therapeutic agent

with a reliable efficacy and good safety. 入藏号: WOS:000291223100006

语种: English 文献类型: Review 作者关键词: cell differentiation; cell therapy; clinical trial; mesenchymal stem cells

KeyWords Plus: MARROW STROMAL CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS;

ACUTE MYOCARDIAL-INFARCTION; HUMAN ADIPOSE-TISSUE;

VERSUS-HOST-DISEASE; ACUTE-RENAL-FAILURE; REGULATORY T-CELLS; HUMAN

UMBILICAL-CORD; IMMUNOSUPPRESSIVE DRUG-INTERACTIONS;

ARTICULAR-CARTILAGE DEFECTS 地址: [Wang, Jin; Tan, Jianming] Xiamen Univ, Fuzhou Gen Hosp, Organ Transplant Inst,

Fuzhou, Peoples R China

[Liao, Lianming] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Peoples R

China 通讯作者地址: Tan, JM (通讯作者),Xiamen Univ, Fuzhou Gen Hosp, Organ Transplant Inst,

Fuzhou, Peoples R China 电子邮件地址: [email protected] 出版商: INFORMA HEALTHCARE 出版商地址: TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND

Web of Science 分类 : Biotechnology & Applied Microbiology; Medicine, Research &

Experimental 学科类别: Biotechnology & Applied Microbiology; Research & Experimental Medicine

IDS 号: 772GU

ISSN: 1471-2598

29 字符的来源出版物名称缩写: EXPERT OPIN BIOL TH

ISO 来源出版物缩写: Expert Opin. Biol. Ther. 来源出版物页码计数: 17 基金资助致谢: 基金资助机构授权号

Natural Science Foundation of Fujian Province 2009Y4001

2008J1006

Fujian Provincial Natural Science Fund 2006J0106


This study was supported by the Major Program of Natural Science Foundation of Fujian Province

(2009Y4001 and 2008J1006), the Fujian Provincial Natural Science Fund (No. 2006J0106) and

the Developmental Fund of Chen Keji Integrative Medicine (No:CKJ2010021).

第 42 条，共 86 条标题: Mechanisms of inhibition of elemene on human lens epithelial cell proliferation in vitro

作者: Hu, YH (Hu, Yan-Hong); Huang, XR (Huang, Xiu-Rong); Qi, MX (Qi, Ming-Xin); Hou,

BY (Hou, Bu-Yuan) 来源出版物 : INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 卷 : 4 期 : 3 页 :

255-258 DOI: 10.3980/j.issn.2222-3959.2011.03.08 出版年: JUN 18 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 13 摘要: AIM: To study the effects of elemene (Ele) on proliferation and cell cycle of human lens

epithelial cells 63 (HLE-B3) and the mechanisms of its signal transduction.

METHODS: Recombinant human basic fibroblast growth factor (rhbFGF) was used to induce

proliferation of HLE-B3 cells, which were incubated with 80mg/L Ele for 24 hours. The inhibitory

effects of Ele on the proliferation of HLE-B3 cells were evaluated by MU method. The effect of

Ele on HLE-B3 cell cycle was analyzed by flow cytometry (FCM). The expressions of protein

kinase A (PKA) and protein kinase G (PKG) of HLE-B3 were also analyzed by FCM.

RESULTS: Ele altered the cell cycle of HLE-B3 and effectively inhibited HLE-B3 cell

proliferation induced by rhbFGF. Ele up-regulated PKA and down-regulated the expression of

PKG in HLE-B3 cell.

CONCLUSION: Ele inhibits HLE-B3 proliferation, making it an attractive potential agent in

regimens to treat after-cataracts. 入藏号: WOS:000291921300008 语种: English 文献类型: Article 作者关键词: lens epithelial cell; cell culture; after-cataract; elemene

KeyWords Plus: BETA-ELEMENE; APOPTOSIS 地址: [Huang, Xiu-Rong; Hou, Bu-Yuan] Fujian Coll Tradit Chinese Med, Res Ctr Pathophysiol,

Fuzhou 350003, Fujian Province, Peoples R China

[Hu, Yan-Hong; Qi, Ming-Xin] Fujian Coll Tradit Chinese Med, Affiliated Peoples Hosp 2, Dept

Ophthalmol, Fuzhou 350003, Fujian Province, Peoples R China 通讯作者地址: Huang, XR (通讯作者),Fujian Coll Tradit Chinese Med, Res Ctr Pathophysiol,

Fuzhou 350003, Fujian Province, Peoples R China 电子邮件地址: [email protected] 出版商: IJO PRESS 出版商地址: NO 269 YOUYI EAST RD, XI AN, 710054, PEOPLES R CHINA

Web of Science 分类: Ophthalmology 学科类别: Ophthalmology

IDS 号: 781HK

ISSN: 1672-5123

29 字符的来源出版物名称缩写: INT J OPHTHALMOL-CHI

ISO 来源出版物缩写: Int. J. Ophthalmol. 来源出版物页码计数: 4

基金资助致谢: 基金资助机构授权号

Youth Foundation of Fujian Scientific Committee, China 2008F3050

Youth Foundation of Fujian Scientific Committee, China (No.2008F3050)

第 43 条，共 86 条标题: Experimental Study on the Suppression of Sodium Nitroprussiate-Induced Chondrocyte

Apoptosis by Tougu Xiaotong Capsule ((sic))-Containing Serum 作者: Li, XH (Li Xi-hai); Wu, MX (Wu Ming-xia); Ye, HZ (Ye Hong-zhi); Chen, WL (Chen

Wen-lie); Lin, JM (Lin Jiu-mao); Zheng, LP (Zheng Liang-pu); Liu, XX (Liu Xian-xiang) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 6 页 :

436-443 DOI: 10.1007/s11655-0751-x 出版年: JUN 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 1 引用的参考文献数: 22 摘要: Objective: To study the mechanism of action of Tougu Xiaotong Capsule ((sic), TGXTC) ex

vivo in suppressing chondrocyte (CD) apoptosis induced by sodium nitroprussiate (SNP).

Methods: Thirty New Zealand rabbits, 2 months old, were randomized by lottery into five groups,

six in each: the blank group treated with saline, the positive control group treated with Zhuanggu

Guanjie Pill ((sic) 70 mg/kg), and the three experimental groups, EGA, EGB, and EGC, treated

with low dose (35 mg/kg), moderate dose (70 mg/kg), and high dose (140 mg/kg) of TGXTC,

respectively. All treatments were administered via gastrogavage twice a day for 3 days. Arterial

blood was collected from the abdominal aorta and drug or drug metabolites-containing serum was

prepared. CDs obtained from knee joints of 16 four-week-old New Zealand rabbits were cultured

to the third passage and confirmed by toluidine blue staining. SNP of various final concentrations

(0, 0.5, 1.0, and 2.0 mmol/L) was used to induce CD apoptosis, and the dosage-effect relationship

of SNP in inducing CD apoptosis was determined. Serum samples from the blank, control, and

three dosages of TGXTC-treated rabbits were tested in the CD culture in the presence of SNP. Cell

apoptosis was determined by Hoechst 33342 staining, viability of CDs was quantified by MTT,

CD apoptosis rate was determined by annexin V-FITC/PI staining, levels of p53 and Bcl-2 mRNA

expression in CDs were determined with RT-PCR, and contents of caspase-3 and caspase-9

proteins were determined by colorimetry. Results: CD apoptosis was induced by SNP at all

concentrations tested and in a dose-dependent manner. The SNP concentration of 1 mmol/L and

treatment duration of 24 h appeared to be optimal and were selected for the study. Serum samples

from the positive control rabbits and from the two higher doses of TGXTC-treated rabbits showed

reduction of SNP-induced CD apoptosis, decrease in p53 mRNA expression, inhibition of catalytic

activities of caspase-3 and caspase-9, and increase in Bcl-2 mRNA expression when compared

with the serum from the blank group (P<0.05). Conclusion: TGXTC-containing sera antagonized

SNP-induced CD apoptosis and the molecular basis for the action was associated with

up-regulation of Bcl-2, down-regulation of p53 expression, and inhibition of caspase-3 and

caspase-9 catalytic activities. 入藏号: WOS:000291406000006 语种: English 文献类型: Article 作者关键词: osteoarthritis; drug-containing serum; chondrocyte; cell apoptosis; Tougu Xiaotong

Capsule

KeyWords Plus: COMPUTATIONAL PHARMACOLOGY; OSTEOARTHRITIS; GRANULE 地址: [Li Xi-hai; Wu Ming-xia; Ye Hong-zhi; Liu Xian-xiang] Fujian Univ Tradit Chinese Med,

Acad Integrat Med, Fuzhou 350108, Peoples R China

[Chen Wen-lie; Lin Jiu-mao; Zheng Liang-pu] Fujian Prov Key Lab Integrat Med Study Senile

Dis, Fuzhou 350108, Peoples R China 通讯作者地址: Wu, MX (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med,



IDS 号: 774SG

ISSN: 1672-0415




Major Project Foundation of Fujian Provincial Administration of Science and

Technology 2009Y0029

Developmental Fund of CHEN Keji Integrative Medicine CKJ2010013

Supported by the National Natural Science Foundation of China (No. 81072826), Major Project

Foundation of Fujian Provincial Administration of Science and Technology (No. 2009Y0029), and

the Developmental Fund of CHEN Keji Integrative Medicine (No. CKJ2010013)

第 44 条，共 86 条标题: (S)-Benzyl 3-(4-hydroxyphenyl)-2-(tritylamino)propanoate 作者: Chen, MM (Chen, Meimei); Lai, XM (Lai, Xinmei); Zhou, CG (Zhou, Changen); Yang, XM

(Yang, Xuemei)

来源出版物 : ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS

ONLINE 卷: 67 页: O1412-U678 DOI: 10.1107/S1600536811017351 子辑: Part 6 出版年:

JUN 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 5 摘要 : The title compound, C(35)H(31)NO(3), was obtained by the reaction of (S)-benzyl

2-amino-3-(4-hydroxyphenyl)propanoate and (chloromethanetriyl)tribenzene. The enantiomer has

been assigned by reference to an unchanging chiral centre in the synthetic procedure. In the

crystal, molecules are linked into chains running along the a axis by intermolecular O-H...O

hydrogen bonds. 入藏号: WOS:000291216100056 语种: English 文献类型: Article 地址: [Chen, Meimei; Lai, Xinmei; Zhou, Changen; Yang, Xuemei] Fujian Univ Tradit Chinese

Med, Coll Tradit Chinese Med, Fujian 350108, Peoples R China 通讯作者地址: Yang, XM (通讯作者),Fujian Univ Tradit Chinese Med, Coll Tradit Chinese Med,

Fujian 350108, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA

Web of Science 分类: Crystallography 学科类别: Crystallography

IDS 号: 772EL

ISSN: 1600-5368

29 字符的来源出版物名称缩写: ACTA CRYSTALLOGR E

ISO 来源出版物缩写: Acta Crystallogr. Sect. E.-Struct Rep. Online 来源出版物页码计数: 11 基金资助致谢: 基金资助机构授权号

Fujian Provincial Department of Education JA09130

Fujian Provincial Health Department wzzsj0901

We gratefully acknowledge financial support by the Fujian Provincial Department of Education

project (JA09130) and the Fujian Provincial Health Department Special Project (wzzsj0901).

第 45 条，共 86 条标题: Antifatigue Activity of the Liposoluble Fraction from Acanthopanax senticosus

作者: Huang, LZ (Huang, Lin-Zhang); Huang, BK (Huang, Bao-Kang); Liang, J (Liang, Jie);

Zheng, CJ (Zheng, Cheng-Jian); Han, T (Han, Ting); Zhang, QY (Zhang, Qiao-Yan); Qin, LP

(Qin, Lu-Ping) 来源出版物 : PHYTOTHERAPY RESEARCH 卷 : 25 期 : 6 页 : 940-943 DOI:

10.1002/ptr.3346 出版年: JUN 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 10 摘要: The crude extract of Acanthopanax senticosus (AS) has been used extensively in Russia,

China, Korea and Japan as an adaptogenic agent to fight against stress and fatigue. However,

whether the liposoluble fraction possesses antifatigue activity or not is still unclear. A liposoluble

fraction was administered orally to mice for 9 days. The swimming time to exhaustion was longer

in the treatment groups (22.2 +/- 3.3, 25.5 +/- 4.8 min) than in the control group (13.7 +/- 1.2 min,

p < 0.05). The plasma TG (triglyceride) and BUN (blood urea nitrogen) levels in the high dose

(500 mg/kg) groups were decreased significantly compared with the control group. Plasma lactate

dehydrogenase (LDH) was lower in the treatment groups than in the control group. Chemical

analysis from GC/MS revealed that the main components of the liposoluble fraction of AS were

saturated fatty acid (12.98%), unsaturated fatty acid (33.13%), unsaturated alcohol (27.46%) and

diolefine (15.76%). In conclusion, the liposoluble fraction enhanced the forced swimming

capacity of mice by decreasing muscle damage, effectively preventing the increase in BUN

concentration and increasing fat utilization. It is proposed that the antioxidant effect may be one of

the antifatigue mechanisms of the liposoluble fraction of AS. Copyright (C) 2010 John Wiley &

Sons, Ltd. 入藏号: WOS:000291060700025 语种: English 文献类型: Article 作者关键词: swimming time; exhaustion; TG; BUN; LDH; GC/MS; antioxidant

KeyWords Plus: ELEUTHEROCOCCUS-SENTICOSUS; EXERCISE; MICE 地址: [Huang, Lin-Zhang; Huang, Bao-Kang; Liang, Jie; Zheng, Cheng-Jian; Han, Ting; Zhang,

Qiao-Yan; Qin, Lu-Ping] Mil Med Coll 2, Dept Pharmacognosy, Sch Pharm, Shanghai 200433,

Peoples R China

[Huang, Lin-Zhang; Liang, Jie] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108,

Peoples R China 通讯作者地址: Qin, LP (通讯作者),Mil Med Coll 2, Dept Pharmacognosy, Sch Pharm, 325

Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA

Web of Science 分类: Chemistry, Medicinal; Pharmacology & Pharmacy 学科类别: Pharmacology & Pharmacy

IDS 号: 770AZ

ISSN: 0951-418X

29 字符的来源出版物名称缩写: PHYTOTHER RES

ISO 来源出版物缩写: Phytother. Res. 来源出版物页码计数: 4

第 46 条，共 86 条标题: Chemical constituents from Salacia amplifolia 作者: Wang, Y (Wang, Yan); Chen, WS (Chen, Wan-Sheng); Wu, ZJ (Wu, Zhi-Jun); Xi, ZX (Xi,

Zhong-Xin); Chen, W (Chen, Wei); Zhao, GJ (Zhao, Gui-Jun); Li, X (Li, Xia); Sun, LN (Sun,

Lian-Na) 来源出版物 : BIOCHEMICAL SYSTEMATICS AND ECOLOGY 卷 : 39 期 : 3 页 :

205-208 DOI: 10.1016/j.bse.2011.03.001 出版年: JUN 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 34 摘要: The present phytochemical investigation on Salacia amplifolia led to the isolations of 13

triterpenes, including quinonemethides, friedelanes, oleananes and ursanes triterpenes, three

simple phenolics, one polyol and one chromanone. All of them were isolated from this plant for

the first time. The presences of quinonemethide triterpenoids might be employed as the common

characteristic constituents of both Hippocrateaceae and Celastraceae families. (C) 2011 Elsevier

Ltd. All rights reserved. 入藏号: WOS:000291902900007 语种: English 文献类型: Article 作者关键词: Salacia amplifolia; Triterpenes; Hippocrateaceae; Quinonemethides

KeyWords Plus: TRITERPENOID CONSTITUENTS; TRIPTERYGIUM-WILFORDII;

ASSIGNMENTS; TERPENOIDS; INHIBITORS 地址: [Wang, Yan; Xi, Zhong-Xin; Chen, Wei; Sun, Lian-Na] Mil Med Coll 2, Sch Pharm, Dept

Pharmacognosy, Shanghai 200433, Peoples R China

[Chen, Wan-Sheng; Wu, Zhi-Jun; Zhao, Gui-Jun; Li, Xia] Mil Med Coll 2, Shanghai Changzheng

Hosp, Dept Pharm, Shanghai 200003, Peoples R China

[Wang, Yan; Xi, Zhong-Xin] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108,

Fujian, Peoples R China 通讯作者地址: Sun, LN (通讯作者),Mil Med Coll 2, Sch Pharm, Dept Pharmacognosy, 325

Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected] 出版商: PERGAMON-ELSEVIER SCIENCE LTD 出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,

ENGLAND

Web of Science 分类: Biochemistry & Molecular Biology; Ecology; Evolutionary Biology

学科类别: Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary

Biology

IDS 号: 781AL

ISSN: 0305-1978

29 字符的来源出版物名称缩写: BIOCHEM SYST ECOL

ISO 来源出版物缩写: Biochem. Syst. Ecol. 来源出版物页码计数: 4 基金资助致谢: 基金资助机构授权号

Shanghai Science and Technology Commission 08DZ1971503

This work was supported by the Program of Shanghai Science and Technology Commission

(08DZ1971503).

第 47 条，共 86 条标题: Scutellaria barbata D. Don induces apoptosis of human colon carcinoma cell through

activation of the mitochondrion-dependent pathway 作者: Wei, LH (Wei, Lihui); Chen, YQ (Chen, Youqin); Lin, JM (Lin, Jiumao); Zhao, JY (Zhao,

Jinyan); Chen, XZ (Chen, Xuzheng); Xu, W (Xu, Wei); Liu, XX (Liu, Xianxiang); Sferra, TJ

(Sferra, Thomas J.); Peng, J (Peng, Jun) 来源出版物 : JOURNAL OF MEDICINAL PLANTS RESEARCH 卷 : 5 期 : 10 页 :

1962-1970 出版年: MAY 18 2011 在 Web of Science 中的被引频次: 3 被引频次合计: 3 引用的参考文献数: 30 摘要: Scutellaria barbata D. Don has long been used in China for the clinical treatment of various

cancers including colorectal cancer. However, the precise mechanisms of its tumorcidal activity

remain unclear. In the present study, we investigated the cellular effects of the ethanol extract of S.

barbata D. Don (EESB) in the HT-29 human colon carcinoma cell line. We found that EESB

inhibited the growth of HT-29 cells as demonstrated EESB-induced cell morphological changes

and reduced cell viability in dose-and time-dependent manners. Furthermore, we observed that

EESB treatment resulted in DNA fragmentation, loss of plasma membrane asymmetry, collapse of

mitochondrial membrane potential, activation of caspase-9 and caspase-3, and increase of the ratio

of pro-apoptotic Bax to anti-apoptotic Bcl-2. These results suggest that promotion of cancer cell

apoptosis through activation of the mitochondrion-dependent pathway is one of the mechanisms

by which S. barbata D. Don can be effective in the treatment of cancer. 入藏号: WOS:000297456800019 语种: English 文献类型: Article

作者关键词: Scutellaria barbata D. Don; apoptosis; colorectal cancer; HT-29 cells; herbal

medicine; mitochondria

KeyWords Plus: CHANNEL-FORMING ACTIVITY; CYTOCHROME-C;

COLORECTAL-CANCER; DRUG-RESISTANCE; LEUKEMIA-CELLS; BCL-2; BAX;

RELEASE; FAMILY; CHEMOPREVENTION 地址: [Wei, Lihui; Lin, Jiumao; Zhao, Jinyan; Chen, Xuzheng; Liu, Xianxiang; Peng, Jun] Fujian

Univ Tradit Chinese Med, Fujian Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China

[Chen, Youqin; Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK

73190 USA


China


Oklahoma City, OK 73190 USA 通讯作者地址: Peng, J (通讯作者),Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med, 1



IDS 号: 853WQ

ISSN: 1996-0875






Fujian Key Laboratory of Integrative Medicine on Geriatrics 2008J1004

This work was sponsored by the National Natural Science Foundation of China (81073097), the

Natural Science Foundation of Fujian Province of China (2010J01195), the Developmental Fund

of Chen Keji Integrative Medicine (CKJ 2010019), and the Open Fund of Fujian Key Laboratory

of Integrative Medicine on Geriatrics (2008J1004).

