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Programa XIII para la financiación de Grupos de Investigación Reconocidos.

ANEXO 1. Listado de Publicaciones

Datos del Grupo de Investigación Reconocido (GIR) solicitante

Nombre del GIR solicitante CANCIRMED

Investigador/a responsable de GIR

Prof. Francisco Javier García Criado

NOTA: Aunque se admitirá un formato libre para relacionar las publicaciones, se recomienda utilizar el siguiente formato:

Requisitos:

1. En todo caso se deberán consignar los autores con indicación, si procede, del GIR de la USAL al quepertenecen, título de la publicación, nombre de la revista o libro, ISBN, ISSN y fecha de publicación. Utilicetantas páginas como sean necesarias.

2. Los libros se valorarán sólo en el caso de las publicaciones de GIR de las ramas de conocimiento de CienciasSociales y Jurídicas y Artes y Humanidades. Para acreditar la calidad de libros y monografías deberáincorporar con la solicitud las evidencias de calidad que considere necesarias. No se valorarán libros quesean actas de congresos.

3. En el caso de publicaciones compartidas con otros GIR indíquese cuáles son.

4. Las publicaciones se organizarán por anualidades, siguiendo el siguiente orden:

-Nivel de la publicación (A, B, C):

-Nombre de otros GIR participantes en la publicación, aparte del solicitante, con indicación del nombre de su responsable:

-Autores (p.o. de firma) con indicación, si procede, del GIR de la USAL al que pertenecen:

-Título del trabajo:

-Revista : (indicar nombre) -Libro (indicar título)

-ISBN /ISSN:

-Clave*: -Volumen: -Páginas, inicial: final:

-Fecha de publicación:

-Editorial (si libro):

-Lugar de publicación:

*( CLAVE: L = libro completo, CL = capítulo de libro, A = artículo, R = “review”, E = editor,S = Documento Científico-

Técnico restringido. )

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Los autores que aparecen subrayados pertenecen al GIR “CANCIRMED” de la Universidad de Salamanca.

2016

Nivel de la publicación A

Misiewicz-Krzeminska I, Sarasquete ME, Vicente Duenas C, Krzeminski P, Wiktorska K, Corchete L, Quwaider D, Rojas E, Corral R, Martin AA, Escalante F, Barez A, Garcia JL, Sanchez-Garcia I, Garcia-Sanz R, San-Miguel JF, Gutierrez NC. Post-transcriptional modifications contribuye to the overexpression of cyclin D2 in multiple myeloma. Clin Cancer Res. 2016 Jan 1;22(1):207-17. Clave A. IF: 8.722 (Q1/D1)

Klionsky DJ, Abdelmohsen K, several authors, Lazo PA, several authors. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222. Q1

Robles EF, Mena-Varas M, Barrio L, Merino-Cortes SV, Balogh P, Du MQ, Akasaka T, Parker A, Roa S, Panizo C, Martin-Guerrero I, Siebert R, Segura V, Agirre X, Macri-Pellizeri L, Aldaz B, Vilas-Zornoza A, Zhang S, Moody S, Calasanz MJ, Tousseyn T, Broccardo C, Brousset P, Campos-Sanchez E, Cobaleda C, Sanchez-Garcia I, Fernandez-Luna JL, Garcia-Muñoz R, Pena E, Bellosillo B, Salar A, Baptista MJ, Hernandez-Rivas JM, Gonzalez M, Terol MJ, Climent J, Ferrandez A, Sagaert X, Melnick AM, Prosper F, Oscier DG, Carrasco YR, Dyer MJ, Martinez-Climent JA. Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics. Nat Commun. 2016 Jun 14;7:11889. doi: 10.1038/ncomms11889. IF: 11,329 (Q1/D1)

Novo-Veleiro I, Cieza-Borrella C, Pastor I, Chamorro AJ, Laso FJ, González-Sarmiento R, Marcos M. A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men. PLoS One. 2016 Dec 19;11(12):e0168685. FI: 3,234 / Q1

Arriba M, García JL, Rueda D, Pérez J, Brandariz L, Nutu OA, Alonso L, Rodríguez Y, Urioste M, González-Sarmiento R, Perea J. Unsupervised Analysis of Array Comparative Genomic Hybridization Data from Early-Onset Colorectal Cancer Reveals Equivalence with Molecular Classification and Phenotypes. Neoplasia. 2016 Dec 14;19(1):28-34. FI: 4.509 / Q1

Fernández-Mateos J, Seijas-Tamayo R, Mesía R, Taberna M, Pastor Borgoñón M, Pérez-Ruiz E, Adansa Klain JC, Vázquez Fernández S, Del Barco Morillo E, Lozano A, González Sarmiento R, Cruz-Hernández JJ; Spanish Head and Neck Cancer Cooperative Group (TTCC). Epidermal growth factor receptor (EGFR) pathway polymorphisms as predictive markers of cetuximab toxicity in locally advanced head and neck squamous cell carcinoma (HNSCC) in a Spanish population. Oral Oncol. 2016 Dec;63:38-43. FI: 4.286 / Q1

Bueno E, Cañueto J, García-Patos V, Vicente MA, Bodet-Castillo D, Hernández-Ruíz ME, González-Sarmiento R. Novel mutations in FATP4 gene in two families with ichthyosis prematurity syndrome. J Eur Acad Dermatol Venereol. 2017 Jan;31(1):e11-e13. FI: 3,10 / Q1

Perea J, Arriba M, Rueda D, Sánchez R, García JL, Pérez J, Rodríguez Y, González-Sarmiento R, Urioste M. Comment on 'Wild-type APC prediction of poor prognosis in microsatellite-stable proximal colorectal cancer differs according to the age of onset'. Br J Cancer. 2016 May 10;114(10):e7. FI: 5.569 / Q1

Anadón C, Guil S, Simó-Riudalbas L, Moutinho C, Setien F, Martínez-Cardús A, Moran S, Villanueva A, Calaf M, Vidal A, Lazo PA, Zondervan I, Savola S, Kohno T, Yokota J, Ribas de Pouplana L, Esteller M. Gene amplification-associated

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overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis. Oncogene. 2016 Aug 18;35(33):4422. FI: 8,459 / Q1

Moura DS, Fernández IF, Marín-Royo G, López-Sánchez I, Martín-Doncel E, Vega FM, Lazo PA. Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation. Sci Rep. 2016 Jun 23;6:28532. FI: 5,578 / Q1

Monsalve DM, Campillo-Marcos I, Salzano M, Sanz-García M, Cantarero L, Lazo PA. VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage. Biochim Biophys Acta. 2016 Apr;1863(4):760-9. FI: 4,49 / Q1

Anadón C, Guil S, Simó-Riudalbas L, Moutinho C, Setien F, Martínez-Cardús A, Moran S, Villanueva A, Calaf M, Vidal A, Lazo PA, Zondervan I, Savola S, Kohno T, Yokota J, de Pouplana LR, Esteller M. Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis. Oncogene. 2016 Aug 18;35(33):4407-13. FI: 8,459 / Q1

Cañueto J, Cardeñoso-Álvarez E, García-Hernández JL, Galindo-Villardón P, Vicente-Galindo P, Vicente-Villardón JL,

Alonso-López D, De Las Rivas J, Valero J, Moyano-Sáez E, Fernández-López E, Mao JH, Castellanos-Martín A, Román-

Curto C, Pérez-Losada J. miR-203 and miR-205 expression patterns identify subgroups of prognosis in cutaneous

squamous cell carcinoma. Br J Dermatol. 2016 Dec 11.

FI: 3,75 / Q1

Cañueto J, Cardeñoso E, García JL, Santos-Briz Á, Castellanos-Martín A, Fernández-López E, Blanco Gómez A, Pérez-

Losada J, Román-Curto C. EGFR expression is associated with poor outcome in cutaneous squamous cell carcinoma. Br

J Dermatol. 2016 Aug 11.

