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- 1. LINA MARA HERRERA AGUDELO STUDENT MEDICINE
- 4. Satellite repeats is not only a inactive part of our genome, their levels are increased in cancer especially HSATII and ALR The tumor suppressor protein p53 This protein induces apoptosis of cancerous cells, impedes the proliferation of cells that have self-repairing capacity in this way tissues can be reparated .
- 5. OVEREXPRESSION OF REPETITIVE DNA SEQUENCES DISCOVERED IN COMMON TUMOR CELLS Sciencedaily (jan. 13, 2011)
- Satellite repeats make up a large part of our genome but, had been thought to be inactive
- It was found that these DNA are very active in cancer but not in normal tissue.
- Using a mouse model of pancreatic, colon and lung cancer, it will be evidenced the increase of satellite repeats. the investigation team proved the importance of these DNA sequence into this malignant process.
- Studies on human tumors were similar results, there were overexpression of two satellites called, HSATII and ALR.
- It supposed that satellites expression begins early in tumor development.
- Although actually biopsy is the principal diagnoses method, satellite RNA expression may provide better and specific biomarker of epithelial cancers.
- 11. P53 DETERMINES ORGAN SIZE Molecular & cell biology (dec. 15, 2010)
- Using wing primordium of the fruit fly as a model, professor Marco Miln demonstrated that the organs control their proportion, by molecular mechanism.
- During the embryonic process, organs establish their proportions and this is vital for the correct body function.
- Alterations in the mechanisms responsible for these processes cause fatal errors in embryos and even cause their death.
- The tumor suppressor protein p53 is activated in response to stress, such as that caused by oncogenic mutations, chemical agents.
- This protein induces the death of cell which the stress has caused irreversible damage and that can become cancerous.
- The study prove that stressed cells send signals to the remaining tissues in order to reduce their growth in order to allow damaged tissue to repair itself and allow the organ to grow in a coordinated manner.
- This observation indicates that this protein is crucial for the coordinated growth of the different parts of an organ.
- These studies are important to mediciene
- They give novel cancer biomarkers.
- They provide new knowledge about cancer behave.
- they show excellent alternatives to create better diagnoses methods.
- ScienceDaily, Your source for the lastests research news, United States.[Index].
- Biology news net. United States. [Index]
- MARTINEZ S, Lina Mara. Biologa Molecular. 6 ed. Medelln . UPB. Facultad de Medicina, 2011. p 42-54