第 48 条，共 86 条

标题: The effect of Eleutheroside E on behavioral alterations in murine sleep deprivation stress

model 作者: Huang, LZ (Huang, Lin-Zhang); Wei, L (Wei, Lei); Zhao, HF (Zhao, Hong-Fang); Huang,

BK (Huang, Bao-Kang); Rahman, K (Rahman, Khalid); Qin, LP (Qin, Lu-Ping) 来源出版物 : EUROPEAN JOURNAL OF PHARMACOLOGY 卷 : 658 期 : 2-3 页 :

150-155 DOI: 10.1016/j.ejphar.2011.02.036 出版年: MAY 11 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 1 摘要: Eleutheroside E (EE), a principal component of Eleutherococcus senticosus, has been

reported to have anti-inflammatory and protective effects in ischemia heart etc. However, whether

it can mitigate behavioral alterations induced by sleep deprivation, has not yet been elucidated.

Numerous studies have demonstrated that memory deficits induced by sleep deprivation in

experimental animals can be used as a model of behavioral alterations. The present study

investigated the effect of EE, on cognitive performances and biochemical parameters of

sleep-deprived mice. Animals were repeatedly treated with saline, 10 or 50 mg/kg EE and

sleep-deprived for 72 h by the multiple platform method. Briefly, groups of 5-6 mice were placed

in water tanks (45 x 34 x 17 cm), containing 12 platforms (3 cm in diameter) each, surrounded by

water up to 1 cm beneath the surface or kept in their home cage. After sleep deprivation, mice

showed significant behavioral impairment as evident by reduced latency entering into a dark

chamber, locomotion and correctly rate in Y maze, and increased monoamines in hippocampus.

However, repeated treatment with EE restored these behavioral and biochemical alterations in

mice. In conclusion, the beneficial effect of EE may provide an effective and powerful strategy to

alleviate behavioral alterations induced by sleep deprivation. (C) 2011 Elsevier B.V. All rights

reserved. 入藏号: WOS:000290010500014 语种: English 文献类型: Article 作者关键词: Eleutheroside E; Behavioral alteration; Locomotor; Passive avoidance; Y maze 地址: [Huang, Lin-Zhang; Zhao, Hong-Fang; Huang, Bao-Kang; Qin, Lu-Ping] Mil Med Coll 2,

Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China

[Huang, Lin-Zhang; Zhao, Hong-Fang] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou


[Wei, Lei] Mil Med Coll 2, Changhai Hosp, Dept Internal Med, Div Field Med, Shanghai 200433,

Peoples R China

[Rahman, Khalid] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Liverpool L3 3AF,

Merseyside, England 通讯作者地址: Qin, LP (通讯作者),Mil Med Coll 2, Sch Pharm, Dept Pharmacognosy, 325

Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected] 出版商: ELSEVIER SCIENCE BV

出版商地址: PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS


IDS 号: 756KQ

ISSN: 0014-2999

29 字符的来源出版物名称缩写: EUR J PHARMACOL

ISO 来源出版物缩写: Eur. J. Pharmacol. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构授权号

military medical and health research fund project 08Z022

This work was supported by a special grant from the military medical and health research fund

project (No. 08Z022).

第 49 条，共 86 条标题: Developments in Microfluidics-based Immunoassays 作者: Chen, ZN (Chen Zhao-Na); Liu, BH (Liu Bao-Hong); Wu, HL (Wu Hui-Ling); Yang, PY

(Yang Peng-Yuan) 来源出版物: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 卷: 32 期:

5 页: 1001-1007 出版年: MAY 10 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 57 摘要: Microfluidics-based immunoassays have become an increasing research field in recent years

owing to their advantages of miniaturization, high throughput, fast detection and low

consumption. Detection is an important part in microfluidics-based immunoassays. Recent

advances in the studies of micro-systems and detection methods, including electrochemical

detection., fluorescence spectrometry, ultraviolet-visible spectrometry, chemiluminescence and

bioluminescence, surface-enhanced Raman scattering, fiber-optic sensor, surface plasmon

resonance, thermal lens microscopy, colorimetry and other new detection methods applied in

microfluidics-based immunoassays, were summarized and reviewed in this paper. The prospects

of the detection methods for microfluidics-based immunoassays were presented. 入藏号: WOS:000291175800001 语种: Chinese 文献类型: Review 作者关键词: Microfluidics; Immunoassays; Detection method

KeyWords Plus: ENHANCED RAMAN-SCATTERING; ENZYME-IMMUNOASSAY; RAPID

DETECTION; CHIP; MICROCHIP; SYSTEM; SURFACE; REACTOR; IMMUNOSENSOR;

PROTEOLYSIS 地址: [Chen Zhao-Na; Liu Bao-Hong; Yang Peng-Yuan] Fudan Univ, Inst Biomed Sci, Dept

Chem, Shanghai 200433, Peoples R China

[Chen Zhao-Na] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108, Peoples R China

[Chen Zhao-Na; Wu Hui-Ling] Mil Med Coll 2, Sch Pharm, Shanghai 200433, Peoples R China 通讯作者地址: Yang, PY (通讯作者),Fudan Univ, Inst Biomed Sci, Dept Chem, Shanghai

200433, Peoples R China 电子邮件地址: [email protected] 出版商: HIGHER EDUCATION PRESS 出版商地址: SHATANHOU ST 55, BEIJING 100009, PEOPLES R CHINA


IDS 号: 771QM

ISSN: 0251-0790

29 字符的来源出版物名称缩写: CHEM J CHINESE U

ISO 来源出版物缩写: Chem. J. Chin. Univ.-Chin. 来源出版物页码计数: 7

第 50 条，共 86 条标题: The use of sodium trimetaphosphate as a biomimetic analog of matrix phosphoproteins for

remineralization of artificial caries-like dentin 作者: Liu, Y (Liu, Yan); Li, N (Li, Nan); Qi, YP (Qi, Yipin); Niu, LN (Niu, Li-na); Elshafiy, S

(Elshafiy, Sally); Mao, J (Mao, Jing); Breschi, L (Breschi, Lorenzo); Pashley, DH (Pashley, David

H.); Tay, FR (Tay, Franklin R.) 来源出版物 : DENTAL MATERIALS 卷 : 27 期 : 5 页 : 465-477 DOI:

10.1016/j.dental.2011.01.008 出版年: MAY 2011 在 Web of Science 中的被引频次: 2 被引频次合计: 2 引用的参考文献数: 62 摘要: Objectives. This study examined the use of sodium trimetaphosphate (STMP) as a

biomimetic analog of matrix phosphoproteins for remineralization of artificial carious-affected

dentin.

Methods. Artificial carious lesions with lesion depths of 300 +/- 30 mu m were created by

pH-cycling. 2.5% hydrolyzed STMP was applied to the artificial carious lesions to phosphorylate

the partially-demineralized collagen matrix. Half of the STMP-treated specimens were bonded

with One-Step. The adhesive and non-adhesive infiltrated specimens were remineralized in a

Portland cement-simulated body fluid system containing polyacrylic acid (PAA) to stabilize

amorphous calcium phosphate as nanoprecursors. Micro-computed tomography (micro-CT) and

transmission electron microscopy (TEM) were used to evaluate the results of remineralization

after a 4-month period.

Results. In absence of PAA and STMP as biomimetic analogs (control groups), there was no

remineralization irrespective of whether the lesions were infiltrated with adhesive. For the

STMP-treated experimental groups immersed in PAA-containing simulated body fluid, specimens

without adhesive infiltration were more heavily remineralized than those infiltrated with adhesive.

Statistical analysis of the 4-month micro-CT data revealed significant differences in the lesion

depth, relative mineral content along the lesion surface and changes in Delta Z between the

non-adhesive and adhesive experimental groups (p < 0.05 for all the three parameters). TEM

examination indicated that collagen degradation occurred in both the non-adhesive and adhesive

control and experimental groups after 4 months of remineralization. 入藏号: WOS:000288941300010 语种: English 文献类型: Article 作者关键词: Artificial carious lesion; Biomimetic; Collagen; Degradation; Remineralization;

Sodium trimetaphosphate

KeyWords Plus: CONFOCAL RAMAN MICROSPECTROSCOPY; IN-VITRO

REMINERALIZATION; CARIOUS DENTIN; CALCIUM-PHOSPHATE; ADHESIVE

SYSTEMS; CRYSTAL-GROWTH; BOND STRENGTH; 2 LAYERS; COLLAGEN; LESIONS 地址: [Elshafiy, Sally; Pashley, David H.; Tay, Franklin R.] Med Coll Georgia, Sch Dent, Dept

Endodont, Augusta, GA 30912 USA

[Elshafiy, Sally; Pashley, David H.; Tay, Franklin R.] Med Coll Georgia, Sch Dent, Dept Oral

Biol, Augusta, GA 30912 USA

[Liu, Yan; Mao, Jing] Huazhong Univ Sci & Technol, Dept Stomatol, Tongji Hosp, Tongji Med

Coll, Wuhan 430074, Peoples R China

[Li, Nan] Fujian Univ Tradit Chinese Med, Dept Osteoped & Traumatol, Fuzhou, Fujian, Peoples

R China

[Qi, Yipin] Sun Yat Sen Univ, Dept Operat Dent & Endodont, Guanghua Sch Stomatol,

Guangzhou 510275, Guangdong, Peoples R China

[Niu, Li-na] Fourth Mil Med Univ, Dept Prosthodont, Sch Stomatol, Xian 710032, Peoples R

China

[Breschi, Lorenzo] Univ Trieste, Dept Biomed, Trieste, Italy

[Breschi, Lorenzo] IOR, IGM CNR, Unit Bologna, Bologna, Italy 通讯作者地址: Tay, FR (通讯作者),Med Coll Georgia, Sch Dent, Dept Endodont, Augusta, GA

30912 USA 电子邮件地址: [email protected] 出版商: ELSEVIER SCI LTD 出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,

OXON, ENGLAND

Web of Science 分类: Dentistry, Oral Surgery & Medicine; Materials Science, Biomaterials 学科类别: Dentistry, Oral Surgery & Medicine; Materials Science

IDS 号: 742KL

ISSN: 0109-5641

29 字符的来源出版物名称缩写: DENT MATER

ISO 来源出版物缩写: Dent. Mater. 来源出版物页码计数: 13 基金资助致谢: 基金资助机构授权号

NIDCR R21 DE019213

Medical College of Georgia

This work was supported by grant R21 DE019213 from NIDCR (PI. Franklin Tay) and the PSRP

award from the Medical College of Georgia.

窗体顶端

Web of Knowledge 第 2 页 (文章 51 -- 86)

[ 1 | 2 ]

第 51 条，共 86 条标题: Inhibitory effect of polysaccharides isolated from Angelica sinensis on hepcidin expression 作者: Wang, KP (Wang, Kai-Ping); Zeng, F (Zeng, Fang); Liu, JY (Liu, Jin-Yu); Guo, D (Guo,

Dan); Zhang, Y (Zhang, Yu)

来源出版物: JOURNAL OF ETHNOPHARMACOLOGY 卷: 134 期: 3 页: 944-948 DOI:

10.1016/j.jep.2011.02.015 出版年: APR 12 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 21 摘要 : Ethnopharmacological relevance: Angelica sinensis polysaccharide is an important

bioactive component of Angelica sinensis (Oliv.) Diels that has been used in traditional Chinese

medicine for treating gynecological disorders and anemia.

Aim of the study: Previous study indicated that Angelica sinensis polysaccharide (ASP) may

promote plasma iron levels by suppressing the expression of hepcidin, a negative regulator of

body iron metabolism, in the liver. The present study aims to clarify the inhibitory effect of ASP

on hepcidin expression as well as the involved mechanisms.

Materials and Methods: ASP (1 g/kg) or vehicle (normal saline) was intragastrically administrated

to rats everyday for 14d. Intraperitoneal injections of recombinant human erythropoietin (rhEPO,

2000 U/kg) were given to positive control group. Erythropoietin and hepcidin levels in serum at

different time points were determined by enzyme-linked immunosorbent assay. Western blot was

used to investigate the expression of 6 pertinent signal proteins in liver.

Results: ASP significantly reduced hepcidin expression by inhibiting the expression of signal

transducer and activator of transcription 3/5 (STAT3/5) and mothers against decapentaplegic

protein 4 (SMAD4) in liver and stimulating the secretion of erythropoietin, which further

down-regulated hepcidin by repressing CCAAT/enhancer-binding protein a (C/EBP alpha).

SMAD4, and the phosphorylation process of STAT3/5.

Conclusions: ASP can suppress the expression of hepcidin in normal rats, and may be used in the

treatments of hepcidin-induced diseases. (C) 2011 Elsevier Ireland Ltd. All rights reserved. 入藏号: WOS:000289866500046 语种: English 文献类型: Article 作者关键词 : Angelica sinensis; Polysaccharides; Erythropoietin; Hepcidin; Iron deficiency

diseases

KeyWords Plus: IRON-DEFICIENCY; C/EBP-ALPHA; ANEMIA; METABOLISM; PEPTIDE;

SMAD4 地址: [Zhang, Yu] Huazhong Univ Sci & Technol, Dept Pharm, Union Hosp, Wuhan 430030,

Peoples R China

[Wang, Kai-Ping; Zeng, Fang; Liu, Jin-Yu] Huazhong Univ Sci & Technol, Tongji Med Coll,

Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

[Guo, Dan] Fujian Inst Tradit Chinese Med, Fuzhou 350003, Peoples R China 通讯作者地址: Zhang, Y (通讯作者),Huazhong Univ Sci & Technol, Dept Pharm, Union Hosp,

1227 Jiefang Rd, Wuhan 430030, Peoples R China 电子邮件地址: [email protected] 出版商: ELSEVIER IRELAND LTD 出版商地址: ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO,




IDS 号: 754OZ

ISSN: 0378-8741


ISO 来源出版物缩写: J. Ethnopharmacol. 来源出版物页码计数: 5 基金资助致谢: 基金资助机构授权号

Nation Natural Science Foundation of China 30973910

The present study was supported by grants from the Nation Natural Science Foundation of China

(Grant No. 30973910).

第 52 条，共 86 条标题: Antitussive Activity of Pseudostellaria heterophylla (Miq.) Pax Extracts and Improvement

in Lung Function via Adjustment of Multi-Cytokine Levels 作者: Pang, WS (Pang, Wensheng); Lin, SD (Lin, Siding); Dai, QW (Dai, Qiwen); Zhang, HC

(Zhang, Hongcheng); Hu, J (Hu, Juan) 来源出版物: MOLECULES 卷: 16 期: 4 页: 3360-3370 DOI: 10.3390/molecules16043360 出版年: APR 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 28 摘要: Pseudostellaria heterophylla (Miq.) Pax is one of the most widespread herbal and healthcare

products in China. Extensive clinical use has shown that it has functions which "strengthens qi and

generates saliva, moistens the lung and relieves cough". The ethyl acetate fraction extracted from

the roots of the plant Pseudostellaria heterophylla exhibited a dose-dependent antitussive effect

between 100 to 500 mg/kg. At a dose of 400 mg/kg, the ethyl acetate fraction treatment markedly

prolonged the cough latent period and reduced the number of coughs in a guinea pig model

induced by citric acid. Fall lung airway resistance, rise in dynamic lung compliance, decreased

serum levels of IL-8, GM-CSF, TNF-alpha, and ET-1 in rat model of stable phase chronic

obstructive pulmonary disease induced by cigarette smoke exposure were also observed. These

results suggest that ethyl acetate fraction has antitussive activity related to its improvement in lung

function via attenuation of airway inflammation by adjustment of multi-cytokine levels. 入藏号: WOS:000289976200023 语种: English

文献类型: Article 作者关键词: Pseudostellaria heterophylla (Miq.) Pax; extracts; antitussive activity; improvement

lung function; multi-cytokine adjusting

KeyWords Plus: STEMONA-TUBEROSA; GENE-EXPRESSION; COPD; MACROPHAGES 地址: [Pang, Wensheng; Lin, Siding; Dai, Qiwen; Zhang, Hongcheng; Hu, Juan] Fujian Univ

Tradit Chinese Med, Sch Pharm, Fuzhou 350108, Peoples R China 通讯作者地址: Hu, J (通讯作者),Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350108,

Peoples R China 电子邮件地址 : [email protected]; [email protected]; [email protected];

[email protected]; [email protected] 出版商: MDPI AG 出版商地址: KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND

Web of Science 分类: Chemistry, Organic 学科类别: Chemistry

IDS 号: 755YE

ISSN: 1420-3049

29 字符的来源出版物名称缩写: MOLECULES

ISO 来源出版物缩写: Molecules 来源出版物页码计数: 11 基金资助致谢: 基金资助机构授权号

Foundation of Social Development

Fujian Provincial Department of Science Technology 2008Y0047

Traditional Chinese Medicine and Quality Control Engineering Technology

Research Center Platform of Fujian Province 2009Y2003

We thank Jianmin Xie from the Zhejiang University School of Medicine for his guidance. The

authors are grateful to the Foundation of Social Development, Fujian Provincial Department of

Science & Technology (2008Y0047) and the support of preclinical studies of the Traditional

Chinese Medicine and Quality Control Engineering Technology Research Center Platform of

Fujian Province (2009Y2003).

第 53 条，共 86 条标题: Prediction of residual/recurrent disease by HPV Genotype after loop excision procedure for

high-grade cervical intraepithelial neoplasia with negative margins 作者: Wu, DM (Wu, Dongmei); Zheng, YZ (Zheng, Yizhen); Chen, W (Chen, Wei); Guo, CR

(Guo, Ciren); Yu, JA (Yu, Jiang); Chen, GL (Chen, Guilin); Huang, YL (Huang, Yanling) 来源出版物 : AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS &

GYNAECOLOGY 卷: 51 期: 2 页: 114-118 DOI: 10.1111/j.1479-828X.2010.01280.x 出版年:

APR 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 25 摘要 : Aims: This study aims to evaluate whether the preconisation of high-risk human

papillomavirus (HR-HPV) genotype and multiple HPV infection is predictive for

residual/recurrent disease during the follow-up of high-grade cervical intraepithelial neoplasia

(CIN) treated by loop electrosurgical excision procedure (LEEP) with negative margins.

Methods: Two hundred and thirty-six women (mean age 37; range 20-61) with CIN2/3 treated by

LEEP conisation with negative margins confirmed by pathology examination of the surgical

specimen were included. The cervical cells for HPV genotype testing by the polymerase chain

reaction (PCR) were collected before, and 6, 12, 24 months after treatment, respectively. HPV

genotype and multiple HPV infection were evaluated as possible predictors of residual/recurrent

disease.

Results: Residual/recurrent disease was demonstrated by colposcopy-guided biopsy in 62 patients

(26.3%) who underwent loop conisation with negative margins. Preoperative infection with either

HPV16 (P = 0.007), HPV18 (P = 0.000), HPV33 (P = 0.001) or HPV45 (P = 0.019) was associated

with higher rates of residual/recurrent lesions after conisation with negative margins. Preoperative

infection with multiple HPV types was associated with the highest rate of residual/recurrent

lesions compared with infection with single HPV type and HPV-negative cases (chi(2) = 16.599, P

< 0.001).