FI: 3,75 / Q1

Blanco-Gómez A, Castillo-Lluva S, Del Mar Sáez-Freire M, Hontecillas-Prieto L, Mao JH, Castellanos-Martín A, Pérez-Losada J. Missing heritability of complex diseases: Enlightenment by genetic variants from intermediate phenotypes. Bioessays. 2016 Jul;38(7):664-73. IF: 4.927 (Q1)

Mesía R, Garcia-Saenz JA, Lozano A, Pastor M, Grau JJ, Martínez-Trufero J, Lambeaz J, Martínez-Galán J, Mel JR, González B, Vázquez S, Mañós M, Taberna M, Cirauqui B, Barco ED, Casado E, Rubió-Casadevall J, Rodríguez-Jaráiz A, Cruz JJ; Spanish Head And Neck Cancer Cooperative Group (Study TTCC-2007/02). Could the Addition of Cetuximab to Conventional Radiation Therapy Improve Organ Preservation in Those Patients With Locally Advanced Larynx Cancer Who Respond to Induction Chemotherapy? An Organ Preservation Spanish Head and Neck Cancer Cooperative Group Phase 2 Study. Int J Radiat Oncol Biol Phys. 2016 Nov 17. pii: S0360-3016(16)33439-3. FI: 4.495 / Q1

Fonseca PJ, Carmona-Bayonas A, García IM, Marcos R, Castañón E, Antonio M, Font C, Biosca M, Blasco A, Lozano R, Ramchandani A, Beato C, de Castro EM, Espinosa J, Martínez-García J, Ghanem I, Cubero JH, Manrique IA, Navalón FG, Sevillano E, Manzano A, Virizuela J, Garrido M, Mondéjar R, Arcusa MÁ, Bonilla Y, Pérez Q, Gallardo E, Del Carmen Soriano M, Cardona M, Lasheras FS, Cruz JJ, Ayala F. A nomogram for predicting complications in patients with solid tumours and seemingly stable febrile neutropenia. Br J Cancer. 2016 May 24;114(11):1191-8. doi: 10.1038/bjc.2016.118. FI: 5.569 / Q1

Camps C, Albanell J, Antón A, Aranda E, Carrato A, Cassinello J, Castellano D, Cruz JJ, Garrido P, Guillem V, Grávalos C, López G, Llorente C, Lorenzo A, Lluch A, Ignacio E, Díaz-Rubio E. Quality Indicators to Assure and Improve Cancer Care in Spain Using the Delphi Technique. J Natl Compr Canc Netw. 2016 May;14(5):553-8. FI: 4.262 / Q1

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Mesía R, Vázquez S, Grau JJ, García-Sáenz JA, Lozano A, García C, Carles J, Irigoyen A, Mañós M, García-Paredes B, del Barco E, Taberna M, Escobar Y, Cruz JJ; Spanish Head and Neck Cancer Cooperative Group (TTCC). A Phase 2 Open Label, Single-Arm Trial to Evaluate the Combination of Cetuximab Plus Taxotere, Cisplatin, and 5-Flurouracil as an Induction Regimen in Patients With Unresectable Squamous Cell Carcinoma of the Head and Neck. Int J Radiat Oncol Biol Phys. 2016 Feb 1;94(2):289-96. FI: 4.495 / Q1

Nivel de la publicación B

Idoia García-Ramírez , Alberto Martín-Lorenzo, Inés González-Herrero, Guillermo Rodriguez-Hernández, Carolina Vicente-Dueñas,* and Isidro Sánchez-García *. Could Vitamin D Analogues Be Used to Target Leukemia Stem Cells? Int. J. Mol. Sci. 2016, 17(6), 889; doi: 10.3390/ijms17060889 (*) Carolina Vicente-Dueñas and Isidro Sanchez-García should be considered as corresponding authors. Clave R IF: 2.862 (Q2) Schüz J, Dasenbrock C, Ravazzani P, Röösli M, Schär P, Bounds PL, Erdmann F, Borkhardt A, Cobaleda C, Fedrowitz M, Hamnerius Y, Sanchez-Garcia I, Seger R, Schmiegelow K, Ziegelberger G, Capstick M, Manser M, Müller M, Schmid CD, Schürmann D, Struchen B, Kuster N. Extremely low-frequency magnetic fields and risk of childhood leukemia: A risk assessment by the ARIMMORA consortium. Bioelectromagnetics. 2016 Mar 15. doi: 10.1002/bem.21963. IF: 1,583 (Q2) Gong Y, Capstick M, Dasenbrock C, Fedrowitz M, Cobaleda C, Sánchez-García I, Kuster N. Comparative dosimetry for children and rodents exposed to extremely low-frequency magnetic fields. Bioelectromagnetics. 2016 Jul;37(5):310-22. doi: 10.1002/bem.21976. IF: 1,583 (Q2) Perea J, Arriba M, Rodríguez Y, Rueda D, García JL, Pérez J, González-Sarmiento R, Urioste M. Frequency and impact of KRAS mutation in early onset colorectal cancer.Hum Pathol. 2016 Nov 2. pii: S0046-8177(16)30274-X. FI: 2.791 / Q2 Gomez-Marcos MA, Martinez-Salgado C, Gonzalez-Sarmiento R, Hernandez-Rivas JM, Sanchez-Fernandez PL, Recio-Rodriguez JI, Rodriguez-Sanchez E, García-Ortiz L. Association between different risk factors and vascular accelerated ageing (EVA study): study protocol for a cross-sectional, descriptive observational study. BMJ Open. 2016 Jun 7;6(6):e011031 FI: 1,58 / Q2 Novo-Veleiro I, Alvela-Suárez L, Chamorro AJ, González-Sarmiento R, Laso FJ, Marcos M. Alcoholic liver disease and hepatitis C virus infection. World J Gastroenterol. 2016 Jan 28;22(4):1411-20. FI: 2.787 / Q2 Blanco F, Muriel C, Labrador J, Gonzalez-Porras JR, Gonzalez-Sarmiento R, Lozano FS. Influence of UGT2B7, CYP3A4, and OPRM1 Gene Polymorphisms on Transdermal Buprenorphine Pain Control in Patients with Critical Lower Limb Ischemia Awaiting Revascularization. Pain Pract. 2016 Sep;16(7):842-9. doi: 10.1111/papr.12343. FI: 2.317 / Q2

Nivel de la publicación C

Auer F, Ingenhag D, Bhatia S, Enczmann J, Cobaleda C, Sanchez-Garcia I, Borkhardt A, Hauer J. GEMMs addressing Pax5 loss-of-function in childhood pB-ALL. Eur J Med Genet. 2016 Mar;59(3):166-72. doi: 10.1016/j.ejmg.2015.11.009. Clave R. IF: 1.466 (Q3)