Conclusions: Results demonstrate that the presence of HPV-16, 18, 33 and 45, as well as multiple

HPV types pre-LEEP, is associated with higher rates of residual/recurrent disease after LEEP. 入藏号: WOS:000289248700004 语种: English 文献类型: Article 作者关键词 : cervical intraepithelial neoplasia; HPV Genotype; negative margins;

residual/recurrence

KeyWords Plus: OF-THE-LITERATURE; HUMAN-PAPILLOMAVIRUS;

ELECTROSURGICAL EXCISION; RECURRENT DISEASE; TREATMENT FAILURE;

NATURAL-HISTORY; PRE-CONIZATION; PERSISTENCE; INFECTION; CANCER 地址: [Wu, Dongmei; Zheng, Yizhen; Yu, Jiang] Fujian Univ Tradit Chinese Med, Affiliated Hosp

2, Dept Gynecol & Obstet, Fuzhou 350003, Peoples R China

[Chen, Wei; Guo, Ciren; Chen, Guilin; Huang, Yanling] Fujian Prov Tumor Hosp, Dept Gynecol,

Fuzhou, Peoples R China 通讯作者地址: Wu, DM (通讯作者),Fujian Univ Tradit Chinese Med, Affiliated Hosp 2, Dept

Gynecol & Obstet, 13 Hudongzhi Rd, Fuzhou 350003, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA

Web of Science 分类: Obstetrics & Gynecology 学科类别: Obstetrics & Gynecology

IDS 号: 746LQ

ISSN: 0004-8666

29 字符的来源出版物名称缩写: AUST NZ J OBSTET GYN

ISO 来源出版物缩写: Aust. N. Z. J. Obstet. Gynaecol. 来源出版物页码计数: 5 基金资助致谢: 基金资助机构授权号

Natural Science Foundation of Fujian Province 2010J01182

This work was supported by Natural Science Foundation of Fujian Province (2010J01182).

第 54 条，共 86 条标题: Effects of Laser Irradiation of Acupuncture Points Shenshu on Ovariectomized Rats 作者: Zhang, YS (Zhang, Yi-Shi); Xu, YX (Xu, Yun-Xiang); Chen, CS (Chen, Chang-Shui);

Chen, GZ (Chen, Gui-Zhen); Weng, ZX (Weng, Zu-Xing); Yao, Y (Yao, Yao) 来源出版物: PHOTOMEDICINE AND LASER SURGERY 卷: 29 期: 4 页: 271-275 DOI:

10.1089/pho.2010.2763 出版年: APR 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 16 摘要: Background and Objective: The effect of laser acupuncture on obesity in postmenopausal

women remains unknown. The aim of this study was to investigate the effects of this form of

treatment using an animal model. Materials and Methods: Seventy-seven female Sprague-Dawley

rats were assigned into seven groups: normal control (Normal), sham-operation control (Sham),

ovariectomized (OVX) control rats (OVX), OVX rats treated with estrogen (OVX + E), and three

groups of ovariectomized rats treated with laser acupuncture (OVX + L). Bilateral ovaries were

removed to decrease estrogen levels. After 2 wk, semiconductor laser irradiation was administered

to bilateral Shenshu (BL 23) acupoints of rats in the three OVX + L groups at 12, 30, and 60

J/cm(2), respectively. Changes in body weight and pituitary estrogen receptor (ER) mRNA

expression were analyzed. Morphological differences in the uterus and pituitary glands were also

observed. Results: The OVX group exhibited marked weight gain and a significant decrease in

pituitary ER alpha mRNA expression. Semiconductor laser irradiation at 30 J/cm(2) reduced body

weight and increased ER alpha expression compared with the control, whereas irradiation at 12 or

60 J/cm(2) presented slightly weaker effects. Significant differences in pituitary ER beta mRNA

were not observed due to lack of optical density data. Conclusions: The semiconductor laser

irradiation of bilateral Shenshu (BL 23) acupoints can exert beneficial effects on OVX rats

through reducing body weight and increasing pituitary ER alpha expression, and 30 J/cm(2) was

the most effective dose among those used.

入藏号: WOS:000289074200009 语种: English 文献类型: Article

KeyWords Plus: FEMALE RAT; SITES 地址 : [Zhang, Yi-Shi; Chen, Chang-Shui; Chen, Gui-Zhen] S China Normal Univ, Coll

Biophoton, Lab Photon Chinese Med, Guangzhou 510631, Guangdong, Peoples R China

[Xu, Yun-Xiang; Chen, Gui-Zhen] Guangzhou Univ Tradit Chinese Med, Guangzhou,

Guangdong, Peoples R China

[Weng, Zu-Xing; Yao, Yao] Fujian Coll Tradit Chinese Med, Fuzhou, Fujian, Peoples R China 通讯作者地址: Chen, GZ (通讯作者),S China Normal Univ, Coll Biophoton, Lab Photon

Chinese Med, Guangzhou 510631, Guangdong, Peoples R China 电子邮件地址: [email protected] 出版商: MARY ANN LIEBERT INC 出版商地址: 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA

Web of Science 分类: Surgery 学科类别: Surgery

IDS 号: 744DK

ISSN: 1549-5418

29 字符的来源出版物名称缩写: PHOTOMED LASER SURG

ISO 来源出版物缩写: Photomed. Laser Surg. 来源出版物页码计数: 5 基金资助致谢: 基金资助机构授权号

Post-doctoral Foundation of China 20070410242

Administration of Traditional Chinese Medicine of Guangdong Province 2007166

Guangdong Natural Science Foundation 8451063101001809

This work was supported by the Post-doctoral Foundation of China under grant No. 20070410242

and the Administration of Traditional Chinese Medicine of Guangdong Province under grant No.

2007166, and grant No. 8451063101001809 of Guangdong Natural Science Foundation.

第 55 条，共 86 条标题: Differences between top-down and bottom-up approaches in mineralizing thick, partially

demineralized collagen scaffolds 作者: Liu, Y (Liu, Yan); Mai, S (Mai, Sui); Li, N (Li, Nan); Yiu, CKY (Yiu, Cynthia K. Y.); Mao,

J (Mao, Jing); Pashley, DH (Pashley, David H.); Tay, FR (Tay, Franklin R.) 来源出版物 : ACTA BIOMATERIALIA 卷 : 7 期 : 4 页 : 1742-1751 DOI:

10.1016/j.actbio.2010.11.028 出版年: APR 2011

在 Web of Science 中的被引频次: 3 被引频次合计: 3 引用的参考文献数: 48 摘要: Biominerals exhibit complex hierarchical structures derived from bottom-up self-assembly

mechanisms. Type I collagen serves as the building block for mineralized tissues such as bone and

dentin. In the present study, 250-300 mu m thick, partially demineralized collagen scaffolds

exhibiting a gradient of demineralization from the base to surface were mineralized using a

classical top-down approach and a non-classical bottom-up approach. The top-down approach

involved epitaxial growth over seed crystallites. The bottom-up approach utilized biomimetic

analogs of matrix proteins to stabilize amorphous calcium phosphate nanoprecursors and template

apatite nucleation and growth within the collagen matrix. Micro-computed tomography and

transmission electron microscopy were employed to examine mineral uptake and apatite

arrangement within the mineralized collagen matrix. The top-down approach could mineralize

only the base of the partially demineralized scaffold, where remnant seed crystallites were

abundant. Minimal mineralization was observed along the surface of the scaffold; extrafibrillar

mineralization was predominantly observed. Conversely, the entire partially demineralized

scaffold, including apatite-depleted collagen fibrils, was mineralized by the bottom-up approach,

with evidence of both intrafibrillar and extrafibrillar mineralization. Understanding the different

mechanisms involved in these two mineralization approaches is pivotal in adopting the optimum

strategy for fabricating novel nanostructured materials in bioengineering research. (C) 2010 Acta

Materialia Inc. Published by Elsevier Ltd. All rights reserved. 入藏号: WOS:000288971300035 语种: English 文献类型: Article 作者关键词: Biomimetics; Bottom-up; Collagen; Particle-mediated; Mineralization; Top-down

KeyWords Plus: IN-VITRO; MECHANICAL-PROPERTIES; CALCIUM-PHOSPHATE;

DENTIN COLLAGEN; CRYSTAL-GROWTH; HARD TISSUES; REMINERALIZATION;

LESIONS; BONE; SYSTEMS 地址: [Pashley, David H.; Tay, Franklin R.] Med Coll Georgia, Sch Dent, Dept Oral Biol,

Augusta, GA 30912 USA

[Tay, Franklin R.] Med Coll Georgia, Sch Dent, Dept Endodont, Augusta, GA 30912 USA


Coll, Wuhan 430074, Peoples R China

[Mai, Sui] Sun Yat Sen Univ, Dept Operat Dent & Endodont, Guanghua Sch Stomatol, Guangzhou

510275, Guangdong, Peoples R China


R China

[Yiu, Cynthia K. Y.] Univ Hong Kong, Fac Dent, Hong Kong, Hong Kong, Peoples R China 通讯作者地址: Tay, FR (通讯作者),Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA

30912 USA 电子邮件地址: [email protected] 出版商: ELSEVIER SCI LTD

出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,

OXON, ENGLAND


IDS 号: 742US

ISSN: 1742-7061

29 字符的来源出版物名称缩写: ACTA BIOMATER

ISO 来源出版物缩写: Acta Biomater. 来源出版物页码计数: 10 基金资助致谢: 基金资助机构授权号

National Institute of Dental and Craniofacial Research R21 DE019213-01


This study was generously supported by Grant R21 DE019213-01 from the National Institute of

Dental and Craniofacial Research and the PSRP grant from the Medical College of Georgia (P.I.

Franklin R. Tay). We thank Lisha Gu for assistance with the operation of the micro-CT, Jongryul

Kim for preparing the completely demineralized specimen in the Supplementary Material, Bob

Smith for TEM technical assistance and Michelle Barnes for secretarial support.

第 56 条，共 86 条标题 : Differential Proteomic Analysis of Temperature-Induced Autolysis in Mycelium of

Pleurotus tuber-regium 作者: Huang, BF (Huang, Bifang); Lin, WX (Lin, Wenxiong); Cheung, PCK (Cheung, Peter C.

K.); Wu, JZ (Wu, Jinzhong) 来源出版物 : CURRENT MICROBIOLOGY 卷 : 62 期 : 4 页 : 1160-1167 DOI:

10.1007/s00284-010-9838-4 出版年: APR 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 31 摘要: Autolysis is an important physiological process found in fungal cultivation. However, there

is hitherto no report on the autolysis of Pleurotus tuber-regium. We have investigated the enzymes

secreted by temperature-induced (40 degrees C as treatment versus 10 degrees C as control)

autolysis of the mycelium of P. tuber-regium grown in submerged cultivation. A comparison

between the intracellular proteins (inside the mycelium) and the extracellular proteins (in the

culture medium) of the treatment and control by proteomic analysis involving 2D PAGE and

MALDI-TOF-MS was made. Twenty-two up-regulated protein spots were detected and eight

proteins were identified. They included proteasome which participates in the ubiquitin-proteasome

pathway; beta-1,3-glucanosyltransferase and tubulin which are involved in the renewal and repair

of cell wall; protease and endoglucanase which promote the natural degradation of cell wall and

cytoplasm; 14-3-3 protein which takes part in cell signal transduction; and two putative proteins

presumably relate to the autolysis process. These identified proteins suggest partially the

metabolic processes of the autolysis in the P. tuber-regium mycelium. 入藏号: WOS:000289166800011 语种: English 文献类型: Article

KeyWords Plus: 14-3-3 PROTEINS; FR. SINGER; IDENTIFICATION; PROTEASE; BINDING;

PART 地址: [Huang, Bifang; Lin, Wenxiong] Fujian Agr & Forestry Univ, Sch Life Sci, Fuzhou 350002,

Peoples R China

[Cheung, Peter C. K.] Chinese Univ Hong Kong, Dept Biol, Shatin, Hong Kong, Peoples R China

[Wu, Jinzhong] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Peoples R

China 通讯作者地址: Lin, WX (通讯作者),Fujian Agr & Forestry Univ, Sch Life Sci, Fuzhou 350002,

Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA

Web of Science 分类: Microbiology 学科类别: Microbiology

IDS 号: 745LL

ISSN: 0343-8651

29 字符的来源出版物名称缩写: CURR MICROBIOL

ISO 来源出版物缩写: Curr. Microbiol. 来源出版物页码计数: 8

第 57 条，共 86 条标题: Mitochondrial dysfunction in long-term neuronal cultures mimics changes with aging 作者: Dong, WG (Dong, Weiguo); Cheng, SW (Cheng, Shaowu); Huang, F (Huang, Fang); Fan,

WG (Fan, Wenguo); Chen, Y (Chen, Yue); Shi, H (Shi, Hong); He, HW (He, Hongwen) 来源出版物: MEDICAL SCIENCE MONITOR 卷: 17 期: 4 页: BR91-BR96 出版年: APR

2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 47 摘要: Background: Aging is a highly complex process that affects various tissues and systems in

the body. Senescent changes are relatively more prevalent and severe in the postmitotic cells.

Mitochondria play an important role in the aging process. Recently, cell cultures have been widely

used as an in vitro model to study aging. The present study was designed to investigate

mitochondrial dysfunction associated with aging in a long-term cell culture system.

Material/Methods: Rat hippocampal neurons were maintained in culture in serum-free medium for

30 days in vitro (DIV). The morphology and development of hippocampal neurons was observed

by phase contrast microscope. The levels of cellular senescence were evaluated by cytochemical

staining of senescence-associated beta-galactosidase (SA-beta-Gal) at DIV 5, 10, 15, 20, 25 and

30. In addition, we investigated the changes in mitochondrial membrane potential (Delta psi m)

and intracellular reactive oxygen species (ROS) generation of hippocampal neurons by flow

cytometry at different ages.

Results: The proportion of the senescent cells steadily increased with age in neuron cultures. Delta

psi m decreased gradually with age in long-term culture, while ROS generation increased.

Conclusions: This study indicates an age-related decrease in mitochondrial function in long-term

hippocampal neuronal culture and suggests that DIV 25 neurons could possibly serve as a

platform for the future study of anti-aging from the perspective of mitochondrial function. 入藏号: WOS:000289374400010 语种: English 文献类型: Article 作者关键词: senescence; mitochondrial membrane potential; reactive oxygen species; long-term

primary neuronal culture

KeyWords Plus: RAT HIPPOCAMPAL-NEURONS; IN-VITRO; CALCIUM HOMEOSTASIS;

CELLULAR SENESCENCE; CORTICAL-NEURONS; COMPLEX I; CELLS; AGE;

EXPRESSION; MELATONIN 地址: [Dong, Weiguo; Cheng, Shaowu; Huang, Fang; Fan, Wenguo; He, Hongwen] Sun Yat Sen

Univ, Guanghua Sch Stomatol, Dept Oral Anat & Physiol, Guangzhou 510080, Peoples R China

[Dong, Weiguo; Chen, Yue; Shi, Hong] Fujian Univ Tradit Chinese Med, Dept Integrated Tradit

Chinese & Western Med, Fuzhou, Peoples R China 通讯作者地址: He, HW (通讯作者),Sun Yat Sen Univ, Guanghua Sch Stomatol, Dept Oral Anat

& Physiol, Guangzhou 510080, Peoples R China 电子邮件地址: [email protected] 出版商: INT SCIENTIFIC LITERATURE, INC 出版商地址: 361 FOREST LANE, SMITHTOWN, NY 11787 USA

Web of Science 分类: Medicine, Research & Experimental 学科类别: Research & Experimental Medicine

IDS 号: 748FC

ISSN: 1234-1010

29 字符的来源出版物名称缩写: MED SCI MONITOR

ISO 来源出版物缩写: Med. Sci. Monitor 来源出版物页码计数: 6 基金资助致谢: 基金资助机构授权号


This work was supported by grants from the National Natural Science Foundation of China (No.

30472248)

第 58 条，共 86 条标题: Hepatoprotection in a Rat Model of Acute Liver Damage Through Inhibition of CY2E1

Activity by Total Alkaloids Extracted From Rubus alceifolius Poir 作者: Lin, JM (Lin, Jiumao); Zhao, JY (Zhao, Jinyan); Li, TJ (Li, Tianjiao); Zhou, JH (Zhou,

Jianheng); Hu, J (Hu, Juan); Hong, ZF (Hong, Zhenfeng) 来源出版物 : INTERNATIONAL JOURNAL OF TOXICOLOGY 卷 : 30 期 : 2 页 :

237-243 DOI: 10.1177/1091581810390711 出版年: MAR 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 27 摘要: We aimed to examine the effect of an alkaloid extract of the roots of Rubus alceifolius Poir

on liver damage and cytochrome enzymes, and underlying mechanism. Hepatotoxicity was

induced in rats by treatment with carbon tetrachloride (CCl(4)). Rats were then treated with the

hepatoprotective drug bifendate, or with low, medium, and high doses of an alkaloid extract from

the roots of R alceifolius Poir. Both bifendate and alkaloid treatment decreased the increase in

liver enzymes and cell damage caused by CCl(4). Carbon tetrachloride treatment alone caused a

decrease in total cytochrome P450 content, an increase in CYP2E1 and CYP3A1 messenger RNA

(mRNA) levels, and an increase in CYP2E1 and a decrease in CYP3A1 enzymatic activity.

Alkaloid treatment brought these concentrations and activities back toward normal. In summary,

these results suggest that alkaloids from R alceifolius Poir may act to protect the liver through

decreasing CYP2E1 enzymatic activity through decreasing its mRNA. 入藏号: WOS:000290113700011 语种: English 文献类型: Article 作者关键词: Rubus alceifolius Poir; total alkaloids; CYP2E1; CYP3A1; CYP450; drug metabolic

enzyme; acute liver damage

KeyWords Plus: CARBON-TETRACHLORIDE; APOPTOSIS; TOXICITY; INJURY; CYP2E1 地址: [Zhou, Jianheng; Hong, Zhenfeng] Fujian Univ Tradit Chinese Med, Dept Integrat Med,

Fuzhou 350108, Fujian, Peoples R China

[Lin, Jiumao; Zhao, Jinyan] Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med, Fuzhou

350108, Fujian, Peoples R China

[Li, Tianjiao] Fujian Univ Tradit Chinese Med, Affiliated Hosp 2, Fuzhou 350108, Fujian, Peoples

R China

[Hu, Juan] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108, Fujian, Peoples R

China 通讯作者地址: Hong, ZF (通讯作者),Fujian Univ Tradit Chinese Med, Dept Integrat Med,

Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: SAGE PUBLICATIONS INC 出版商地址: 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA

Web of Science 分类: Pharmacology & Pharmacy; Toxicology 学科类别: Pharmacology & Pharmacy; Toxicology

IDS 号: 757UR

ISSN: 1091-5818

29 字符的来源出版物名称缩写: INT J TOXICOL

ISO 来源出版物缩写: Int. J. Toxicol. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构授权号

Nature Science Foundation of Fujian Province of China 2006J0109

Fujian Key Laboratory of Integrative Medicine on Geriatrics (Fujian University

of TCM)

2008J1004-19

2008J1004-17


CKJ2008056

The author(s) disclosed receipt of the following financial support for the research and/or

authorship of this article: The project was supported by the Nature Science Foundation of Fujian

Province of China (No. 2006J0109); The Project Sponsored by Open Fund of Fujian Key

Laboratory of Integrative Medicine on Geriatrics (Fujian University of TCM)(No. 2008J1004-19

and 2008J1004-17); Developmental Fund of Chen Keji Integrative Medicine (CKJ2008054 and

CKJ2008056).

第 59 条，共 86 条标题: Spica Prunellae extract promotes mitochondrion-dependent apoptosis in human colon

carcinoma cell line 作者: Zheng, LP (Zheng, Liangpu); Chen, YQ (Chen, Youqin); Lin, W (Lin, Wei); Zhuang, QC

(Zhuang, Qunchuan); Chen, XZ (Chen, Xuzheng); Xu, W (Xu, Wei); Liu, XX (Liu, Xianxiang);

Peng, J (Peng, Jun); Sferra, TJ (Sferra, Thomas J.) 来源出版物: AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY 卷: 5 期:

3 页: 327-335 出版年: MAR 2011 在 Web of Science 中的被引频次: 3 被引频次合计: 3 引用的参考文献数: 29 摘要: Spica Prunellae (Prunella vulgaris fruiting spikes) has long been used as an important

component in formulated prescriptions of Chinese traditional medicine to treat various kinds of

cancer. However, the precise mechanism of the anti-cancer activity of Spica Prunellae remains to

be elucidated. In this report, we investigated the cellular effects of the ethanol extract of Spica

Prunellae (EESP) in the HT-29 human colon carcinoma cell line. We found that EESP inhibited

the growth of HT-29 cells as evidenced by EESP-induced cell morphological changes and reduced

cell viability in dose-and time-dependent manners. Furthermore, we demonstrated that the HT-29

cell growth inhibitory activity of EESP was due to apoptosis, as EESP treatment resulted in the

loss of plasma membrane asymmetry (externalization of phosphatidylserine), collapse of

mitochondrial membrane potential, activation of caspase-9 and caspase-3, and increase in the ratio

of pro-apoptotic Bax to anti-apoptotic Bcl-2. Taken together, these results suggest that Spica

Prunellae inhibits the growth of HT-29 colon cancer cells through mitochondrion-mediated

apoptosis, which may, in part, explain its anti-cancer activity. 入藏号: WOS:000295797300007 语种: English 文献类型: Article 作者关键词: Apoptosis; anti-tumor; HT-29 cells; phytotherapy; mitochondria; Spica Prunellae

KeyWords Plus: CHANNEL-FORMING ACTIVITY; BCL-2 FAMILY-MEMBERS;

CYTOCHROME-C; BAX; RELEASE; DEATH; PROTEINS; CYTOSOL; CANCER; SWITCH 地址: [Zheng, Liangpu; Lin, Wei; Zhuang, Qunchuan; Chen, Xuzheng; Liu, Xianxiang; Peng, Jun]

Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China


73190 USA


China


Oklahoma City, OK 73190 USA 通讯作者地址: Peng, J (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, 1



IDS 号: 832IF

ISSN: 1996-0816


ISO 来源出版物缩写: Afr. J. Pharm. Pharmacol. 来源出版物页码计数: 9 基金资助致谢: 基金资助机构授权号





This work was sponsored by the Open Fund of Fujian Key Laboratory of Integrative Medicine on

Geriatrics (2008J1004), the Natural Science Foundation of Fujian Province of China

(2010J01195), the Research Foundation of Education Bureau of Fujian Province of China

(JA10162), and the Developmental Fund of Chen Keji Integrative Medicine (CKJ 2010019).

第 60 条，共 86 条标题: The critical barrier to progress in dentine bonding with the etch-and-rinse technique 作者: Brackett, MG (Brackett, M. G.); Li, N (Li, N.); Brackett, WW (Brackett, W. W.); Sword, RJ

(Sword, R. J.); Qi, YP (Qi, Y. P.); Niu, LN (Niu, L. N.); Pucci, CR (Pucci, C. R.); Dib, A (Dib, A.);

Pashley, DH (Pashley, D. H.); Tay, FR (Tay, F. R.) 来源出版物 : JOURNAL OF DENTISTRY 卷 : 39 期 : 3 页 : 238-248 DOI:

10.1016/j.jdent.2010.12.009 出版年: MAR 2011 在 Web of Science 中的被引频次: 5 被引频次合计: 5 引用的参考文献数: 63 摘要: Objectives: The lack of durability in resin-dentine bonds led to the use of chlorhexidine as

MMP-inhibitor to prevent the degradation of hybrid layers. Biomimetic remineralisation is a

concept-proven approach in preventing the degradation of resin-dentine bonds. The purpose of

this study is to examine the integrity of aged resin-dentine interfaces created with a

nanofiller-containing etch-and-rinse adhesive after the application of these two approaches.

Methods: The more established MMP-inhibition approach was examined using a parallel in vivo

and in vitro ageing design to facilitate comparison with the biomimetic remineralisation approach

using an in vitro ageing design. Specimens bonded without chlorhexidine exhibited extensive

degradation of the hybrid layer after 12 months of in vivo ageing.

Results: Dissolution of nanofillers could be seen within a water-rich zone within the adhesive

layer. Although specimens bonded with chlorhexidine exhibited intact hybrid layers, water-rich

regions remained in those hybrid layers and degradation of nanofillers occurred within the

adhesive layer. Specimens subjected to in vitro biomimetic remineralisation followed by in vitro

ageing demonstrated intrafibrillar collagen remineralisation within hybrid layers and deposition of

mineral nanocrystals in nanovoids within the adhesive.

Conclusions: The impact was realized by understanding the lack of an inherent mechanism to

remove water from resin-dentine interfaces as the critical barrier to progress in bonding with the

etch-and-rinse technique. The experimental biomimetic remineralisation strategy offers a creative

solution for incorporating a progressive hydration mechanism to achieve this goal, which warrants

its translation into a clinically applicable technique. (C) 2011 Elsevier Ltd. All rights reserved. 入藏号: WOS:000288890600008

语种: English 文献类型: Article 作者关键词: Ageing; Biomimetic remineralisation; Chlorhexidine; Degradation; Hybrid layer;

Matrix metalloproteinase

KeyWords Plus: MULTIPLE WATER COMPARTMENTS; THERMAL STABILIZATION;

IN-VIVO; MATRIX METALLOPROTEINASES; MECHANICAL-PROPERTIES; RESIN

HYDROPHILICITY; ARCHAEOLOGICAL BONE; POLYMER COMPOSITES; COLLAGEN

MOLECULES; HYBRID LAYERS 地址: [Tay, F. R.] Med Coll Georgia, Sch Dent, Dept Endodont, Augusta, GA 30912 USA

[Brackett, M. G.; Brackett, W. W.; Sword, R. J.] Med Coll Georgia, Sch Dent, Dept Oral Rehabil,


[Li, N.] Fujian Univ Tradit Chinese Med, Coll Osteoped & Traumatol, Fuzhou, Fujian, Peoples R

China

[Qi, Y. P.] Sun Yat Sen Univ, Guanghua Sch Stomatol, Dept Operat Dent & Endodont, Guangzhou

510275, Guangdong, Peoples R China

[Niu, L. N.] Fourth Mil Med Univ, Sch Stomatol, Dept Prosthodont, Xian 710032, Peoples R

China

[Pucci, C. R.] Univ Estadual Paulista, UNESP, Fac Odontol Sao Jose dos Campos, Sao Paulo,

Brazil

[Dib, A.] Benemerita Univ Autonoma Puebla, Fac Estomatol, Puebla, Mexico

[Pashley, D. H.; Tay, F. R.] Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA 30912 USA 通讯作者地址: Tay, FR (通讯作者),Med Coll Georgia, Sch Dent, Dept Endodont, 1120,15th

St,CL 2132, Augusta, GA 30912 USA 电子邮件地址: [email protected] 出版商: ELSEVIER SCI LTD 出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,

OXON, ENGLAND

Web of Science 分类: Dentistry, Oral Surgery & Medicine 学科类别: Dentistry, Oral Surgery & Medicine

IDS 号: 741UL

ISSN: 0300-5712

29 字符的来源出版物名称缩写: J DENT

ISO 来源出版物缩写: J. Dent. 来源出版物页码计数: 11 基金资助致谢: 基金资助机构授权号

Benemerita Universidad Autonoma de Puebla, Mexico

National Institute of Dental and Craniofacial Research

R01 DE015306-06

R21 DE019213-01

The in vivo part of this study was funded by the Benemerita Universidad Autonoma de Puebla,

Mexico. The in vitro part of the study was supported by the National Institute of Dental and

Craniofacial Research. Specifically, the funds were used to support transmission electron

microscopy (R01 DE015306-06; PI. David H. Pashley) and biomimetic remineralisation of

resin-dentine bonds (R21 DE019213-01; PI. Franklin R. Tay). We thank Michelle Barnes for her

secretarial support and Thomas Bryan for his technical support.

第 61 条，共 86 条标题: Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting

the STAT3 pathway in human multiple myeloma cells 作者: Peng, J (Peng, Jun); Chen, YQ (Chen, Youqin); Lin, JM (Lin, Jiumao); Zhuang, QC

(Zhuang, Qunchuan); Xu, W (Xu, Wei); Hong, ZF (Hong, Zhenfeng); Sferra, TJ (Sferra, Thomas

J.) 来源出版物 : MOLECULAR MEDICINE REPORTS 卷 : 4 期 : 2 页 : 313-318 DOI:

10.3892/mmr.2011.413 出版年: MAR-APR 2011 在 Web of Science 中的被引频次: 2 被引频次合计: 2 引用的参考文献数: 30 摘要: Signal transducer and activator of transcription 3 (STAT3) plays an important role in tumor

cell survival and proliferation and thus has become a major focus in the development of

anti-cancer therapies. Patrinia scabiosaefolia has been used for the treatment of various types of

cancer. However, the precise mechanism of the anti-cancer activity of Patrinia scabiosaefolia

remains unclear. In this study, we evaluated the effect of the ethanol extract of Patrinia

scabiosaefolia (EEPS) on proliferation and apoptosis in human multiple myelorna U266 cells that

persistently express phosphorylated STAT3, and investigated the possible molecular mechanisms

mediating its biological effects. We found that EEPS inhibited the phosphorylation of STAT3 in

U266 cells. Consequently, the inhibitory effect of EEPS on STAT3 activation resulted in the

suppression of cell proliferation and the induction of cell apoptosis. Moreover, EEPS treatment

inhibited the expression of cyclin D1 (a promoter of cell proliferation) and Bcl-2 (an inhibitor of

apoptosis), two important target genes of the STAT3 signaling pathway. Our findings for the first

time demonstrate that Patrinia scabiosaefolia inhibits proliferation and promotes the apoptosis of

cancer cells via inhibition of the STAT3 pathway, which may in part explain its anti-cancer

activity. 入藏号: WOS:000287785800019 语种: English 文献类型: Article 作者关键词: anti-tumor; U266 cells; phytotherapy; signal transducer and activator of transcription

3 pathway; Patrinia scabiosaefolia

KeyWords Plus: INTESTINAL EPITHELIAL-CELLS; EPIDERMAL-GROWTH-FACTOR;

SIGNAL TRANSDUCER; CONSTITUTIVE ACTIVATION; COLORECTAL-CANCER;

MOLECULAR TARGETS; NATURAL-PRODUCTS; DRUG DISCOVERY;

TRANSCRIPTION-3; CARCINOMA 地址: [Peng, Jun; Lin, Jiumao; Zhuang, Qunchuan; Hong, Zhenfeng] Fujian Univ Tradit Chinese

Med, Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China


China


73190 USA

[Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, Oklahoma City, OK

73190 USA 通讯作者地址: Hong, ZF (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, 1

Huatuo Rd, Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE


IDS 号: 727GK

ISSN: 1791-2997






Chen Keji Integrative Medicine CKJ 2010019

This study was sponsored by the Open Fund of Fujian Key Laboratory of Integrative Medicine on

Geriatrics (2008J1004), the Natural Science Foundation of Fujian Province (2010J01195), the

National Natural Science Foundation of China (81073097) and the Developmental Fund of Chen

Keji Integrative Medicine (CKJ 2010019).

第 62 条，共 86 条标题: Chromatographic Fingerprint and Quantitative Analysis of Seven Bioactive Compounds of

Scutellaria barbata

作者: Yao, H (Yao, Hong); Li, SG (Li, Shaoguang); Hu, JA (Hu, Juan); Chen, Y (Chen, Yan);

Huang, LY (Huang, Liying); Lin, JH (Lin, Jianhua); Li, GW (Li, Guangwen); Lin, XH (Lin,

Xinhua) 来源出版物: PLANTA MEDICA 卷: 77 期: 4 页: 388-393 DOI: 10.1055/s-0030-1250353 出版年: MAR 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 23 摘要: Scutellaria barbata D. Don is widely used as a folk antitumor and anti-inflammatory agent

in Asia. However, a simple and global quality control method for S. barbata was lacking. In this

study, six phenolic compounds, including p-coumaric acid, scutellarin, apigenin

5-O-beta-glucopyranoside, luteolin, apigenin and 4'-hydroxywogonin were obtained from S.

barbata by phytochemical investigations. The six compounds plus baicalein show cytotoxcities to

the nine human cancer cells, K562, MGC-803, HL60, SH-SY5Y, SW1116, SMMC-7221, SW480,

HepG2 and KB. Subsequently, a high-performance liquid chromatography with photodiode array

detector (HPLC-DAD) was developed for both fingerprint analysis of S. barbata and quantitative

determination of the seven anticancer active compounds in S. barbata. The chromatographic

separation was accomplished on an Ultimate (TM) XB-C18 column (4.6 x 250 mm, 5 mu m) in 65

min. For fingerprinting, 26 common peaks were found and selected as characteristic peaks to

assess the consistency of S. barbata samples. For quantitative analysis, the seven bioactive

compounds showed good regression relationship (R(2) > 0.999) within test ranges and the

recovery of the method was in the range of 90-105%. In brief, the present study provides the

fingerprint analysis and quantitative methods for global and systematical quality control of S.

barbata for its anticancer usage. 入藏号: WOS:000288116200014 语种: English 文献类型: Article 作者关键词: Scutellaria barbata; Labiatae; chromatographic fingerprint; phenolic components;

cytotoxicity; quantity control; HPLC-DAD

KeyWords Plus: QUALITY-CONTROL; APOPTOSIS; RIVULARIS; CELLS 地址: [Yao, Hong; Li, Shaoguang; Chen, Yan; Huang, Liying; Li, Guangwen; Lin, Xinhua] Fujian

Med Univ, Dept Pharmaceut Anal, Fac Pharm, Fuzhou 350004, Fujian, Peoples R China

[Hu, Juan] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou, Fujian, Peoples R China

[Lin, Jianhua] Fujian Med Univ, Affiliated Hosp 1, Dept Orthoped, Fuzhou 350004, Fujian,

Peoples R China 通讯作者地址: Lin, XH (通讯作者),Fujian Med Univ, Dept Pharmaceut Anal, Fac Pharm,

Fuzhou 350004, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: GEORG THIEME VERLAG KG 出版商地址: RUDIGERSTR 14, D-70469 STUTTGART, GERMANY

Web of Science 分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy

学科类别: Plant Sciences; Pharmacology & Pharmacy

IDS 号: 731NQ

ISSN: 0032-0943

29 字符的来源出版物名称缩写: PLANTA MED

ISO 来源出版物缩写: Planta Med. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构授权号

foundation of National High Technology and Development of China 2007AA02Z4A4

Fujian Provincial Education Department Foundation JA07101

Fujian Provincial Natural Science Foundation 2009J01157

Fujian Provincial Health Department Foundation 2008-1-20

Preclinical Study of Traditional Chinese Medicine and Quality Control

Engineering Technology Center of Fujian Province of China for help in

equipment and technology

2009Y2003

The authors gratefully acknowledge the financial support of the foundation of National High

Technology and Development of China (863 projects: 2007AA02Z4A4), the Fujian Provincial

Education Department Foundation (JA07101) the Fujian Provincial Natural Science Foundation

(2009J01157), the Fujian Provincial Health Department Foundation (2008-1-20) and Preclinical

Study of Traditional Chinese Medicine and Quality Control Engineering Technology Center of

Fujian Province of China for help in equipment and technology (2009Y2003).

第 63 条，共 86 条标题: Formation mechanism of propagated sensation along the meridians, as verified by cortical

somatosensory-evoked potential topographic maps 作者: Xu, JS (Xu, Jinsen); Pan, XH (Pan, Xiaohua); Zheng, SX (Zheng, Shuxia); Hu, XL (Hu,

Xianglong); Sa, ZY (Sa, Zheyan) 来源出版物 : NEURAL REGENERATION RESEARCH 卷 : 6 期 : 6 页 : 435-439 DOI:

10.3969/j.issn.1673-5374.2011.06.006 出版年: FEB 25 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 20 摘要: The peripheral driver stimulating theory states that as a driver passes along a certain

meridian during acupuncture; the driver provokes nerve sense devices along the meridian,

resulting in the nerve impulse entering the central nervous system. Accordingly, volunteers have

reported propagated sensations along the meridians (PSM). The present study was designed to

utilize a cortical somatosensory-evoked potential (CSEP) topographic map for determining

whether stimulation expansion occurs in somatosensory area I when sensation was provoked in

individuals with obvious PSM. The sensation was blocked by mechanical compression, and the

sensation was imitated in individuals without PSM. Results revealed a red, high-potential signal in

the representative area of the lower limbs in individuals with obvious PSM symptoms when the

Gall Bladder Meridian (GBM) sensation passed to the head and face. This representative area was

near the middle line of the CSEP topographic map, and a red, high-potential signal, which jumps

over the representative area of the upper limbs, also appeared in the representative face area,

which was at the external region of the CSEP topographic map. However, in individuals exhibiting

no PSM, only a red high-potential signal appeared in the representative lower limb area. When

Hegu (LI 4) was stimulated in individuals without PSM, an obvious evoked response appeared

only in the representative upper limb area. However, when Hegu was stimulated in individuals

exhibiting PSM, the response area was larger in the representative upper limb area and extended to

the representative face area. When Guangming (GB 37) was stimulated in PSM individuals, the

face representation response disappeared and was confined to a foot representation of the

somatosensory area I when PSM was blocked by mechanical pressure. Results suggested that

mechanical compression blocked PSM, and corresponding changes were exhibited in the CSEP

topographic map. These results provide compelling evidence for the hypothesis that peripheral

driver stimulation is the key element in producing PSM. 入藏号: WOS:000288931100006 语种: English 文献类型: Article 作者关键词: propagated sensation along the meridians; meridian; cortical somatosensory-evoked

potential; evoked potential topographic map

KeyWords Plus: STIMULATION; REPRESENTATION; CORTEX 地址: [Xu, Jinsen; Pan, Xiaohua; Zheng, Shuxia; Hu, Xianglong; Sa, Zheyan] Fujian Acad Tradit

Chinese Med, Key Unit Propagated Sensat Meridian, State Adm Tradit Chinese Med, Fuzhou

350003, Fujian Province, Peoples R China 通讯作者地址: Xu, JS (通讯作者),Fujian Acad Tradit Chinese Med, Key Unit Propagated Sensat

Meridian, State Adm Tradit Chinese Med, Fuzhou 350003, Fujian Province, Peoples R China 电子邮件地址: [email protected] 出版商: SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES 出版商地址: PO BOX 1234, SHENYANG, LIAONING 110004, PEOPLES R CHINA

Web of Science 分类: Cell Biology; Neurosciences 学科类别: Cell Biology; Neurosciences & Neurology

IDS 号: 742HE

ISSN: 1673-5374

29 字符的来源出版物名称缩写: NEURAL REGEN RES

ISO 来源出版物缩写: Neural Regen. Res. 来源出版物页码计数: 5 基金资助致谢:

基金资助机构授权号


Science Research Foundation of Ministry of Health

United Fujian Provincial Health and Education Project WKJ2005-2-004

This study was supported by the National Natural Science Foundation of China, No. 30973720;

the Science Research Foundation of Ministry of Health and United Fujian Provincial Health and

Education Project for Tackling the Key Research of China, No. WKJ2005-2-004.