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López-Valverde G, Garcia-Martin E, Fernández-Mateos J, Cruz-González F, Larrosa-Povés JM, Polo-Llorens V, Pablo-Júlvez LE, González-Sarmiento R. Study of association between pre-senile cataracts and rs11615 of ERCC1, rs13181 of ERCC2, and rs25487 of XRCC1 polymorphisms in a Spanish population. Ophthalmic Genet. 2016 Sep 26:1-6. FI: 1.07 / Q3 Al-Ali R, González-Sarmiento R. Proximity of AUG sequences to initiation codon in genomic 5' UTR regulates mammalian protein expression. Gene. 2016 Dec 15;594(2):268-271. FI: 2,08 / Q3 Cubino N, Montilla C, Usategui-Martín R, Cieza-Borrela C, Carranco T, Calero-Paniagua I, Quesada A, Cañete JD, Queiro R, Sánchez MD, Hidalgo C, Martínez O, Del Pino-Montes J, Díaz-Álvarez A, González-Sarmiento R. Association of IL1Β (-511 A/C) and IL6 (-174 G > C) polymorphisms with higher disease activity and clinical pattern of psoriatic arthritis. Clin Rheumatol. 2016 Jul;35(7):1789-94. FI: 2.042 / Q3 Noguera-Morel L, Feito-Rodríguez M, Maldonado-Cid P, García-Miñáur S, Kamsteeg EJ, González-Sarmiento R, De Lucas-Laguna R, Hernández-Martín A, Torrelo A. Two Cases of Autosomal Recessive Congenital Ichthyosis due to CYP4F22 Mutations: Expanding the Genotype of Self-Healing Collodion Baby. Pediatr Dermatol. 2016 Mar-Apr;33(2):e48-51 FI: 1.163 / Q3 de Juan-Marcos L, Escudero-Domínguez FA, Hernández-Galilea E, Cruz-González F, Follana-Neira I, González-Sarmiento R. Investigation of Association between Autophagy-Related Gene Polymorphisms and Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in a Spanish Population. Semin Ophthalmol. 2016 Dec 14:1-6. FI: 1.184 / Q4 Cruz-Gonzalez F, Cabrillo-Estevez L, Rivero-Gutierrez V, Sanchez-Jara A, De Juan-Marcos L, Gonzalez-Sarmiento R. Influence of CFH, HTRA1 and ARMS2 polymorphisms in the response to intravitreal ranibizumab treatment for wet age-related macular degeneration in a Spanish population. Int J Ophthalmol. 2016 Sep 18;9(9):1304-9. FI: 0.939 / Q4 Usategui-Martín R, Calero-Paniagua I, García-Aparicio J, Corral-Gudino L, Del Pino Montes J, González Sarmiento R. VAV3 Gene Polymorphism Is Associated with Paget's Disease of Bone. Genet Test Mol Biomarkers. 2016 Jun;20(6):335-7. FI: 1.297 / Q4 Cañueto J, Cardeñoso-Álvarez E, Cosano-Quero A, Santos-Briz Á, Fernández-López E, Pérez-Losada J, Román-Curto C. The expression of podoplanin is associated with poor outcome in cutaneous squamous cell carcinoma. J Cutan Pathol. 2017 Feb;44(2):144-151. FI: 1.409 / Q3 García-Cenador MB, Lorenzo-Gómez MF, García-Moro M, García-García MI, Sánchez-Conde MP, García-Criado FJ, García-Sánchez E, Lozano-Sánchez F, García-Sánchez JE. Comparative study of bacterial translocation control with nitric oxide donors and COX2 inhibitor. Enferm Infecc Microbiol Clin. 2016 Oct;34(8):490-8. doi: 10.1016/j.eimc.2015.11.005. FI: 1.530 (Q3) Montejo ÁL, Arango C, Bernardo M, Carrasco JL, Crespo-Facorro B, Cruz JJ, Del Pino J, García Escudero MA, García Rizo C, González-Pinto A, Hernández AI, Martín Carrasco M, Mayoral Cleries F, Mayoral van Son J, Mories MT, Pachiarotti I, Ros S, Vieta E. Spanish consensus on the risks and detection of antipsychotic drug-related hyperprolactinaemia. Rev Psiquiatr Salud Ment. 2016 Jul-Sep;9(3):158-73. FI: 1.650 / Q3 Virizuela JA, Carratalà J, Aguado JM, Vicente D, Salavert M, Ruiz M, Ruiz I, Marco F, Lizasoain M, Jiménez-Fonseca P, Gudiol C, Cassinello J, Carmona-Bayonas A, Aguilar M, Cruz JJ. Management of infection and febrile neutropenia in patients with solid cancer. Clin Transl Oncol. 2016 Jun;18(6):557-70. doi: 10.1007/s12094-015-1442-4. FI: 1,60 / Q4

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2015

Nivel de la publicación A

Vicente-Dueñas C, Hauer J, Ruiz-Roca L, Ingenhag D, Rodríguez-Meira A, Auer F, Borkhardt A, Sánchez-García I. Tumoral stem cell reprogramming as a driver of cancer: Theory, biological models, implications in cancer therapy. Seminars in Cancer Biology 2015, 32: 3-9. Clave R. IF: 9.143 (Q1/D1)

Sánchez-García I. How tumour cell identity is established? Seminars in Cancer Biology 2015, 32: 1-2. Clave R. IF: 9.143 (Q1/D1) Mark A. Feitelson, Alla Arzumanyan, Rob J. Kulathinal, Stacy W. Blain, Randall F. Holcombe, Jamal Mahajna, Maria Marino, Maria L. Martinez-Chantar,

Roman Nawroth,

Isidro Sanchez-Garcia, Dipali Sharma, Neeraj K. Saxena,

Neetu Singh,

Panagiotis J. Vlachostergios, Shanchun Guo, Alexzander A. A. Asea, Kanya Honoki,

Hiromasa Fujii,

Alexandros Georgakilas, Amedeo Amedei, Elena Niccolai, Amr Amin, S. Salman Ashraf, Chandra S. Boosani, Gunjan Guha, Maria Rosa Ciriolo, Katia Aquilano,

Sophie Chen,

Sulma Mohammed,

Asfar S. Azmi, Dipita Bhakta, Dorota Halicka,

Somaira

Nowsheen. Sustained Proliferation in Cancer: Mechanisms and Novel Therapeutic Targets. Semin Cancer Biol. 2015 Apr 16. Clave R. IF: 9.143 (Q1/D1) Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin AR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AM, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HP, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HM, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 2015 Dec;35S:S276-S304. Clave R. IF: 9.143 (Q1/D1) Michael Green, Shingo Kihira, Chih Long Liu, Ramesh Nair, Raheleh Salari, Andrew Gentles, Jonathan Irish, Henning Stehr, Carolina Vicente-Duenas, Isabel Romero-Camero, Isidro Sanchez-Garcia, Sylvia Plevritis, Daniel Arber, Serafim Batzoglou, Ronald Levy, and Ash Alizadeh. Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1116-25. Clave A. IF: 9.674 (Q1/D1) Martin-Lorenzo A, Hauer J, Vicente-Duenas C, Auer F, Gonzalez-Herrero I, Garcia-Ramirez I, Ginzel S, Thiele R, Constantinescu SN Prof, Bartenhagen C, Dugas M, Gombert M, Schafer D, Blanco O, Mayado A, Orfao A, Alonso-Lopez D, De Las Rivas J, Cobaleda C, Garcia-Cenador MB, Garcia-Criado FJ, Sanchez-Garcia I*, Borkhardt A*. Infection