第 64 条，共 86 条标题: Intrafibrillar Collagen Mineralization Produced by Biomimetic Hierarchical Nanoapatite

Assembly 作者: Liu, Y (Liu, Yan); Li, N (Li, Nan); Qi, YP (Qi, Yi-pin); Dai, L (Dai, Lin); Bryan, TE (Bryan,

Thomas E.); Mao, J (Mao, Jing); Pashley, DH (Pashley, David H.); Tay, FR (Tay, Franklin R.) 来源出版物 : ADVANCED MATERIALS 卷 : 23 期 : 8 页 : 975-980 DOI:

10.1002/adma.201003882 出版年: FEB 22 2011 在 Web of Science 中的被引频次: 4 被引频次合计: 4 引用的参考文献数: 52 入藏号: WOS:000287669000004 语种: English 文献类型: Article

KeyWords Plus: CALCIUM-PHOSPHATE; COMPOSITE SCAFFOLD; MATRIX PROTEIN;

BONE-STRUCTURE; IN-VITRO; FIBRILS; PRECURSOR; HYDROXYAPATITE;

NUCLEATION; NANOSCALE 地址: [Bryan, Thomas E.; Pashley, David H.; Tay, Franklin R.] Med Coll Georgia, Sch Dent, Dept

Oral Biol, Augusta, GA 30912 USA

[Bryan, Thomas E.; Pashley, David H.; Tay, Franklin R.] Med Coll Georgia, Dept Endodont,


[Dai, Lin] First Hosp Wuhan, Dept Stomatol, Wuhan, Peoples R China

[Qi, Yi-pin] Sun Yat Sen Univ, Guanghua Sch Stomatol, Dept Operat Dent & Endodont,

Guangzhou 510275, Guangdong, Peoples R China

[Li, Nan] Fujian Univ Tradit Chinese Med, Coll Osteoped & Traumatol, Fuzhou, Fujian, Peoples

R China


Coll, Wuhan 430074, Peoples R China 通讯作者地址: Tay, FR (通讯作者),Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA

30912 USA 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL

出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA

Web of Science 分类 : Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &

Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed

Matter 学科类别: Chemistry; Science & Technology - Other Topics; Materials Science; Physics

IDS 号: 725TM

ISSN: 0935-9648

29 字符的来源出版物名称缩写: ADV MATER

ISO 来源出版物缩写: Adv. Mater. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构授权号

NIDCR R21 DE019213


This work was supported by grant R21 DE019213 from NIDCR (P.I., F.T.) and the PSRP award

from the Medical College of Georgia. We thank Michelle Barnes for secretarial support, Jongryul

Kim for SEM preparation, and Robert Smith for TEM assistance.

第 65 条，共 86 条标题: Anticolchicine Cytotoxicity Enhanced by Dan Gua-Fang (sic), A Chinese Herb Prescription

in ECV304 in Mediums 作者: Heng, XP (Heng Xian-pei); Chen, KJ (Chen Ke-ji); Hong, ZF (Hong Zhen-feng); He, WD

(He Wei-dong); Chu, KD (Chu Ke-dan); Chen, WL (Chen Wen-lie); Zheng, HX (Zheng Hai-xia);

Yang, LQ (Yang Liu-qing); Chen, L (Chen Ling); Guo, F (Guo Fang) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 2 页 :

126-133 DOI: 10.1007/s11655-011-0646-X 出版年: FEB 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 12 摘要: Objective: To study the effect of anticolchicine cytotoxicity of Dan Gua-Fang (sic), a

Chinese herbal compound prescription on endothelial cells of vein (ECV304) cultivated in

mediums of different glucose concentrations as well as the proliferation of those cells in the same

conditions, in order to reveal the value of Dan Gua-Fang in preventing and treating endothelial

damage caused by hyperglycemia in diabetes mellitus. Methods: The research was designed as

three stages. The growing state and morphological changes were observed when ECV304 were

cultivated in the culture mediums, which have different glucose concentrations with or without

Dan Gua-Fang and at the same time with or without colchicine. Results: (1) Dan Gua-Fang at all

concentrations reduced the floating cell population of ECV304 cultivated in hyperglycemia

mediums. (2) Dan Gua-Fang at all concentrations and hyperglycemia both had a function of

promoting "pseudopod-like" structure formation in cultivated ECV304, but the function was not

superimposed in mediums containing both hyperglycemia and Dan Gua-Fang. (3) Colchicine

reduced and even vanished the "pseudopod-like" structure of the endotheliocyte apparently

cultivated in mediums of hyperglycemia or with Dan Gua-Fang. The "pseudopod-like" structure of

the endotheliocyte emerged quickly in Dan Gua-Fang groups after colchicine was removed, but it

was not the case in hyperglycemia only without Dan Gua-Fang groups. (4) Dan Gua-Fang reduced

the mortality of cells cultivated in mediums containing colchicine. The cell revived to its normal

state fast after colchicine was removed. Conclusion: Dan Gua-Fang has the functions of promoting

the formation of cytoskeleton and fighting against colchicine cytotoxicity. 入藏号: WOS:000286908700009 语种: English 文献类型: Article 作者关键词: Dan Gua-Fang; endothelial cell; colchicine; diabetes mellitus

KeyWords Plus: ENDOTHELIAL-CELLS; HYPERGLYCEMIA 地址: [Heng Xian-pei; He Wei-dong; Chu Ke-dan; Zheng Hai-xia; Yang Liu-qing; Guo Fang]

Fujian Univ, Dept Endocrinol, Peoples Hosp Affiliated, Fuzhou 350004, Peoples R China

[Heng Xian-pei; Chen Ke-ji] China Acad Chinese Med Sci, Beijing 100091, Peoples R China

[Hong Zhen-feng; Chen Ling] Fujian Univ Tradit Chinese Med, Fuzhou 350108, Peoples R China

[Chen Ke-ji; Chen Wen-lie] Fujian Inst Integrat Chinese & Western Med, Fuzhou 350108, Peoples

R China 通讯作者地址: Heng, XP (通讯作者),Fujian Univ, Dept Endocrinol, Peoples Hosp Affiliated,



IDS 号: 715SU

ISSN: 1672-0415



China Postdoctoral Science Foundation 20070410128

CHEN Ke-ji Development Fund of Integrative Medicine CKJ2006001

Science Foundation of Health Department, Fujian Province WZY0618

Supported by the China Postdoctoral Science Foundation (No. 20070410128), CHEN Ke-ji

Development Fund of Integrative Medicine (No. CKJ2006001) and Science Foundation of Health

Department, Fujian Province (No. WZY0618)

第 66 条，共 86 条标题: Hierarchical and non-hierarchical mineralisation of collagen 作者: Liu, Y (Liu, Yan); Kim, YK (Kim, Young-Kyung); Dai, L (Dai, Lin); Li, N (Li, Nan); Khan,

SO (Khan, Sara O.); Pashley, DH (Pashley, David H.); Tay, FR (Tay, Franklin R.) 来源出版物 : BIOMATERIALS 卷 : 32 期 : 5 页 : 1291-1300 DOI:

10.1016/j.biomaterials.2010.10.018 出版年: FEB 2011 在 Web of Science 中的被引频次: 11 被引频次合计: 11 引用的参考文献数: 51 摘要: Biomineralisation of collagen involves functional motifs incorporated in extracellular

matrix protein molecules to accomplish the objectives of stabilising amorphous calcium phosphate

into nanoprecursors and directing the nucleation and growth of apatite within collagen fibrils.

Here we report the use of small inorganic polyphosphate molecules to template hierarchical

intrafibrillar apatite assembly in reconstituted collagen in the presence of polyacrylic acid to

sequester calcium and phosphate into transient amorphous nanophases. The use of polyphosphate

without a sequestration analogue resulted only in randomly-oriented extrafibrillar precipitations

along the fibrillar surface. Conversely, the use of polyacrylic acid without a templating analogue

resulted only in non-hierarchical intrafibrillar mineralisation with continuous apatite strands

instead of discrete crystallites. The ability of using simple non-protein molecules to recapitulate

different levels of structural hierarchy in mineralised collagen signifies the ultimate simplicity in

Nature's biomineralisation design principles and challenges the need for using more complex

recombinant matrix proteins in bioengineering applications. (C) 2010 Elsevier Ltd. All rights

reserved. 入藏号: WOS:000287073000005 语种: English 文献类型: Article 作者关键词: Biomineralisation; Non-protein molecules; Hierarchical intrafibrillar mineralisation;

Crossbanding; Non-hierarchical intrafibrillar mineralisation; Extrafibrillar mineralisation

KeyWords Plus: AMORPHOUS CALCIUM-PHOSPHATE; BIOMINERALIZATION; BONE;

PHOSPHORYLATION; PROTEINS; NUCLEATION; CRYSTALS; FIBRILS; DENTIN;

HYDROXYAPATITE 地址: [Pashley, David H.; Tay, Franklin R.] Med Coll Georgia, Sch Dent, Dept Oral Biol,


[Tay, Franklin R.] Med Coll Georgia, Sch Dent, Dept Endodont, Augusta, GA 30912 USA

[Liu, Yan] Huazhong Univ Sci & Technol, Dept Stomatol, Tongji Hosp, Tongji Med Coll, Wuhan


[Kim, Young-Kyung] Kyungpook Natl Univ, Sch Dent, Dept Conservat Dent, Taegu, South Korea

[Dai, Lin] First Hosp Wuhan, Dept Stomatol, Wuhan, Peoples R China


R China 通讯作者地址: Tay, FR (通讯作者),Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA

30912 USA 电子邮件地址: [email protected] 出版商: ELSEVIER SCI LTD 出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,

OXON, ENGLAND


IDS 号: 717UN

ISSN: 0142-9612

29 字符的来源出版物名称缩写: BIOMATERIALS

ISO 来源出版物缩写: Biomaterials 来源出版物页码计数: 10 基金资助致谢: 基金资助机构授权号

NIDCR R21 DE019213

This work was supported by grant R21 DE019213 from NIDCR (PI. Franklin Tay). We thank

Michelle Barnes for secretarial support, Robert Smith for TEM assistance.

第 67 条，共 86 条标题: Acanthopanax senticosus: review of botany, chemistry and pharmacology 作者 : Huang, LZ (Huang, LinZhang); Zhao, HF (Zhao, HongFang); Huang, BK (Huang,

BaoKang); Zheng, CJ (Zheng, ChengJian); Peng, W (Peng, Wei); Qin, LP (Qin, LuPing) 来源出版物: PHARMAZIE 卷: 66 期: 2 页: 83-97 DOI: 10.1691/ph.2011.0744 出版年: FEB

2011 在 Web of Science 中的被引频次: 3 被引频次合计: 3 引用的参考文献数: 103 摘要: Acanthopanax senticosus (Rupr. et Maxim) Harms (Araliaceae), also called Siberian

Ginseng, Eleutherococcus senticosus, and Ciwujia in Chinese, is a widely used traditional Chinese

herb that could invigorate qi, strengthen the spleen, and nourish kidney in the theory of Traditional

Chinese Medicine. With high medicinal value, Acanthopanax senticosus (AS, thereafter) is

popularly used as an "adaptogen" like Panax ginseng. In recent decades, a great number of

chemical, pharmacological, and clinical studies on AS have been carried out worldwide. Several

kinds of chemical compounds have been reported, including triterpenoid saponins, lignans,

coumarins, and flavones, among which, phenolic compounds such as syringin and eleutheroside E,

were considered to be the most active components. Considerable pharmacological experiments

both in vitro and in vivo have persuasively demonstrated that AS possessed anti-stress, anti-ulcer,

anti-irradiation, anticancer, anti-inflammatory and hepatoprotective activities, etc. The present

review is an up-to-date and comprehensive analysis of the botany, chemistry, pharmacology,

toxicity and clinical trials of AS. 入藏号: WOS:000288052700001 语种: English 文献类型: Review

KeyWords Plus: PERFORMANCE LIQUID-CHROMATOGRAPHY; CELL-DEPENDENT

ANAPHYLAXIS; MACROPHAGES IN-VITRO; ELEUTHEROCOCCUS-SENTICOSUS;

SIBERIAN GINSENG; PANAX-GINSENG; TRITERPENOID SAPONINS;

PLATELET-AGGREGATION; ACTIVE PRINCIPLE; ELEUTHEROSIDE-B 地址: [Huang, LinZhang; Zhao, HongFang; Huang, BaoKang; Zheng, ChengJian; Peng, Wei; Qin,

LuPing] Mil Med Coll 2, Dept Pharmacognosy, Sch Pharm, Shanghai 200433, Peoples R China

[Huang, LinZhang; Zhao, HongFang] Fujian Univ Tradit Chinese Med, Dept Pharm, Sch Pharm,

Fuzhou, Peoples R China 通讯作者地址: Qin, LP (通讯作者),Mil Med Coll 2, Dept Pharmacognosy, Sch Pharm, 325

Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected] 出版商: GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH 出版商地址 : PHARMAZEUTISCCARL MANNICH STR 26, D-65760 ESCHBORN,

GERMANY

Web of Science 分类: Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &

Pharmacy 学科类别: Pharmacology & Pharmacy; Chemistry

IDS 号: 730RU

ISSN: 0031-7144

29 字符的来源出版物名称缩写: PHARMAZIE

ISO 来源出版物缩写: Pharmazie 来源出版物页码计数: 15

第 68 条，共 86 条标题 : Qualitative and Quantitative Analysis of Alkaloids in Cortex Phellodendri by

HPLC-ESI-MS/MS and HPLC-DAD 作者: Zhu, SL (Zhu Shuang-lai); Dou, SS (Dou Sheng-shan); Liu, XR (Liu Xin-ru); Liu, RH (Liu

Run-Hui); Zhang, WD (Zhang Wei-dong); Huang, HL (Huang Hong-lin); Zhang, Y (Zhang Yi);

Hu, YH (Hu Yao-hua); Wang, SP (Wang Shu-ping) 来源出版物: CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 卷: 27 期: 1 页:

38-44 出版年: JAN 25 2011

在 Web of Science 中的被引频次: 2 被引频次合计: 2 引用的参考文献数: 28 摘要: A combined method of high performance liquid chromatograph-elecrtrospray-ionization

mass spectrometer(HPLC-ESI-MS/MS) coupled with a photodiode array detector(HPLC-DAD)

and principal component analysis(PCA) was applied to the qualitative and quantitative analyses of

alkaloids in Cortex Phellodendri(CP) samples, and to the differentiation of two species of CP,

Cortex Phellodendri Chinensis(CPC) and Cortex Phellodendri Amurensis(CPA). Twenty-two

peaks appeared in the HPLC-MS base peak chromatogram of CP detected by the

HPLC-ESI-MS/MS analysis, and the alkaloids were identified according to the MS(n) data, the

known MS fragmentation rules and the literature data. Five alkaloids including berberine,

palmatine, jatrorrhizine, phellodendrine and magnoflorine were simultaneously determinated by

the HPLC-DAD. Berberine was the primary component in all CP samples, and the contents of

berberine and palmatine were exploited to be two critical parameters for effective discrimination

between the two species of CP. The average content of berberine in CPC(58.75 mg/g) was higher

than that in CPA(9.16 mg/g), while the content of palmatine was less, only 0.25 mg/g in CPC and

4.19 mg/g in CPA. With the use of PCA, samples datasets were separated successfully into two

different clusters corresponding to the two species, and berberine, palmatine, phellodendrine and

magnoflorine contribute most to the above mentioned calssifying. The proposed method proved to

be a useful tool in the quality control of Chinese herbal medicines. 入藏号: WOS:000287825400009 语种: English 文献类型: Article 作者关键词 : Cortex Phellodendri; Alkaloid; HPLC-ESI-MS/MS; Quantitative analysis;

Qualitative analysis; Principal component analysis

KeyWords Plus: PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM

MASS-SPECTROMETRY; PROTOBERBERINE ALKALOIDS; IDENTIFICATION;

CHEMOMETRICS; SPECTROSCOPY 地址: [Zhu Shuang-lai; Dou Sheng-shan; Liu Xin-ru; Liu Run-Hui; Zhang Wei-dong; Hu Yao-hua;

Wang Shu-ping] Mil Med Coll 2, Sch Pharm, Shanghai 200433, Peoples R China

[Zhu Shuang-lai; Huang Hong-lin] Jiangxi Univ Tradit Chinese Med, Sch Pharm, Nanchang


[Zhang Wei-dong] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[Hu Yao-hua] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350108, Peoples R China

[Zhang Yi] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 610075, Peoples R China 通讯作者地址: Liu, RH (通讯作者),Mil Med Coll 2, Sch Pharm, Shanghai 200433, Peoples R

China 电子邮件地址: [email protected] 出版商: HIGHER EDUCATION PRESS 出版商地址: SHATANHOU ST 55, BEIJING 100009, PEOPLES R CHINA

Web of Science 分类: Chemistry, Multidisciplinary

学科类别: Chemistry

IDS 号: 727TN

ISSN: 1005-9040

29 字符的来源出版物名称缩写: CHEM RES CHINESE U

ISO 来源出版物缩写: Chem. Res. Chin. Univ. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构授权号


Foundation of Eleventh Five-Year-Plan of China 2008ZX09202-002

Shanghai Leading Academic Discipline Project, China B906

Scientific Foundation of Shanghai City, China 07DZ19702

Supported by the National Natural Science Foundation of China(No.30725045), the Foundation of

Eleventh Five-Year-Plan of China(No.2008ZX09202-002), the Shanghai Leading Academic

Discipline Project, China(No.B906) and the Scientific Foundation of Shanghai City,

China(No.07DZ19702).

第 69 条，共 86 条标题: Bioactivity-guided fractionation for anti-fatigue property of Acanthopanax senticosus 作者: Huang, LZ (Huang, Lin-Zhang); Huang, BK (Huang, Bao-Kang); Ye, Q (Ye, Qi); Qin, LP

(Qin, Lu-Ping) 来源出版物: JOURNAL OF ETHNOPHARMACOLOGY 卷: 133 期: 1 页: 213-219 DOI:

10.1016/j.jep.2010.09.032 出版年: JAN 7 2011 在 Web of Science 中的被引频次: 5 被引频次合计: 5 引用的参考文献数: 27 摘要 : Ethnopharmacological relevance: The root of Acanthopanax senticosus (also called

Eleutherococcus senticosus or Siberian ginseng) has been used extensively in China, Russia and

Japan as an adaptogen to fight against stress and fatigue.

Aim of the study: The present study was designed to ascertain the anti-fatigue property of

Acanthopanax senticosus by load-weighted swimming test, sleep deprivation test, also to isolate

and characterize the active constituents.

Materials and methods: Animals were orally administered with the extract of Acanthopanax

senticosus. The anti-fatigue effects of the four fractions with different polarities from the 80%

ethanol extract, and the different eluates collected from D101 macroporous resin chromatography

and eleutheroside E, were examined based on the weight-loaded swimming capacity (physical

fatigue) and the change of biochemical parameters in ICR mice. Moreover, the active fraction was

later submitted to sleep-deprived mice (mental fatigue).

Results: The results shown that the n-butanol fraction significant extends the swimming time of

mice to exhaustion. Furthermore, the 60% ethanol-water eluate, more purified eleutherosides

(including eleutheroside E. E(2) and derivatives), were the exactly active constituents. Two

compounds were isolated, which were identified as eleutheroside E, E(2).

Conclusions:The eleutherosides possess the potent abilities to alleviate fatigue both in physical

and mental fatigue. Eleutheroside E may be responsible for the pharmacological effect of

anti-fatigue. Furthermore, the possible mechanisms were reduced the level of TG by increasing fat

utilization, delayed the accumulation of blood urea nitrogen (BUN), and increased the LDH to

reduce the accumulation of lactic acid in muscle and then protect the muscle tissue. (C) 2010

Elsevier Ireland Ltd. All rights reserved. 入藏号: WOS:000286854100029 语种: English 文献类型: Article 作者关键词 : Acanthopanax senticosus; Eleutherococcus senticosus; Anti-fatigue;

Bioassay-guided; Sleep-deprived; Behavioral; Macroporous resin

KeyWords Plus: ELEUTHEROCOCCUS-SENTICOSUS; MICE; MEMORY; RATS;

CONSTITUENTS; EXTRACTS; STRESS 地址: [Huang, Lin-Zhang; Huang, Bao-Kang; Ye, Qi; Qin, Lu-Ping] Mil Med Coll 2, Sch Pharm,

Dept Pharmacognosy, Shanghai 200433, Peoples R China

[Huang, Lin-Zhang] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108, Peoples R

China 通讯作者地址: Qin, LP (通讯作者),Mil Med Coll 2, Sch Pharm, Dept Pharmacognosy, 325

Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected] 出版商: ELSEVIER IRELAND LTD 出版商地址: ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO,




IDS 号: 715AZ

ISSN: 0378-8741


ISO 来源出版物缩写: J. Ethnopharmacol. 来源出版物页码计数: 7

第 70 条，共 86 条标题 : Comparison of Adjunctive Naoxintong versus Clopidogrel in Volunteers with the

CYP2C19*2 Gene Mutation Accompanied with Qi Deficiency and Blood Stasis Constitution 作者: Chen, H (Chen, Hui); Yu, GW (Yu, Guangwei); Sun, H (Sun, Hong); Wu, XY (Wu,

Xiaoying); Wang, H (Wang, Huan) 来源出版物: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 页:

1-10 DOI: 10.1155/2011/207034 出版年: 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 26 摘要: This study was to determine the impact of adjunctive Buchang Naoxintong Jiaonang (BNJ)

to clopidogrel on volunteers with the CYP2C19*2 gene mutation accompanied with qi deficiency

and blood stasis (QDBS) constitution. Eighteen males with QDBS constitution were selected, who

were 6 CYP2C19*1/*1, 6 CYP2C19*1/*2, and 6 CYP2C19*2/*2, and signed informed consent.

Results showed that the maximal platelet aggregation (Agg(max)) and 5 min aggregation

(Agg(late)) with 5-mu mol/L ADP in three different CYP2C19*2 genotypes were significantly

decreased after any drug therapy compared with corresponding baseline measurements (all values

P < .05). But percent inhibitions of Agg(max) and Agg(late) (IPAs) in CYP2C19*2/*2 genotype at

4 hours, 24 hours, 3 days, and 7 days after clopidogrel administration were all the lowest among

three CYP2C19*2 genotypes (P < .01), and IPAs in CYP2C19*1/*2 genotype were between

CYP2C19*1/*1 and CYP2C19*2/*2. IPAs had no significant difference among three different

CYP2C19*2 genotypes after BNJ or adjunctive BNJ. In addition, changes of CD62P, PAC1, and

sCD40L were similar to changes of ADP-induced platelet aggregation in three different

CYP2C19*2 genotypes. Conclusion was that adjunctive BNJ to clopidogrel can enhance the

antiplatelet effect in volunteers with the CYP2C19*2 gene mutation. 入藏号: WOS:000293395700001 语种: English 文献类型: Article

KeyWords Plus: PERCUTANEOUS CORONARY INTERVENTION; HEART-DISEASE;

THERAPY; POLYMORPHISMS; AGGREGATION; ASSOCIATION; INHIBITION;

EFFICACY; ASPIRIN; STENTS 地址: [Chen, Hui; Yu, Guangwei; Wu, Xiaoying; Wang, Huan] Fujian Med Univ, Dept Internal

Med, Prov Clin Coll, Fujian Prov Cardiovasc Dis Inst, Fuzhou 350001, Fujian, Peoples R China

[Chen, Hui] Fujian Univ Tradit Chinese Med, Clin Discipline Chinese & Western Integrat Med,


[Sun, Hong] Fujian Prov Hosp, Dept Pharm, Fuzhou 350001, Peoples R China 通讯作者地址: Chen, H (通讯作者),Fujian Med Univ, Dept Internal Med, Prov Clin Coll, Fujian

Prov Cardiovasc Dis Inst, Fuzhou 350001, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: HINDAWI PUBLISHING CORPORATION 出版商地址: 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA


IDS 号: 800VM

ISSN: 1741-427X

29 字符的来源出版物名称缩写: EVID-BASED COMPL ALT

ISO 来源出版物缩写: Evid.-based Complement Altern. Med. 来源出版物页码计数: 10 基金资助致谢: 基金资助机构授权号

Ministry of Health of the People's Republic of China WKJ 2008-2-59

Chinese Medical Association of Clinical Medicine Scientific Research 09010150170

This work was supported by the Ministry of Health of the People's Republic of China of Fujian

Province Health Education Union Scientific Grants (WKJ 2008-2-59) and Chinese Medical

Association of Clinical Medicine Scientific Research Special-Purpose Grants (09010150170).

第 71 条，共 86 条标题: 5-(4-Hydroxy-3-methoxybenzyl)-1,3-thiazolidine-2,4-dione monohydrate 作者: Xiong, LY (Xiong, Li-Yan); Wang, TF (Wang, Ting-Fang); Zheng, LP (Zheng, Li-Ping);

Zhang, CA (Zhang, Chuan); Wang, FC (Wang, Feng-Chun) 来源出版物 : ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS

ONLINE 卷: 67 页: O16-U1454 DOI: 10.1107/S1600536810049895 子辑: Part 1 出版年:

JAN 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 9 摘要 : In the title compound, C(11)H(11)NO(4)S center dot H(2)O, the five-membered

thiazolidine ring is nearly planar, with a maximum deviation of 0.010 (2) angstrom. The dihedral

angle between the thiazolidine and benzene rings is 49.16 (9)degrees. Intermolecular O-H center

dot center dot center dot O and N-H center dot center dot center dot O hydrogen bonding is

present in the crystal structure. 入藏号: WOS:000285628900120 语种: English 文献类型: Article 地址: [Xiong, Li-Yan; Zhang, Chuan] Mil Med Coll 2, Sch Pharm, New Drug Res Ctr, Shanghai


[Wang, Ting-Fang; Zheng, Li-Ping] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350108,

Peoples R China

[Wang, Feng-Chun] Gen Hosp Beijing Mil Command, Dept Med, Beijing 100700, Peoples R

China 通讯作者地址: Zhang, CA (通讯作者),Mil Med Coll 2, Sch Pharm, New Drug Res Ctr, Shanghai

200433, Peoples R China 电子邮件地址: [email protected]

出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA

Web of Science 分类: Crystallography 学科类别: Crystallography

IDS 号: 698XQ

ISSN: 1600-5368

29 字符的来源出版物名称缩写: ACTA CRYSTALLOGR E

ISO 来源出版物缩写: Acta Crystallogr. Sect. E.-Struct Rep. Online 来源出版物页码计数: 9 基金资助致谢: 基金资助机构授权号

Science and Technology Commission of Shanghai 08DZ1970802


2009CB521907

This study was supported by the Science and Technology Commission of Shanghai special

purpose for modernization of traditional Chinese medicine in 2008 (No 08DZ1970802) and the

National Basic Research Program of China (No 2006CB504100 and 2009CB521907).

第 72 条，共 86 条标题 : Ganoderma lucidum Polysaccharides: Immunomodulation and Potential Anti-Tumor

Activities 作者: Xu, ZT (Xu, Zengtao); Chen, XU (Chen, Xiuping); Zhong, ZF (Zhong, Zhangfeng); Chen,

LD (Chen, Lidian); Wang, YT (Wang, Yitao) 来源出版物: AMERICAN JOURNAL OF CHINESE MEDICINE 卷: 39 期: 1 页: 15-27 DOI:

10.1142/S0192415X11008610 出版年: 2011 在 Web of Science 中的被引频次: 13 被引频次合计: 14 引用的参考文献数: 54 摘要: Ganoderma lucidum (G. lucidum), a basidiomycete white rot fungus, has long been

prescribed to prevent and treat various human diseases, particularly in China, Japan, and Korea.

Several classes of bioactive substances have been isolated and identified from G. lucidum, such as

triterpenoids, polysaccharides, nucleosides, sterols, and alkaloids, among others. This paper

examines the potential role of G. lucidum polysaccharide (GLPS) in tumor therapy and the

possible mechanisms involved. Both in vitro and in vivo studies suggested that the anti-tumor

activities of GLPS are mediated by its immunomodulatory, anti-angiogenic, and cytotoxic effects.

GLPS affects immune cells and immune-related cells including B lymphocytes, T lymphocytes,

dendritic cells, macrophages, and natural killer cells. In addition, recent data also suggest that

GLPS suppresses tumorigenesis or inhibits tumor growth through direct cytotoxic effect and

anti-angiogenic actions. However, many questions still need to be answered before both G.

lucidum and GLPS can be widely accepted and used as anti-tumor agents. 入藏号: WOS:000287004800002 语种: English 文献类型: Article 作者关键词: Ganoderma lucidum; Polysaccharides; Immunomodulation; Anti-Angiogenesis;

Anti-Proliferation

KeyWords Plus: ANTI-ANGIOGENIC ACTIVITY; DENDRITIC CELLS; T-LYMPHOCYTES;

CANCER-IMMUNOTHERAPY; IMMUNE FUNCTIONS; LUNG-CANCER;

MACROPHAGES; MECHANISMS; ACTIVATION; EXTRACT 地址: [Xu, Zengtao; Chen, Lidian] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou,

Peoples R China

[Xu, Zengtao; Chen, Xiuping; Zhong, Zhangfeng; Wang, Yitao] Univ Macau, Inst Chinese Med

Sci, Macao, Peoples R China 通讯作者地址: Chen, LD (通讯作者),Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou,

Peoples R China 电子邮件地址: [email protected] 出版商: WORLD SCIENTIFIC PUBL CO PTE LTD 出版商地址: 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE

Web of Science 分类: Integrative & Complementary Medicine; Medicine, General & Internal 学科类别: Integrative & Complementary Medicine; General & Internal Medicine

IDS 号: 716WS

ISSN: 0192-415X

29 字符的来源出版物名称缩写: AM J CHINESE MED

ISO 来源出版物缩写: Am. J. Chin. Med. 来源出版物页码计数: 13 基金资助致谢: 基金资助机构授权号

Macao Science and Technology Development Fund 029/2007/A2

University of Macau UL016A/09-Y2/CMS/WYT01/ICMS

This study was supported by the Macao Science and Technology Development Fund

(029/2007/A2) and Research Fund of the University of Macau

(UL016A/09-Y2/CMS/WYT01/ICMS).

第 73 条，共 86 条标题: Corydalis yanhusuo WT Wang Extract Inhibits MCF-7 Cell Proliferation by Inducing Cell

Cycle G2/M Arrest

作者: Xu, ZT (Xu, Zengtao); Chen, XP (Chen, Xiuping); Zhang, QW (Zhang, Qingwen); Chen,

LDA (Chen, Lidian); Wang, YT (Wang, Yitao) 来源出版物 : AMERICAN JOURNAL OF CHINESE MEDICINE 卷 : 39 期 : 3 页 :

579-586 DOI: 10.1142/S0192415X11009044 出版年: 2011 在 Web of Science 中的被引频次: 2 被引频次合计: 2 引用的参考文献数: 21 摘要: Corydalis yanhusuo W. T. Wang (YHS) is a traditional Chinese herb widely prescribed for

promoting blood circulation, reinforcing vital energy and alleviating pain. Our previous studies

showed that an ethanol extract of YHS inhibits metastasis of breast cancer cells in vitro. In the

present study, the anti-proliferative effect of the extract was determined by MTT assay and the

LDH release was measured with a commercial kit. Intracellular reactive oxygen species (ROS)

production and mitochondrial membrane potential (Delta Psi m) were monitored by

CM-H(2)DCF-DA and JC-1 staining, respectively. Cell cycle was analyzed with propidium iodide

(PI) staining by flow cytometry and protein expressions were measured by Western blotting. The

YHS extract significantly inhibited MCF-7 cell proliferation in a dose-dependent manner.

Significant increase of ROS formation and decrease of Delta Psi m were observed. Furthermore, it

induced MCF-7 cell cycle arrest at the G2/M phases. In addition, the p-cdc-2/cdc-2 protein

expression ratio was increased while Rb and p21 protein expressions were decreased.

The YHS extract inhibited MCF-7 proliferation by inducing G2/M cell cycle arrest, which might

be mediated by inducing ROS formation, decreasing Delta Psi m and regulating cell cycle related

protein expressions. 入藏号: WOS:000290857500013 语种: English 文献类型: Article 作者关键词: Corydalis yanhusuo WT Wang Extract; Proliferation; Reactive Oxygen Species;

Mitochondrial Membrane Potential; Cell Cycle Arrest

KeyWords Plus: METHANOLIC EXTRACT; EPITHELIAL-CELLS; APOPTOSIS; TUBER;

CDC2; PATHWAY; RATS 地址: [Chen, Lidian] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou, Peoples R China

[Xu, Zengtao; Chen, Xiuping; Zhang, Qingwen; Wang, Yitao] Univ Macau, Inst Chinese Med Sci,

Macao, Peoples R China 通讯作者地址: Chen, LD (通讯作者),Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou,

Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: WORLD SCIENTIFIC PUBL CO PTE LTD 出版商地址: 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE

Web of Science 分类: Integrative & Complementary Medicine; Medicine, General & Internal 学科类别: Integrative & Complementary Medicine; General & Internal Medicine

IDS 号: 767LG

ISSN: 0192-415X

29 字符的来源出版物名称缩写: AM J CHINESE MED

ISO 来源出版物缩写: Am. J. Chin. Med. 来源出版物页码计数: 8 基金资助致谢: 基金资助机构授权号

Macao Science and Technology Development Fund 029/2007/A2

University of Macau UL016/09-Y2/CMS/WYT01/ICMS

Fujian University of Traditional Chinese Medicine

This study was supported by the Macao Science and Technology Development Fund

(029/2007/A2) and Research Fund of University of Macau (UL016/09-Y2/CMS/WYT01/ICMS).

Mr. Zengtao Xu was supported by scholarship kindly provided by Fujian University of Traditional

Chinese Medicine.

第 74 条，共 86 条标题: Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic

lupus erythematosus in Chinese population 作者: Liao, LH (Liao, Ling-hong); Zhang, H (Zhang, Hao); Lai, MP (Lai, Man-Po); Chen, SL

(Chen, Shun-Le); Wu, M (Wu, Madeline); Shen, N (Shen, Nan) 来源出版物 : ARTHRITIS RESEARCH & THERAPY 卷 : 13 期 : 1 文献号 : R11 DOI:

10.1186/ar3232 出版年: 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 54 摘要: Introduction: Cytochrome P-450 2E1 (CYP2E1) is an important member of the CYP

superfamily, which is involved in the metabolism and activation of many low molecular weight

toxic compounds. We tried to investigate the possible association of CYP2E1 tag single nucleotide

polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) in a Chinese

Han population.

Methods: The coding and flanking regions of the CYP2E1 gene were scanned for polymorphisms

and tag SNPs were selected. A two-stage case-control study was performed to genotype a total of

876 SLE patients and 680 geographically matched healthy controls (265 cases and 288 controls in

stage I and 611 cases and 392 controls in stage II). SLE associations of alleles, genotypes and

haplotypes were tested by age and sex adjusted logistic regression. The gene transcription

quantitation was carried out for peripheral blood mononuclear cell (PBMC) samples from 120

healthy controls.

Results: Tag SNP rs2480256 was found significantly associated with SLE in both stages of the

study. The "A" allele was associated with slightly higher risk (odds ratio (OR) = 1.165, 95%

confidence interval (CI) 1.073 to 1.265, P = 2.75E-4) and "A/A" genotype carriers were with even

higher SLE risk (OR = 1.464 95% CI 1.259 to 1.702, P = 7.48E-7). When combined with another

tag SNP rs8192772, we identified haplotype "rs8192772-rs2480256/TA" over presented in SLE

patients (OR 1.407, 95% CI 1.182 to 1.675, P = 0.0001) and haplotype "TG" over presented in the

controls (OR 0.771, 95% CI 0.667 to 0.890, P = 0.0004). The gene transcription quantitation

analysis further proved the dominant effect of rs2480256 as the "A/A" genotype showed highest

transcription.

Conclusions: Our results suggest the involvement of CYP2E1 as a susceptibility gene for SLE in

the Chinese population. 入藏号: WOS:000289523500022 语种: English 文献类型: Article

KeyWords Plus: GENOME-WIDE ASSOCIATION; SIB-PAIR FAMILIES;

T-CELL-ACTIVATION; LINKAGE DISEQUILIBRIUM; AUTOIMMU NE-RESPONSE;

SUSCEPTIBILITY GENES; TRICHLOROETHYLENE; SCAN; CYTOCHROME-P450;

VARIANTS 地址: [Chen, Shun-Le; Shen, Nan] Chinese Acad Sci, Joint Mol Rheumatol Lab, Inst Hlth Sci,


[Liao, Ling-hong] Fujian Univ Tradit Chinese Med, Res Base TCM Syndrom, Fuzhou 350108,

Peoples R China

[Zhang, Hao; Lai, Man-Po; Wu, Madeline] Hong Kong Univ Sci & Technol, Dept Biol, Hong

Kong, Hong Kong, Peoples R China

[Zhang, Hao; Lai, Man-Po; Wu, Madeline] Hong Kong Univ Sci & Technol, Ctr Canc Res, Hong

Kong, Hong Kong, Peoples R China

[Chen, Shun-Le; Shen, Nan] Chinese Acad Sci, Shanghai Ren Ji Hosp, Shanghai Inst Biol Sci,


[Chen, Shun-Le; Shen, Nan] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200001, Peoples R

China 通讯作者地址: Shen, N (通讯作者),Chinese Acad Sci, Joint Mol Rheumatol Lab, Inst Hlth Sci,

145 Shan Dong Middle Rd, Shanghai 200001, Peoples R China 电子邮件地址: [email protected] 出版商: BIOMED CENTRAL LTD 出版商地址: 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND

Web of Science 分类: Rheumatology 学科类别: Rheumatology

IDS 号: 750DA

ISSN: 1478-6354

29 字符的来源出版物名称缩写: ARTHRITIS RES THER

ISO 来源出版物缩写: Arthritis Res. Ther. 来源出版物页码计数: 9 基金资助致谢:


Fujian Provincial Department of Science Technology 2010J05071

RGC 471 HKUST6117/01M

HKUST472 CMI03/04.SC03

Mochtar Riady Institute for 473 nanotechnology 06/07.SC01

We acknowledge the financial support of Grant 2010J05071 from Fujian Provincial Department of

Science & Technology, 471 HKUST6117/01M from RGC, Grant CMI03/04.SC03 from

HKUST472 and Grant UPHMSGF 06/07.SC01 from Mochtar Riady Institute for 473

nanotechnology.