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exposure is a causal factor in B-precursor acute lymphoblastic leukemia as a result of Pax5 inherited susceptibility. Cancer Discov (research article) December 2015 5:1328-1343. Clave A. IF: 19.453 (Q1/D1) Brown G and Sanchez-Garcia I. “Is lineage decision-making restricted during tumoral reprograming of haematopoietic stem cells? Oncotarget 2015 Oct 19. 6(41): 43326- 43341.doi: 10.18632/oncotarget.6145. Clave R. IF: 6.359 (Q1) Mir-Bonafe JF, Torres EB, Sarmiento RG. A 2-Year-Old Girl With Skin Fragility. JAMA Dermatol. 2015 Feb;151(2):225-6. FI: 4,426 / Q1 Perea J, Cano JM, Rueda D, García JL, Inglada L, Osorio I, Arriba M, Pérez J, Gaspar M, Fernández-Miguel T, Rodríguez Y, Benítez J, González-Sarmiento R, Urioste M. Classifying early-onset colorectal cancer according to tumor location: new potential subcategories to explore. Am J Cancer Res. 2015 Jun 15;5(7):2308-13. FI: 4,165 / Q1 Hernández-Martín A, González-Sarmiento R. Recent advances in congenital ichthyoses. Curr Opin Pediatr. 2015 Aug;27(4):473-9. FI: 2,528 / Q1 Usategui-Martín R, García-Aparicio J, Corral-Gudino L, Calero-Paniagua I, Del Pino-Montes J, González Sarmiento R. Polymorphisms in autophagy genes are associated with paget disease of bone. PLoS One. 2015 Jun 1;10(6):e0128984. FI: 3,234 / Q1 Pastor-Idoate S, Rodríguez-Hernández I, Rojas J, Fernández I, García-Gutierrez MT, Ruiz-Moreno JM, Rocha-Sousa A, Ramkissoon YD, Harsum S, MacLaren RE, Charteris DG, Van Meurs JC, González-Sarmiento R, Pastor JC; Genetics on PVR Study Group. BAX and BCL-2 polymorphisms, as predictors of proliferative vitreoretinopathy development in patients suffering retinal detachment: the Retina 4 project Acta Ophthalmol. 2015 Nov;93(7):e541-9. FI: 2,844 / Q1 Chamorro AJ, Torres JL, Mirón-Canelo JA, González-Sarmiento R, Laso FJ, Marcos M. Letter: PNPLA3 and alcoholic liver disease--an alert to methodological limitations. Authors' reply. Aliment Pharmacol Ther. 2015 Mar;41(6):594. FI: 5,727 / Q1 Citterio CE, Morales CM, Bouhours-Nouet N, Machiavelli GA, Bueno E, Gatelais F, Coutant R, González-Sarmiento R, Rivolta CM, Targovnik HM. Novel compound heterozygous Thyroglobulin mutations c.745+1G>A/c.7036+2T>A associated with congenital goiter and hypothyroidism in a Vietnamese family. Identification of a new cryptic 5' splice site in the exon 6. Mol Cell Endocrinol. 2015 Mar 15;404:102-12. FI: 4,405 / Q1

Belforte FS, Targovnik AM, González-Lebrero RM, Osorio Larroche C, Citterio CE, González-Sarmiento R, Miranda MV, Targovnik HM, Rivolta CM. Kinetic characterization of human thyroperoxidase. Normal and pathological enzyme expression in Baculovirus system: a molecular model of functional expression. Mol Cell Endocrinol. 2015 Mar 15;404:9-15. FI: 4,405 / Q1

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Castellanos-Martín A, Castillo-Lluva S, Sáez-Freire Mdel M, Blanco-Gómez A, Hontecillas-Prieto L, Patino-Alonso C, Galindo-Villardon P, Pérez Del Villar L, Martín-Seisdedos C, Isidoro-Garcia M, Abad-Hernández Mdel M, Cruz-Hernández JJ, Rodríguez-Sánchez CA, González-Sarmiento R, Alonso-López D, De Las Rivas J, García-Cenador B, García-Criado J, Lee do Y, Bowen B, Reindl W, Northen T, Mao JH, Pérez-Losada J. Unraveling heterogeneous susceptibility and the evolution of breast cancer using a systems biology approach. Genome Biol. 2015 Feb 21;16:40. FI: 10,810 / Q1

Castillo-Lluva S, Hontecillas-Prieto L, Blanco-Gómez A, Del Mar Sáez-Freire M, García-Cenador B, García-Criado J, Pérez-Andrés M, Orfao A, Cañamero M, Mao JH, Gridley T, Castellanos-Martín A, Pérez-Losada J. A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development. Oncogene. 2015 Sep 3;34(36):4797-8. Clave:A FI: 8,459 / Q1

Cantarero L, Sanz-García M, Vinograd-Byk H, Renbaum P, Levy-Lahad E, Lazo PA. VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle. Sci Rep. 2015 Jun 12;5:10543. FI: 5,578 / Q1 Salzano M, Sanz-García M, Monsalve DM, Moura DS, Lazo PA. VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage. Epigenetics. 2015;10(5):373-83. FI: 4,780 / Q1 Lorenzo-Gómez MF, Padilla-Fernández B, García-Cenador MB, Virseda-Rodríguez ÁJ, Martín-García I, Sánchez-Escudero A, Vicente-Arroyo MJ, Mirón-Canelo JA. Comparison of sublingual therapeutic vaccine with antibiotics for the prophylaxis of recurrent urinary tract infections. Front Cell Infect Microbiol. 2015 Jun 3;5:50. FI: 5.218 (Q1)

Nivel de la publicación B

Rosado C, Bueno E, Felipe C, Valverde S, González-Sarmiento R. Study of the True Clinical Progression of Autosomal Dominant Alport Syndrome in a European Population. Kidney Blood Press Res. 2015;40(4):435-42. FI: 2,123 / Q2

Dilla T, Lizan L, Paz S, Garrido P, Avendaño C, Cruz-Hernández JJ, Espinosa J, Sacristán JA. Do new cancer drugs offer good value for money? The perspectives of oncologists, health care policy makers, patients, and the general population. Patient Prefer Adherence. 2015 Dec 18;10:1-7. Q2

Castaño M, González-Santos JM, López J, García Cenador B, Centeno JE, Aparicio B, Bueno MJ, Díez R, Sagredo V, Rodríguez JM, García-Criado FJ. Effect of preoperative oral pravastatin reload in systemic inflammatory response and myocardial damage after coronary artery bypass grafting. A pilot double-blind placebo-controlled study. J Cardiovasc Surg (Torino). 2015 Aug; 56(4):617-29. FI: 1,632 / Q2

Nivel de la publicación C

Rosado C, Bueno E, Fraile P, García-Cosmes P, González-Sarmiento R. A new mutation in the COL4A3 gene responsible for autosomal dominant Alport syndrome, which only generates hearing loss in some carriers.

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Eur J Med Genet. 2015 Jan;58(1):35-8. FI: 1,48 / Q4 Perez-Rivera JA, Pabon-Osuna P, Cieza-Borrella C, Lugo-Godoy C, Martin-Herrero F, Gonzalez-Porras JR, Sanchez-Fernandez PL, Gonzalez-Sarmiento R. The role of the terc-63g>a and tert-1327c>t telomerase polymorphisms in the study of men with acute coronary syndrome. Minerva Cardioangiol. 2015 Dec;63(6):467-74. FI: 0,48 / Q4 Lorenzo-Gómez MF, Padilla-Fernández B, Virseda-Rodríguez AJ, Collazos-Robles RE, García-Cenador MB, Mirón-Canelo JA. Severe complications and failures of incontinence surgery using the Remeex(®) adjustable tension sling (external mechanical regulator). Actas Urol Esp. 2015 Nov;39(9):558-63. FI: 0.964 (Q4)

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2014

Nivel de la publicación A

Green MR, Vicente-Dueñas C, Romero-Camarero I, Long Liu C, Dai B, González-Herrero I, García-Ramírez I, Alonso-Escudero E, Iqbal J, Chan WC, Campos-Sanchez E, Orfao A, Pintado B, Flores T, Blanco O, Jiménez R, Martínez-Climent JA, Garcia Criado FJ, Garcia Cenador MB, Zhao S, Natkunam Y, Lossos IS, Majeti R, Melnick A, Cobaleda C, Alizadeh AA, Sánchez-García I. Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma. Nature Communications 2014 Jun 2;5:3904. Clave A. IF: 11.47 (Q1/D1) Sara Mainardi, Nieves Mijimolle, Sarah Francoz, Carolina Vicente-Dueñas, Isidro Sánchez-García and Mariano Barbacid. Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):255-60. Clave A. IF: 9.674 (Q1/D1)