第 75 条，共 86 条标题: Design of a DNA electronic logic gate (INHIBIT gate) with an assaying application for Ag+

and cysteine 作者: Zhu, X (Zhu, Xi); Xu, HF (Xu, Huifeng); Gao, XY (Gao, Xiaoyao); Li, XH (Li, Xianghui);

Liu, QD (Liu, Qida); Lin, ZY (Lin, Zhenyu); Qiu, B (Qiu, Bin); Chen, GN (Chen, Guonan) 来源出版物 : CHEMICAL COMMUNICATIONS 卷 : 47 期 : 32 页 : 9080-9082 DOI:

10.1039/c1cc12734a 出版年: 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 40 摘要: A DNA electronic logic gate (INHIBIT gate) with good selectivity and reversibility is

developed based on using Ag+ and Cys as inputs and current signal as output. 入藏号: WOS:000293346700019 语种: English 文献类型: Article

KeyWords Plus: BASE-PAIRS; COLORIMETRIC DETECTION; GOLD NANOPARTICLES;

HG-II; MERCURY(II); CIRCUITS; IONS; OPERATIONS; COMPLEXES; DNAZYMES 地址: [Zhu, Xi; Gao, Xiaoyao; Li, Xianghui; Lin, Zhenyu; Qiu, Bin; Chen, Guonan] Fuzhou Univ,

Dept Chem, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Minist Educ Key Lab Anal &

Detect Food Safety, Fuzhou 350002, Fujian, Peoples R China

[Xu, Huifeng] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Fujian,

Peoples R China

[Liu, Qida] Xi An Jiao Tong Univ, MOE Key Lab Strength & Vibrat, Xian 710049, Peoples R

China 通讯作者地址: Lin, ZY (通讯作者),Fuzhou Univ, Dept Chem, Fujian Prov Key Lab Anal &

Detect Technol Food Sa, Minist Educ Key Lab Anal & Detect Food Safety, Fuzhou 350002,

Fujian, Peoples R China 电子邮件地址: [email protected]; [email protected]

出版商: ROYAL SOC CHEMISTRY 出版商地址: THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE

CB4 0WF, CAMBS, ENGLAND


IDS 号: 800GB

ISSN: 1359-7345

29 字符的来源出版物名称缩写: CHEM COMMUN

ISO 来源出版物缩写: Chem. Commun. 来源出版物页码计数: 3 基金资助致谢: 基金资助机构授权号

NSFC

40875087

20735002

41076059

20975023


Education Department of Fujian Province XSJRC2007-03

JA09116

National Science Foundation of Fujian Province 2009J01023

The authors gratefully acknowledge the financial support of the NSFC (40875087, 20735002,

41076059 and 20975023), the National Basic Research Program of China (No. 2010CB732403),

Education Department of Fujian Province (XSJRC2007-03, JA09116) and National Science

Foundation of Fujian Province (2009J01023).

第 76 条，共 86 条标题: A simple "molecular beacon"-based fluorescent sensing strategy for sensitive and selective

detection of mercury (II) 作者: Xu, HF (Xu, Huifeng); Zhu, X (Zhu, Xi); Ye, HZ (Ye, Hongzhi); Yu, LS (Yu, Lishuang);

Liu, XX (Liu, Xianxiang); Chen, GN (Chen, Guonan) 来源出版物 : CHEMICAL COMMUNICATIONS 卷 : 47 期 : 44 页 : 12158-12160 DOI:

10.1039/c1cc14265h 出版年: 2011 在 Web of Science 中的被引频次: 3 被引频次合计: 3 引用的参考文献数: 23 摘要: A novel fluorescent sensor for the detection of Hg(2+) in aqueous media was developed.

The method takes advantages of the highly selective thymine-Hg(2+)-thymine coordination and

the sensitive "signal-on" structure-switching molecular beacon. 入藏号: WOS:000296342800037 语种: English 文献类型: Article

KeyWords Plus: COLORIMETRIC DETECTION; ION HG2+; GOLD NANOPARTICLES;

AQUEOUS-SOLUTION; DNA; SENSOR; MEDIA 地址: [Xu, Huifeng; Ye, Hongzhi; Yu, Lishuang; Liu, Xianxiang] Fujian Univ Tradit Chinese

Med, Acad Integrat Med, Fuzhou, Fujian, Peoples R China

[Xu, Huifeng; Zhu, Xi; Yu, Lishuang; Chen, Guonan] Fuzhou Univ, Dept Chem, Minist Educ, Key

Lab Anal & Detect Food Safety,Fujian Prov Key, Fuzhou 350002, Fujian, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med,

Fuzhou, Fujian, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: ROYAL SOC CHEMISTRY 出版商地址: THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE

CB4 0WF, CAMBS, ENGLAND


IDS 号: 839CR

ISSN: 1359-7345

29 字符的来源出版物名称缩写: CHEM COMMUN

ISO 来源出版物缩写: Chem. Commun. 来源出版物页码计数: 3 基金资助致谢: 基金资助机构授权号

NSFC

20735002

41076059

20877019

Key Foundation of Education Department of Fujian Province JK2009016


This project was financially supported by the NSFC (20735002, 41076059, 20877019), the Key

Foundation of Education Department of Fujian Province (JK2009016) and the Developmental

Fund of Chen Keji Integrative Medicine (Grant No.CKJ2010022).

第 77 条，共 86 条标题: Effect of Aike Mixture (sic) on the Inflammatory Infiltration in Patients with Chronic

Prostatitis Type III A

作者: Zhang, MJ (Zhang Min-jian); Weng, JF (Weng Jian-fei); Shi, YL (Shi Ya-lei); Cheng, WJ

(Cheng Wan-Jun); Ruan, XJ (Ruan Xiao-jun); Zhang, QY (Zhang Qiu-yong) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 1 页 :

26-30 DOI: 10.1007/s11655-011-0620-7 出版年: JAN 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 10 摘要: Objective: To observe the effect of Aike Mixture ((sic), AKM) on prostatic inflammatory

infiltration in patients with chronic prostatitis type III A (III A-CP/CPPS) and evaluate its

anti-inflammatory action. Methods: A total of 60 patients with III A-CP/CPPS suitable to

operation and differentiated as Chinese medicine Gan (sic)-qi stagnancy syndrome type were

selected. They were assigned with the random number table to two groups equally. Before

operation, the patients in the treated group were administered with Proscar combined with AKM,

but those in the control group treated with Proscar only. Suprapubic transvesical prostatectomy

was performed two weeks later, and prostatic pathological examination was conducted. Results:

Grading of inflammatory cell infiltration showed that the mean grade in the treated group was 0.78

+/- 0.90 grades, which was sihnificantly lower than that in the control group 1.68 +/- 0.87 grades

(P<0.05). However, the two groups were not different in the grades of fibroblast proliferation

(1.50 +/- 0.70 grades vs 1.62 +/- 0.87 grades, P>0.05). Conclusion: AKM could suppress the

inflammatory cell infiltration, be an effective and safe remedy for the treatment of IIIA-CP/CPPS

of Gan-qi stagnancy syndrome type, and worthy for spreading in clinical use. 入藏号: WOS:000286121200005 语种: English 文献类型: Article 作者关键词: Aike Mixture; Chinese medicine; chronic prostatitis; pathology; inflammatory

infiltration 地址: [Zhang Min-jian; Shi Ya-lei; Cheng Wan-Jun; Ruan Xiao-jun; Zhang Qiu-yong] Fujian Coll

Tradit Chinese Med, Peoples Hosp, Fuzhou 350004, Peoples R China

[Weng Jian-fei] Second Fujian Prov Peoples Hosp, Fuzhou 350004, Peoples R China 通讯作者地址: Zhang, MJ (通讯作者),Fujian Coll Tradit Chinese Med, Peoples Hosp, Fuzhou

350004, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA


IDS 号: 705ID

ISSN: 1672-0415


ISO 来源出版物缩写: Chin. J. Integr. Med.


Fujian Provincial Fund of Natural Sciences C0440014

Supported by the Fujian Provincial Fund of Natural Sciences (No. C0440014)

第 78 条，共 86 条标题: Clinical Practice Guideline of Traditional Medicine for Primary Osteoporosis 作者: Xie, YM (Xie Yan-ming); Yuwen, Y (Yuwen Ya); Dong, FH (Dong Fu-hui); Sun, SC (Sun

Shu-chun); Wang, HM (Wang He-ming); Liu, QS (Liu Qing-si); Hua, ZJ (Hua Zhong-jian); Ma,

LX (Ma Liang-xiao); Liao, X (Liao Xing); Xu, GQ (Xu Gui-qin); Zhi, YJ (Zhi Ying-jie); Niu, LF

(Niu Lu-fang); Wu, CS (Wu Chang-sheng) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 1 页 :

52-63 DOI: 10.1007/s11655-011-0613-6 出版年: JAN 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 90 入藏号: WOS:000286121200010 语种: English 文献类型: Article

KeyWords Plus: PERCUTANEOUS VERTEBROPLASTY; POSTMENOPAUSAL WOMEN;

METAANALYSIS; FRACTURES; QUALITY; HEALTH; FALLS 地址: [Xie Yan-ming; Yuwen Ya; Liao Xing; Xu Gui-qin; Zhi Ying-jie; Niu Lu-fang; Wu

Chang-sheng] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R

China

[Dong Fu-hui; Sun Shu-chun] China Acad Chinese Med Sci, Wangjing Hosp, Beijing 100102,

Peoples R China

[Wang He-ming] Fujian Univ Chinese Med, Fuzhou 350108, Peoples R China

[Liu Qing-si] Guangzhou Univ Tradit Chinese Med, Orthoped Hosp, Guangzhou 510405,

Guangdong, Peoples R China

[Hua Zhong-jian] China Tradit Chinese Med Publishing House, Beijing 100013, Peoples R China

[Ma Liang-xiao] Beijing Univ Chinese Med, Beijing 100029, Peoples R China 通讯作者地址: Yuwen, Y (通讯作者),China Acad Chinese Med Sci, Inst Basic Res Clin Med,

Beijing 100700, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA

Web of Science 分类: Integrative & Complementary Medicine

学科类别: Integrative & Complementary Medicine

IDS 号: 705ID

ISSN: 1672-0415



West-Pacific Region of World Health Organization WP/2006/CHN/EDM/3.2/001

Supported by a granted from West-Pacific Region of World Health Organization (No.

WP/2006/CHN/EDM/3.2/001)

第 79 条，共 86 条标题: Association study of interleukin-12A gene polymorphisms with Graves' disease in two

Chinese populations 作者: Guo, T (Guo, Ting); Yang, S (Yang, Shuyu); Liu, N (Liu, Nan); Wang, S (Wang, Shu); Cui,

B (Cui, Bin); Ning, GA (Ning, Guang) 来源出版物 : CLINICAL ENDOCRINOLOGY 卷 : 74 期 : 1 页 : 125-129 DOI:

10.1111/j.1365-2265.2010.03905.x 出版年: JAN 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 1 引用的参考文献数: 33 摘要: Objective Graves' disease (GD) is a common autoimmune disorder and genetic and

environmental factors contributing to its aetiology. The pro-inflammatory cytokine interleukin-12

(IL-12) is believed to be critically involved in the pathogenesis of GD. This study aims to

elucidate the effect of IL-12A gene polymorphisms on GD.

Design and methods A case-control association study of five tag single nucleotide polymorphisms

(SNPs) (rs2243115, rs2243123, rs583911, rs568408 and rs2243143) within the IL-12A gene was

performed in two independent Chinese cohorts. A pilot cohort conducted in Shanghai consisted of

701 patients and 686 controls and a replicate cohort in Xiamen Island included 378 patients and

312 controls. The five SNPs were genotyped by the SNPstream Genotyping Systems and Taqman

PCR method.

Results Polymorphism of rs568408, located at the 3'-UTRregion, was found to have a significant

association with GD in both the cohorts (P(allele) = 2.96 x 10(-7) and Pallele = 0 013 for Shanghai

and Xiamen Island cohorts, respectively). Haplotype analysis showed that the haplotype of the

five SNPs (TTAAG) was associated with a significant risk of GD in both the cohorts (OR = 2.04

and OR = 1.70 for Shanghai and Xiamen Island cohorts, respectively).

Conclusion Our results have established an association between IL-12A polymorphism and GD

susceptibility in the Chinese population.

入藏号: WOS:000285355500017 语种: English 文献类型: Article

KeyWords Plus: SUSCEPTIBILITY; VARIANTS; IL-12; MECHANISMS; CYTOKINES;

MULTIPLE; REGION; IL12B; GAMMA; RISK 地址: [Guo, Ting; Wang, Shu; Cui, Bin; Ning, Guang] Chinese Acad Sci, Shanghai Inst Biol Sci,

Inst Hlth Sci, Lab Endocrine & Metab Dis, Shanghai, Peoples R China

[Guo, Ting; Wang, Shu; Cui, Bin; Ning, Guang] Shanghai Jiao Tong Univ, Sch Med, Shanghai


[Yang, Shuyu] Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med, Univ Town, Fujian,

Peoples R China

[Liu, Nan; Wang, Shu; Cui, Bin; Ning, Guang] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp,

Shanghai Clin Ctr Endocrine & Metab Dis,Shanghai, Shanghai 200030, Peoples R China 通讯作者地址: Ning, GA (通讯作者),197 Ruijin Er Lu, Shanghai 200025, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL PUBLISHING, INC 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA

Web of Science 分类: Endocrinology & Metabolism 学科类别: Endocrinology & Metabolism

IDS 号: 695FH

ISSN: 0300-0664

29 字符的来源出版物名称缩写: CLIN ENDOCRINOL

ISO 来源出版物缩写: Clin. Endocrinol. 来源出版物页码计数: 5 基金资助致谢: 基金资助机构授权号

Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Public

Health 1994DP131044


The present study would not have been possible without the participation of the patients and

healthy volunteers. The study was partly supported by the Key Laboratory for Endocrine and

Metabolic Diseases of Ministry of Public Health (No. 1994DP131044) and National Natural

Science Foundation of China (No. 81070670).

第 80 条，共 86 条标题: Electroacupuncture Protected Pyramidal Cells in Hippocampal CA1 Region of Vascular

Dementia Rats by Inhibiting the Expression of P53 and Noxa 作者: Zhu, YZ (Zhu, Yanzhen); Zeng, YJ (Zeng, Yanjun)

来源出版物: CNS NEUROSCIENCE & THERAPEUTICS 卷: 17 期: 6 页: 599-604 DOI:

10.1111/j.1755-5949.2010.00192.x 出版年: 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 15 摘要: Aim: Clinically electroacupuncture (EA) is proved an effective therapy for vascular

dementia (VD), but their mechanisms remain uncertain. The aim of this study was to determine

whether EA protects pyramidal cells from apoptosis in hippocampus of a VD rat model by

inhibiting the expression of p53 and Noxa. Methods: One month after a VD animal model was

established by bilateral occlusion of common carotid arteries, EA treatment was given at Baihui

(DU20), Dazhui (DU14), and Shenshu (BL23). The learning and memory ability was assessed by

Morris water maze. Neuronal apoptosis in hippocampus was evaluated with hematoxylineosin

(HE) staining, and the expression of p53 and Noxa was analyzed by confocal laser scanning

microscope with immunofluorescence staining. Results: Expressions of p53 and Noxa in the EA

group and sham-operated group were less than in the VD model group (P < 0.01), and the

expression of p53 was positively correlated to expression of Noxa in hippocampus of VD rats (r =

0.918, P < 0.01). EA treatment could reduce the amount of apoptotic neurons in hippocampal CA1

area of rats with VD. The average latency in the Morris water maze test was significantly shorter,

and escape strategies improved from edge and random searches to more linear swim pathway in

the EA group compared with the VD model group (P < 0.01). Conclusions: The increasing

expressions of p53 and Noxa play important roles in the pathogenesis of VD. EA improves

learning and memory ability and protects pyramidal cells from apoptosis by blocking expression

of p53 and Noxa in the hippocampal CA1 region of VD rats. These results suggest a novel

mechanism of EA treatment to VD. 入藏号: WOS:000297316900004 语种: English 文献类型: Article 作者关键词: Apoptosis; Electroacupuncture; p53; Noxa; Vascular dementia

KeyWords Plus: CEREBRAL-ISCHEMIA; APOPTOSIS; DEATH; MEDIATOR; PROTEIN;

GENE 地址: [Zeng, Yanjun] Beijing Univ Technol, Biomech & Med Informat Inst, Beijing 100022,

Peoples R China

[Zhu, Yanzhen] Fujian Univ Tradit Chinese Med, Dept Integrat Med, Fuzhou, Fujian Province,

Peoples R China 通讯作者地址: Zeng, YJ (通讯作者),Beijing Univ Technol, Biomech & Med Informat Inst,

Beijing 100022, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA

Web of Science 分类: Neurosciences; Pharmacology & Pharmacy 学科类别: Neurosciences & Neurology; Pharmacology & Pharmacy

IDS 号: 852AT

ISSN: 1755-5930

29 字符的来源出版物名称缩写: CNS NEUROSCI THER

ISO 来源出版物缩写: CNS Neurosci. Ther. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构授权号

Fujian Provincial Health Department 2005-2-40

This study was supported by fund for Youth Teacher from Fujian Provincial Health Department,

No. 2005-2-40.

第 81 条，共 86 条标题 : Determination of the epimerization rate constant of amygdalin by microemulsion

electrokinetic chromatography 作者: Yu, LS (Yu, Lishuang); Ye, HZ (Ye, Hongzhi); Zheng, LL (Zheng, Lili); Chen, LD (Chen,

Lidian); Chu, KD (Chu, Kedan); Liu, XX (Liu, Xianxiang); Xu, XQ (Xu, Xueqin); Chen, GN

(Chen, Guonan) 来源出版物 : ELECTROPHORESIS 卷 : 32 期 : 2 页 : 218-222 DOI:

10.1002/elps.201000287 出版年: JAN 2011 在 Web of Science 中的被引频次: 2 被引频次合计: 2 引用的参考文献数: 36 摘要 : A new method for separation and determination of amygdalin and its epimer

(neoamygdalin) in the epimerization of amygdalin by MEEKC is proposed. For the chiral

separation of amygdalin and neoamygdalin, a running buffer composed of 80 mM sodium cholate,

5.0% v/v butan-1-ol, 0.5% v/v heptane and 94.5% v/v 30 mM Na(2)B(4)O(7) buffer (pH 9.00) is

proposed. Under optimum conditions, the basic separation of amygdalin and neoamygdalin can be

achieved within 7 min. The calibration curve for amygdalin showed excellent linearity in the

concentration range of 20-1000 mu g/mL with a detection limit of 5.0 mu g/mL (S/N = 3). The

epimerization rate constant of amygdalin in basic microemulsion was first determined by

monitoring the concentration changes of amygdalin, and the epimerization rate constant of

amygdalin was found to be 2 x 10(-3) min(-1) at 25 degrees C under the above optimum

microemulsion conditions. 入藏号: WOS:000287156700003 语种: English 文献类型: Article 作者关键词 : Amygdalin; Electrokinetic chromatography; Epimerization rate constant;

Microemulsion

KeyWords Plus: WATER PARTITION-COEFFICIENTS; CAPILLARY-ELECTROPHORESIS;

LIQUID-CHROMATOGRAPHY; SEPARATION; MICELLAR; OIL; ENANTIOMERIZATION;

SELECTIVITY; CATECHINS; TARTRATE 地址: [Yu, Lishuang; Ye, Hongzhi; Chen, Lidian; Chu, Kedan; Liu, Xianxiang] Fujian Univ Tradit

Chinese Med, Coll Pharm, Fuzhou 350108, Fujian, Peoples R China

[Yu, Lishuang; Zheng, Lili; Xu, Xueqin; Chen, Guonan] Fuzhou Univ, Minist Educ, Key Lab Anal

& Detect Technol Food Safety, Fuzhou 350002, Fujian, Peoples R China

[Yu, Lishuang; Zheng, Lili; Xu, Xueqin; Chen, Guonan] Fuzhou Univ, Dept Chem, Fuzhou

350002, Fujian, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Coll Pharm, Fuzhou

350108, Fujian, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: WILEY-V C H VERLAG GMBH 出版商地址: PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY


IDS 号: 718WH

ISSN: 0173-0835

29 字符的来源出版物名称缩写: ELECTROPHORESIS

ISO 来源出版物缩写: Electrophoresis 来源出版物页码计数: 5 基金资助致谢: 基金资助机构授权号


Key Natural Sciences Foundation of Fujian Province, China D0520001

Natural Sciences Foundation of Fujian Province, China 2010J05020

Key Science and Technology Projects of Fujian Province, China 2009YZ0001-1-1

Program for New Century Excellent Talents in Fujian Province

University XSJRC2007-13

Developmental Fund of Chen Keji Integrative Medicine CKJ2007020ZXYJH200710

This project was financially supported by the National Natural Science Foundation of China

(20735002), the Key Natural Sciences Foundation of Fujian Province, China (D0520001), the

Natural Sciences Foundation of Fujian Province, China (2010J05020) and the Key Science and

Technology Projects of Fujian Province, China (2009YZ0001-1-1), the Program for New Century

Excellent Talents in Fujian Province University (XSJRC2007-13), and the Developmental Fund of

Chen Keji Integrative Medicine (CKJ2007020ZXYJH200710).

第 82 条，共 86 条标题: In vitro antioxidant activities of endophytic fungi isolated from the liverwort Scapania

verrucosa 作者: Zeng, PY (Zeng, P. Y.); Wu, JG (Wu, J. G.); Liao, LM (Liao, L. M.); Chen, TQ (Chen, T.

-Q.); Wu, JZ (Wu, J. Z.); Wong, KH (Wong, K. -H.) 来源出版物: GENETICS AND MOLECULAR RESEARCH 卷: 10 期: 4 页: 3169-3179 DOI:

10.4238/2011.December.20.1 出版年: 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 39 摘要: We investigated in vitro antioxidant activities of 49 endophytic fungi isolated from the

liverwort Scapania verrucosa. Based on morphological and molecular identification, the

endophytic fungi isolated were classified into seven genera (Hypocrea, Penicillium,

Tolypocladium, Chaetomium, Xylaria, Nemania, and Creosphaeria), all belonging to one family

(Xylariaceae). By screening with the 2,2'-azino-di(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS)

decolorization assay, the ethyl acetate extracts of five endophytic fungi (T7, T21, T24, T32, and

T38 strains), which exhibited remarkable Trolox equivalent (TE) antioxidant capacity (ranging

from 997.06 to 1248.10 mu mol TE/g extract), were selected and their antioxidant capacity was

further evaluated by assays for 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging,

hydroxyl radical scavenging, reducing power, and ferrous ion chelating. The ethyl acetate extracts

of two endophytic fungi (T24 and T38) were found to have comparable scavenging abilities on

both DPPH-free radicals (93.9 and 88.7%, respectively, at 50 mu g/mL) and hydroxyl radicals

(97.1 and 89.4%, respectively, at 2 mg/mL) when compared with those of the positive controls

(ascorbic acid and butylated hydroxytoluene, respectively). Although their reducing powers were

similar to that of butylated hydroxytoluene, as indicated by absorbance (0.35 and 0.30 at 50 mu

g/mL, respectively), only the T38 strain's ethyl acetate extract showed ferrous ion chelating ability

(92.9% at 1 mg/mL) comparable to that of the EDTA-2Na control. These endophytic fungi in S.

verrucosa are a potential novel source of natural antioxidants. 入藏号: WOS:000300617600090 语种: English 文献类型: Article 作者关键词: Endophytic fungi; Antioxidant activity; ABTS; DPPH; Scavenging ability; Ferrous

ion chelating ability

KeyWords Plus: RADICAL SCAVENGING ACTIVITY; PESTALOTIOPSIS-MICROSPORA;

EXTRACTS; METABOLITES; ANTIFUNGAL; FOODS 地址: [Zeng, P. Y.; Wu, J. G.; Liao, L. M.; Wu, J. Z.] Fujian Univ Tradit Chinese Med, Acad

Integrat Med, Fuzhou, Peoples R China

[Chen, T. -Q.] Fujian Acad Agr Sci, Inst Edible & Med Fungi, Fuzhou, Peoples R China

[Wong, K. -H.] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong

Kong, Peoples R China 通讯作者地址: Wu, JZ (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou,

Peoples R China 电子邮件地址: [email protected] 出版商: FUNPEC-EDITORA 出版商地址: RUA HUDSON 655, JARDIM CANADA, RIBEIRAO PRETO, SP, BRAZIL

Web of Science 分类: Biochemistry & Molecular Biology; Genetics & Heredity 学科类别: Biochemistry & Molecular Biology; Genetics & Heredity

IDS 号: 897CA

ISSN: 1676-5680

29 字符的来源出版物名称缩写: GENET MOL RES

ISO 来源出版物缩写: Genet. Mol. Res. 来源出版物页码计数: 11 基金资助致谢: 基金资助机构授权号


Fujian Provincial Universities for Haixi Development

Research supported by the Natural Science Foundation of Fujian Province (#2008J0097) and the

Fujian Provincial Universities for Haixi Development (Grant #5). We thank Dr. Lu Ping Qin and

Lei Guo (Second Military Medical University, Shanghai, P. R. China) for their assistance in

identifying the endophytic fungi.

第 83 条，共 86 条标题: In vitro study of inhibitory millimeter wave treatment effects on the TNF-alpha-induced

NF-kappa B signal transduction pathway 作者: Li, XH (Li, Xihai); Wu, GW (Wu, Guangwen); Wu, MX (Wu, Mingxia); Chen, WL (Chen,

Wenlie); Liu, XX (Liu, Xianxiang) 来源出版物: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 卷: 27 期: 1 页:

71-78 DOI: 10.3892/ijmm.2010.549 出版年: JAN 2011 在 Web of Science 中的被引频次: 3 被引频次合计: 4 引用的参考文献数: 25 摘要: Abnormal activation of the nuclear factor-kappa B (NF-kappa B) in chondrocytes initiates

the transcription of inflammatory mediators, promotes their generation and release, and amplifies

initial inflammatory signals. This results in the release of chondral matrix-degrading enzymes and

accelerates the degeneration of articular cartilage. As a non-pharmaceutical and non-invasive

physical therapy regimen, millimeter wave treatment has been successfully used for the treatment

of osteoarthritis. In this study, chondrocytes were derived from the cartilages of knee joints of

4-week-old male Sprague-Dawley rats and were mechanically digested by collagenase type II

treatment for further culture in vitro. The third-passage chondrocytes were stained with toluidine

blue and treated with a gradient of tumor necrosis factor-a (TNF-alpha) for various times.

Chondrocytic activity was measured by MTT assay, and the apoptotic rate of the chondrocytes

was determined with Hocehst 33342 staining to identify effective treatment concentrations and

durations and to establish an apoptosis model for the chondrocytes in response to TNF-a. Using

this model, the chondrocytes were randomly divided to receive millimeter wave treatment for

various times. The apoptotic rate of the chondrocytes was measured by Annexin V-FITC staining

and the protein expression levels of RIP, TAK1, I kappa B kinase (IKK)-beta, I beta B-alpha and

NF-kappa B, were determined by Western blotting. Chondrocytic structure was examined by

transmission electronic microscopy. The apoptotic rates were significantly lower at 4 and 8 h of

treatment than at 0 and 2 h. The expression levels of RIP, TAK1, IKK-B and NF-kappa B were

also significantly lower at 4 and 8 h than at 0 and 2 h, whereas that of I kappa B-alpha was

significantly higher at 4 and 8 h than at 0 and 2 h. Therefore, we can conclude that millimeter

wave treatment can inhibit the activation of the TNF-alpha-mediated NF-kappa B signal

transduction pathway through the down-regulation of RIP, TAK1, IKK-beta and NF-kappa B, and

the up-regulation of I kappa B-alpha, in chondrocytes. 入藏号: WOS:000286293100008 语种: English 文献类型: Article 作者关键词 : osteoarthritis; millimeter wave; chondrocyte; signal transduction; nuclear

factor-kappa B

KeyWords Plus: RHEUMATOID-ARTHRITIS; INFLAMMATORY CYTOKINES; RECEPTOR

ACTIVATOR; SUBCHONDRAL BONE; CHONDROCYTES; EXPRESSION;

OSTEOARTHRITIS; CELLS; DIFFERENTIATION; APOPTOSIS 地址: [Li, Xihai; Wu, Guangwen; Chen, Wenlie; Liu, Xianxiang] Fujian Univ Tradit Chinese

Med, Inst Integrat Med, Fuzhou 350108, Peoples R China

[Wu, Mingxia] Fujian Univ Tradit Chinese Med, Hosp 2, Dept Acupuncture & Moxibust, Fuzhou

350003, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Inst Integrat Med, Fuzhou

350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE


IDS 号: 707NK

ISSN: 1107-3756

29 字符的来源出版物名称缩写: INT J MOL MED

ISO 来源出版物缩写: Int. J. Mol. Med. 来源出版物页码计数: 8 基金资助致谢:


Small Invention and Small Program of Fujian Province

Open Fund of Fujian Key Laboratory of Integrative Medicine on Geriatrics 2008J1004-16

This study was supported by the 2008 Small Invention and Small Program of Fujian Province (no.

1) and the Open Fund of Fujian Key Laboratory of Integrative Medicine on Geriatrics (grant no.

2008J1004-16).

第 84 条，共 86 条标题: Experimental study of low-frequency electroacupuncture-induced differentiation of bone

marrow mesenchymal stem cells into chondrocytes 作者: Wu, GW (Wu, Guangwen); Peng, J (Peng, Jun); Wu, MX (Wu, Mingxia); Li, YR (Li,

Yurong); Huang, YM (Huang, Yunmei); Lin, RH (Lin, Ruhui); Cai, QY (Cai, Qiaoyan); Liu, XX

(Liu, Xianxiang) 来源出版物: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 卷: 27 期: 1 页:

79-86 DOI: 10.3892/ijmm.2010.555 出版年: JAN 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 31 摘要: in the present study, we investigated the effect of low-frequency electroacupuncture (EA) on

the differentiation of bone mesenchymal stem cells (BMSCs) into chondrocytes and the molecular

mechanism involved. We isolated BMSCs from Sprague-Dawley (SD) rat bone marrow.

Third-generation SD rat BMSCs (P3 BMSCs) were harvested and characterized by flow

cytometry with FITC staining. Data indicated that the positive rates of CD90 and CD45 were

98.22 and 1.91%, respectively, indicating the high purity of the BMSCs. The P3 BMSCs were

treated with EA for 15 or 30 min daily for 7 or 14 days. Using optical microscopy and

transmission electron microscopy, we found that EA induced morphological changes in the

BMSCs, displaying typical morphology of early chondrocytes. In addition, we found that the

cytoplasm and extracellular matrices were metachromatically stained by toluidine blue in the

treated cells in a dose-dependent manner, indicating that EA treatment resulted in the expression

of glycosaminoglycan. Furthermore, upon immunohistocyto-chemical staining and Western

blotting, we found that EA treatment significantly and dose-dependently induced expression of

chondrocyte-specific matrix protein type II collagen, which may have been mediated by the

transcription factor Sox9, as the mRNA expression of Sox9 was found to be significantly

increased after EA treatment. Taken together, these results suggest that EA can be employed as a

novel non-drug-inducing method for the differentiation of BMSCs into chondrocytes. 入藏号: WOS:000286293100009 语种: English 文献类型: Article 作者关键词: bone mesenchymal stem cells; low-frequency electroacupuncture; differentiation;

chondrocytes; tissue engineering

KeyWords Plus: II COLLAGEN; UMBILICAL-CORD; STROMAL CELLS; TISSUE; SOX9;

OSTEOARTHRITIS; ACUPUNCTURE; EXPRESSION; MOUSE; CHONDROGENESIS 地址: [Wu, Guangwen; Peng, Jun; Wu, Mingxia; Huang, Yunmei; Lin, Ruhui; Cai, Qiaoyan; Liu,

Xianxiang] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Peoples R

China

[Li, Yurong] Fuzhou Univ, Inst Precis Instruments, Fuzhou 350002, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, 1

Huatuo Rd, Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE


IDS 号: 707NK

ISSN: 1107-3756

29 字符的来源出版物名称缩写: INT J MOL MED

ISO 来源出版物缩写: Int. J. Mol. Med. 来源出版物页码计数: 8 基金资助致谢: 基金资助机构授权号

Fujian Province Small Creations and Projects

Fujian Provincial Health Department WZZG0601

This research was supported by 2008 Fujian Province Small Creations and Projects (no.1) and Key

Project of Traditional Chinese Medicine of Fujian Provincial Health Department (WZZG0601).

第 85 条，共 86 条标题: Cognitive Obstacles Against Organ Donation: The Influence of Negative Attitudes, Norms,

and Traditional Beliefs on Chinese People's Intention to Donate Organs after Death 作者: Wu, AMS (Wu, Anise M. S.); Lu, LS (Lu, Lu-Sha) 来源出版物: JOURNAL OF COMMUNITY & APPLIED SOCIAL PSYCHOLOGY 卷: 21 期:

1 页: 87-93 DOI: 10.1002/casp.1054 出版年: JAN-FEB 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 21 摘要: In China, the organ supply is severely insufficient to cover all people on the waiting list for

donated organs, and numerous patients die awaiting transplant. To achieve a better understanding

of cadaveric organ donation in Chinese culture, this study examined 300 Chinese adults, in both

Fujian Province and Macao, regarding attitudes towards organ donation, subjective norms about

organ donation and traditional beliefs about the body and death, examining the influences of these

factors on respondents' donation intentions. Multiple hierarchical regression results suggest that

more negative attitudes, unfavourable norms and traditional beliefs lead to lower donation

intentions. Copyright (C) 2010 John Wiley & Sons, Ltd. 入藏号: WOS:000285310300007 语种: English 文献类型: Article 作者关键词: organ donation; intention; attitudes; norms; beliefs

KeyWords Plus: PLANNED BEHAVIOR; KNOWLEDGE; STUDENTS; DONORS 地址: [Wu, Anise M. S.] Lingnan Univ, Dept Sociol & Social Policy, Hong Kong, Hong Kong,

Peoples R China

[Lu, Lu-Sha] Fujian Univ Tradit Chinese Med, Fujian, Peoples R China 通讯作者地址: Wu, AMS (通讯作者),Lingnan Univ, Dept Sociol & Social Policy, Hong Kong,

Hong Kong, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA

Web of Science 分类: Psychology, Social 学科类别: Psychology

IDS 号: 694PO

ISSN: 1052-9284

29 字符的来源出版物名称缩写: J COMMUNITY APPL SOC

ISO 来源出版物缩写: J. Community Appl. Soc. Psychol. 来源出版物页码计数: 7

第 86 条，共 86 条标题: SERS spectra of a single nasopharyngeal carcinoma cell based on intracellularly grown and

passive uptake Au nanoparticles 作者: Huang, H (Huang, Hao); Chen, WW (Chen, Weiwei); Pan, JJ (Pan, Jianji); Chen, QS (Chen,

Qisong); Feng, SY (Feng, Shangyuan); Yu, Y (Yu, Yun); Chen, YP (Chen, Yanping); Su, Y (Su,

Ying); Chen, R (Chen, Rong) 来源出版物 : SPECTROSCOPY-BIOMEDICAL APPLICATIONS 卷 : 26 期 : 3 页 :

187-194 DOI: 10.3233/SPE-2011-0540 出版年: 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 23 摘要: The intracellularly-grown-Au-nanoparticles (IGAuNs) technique was employed to analyze

the surface-enhanced Raman scattering (SERS) spectra of nasopharyngeal carcinoma cells

(CNE-1 cell line). There are only six obvious Raman bands (718, 1001, 1123, 1336, 1446, 1660

cm(-1)) in the normal Raman spectrum of living CNE-1 cells. However, over twenty SERS

Raman bands have been detected in the SERS spectra of IGAuNs-induced cells, among which five

bands are of the DNA backbone (673, 1097, 1306, 1336 and 1585 cm(-1)). There are four

vibrations of the DNA backbone (1026, 1097, 1336 and 1585 cm-1) in the SERS spectra of living

CNE-1 cells induced by the passive uptake gold nanoparticles (PUAuNS), but one more DNA

backbone and many nucleus Raman peaks appeared in the IGAuNs-induced SERS spectra. Many

Raman peaks in the PUAuNs-induced SERS spectra are stronger than those in the

IGAuNs-induced ones. This study has shown that the PUAuNs technique can achieve stronger

Raman signals, and that the IGAuNs technique can enable the gold element to access to the

nucleus more easily, which could help to obtain more surface-enhanced Raman signals of the

intracellular biochemical molecules. Thus, the two techniques can work together to attain the

Raman spectral information of the cytoplasm and the nucleus in a better way, which might provide

a sensitive method for broad biomedical applications such as intracellular SERS analysis of living

cells. 入藏号: WOS:000299109400005 语种: English 文献类型: Article 作者关键词 : Surface-enhanced Raman scattering (SERS); intracellularly grown gold

nanoparticles (IGAuNs); passively uptaken gold nanoparticles (PUAuNS); nasopharyngeal

carcinoma cell

KeyWords Plus: ENHANCED RAMAN-SPECTROSCOPY; LIVING CELLS; LIVE CELLS;

NANOSENSORS; SCATTERING; TISSUES 地址: [Chen, Weiwei; Feng, Shangyuan; Yu, Yun; Chen, Rong] Fujian Normal Univ, Key Lab

Optoelect Sci & Technol Med, Minist Educ, Fujian Prov Key Lab Photon Technol, Fuzhou


[Huang, Hao; Chen, Weiwei; Yu, Yun] Fujian Univ Tradit Chinese Med, Coll Integrated Tradit

Chinese & Western Med, Fuzhou, Peoples R China

[Pan, Jianji; Chen, Qisong; Su, Ying] Fujian Prov Canc Hosp, Fuzhou, Peoples R China

[Chen, Yanping] Fujian Prov Tumor Hosp, Fuzhou, Peoples R China 通讯作者地址: Feng, SY (通讯作者),Fujian Normal Univ, Key Lab Optoelect Sci & Technol

Med, Minist Educ, Fujian Prov Key Lab Photon Technol, Fuzhou 350007, Peoples R China 电子邮件地址: [email protected] 出版商: IOS PRESS 出版商地址: NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS

Web of Science 分类: Biochemical Research Methods; Spectroscopy 学科类别: Biochemistry & Molecular Biology; Spectroscopy

IDS 号: 876LQ

ISSN: 0712-4813

29 字符的来源出版物名称缩写: SPECTROSC-BIOMED APP

ISO 来源出版物缩写: Spectrosc.-Biomed. Appl.


National Natural Science Foundation of China

11104030

61178090

81101110

Project of Fujian Province

2008J0016

2009J01276

JA11055

Science Foundation of Ministry of Health

United Fujian Provincial Health and Education Project for Tackling the Key

Research WKJ2008-2-046

State Key Laboratory of Physical Chemistry of Solid Surface and Fujian Key

Lab. of Semiconductors and Applications, Xiamen University

The study was supported by the National Natural Science Foundation of China (Nos 11104030,

61178090, 81101110), the Project of Fujian Province (Nos 2008J0016, 2009J01276, JA11055), the

Project of Science Foundation of Ministry of Health and United Fujian Provincial Health and

Education Project for Tackling the Key Research (No. WKJ2008-2-046), and the Project of State

Key Laboratory of Physical Chemistry of Solid Surface and Fujian Key Lab. of Semiconductors

and Applications, Xiamen University. We greatly appreciate all the support of the above

organizations and the assistance from Dr. Haishan Zeng and Dr. Zhiwei Huang.

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