Torrelo A, Vicente A, Navarro L, Planaguma M, Bueno E, González-Sarmiento R, Hernández-Martín A, Noguera-Morel L, Requena L, Colmenero I, Parareda A, González-Enseñat MA, Haple R. Early-onset acral basal cell carcinomas in Gorlin syndrome. Br J Dermatol. 2014 May 16. FI: 3,75 / Q1 Chamorro AJ, Torres JL, Mirón-Canelo JA, González-Sarmiento R, Laso FJ, Marcos M. Systematic review with meta-analysis: the I148M variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis. Aliment Pharmacol Ther. 40: 571-581. 2014 FI: 4,54 / Q1 Zugazagoitia J, Pérez-Segura P, Manzano A, Blanco I, Vega A, Custodio A, Teulé A, Fachal L, Martínez B, González-Sarmiento R, Cruz-Hernández JJ, Chirivella I, Garcés V, Garre P, Romero A, Caldés T, Díaz-Rubio E, de la Hoya M. Limited family structure and triple-negative breast cancer (TNBC) subtype as predictors of BRCA mutations in a genetic counseling cohort of early-onset sporadic breast cancers. Breast Cancer Res Treat. 148: 415-21. 2014 FI: 4,19 / Q1 Cañueto J, Bueno E, Rodríguez-Diaz E, Vicente-Díaz MA, Alvarez-Cuesta CC, Gonzalvo-Rodríguez P, González-Sarmiento R. Acral peeling skin syndrome resulting from mutations in TGM5. J Eur Acad Dermatol Venereol. 2014 Dec 16. FI: 3,10 / Q1 Salzano M, Vázquez-Cedeira M, Sanz-García M, Valbuena A, Blanco S, Fernández IF, Lazo PA. Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response. Oncotarget. 2014 Apr 15;5(7):1770-8. Q1 Rodriguez-Paredes M, Martinez de Paz A, Simó-Riudalbas L, Sayols S, Moutinho C, Moran S, Villanueva A, Vázquez-Cedeira M, Lazo PA, Carneiro F, Moura CS, Vieira J, Teixeira MR, Esteller M. Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis. Oncogene. 2014 May 22;33(21):2807-13. Q1

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Popescu RA, Schäfer R, Califano R, Eckert R, Coleman R, Douillard JY, Cervantes A, Casali PG, Sessa C, Van Cutsem E, de Vries E, Pavlidis N, Fumasoli K, Wörmann B, Samonigg H, Cascinu S, Cruz Hernández JJ, Howard AJ, Ciardiello F, Stahel RA, Piccart M. The current and future role of the medical oncologist in the professional care for cancer patients: a position paper by the European Society for Medical Oncology (ESMO). Ann Oncol. 2014 Jan;25(1):9-15. Q1 Hitt R, Grau JJ, López-Pousa A, Berrocal A, García-Girón C, Irigoyen A, Sastre J, Martínez-Trufero J, Brandariz Castelo JA, Verger E, Cruz-Hernández JJ; Spanish Head and Neck Cancer Cooperative Group (TTCC). A randomized phase III trial comparing induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as treatment of unresectable head and neck cancer. Ann Oncol. 2014 Jan;25(1):216-25. Q1

Nivel de la publicación B

Green MR, Vicente-Dueñas C, Alizadeh AA, Sánchez-García I. Hit-and-run lymphomagenesis by the Bcl6 Oncogene. Cell Cycle. 2014 June 15;13(12): 1831-1832. Clave R. IF: 4.565 (Q2) Abollo-Jiménez F, Campos-Sánchez E, Toboso-Navasa A, Vicente-Dueñas C, González-Herrero I, Alonso-Escudero E, González M, Segura V, Blanco O, Martínez-Climent JA, Sánchez-García I, Cobaleda C. Lineage-specific function of Engrailed-2 in the progression of chronic myelogenous leukemia to T cell blast crisis. Cell Cycle. 2014 Jun 1;13(11):1717-26. Clave A. IF: 4.565 (Q2) Alberto Martín-Lorenzo, Inés Gonzalez-Herrero, Guillermo Rodríguez-Hernández, Idoia García-Ramírez, Carolina Vicente-Dueñas, Isidro Sánchez-García. Early epigenetic cancer decisions. Biological Chemistry. 2014 Nov 1;395(11):1315-20. Clave R. IF: 3.268 (Q2)

Julia Hauer, Arndt Borkhardt, Isidro Sánchez-García & César Cobaleda- Genetically engineered mouse models of human B-cell precursor leucemias. Cell Cycle, 2014 Sep 15;13(18):2836-2846. Clave R. IF: 4.565 (Q2) Cruz-González F, Cabrillo-Estevez L, López Valverde G, Cieza-Borrella C, Hernández Galilea E, González Sarmiento R. Predictive value of VEGFA and VEGFR2 polymorphisms in the response to intravitreal Ranibizumab treatment for wet AMD. Graefe's Arch Clin Exp Ophthalmol. 252: 469-475. 2014. FI: 2,33 / Q2 Novo-Veleiro I, González-Sarmiento R, Cieza-Borrella C, Pastor I, Laso FJ, Marcos M. A genetic variant in the microRNA-146a gene is associated with susceptibility to alcohol use disorders. Eur Psychiatry. 29: 288-292. 2014. FI: 3,28 / Q2 Gomez-Marcos MA, Gonzalez-Sarmiento R, Recio-Rodríguez JI, Agudo-Conde C, Gamella-Pozuelo L, Perretta-Tejedor N, Martínez-Salgado C, García-Ortiz L. Relationship between target organ damage and blood pressure, retinal vessel calibre, oxidative stress and polymorphisms in VAV-2 and VAV-3 genes in patients with hypertension: a case-control study protocol (LOD-Hipertension). BMJ Open. 4:e005112. 2014 FI: 1,58 / Q2

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Cieza-Borrella C, Díaz-Soto G, Martínez-Pino I, Puig-Domingo M, González-Sarmiento R. Early-Onset Type 2 Diabetes Mellitus Is Associated to HNF4A T130I Polymorphism in Families of Central Spain. J Investig Med. 62: 968-74. 2014 FI: 1,5 / Q2 López-Sánchez I, Valbuena A, Vázquez-Cedeira M, Khadake J, Sanz-García M, Carrillo-Jiménez A, Lazo PA. VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage. FEBS Lett. 2014 Mar 3;588(5):692-700. Q2 Zugazagoitia J, Pérez-Segura P, Manzano A, Blanco I, Vega A, Custodio A, Teulé A, Fachal L, Martínez B, González-Sarmiento R, Cruz-Hernández JJ, Chirivella I, Garcés V, Garre P, Romero A, Caldés T, Díaz-Rubio E, de la Hoya M. Limited family structure and triple-negative breast cancer (TNBC) subtype as predictors of BRCA mutations in a genetic counseling cohort of early-onset sporadic breast cancers. Breast Cancer Res Treat. 2014 Nov;148(2):415-21 Q2

Nivel de la publicación C

Cruz-González F, Cieza-Borrella C, López Valverde G, Lorenzo-Pérez R, Hernández-Galilea E, González-Sarmiento R. CFH (rs1410996), HTRA1 (rs112000638) and ARMS2 (rs10490923) Gene Polymorphisms are Associated with AMD Risk in Spanish Patients. Ophthalmic Genet. 35: 68-73. 2014 FI: 1,23 / Q3

de Juan-Marcos L, Escudero-Domínguez FA, Hernández-Galilea E, Cabrillo-Estévez L, Cruz-González F, Cieza-Borrella C, Sánchez-Barba M, González-Sarmiento R. Association of lysyl oxidase-like 1 gene polymorphisms in pseudoexfoliation syndrome and pseudoexfoliation glaucoma in a Spanish population. Ophthalmic Genet. 3:1-6. 2014 FI: 1.07 / Q3

Díez A, Cieza-Borrella C, Suazo V, González-Sarmiento R, Papiol S, Molina V. Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia. Ann Gen Psychiatry. 13:18. 2014 FI: 1,57 / Q3

Sklate RT, Olcese MC, Maccallini GC, Sarmiento RG, Targovnik HM, Rivolta CM. Novel mutation p.A64D in the Serpina7 gene as a cause of partial thyroxine-binding globulin deficiency associated with increases affinity in transthyretin by a known p.A109T mutation in the TTR gene. Horm Metab Res. 46(2):100-8. 2014 FI: 2,03 / Q3

Pérez del Villar L, Vicente B, Blanco-Gómez A, Castellanos A, Pérez-Losada J, Muro A. Identifying phenotypes involved in susceptibility to Schistosoma mansoni infection in F1B6CBA mice. Acta Parasitol. 2014 Sep;59(3):529-39. Clave:A FI: 0,905 / Q4

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2013

Nivel de la publicación A

Isabel Romero-Camarero, Xiaoyu Jiang, Yasodha Natkunam, Xiaoqing Lu, Carolina Vicente-Dueñas, Ines Gonzalez-Herrero, Teresa Flores, Juan Luis Garcia, George McNamara, Christian Kunder, Shuchun Zhao, Victor Segura, Lorena Fontan, Jose A. Martínez-Climent, Francisco Javier García-Criado, Jason D. Theis, Ahmet Dogan, Elena Campos-Sánchez, Michael R. Green, Ash A. Alizadeh, Cesar Cobaleda, Isidro Sánchez-García*, Izidore S. Lossos*. Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation. Nature Communications 2013 Jan 8;4:1338.*Should be considered as equal senior authors. Clave A. IF: 10.742 (Q1/D1)

Inés González-Herrero, Isabel Romero-Camarero, Javier Cañueto, Esther Cardeñoso-Álvarez, Emiliana Fernández-López, J. Pérez-Losada, Isidro Sánchez-García* and Concepción Román-Curto*. The CD133

+ cell content correlates with

tumor growth in melanomas from skin with chronic sun-induced damage. Br J Dermatol. 2013 Oct;169(4):830-837. *Should be considered as equal senior authors. Clave A. IF: 4.1 (Q1/D1) Carolina Vicente-Dueñas, Isabel Romero-Camarero, César Cobaleda, and Isidro Sánchez-García. Function of oncogenes in cancer development: a changing paradigm. The EMBO Journal (2013), 32, 1502 – 1513. (review by invitation). Clave R. IF: 10.748 (Q1/D1) César Cobaleda, and Isidro Sánchez-García. Back to the beginning: the initiation of cancer. BioEssays 2013 May;35(5):413. Clave R. IF: 4.927 (Q1)

Citterio CE, Machiavelli GA, Miras MB, Gruñeiro-Papendieck L, Lachlan K, Sobrero G, Chiesa A, Walker J, Muñoz L, Testa G, Belforte FS, González-Sarmiento R, Rivolta CM, Targovnik HM. New insights into thyroglobulin gene: Molecular analysis of seven novel mutations associated with goiter and hypothyroidism. Mol Cell Endocrinol. 365: 277-91. 2013 FI: 4,24 / Q1 Pastor-Idoate S, Rodriguez-Hernández I, Rojas J, Fernández I, García-Gutierrez MT, Ruiz-Moreno JM, Rocha-Sousa A, Ramkissoon Y, Harsum S, Maclaren RE, Charteris D, van Meurs J, González-Sarmiento R, Pastor JC; Genetics on PVR Study Group*. The p53 Codon 72 Polymorphism (rs1042522) is Associated with Proliferative Vitreoretinopathy: The Retina 4 Project. Ophthalmology. 120: 623-628. 2013 FI.: 6,17 / Q1 Albagha OM, Visconti MR, Alonso N, Wani S, Goodman K, Fraser WD, Gennari L, Merlotti D, Gianfrancesco F, Esposito T, Rendina D, di Stefano M, Isaia G, Brandi ML, Guisti F, Del Pino-Montes J, Corral-Gudino L, Gonzalez-Sarmiento R, Ward L, Rea SL, Ratajczak T, Walsh JP, Ralston SH. Common susceptibility alleles and SQSTM1 mutations predict disease extent and severity in a multinational study of patients with Paget's disease. J Bone Miner Res. 28: 2338-2346. 2013 FI: 6,58 / Q1 Torrelo A, Hernández-Martín A, Bueno E, Colmenero I, Rivera I, Requena L, Happle R, González-Sarmiento R. Molecular evidence of type 2 mosaicism in Gorlin syndrome. Br J Dermatol. 169: 1342-1345. 2013 FI: 4,10 / Q1

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Infante M, Durán M, Acedo A, Sánchez-Tapia EM, Díez-Gómez B, Barroso A, García-González M, Feliubadaló L, Lasa A, de la Hoya M, Esteban-Cardeñosa E, Díez O, Martínez-Bouzas C, Godino J, Teulé A, Osorio A, Lastra E, González-Sarmiento R, Miner C, Velasco EA. The highly prevalent BRCA2 mutation c.2808_2811del (3036delACAA) is located in a mutational hotspot and has multiple origins. Carcinogenesis. 34: 2505-2511. 2013 FI: 5,26 / Q1

Citterio CE, Rossetti LC, Souchon PF, Morales C, Thouvard-Viprey M, Salmon-Musial AS, Mauran PL, Doco-Fenzy M, González-Sarmiento R, Rivolta CM, De Brasi CD, Targovnik HM. Novel mutational mechanism in the thyroglobulin gene: Imperfect DNA inversion as a cause for hereditary hypothyroidism. Mol Cell Endocrinol. 381: 220-229. 2013 FI: 4,24 / Q1

Cañueto J, Girós M, González-Sarmiento R. The role of the abnormalities in the distal pathway of cholesterol biosynthesis in the Conradi-Hünermann-Happle syndrome. Biochim Biophys Acta. 1841: 336-344. 2013 FI: 4,49 / Q1 Osorio A, Bogliolo M, Fernández V, Barroso A, de la Hoya M, Caldés T, Lasa A, Cajal TR, Santamariña M, Vega A, Quiles F, Lázaro C, Díez O, Fernández D, González-Sarmiento R, Durán M, Piqueras JF, Marín M, Pujol R, Surrallés J, Benítez J. Evaluation of Rare Variants in the New Fanconi Anemia Gene ERCC4 (FANCQ) as Familial Breast/Ovarian Cancer Susceptibility Alleles. Hum Mutat. 34: 1615-1618. 2013. FI: 5.12 / Q1 Rodríguez-Hernández I, García JL, Santos-Briz A, Hernández Laín A, González Valero JM, Gómez-Moreta JA, Toldos-González, Cruz JJ, Martin-Vallejo J, Rogelio González-Sarmiento. Integrated analysis of mismatch repair system in malignant astrocytomas. PlosOne. 8: e76401. 2013 FI: 3,53 / Q1 Pastor-Idoate S, Rodríguez-Hernández I, Rojas J, Fernández I, García-Gutiérrez MT, Ruiz-Moreno JM, Rocha-Sousa A, Ramkissoon Y, Harsum S, Maclaren RE, Charteris D, Vanmeurs JC, González-Sarmiento R, Pastor JC; Genetics on PVR Study Group. The T309G MDM2 Gene Polymorphism Is a Novel Risk Factor for Proliferative Vitreoretinopathy. PLoS One. 8(12):e82283. 2013 FI: 3,53 / Q1 Barcia-Sanjurjo I, Vázquez-Cedeira M, Barcia R, Lazo PA. Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals. J Biol Inorg Chem. 2013 Apr;18(4):473-82. Q1 Garcia-Cenador MB, Lorenzo-Gomez MF, Herrero-Payo JJ, Ruiz J, Perez de Obanos MP, Pascual J, Lopez-Novoa JM, Garcia-Criado FJ. Cardiotrophin-1 administration protects from ischemia-reperfusion renal injury and inflammation. Transplantation. 2013 Dec 27;96(12):1034-42. FI: 3,535 / Q1 García-Cenador MB, Lopez-Novoa JM, Díez J, García-Criado FJ. Effects and mechanism of organ protection by cardiotrophin-1. Curr Med Chem. 2013;20(2):246-56. Review.

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FI: 3,715 / Q1 Lu J, Wen M, Huang Y, He X, Wang Y, Wu Q, Li Z, Castellanos-Martin A, Abad M, Cruz-Hernandez JJ, Rodriguez CA, Pérez-Losada J, Mao JH, Wei G. C2ORF40 suppresses breast cancer cell proliferation and invasion through modulating expression of M phase cell cycle genes. Epigenetics. 2013 Jun;8(6):571-83. Clave:A. FI: 4,780 / Q1

Nivel de la publicación B

García-Ramírez I, Ruiz-Roca L, Martín-Lorenzo A, Blanco O, García-Cenador MB, García-Criado FJ, Vicente-Dueñas C, Sánchez-García I. Genetic background affects susceptibility to tumoral stem cell reprogramming. Cell Cycle (issue cover) 2013 Aug 1;12(15):2505-9. doi: 10.4161/cc.25544. Epub 2013 Jul 8. Clave A. IF: 5.006 (Q2) Velasco-Hernández T., Vicente-Dueñas C., Sánchez-García I., and Martín-Zanca D. P53 restoration kills primitive leukemia cells in vivo and increases survival of leukemic mice. Cell Cycle. 2013 January 1;12(1): 122-132. Clave A. IF: 5.006 (Q2)

Martínez-Urueña N, Macías L, Pérez-Carbonero L, Infante M, Lastra E, Cruz JJ, Miner C, González R, Durán M Incidence of -93 MLH1 promoter polymorphism in familial and sporadic colorectal cancer. Colorectal Dis. 15: e118-123. 2013 FI: 2,01 / Q2

Barrio-Real L, Barrueco M, González-Sarmiento R, Caloca MJ. Association of a Novel Polymorphism of the β2-Chimaerin Gene (CHN2) With Smoking. J Investig Med. 61: 1129-1131. 2013 FI: 1,50 / Q2 Sastre JA, Varela G, López M, Muriel C, González-Sarmiento R . Influence of Uridine Diphosphate-Glucuronyltransferase 2B7 (UGT2B7) Variants on Postoperative Buprenorphine Analgesia. Pain Pract. 2013 Nov 20 FI: 2,18 / Q2 Perez-Rivera JA, Pabon-Osuna P, Cieza-Borrella C, Duran-Bobin O, Martin-Herrero F, Gonzalez-Porras JR, Gonzalez-Sarmiento R. Effect of Telomere Length on Prognosis in Men With Acute Coronary Syndrome. Am J Cardiol. 113: 418-421. 2013 FI: 3,42 / Q2

Monsalve DM, Merced T, Fernández IF, Blanco S, Vázquez-Cedeira M, Lazo PA. Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression. Cell Death Dis. 2013 Feb 28;4:e513. Q2 Lorenzo-Gómez MF, Padilla-Fernández B, García-Criado FJ, Mirón-Canelo JA, Gil-Vicente A, Nieto-Huertos A, Silva-Abuin JM. Evaluation of a therapeutic vaccine for the prevention of recurrent urinary tract infections versus prophylactic treatment with antibiotics Int Urogynecol J. 2013 Jan;24(1):127-34. Q2

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Nivel de la publicación C

Sklate RT, Olcese MC, Maccallini GC, Sarmiento RG, Targovnik HM, Rivolta CM. Novel Mutation p.A64D in the Serpina7 Gene as a Cause of Partial Thyroxine-binding Globulin Deficiency Associated with Increases Affinity in Transthyretin by a Known p.A109T Mutation in the TTR Gene. Horm Metab Res. 46: 100-108. 2013. FI: 2,03 / Q3

Castro E, Olmos D, Garcia A, Cruz JJ, González-Sarmiento R. Role of XRCC3, XRCC1 and XPD single-nucleotide polymorphisms in survival outcomes following adjuvant chemotherapy in early stage breast cancer patients. Clin Transl Oncol. 16: 158-165. 2013 FI: 1,60 / Q4

Cruz-González F, Cieza-Borrella C, Cabrillo-Estévez L, Cañete-Campos C, Escudero-Domínguez F, González-Sarmiento R. VEGF A (rs699947 and rs833061) and VEGFR2 (rs2071559) Gene Polymorphisms are not Associated with AMD Susceptibility in a Spanish Population. Curr Eye Res. 38: 1274-1277. 2013 FI: 1,66 / Q3 Hernández-Martín A, Torrelo A, Ciria S, Colmenero I, Aguilar A, Grimalt R, González-Sarmiento R. Ectodermal dysplasia-skin fragility syndrome: a novel mutation in the PKP1 gene. Clin Exp Dermatol. 38: 787-90. 2013 FI: 1,23 / Q3 Rodríguez-Hernández I, Vázquez-Cedeira M, Santos-Briz A, García JL, Fernández IF, Gómez-Moreta JA, Martin-Vallejo J, González-Sarmiento R, Lazo PA. VRK2 identifies a subgroup of primary high-grade astrocytomas with a better prognosis. BMC Clin Pathol. 13: 23. 2013 FI: 2,15 / Q3 Rodriguez-Hernandez I, Perdomo S, Santos-Briz A, Garcia JL, Gomez-Moreta JA, Cruz JJ, Gonzalez-Sarmiento R. Analysis of DNA repair gene polymorphisms in glioblastoma. Gene. 536: 79-83. 2013 FI: 2,08 / Q3 Pérez del Villar L, Vicente B, Galindo-Villardón P, Castellanos A, Pérez-Losada J, Muro A. Schistosoma mansoni experimental infection in Mus spretus (SPRET/EiJ strain) mice. Parasite. 2013;20:27. Clave:A FI: 1,092 / Q3 Coelho TR, Gaspar R, Figueiredo P, Mendonça C, Lazo PA, Almeida L. Human JC polyomavirus in normal colorectal mucosa, hyperplastic polyps, sporadic adenomas, and adenocarcinomas in Portugal. J Med Virol. 2013 Dec;85(12):2119-27. FI: 2,347 / Q3

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17

2012

Nivel de la publicación A

Carolina Vicente-Dueñas, Marcos Barajas-Diego, Isabel Romero-Camarero, Inés Gonzalez-Herrero, Teresa Flores, Isidro Sánchez-García. Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL inmice. Oncotarget (issue cover) 2012;3(3):261-6. Clave A. IF: 6.636 (Q1) Carolina Vicente-Dueñas, Isabel Romero-Camarero, and Isidro Sánchez-García. Understanding telomerase in Cancer Stem Cell Biology. Cell Cycle. 2012 Apr 15;11(8):1479-80. Epub 2012 Apr 15. (News & Views by invitation) Clave R. IF: 5.321 (Q1)

Elena Cubedo, Andrew J. Gentles, Chuanxin Huang, Yasodha Natkunam, Shruti Bhatt, Xiaoqing Lu, Xiaoyu Jiang, Isabel Romero-Camarero, Aharon Freud, Shuchun Zhao, Carlos E Bacchi, Jose A. Martínez-Climent, Isidro Sánchez-García, Ari Melnick, and Izidore S Lossos. Identification of LMO2 Transcriptome and Interactome in Diffuse Large B-cell Lymphoma. Blood 2012;119: 5478-5491. Clave A. IF: 9.06 (Q1/D1) Vicente-Dueñas C, Fontán L, Gonzalez-Herrero I, Romero-Camarero I, Segura V, Aznar MA, Alonso-Escudero E, Campos-Sanchez E, Ruiz-Roca L, Barajas-Diego M, Sagardoy A, Martinez-Ferrandis JI, Abollo-Jimenez F, Bertolo C, Peñuelas I, Garcia-Criado FJ, García-Cenador MB, Tousseyn T, Agirre X, Prosper F, Garcia-Bragado F, McPhail ED, Lossos IS, Du MQ, Flores T, Hernandez-Rivas JM, Gonzalez M, Salar A, Bellosillo B, Conde E, Siebert R, Sagaert X, Cobaleda C, Sanchez-Garcia I*, Martinez-Climent JA*. Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice. Proc Natl Acad Sci U S A. 2012; 109(26): 10534-10539. *Should be considered as equal senior authors. Clave A. IF: 9.737 (Q1/D1)

Carolina Vicente-Dueñas, César Cobaleda, José Ángel Martínez-Climent, and Isidro Sánchez-García. MALT Lymphoma meets stem cells. Cell Cycle 2012 Aug 15;11(16): 2961-2962. (News & Views by invitation) Clave R. IF: 5.321 (Q1) Vicente-Dueñas C, Romero-Camarero I, González-Herrero I, Alonso-Escudero E, Abollo-Jiménez F, Jiang X, Gutierrez NC, Orfao A, Marín N, Villar LM, Criado MC, Pintado B, Flores T, Alonso-López D, De Las Rivas J, Jiménez R, Criado FJ, Cenador MB, Lossos IS, Cobaleda C, and Sánchez-García I. A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to hematopoietic progenitors. The EMBO Journal (2012), 31, 3704 - 3717; 10.1038/emboj.2012.227. Clave A. IF: 9.822 (Q1/D1) Carolina Vicente-Dueñas, Isabel Romero-Camarero, Francisco Javier García-Criado, César Cobaleda, and Isidro Sánchez-García. The cellular architecture of multiple myeloma. Cell Cycle 2012 Oct 15;11(20):3715-7. doi: 10.4161/cc.22178. Epub 2012 Sep 14. (News & Views by invitation) Clave R. IF: 5.321 (Q1) Carolina Vicente-Dueñas, Inés González-Herrero, María Begoña García Cenador, Francisco Javier García Criado, and Isidro Sánchez-García. Loss of p53 exacerbates multiple myeloma phenotype by facilitating the reprogramming of hematopoietic stem/progenitor cells to malignant plasma cells by MafB. Cell Cycle (issue cover) 2012 Oct 15;11(20):3896-900. Clave A. IF: 5.321 (Q1) Targovnik HM, Edouard T, Varela V, Tauber M, Citterio CE, González-Sarmiento R, Rivolta CM. Two novel mutations in the thyroglobulin gene as cause of congenital hypothyroidism: Identification a cryptic donor splice site in the exon 19. Molecular Cellular Endocrinology 348: 313-321. 2012

VICERRECTORADO DE INVESTIGACIÓN Y

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18

FI: 4,24 / Q1

Hernández-Martín A, Garcia-Doval I, Aranegui B, de Unamuno P, Rodríguez-Pazos L, González-Enseñat MA, Vicente A, Martín-Santiago A, Garcia-Bravo B, Feito M, Baselga E, Círia S, de Lucas R, Ginarte M, González-Sarmiento R, Torrelo A. Prevalence of autosomal recessive congenital ichthyosis: A population-based study using the capture-recapture method in Spain. J Am Acad Dermatol 67: 240-244. 2012 FI: 5,00 / Q1

Marcos M, Pastor I, de la Calle C, Barrio-Real L, Laso FJ, González-Sarmiento R. Cannabinoid Receptor 1 Gene is Associated with Alcohol Dependence. Alcoholism: Clin Exp Res 36: 267-271.2012 FI: 3,31 / Q1 Cañueto J, Girós M, Ciria S, Pi-Castán G, Artigas M, García-Dorado J, García-Patos V, Virós A, Vendrell T, Torrelo A, Hernández-Martín A, Martín-Hernández E, Garcia-Silva MT, Fernández-Burriel M, Rosell J, Tejedor M, Martínez F, Valero J, García JL, Sánchez-Tapia EM, Unamuno P, González-Sarmiento R. Clinical, Molecular and Biochemical Characterization of Nine Spanish Families with Conradi-Hünermann-Happle Syndrome: New Insights into CDPX2 With A Comprehensive Review of the Literature. Br J Dermatol 166: 830-838. 2012 FI: 4,10 / Q1 Martinez-Delgado B, Yanowsky K, Inglada-Perez L, de la Hoya M, Caldes T, Vega A, Blanco A, Martin T, Gonzalez-Sarmiento R, Blasco M, Robledo M, Urioste M, Song H, Pharoah P, Benitez J. Shorter telomere length is associated with increased ovarian cancer risk in both familial and sporadic cases. J Med Genet. 49: 341-344. 2012 FI: 5,63 / Q1 Chamorro AJ, Marcos M, Mirón-Canelo JA, Pastor I, González-Sarmiento R, Laso FJ. Association of µ-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: a systematic review and meta-analysis. Addict Biol. 17: 505-12. 2012 FI: 5,92 / Q1 Perez-Rivera JA, Pabon-Osuna P, Cieza-Borrella C, Martin-Herrero F, Gonzalez-Porras JR, Gonzalez-Sarmiento R. Prognostic value of telomere length in acute coronary syndrome. Mech Ageing Dev. 133: 695-697. 2012 FI: 3,51 / Q1 Liu Y, Ren S, Castellanos-Martin A, Perez-Losada J, Kwon YW, Huang Y, Wang Z, Abad M, Cruz-Hernandez JJ, Rodriguez CA, Sun Y, Mao JH. Multiple novel alternative splicing forms of FBXW7α have a translational modulatory function and show specific alteration in human cancer. PLoS One. 2012;7(11):e49453. Clave:A FI: 3,234 / Q1 Kwon YW, Kim IJ, Wu D, Lu J, Stock WA Jr, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao JH. Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol Cancer Res. 2012 Jun;10(6):834-44. Clave:A FI: 4,380 / Q1 Perez-Losada J, Wu D, DelRosario R, Balmain A, Mao JH. Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility. PLoS One. 2012;7(2):e31301. Clave:A

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19

FI: 3,234 / Q1

Vázquez-Cedeira M, Lazo PA. Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2. J Biol Chem. 2012 Dec 14;287(51):42739-50. Q1

Klionsky, D. J., Abdalla, F. C., several authors, Lazo, P.A., several authors Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(4):445-544. Q1

VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling. Fernández IF, Pérez-Rivas LG, Blanco S, Castillo-Dominguez AA, Lozano J, Lazo PA. Cell Mol Life Sci. 2012 Nov;69(22):3881-93. Q1

Sanz-García M, Monsalve DM, Sevilla A, Lazo PA. Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage. J Biol Chem. 2012 Jul 6;287(28):23757-68. Q1

Hitt R, Irigoyen A, Cortes-Funes H, Grau JJ, García-Sáenz JA, Cruz-Hernandez JJ; Spanish Head and Neck Cancer Cooperative Group (TTCC). Phase II study of the combination of cetuximab and weekly paclitaxel in the first-line treatment of patients with recurrent and/or metastatic squamous cell carcinoma of head and neck. Ann Oncol. 2012 Apr;23(4):1016-22. Q1

Nivel de la publicación B

Isabel Romero-Camamero, Marcos Barajas-Diego, Andrés Castellanos Martín, Angel García Martín, Gonzalo Varela, Mar Abad, María Dolores Ludeña, Jesús Perez-Losada and Isidro Sánchez-García. New models towards assessing anti-cancer therapeutics. Histol Histopathol 2012 Feb;27(2):157-170. Clave R. IF: 2.236 (Q2)

Belforte FS, Miras MB, Olcese MC, Sobrero G, Testa G, Muñoz L, Gruñeiro-Papendieck L, Chiesa A, González-Sarmiento R, Targovnik HM, Rivolta CM. Congenital Goitrous Hypothyroidism: Mutation Analysis in the Thyroid Peroxidase Gene. Clin Endocrinol. 76: 568-576. 2012 FI: 3,35 / Q2

Nivel de la publicación C

Lorenzo-Gómez MF, Padilla-Fernández B, Antúnez-Plaza P, García-Criado FJ, Mirón-Canelo JA, Silva Abuín JM. Clinical profile and epidemiological changes of clear cell renal carcinoma during 12 years in our health area. Archivos Espanoles De Urologia [Arch Esp Urol] 2012 Nov; Vol. 65 (9), pp. 823-9. Q4

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