Molecular Machine Could Hold Key to More Efficient Manufacturing.

And

Protein Origami: Quick Folders Are the Best.

José Alejandro Ramírez QuirósMedicine Student. UPB. 2013

INTRODUCCIÓN The celular mechanism to soporting the life, buildin its own molucules, is an

incredible sistem, and here act proteins, ribozomes,

DNA , RNA, and cofactors.

The structure of proteins is so

important, these give them the posibility to

have actives sites, and these folding proces is

guard by R.E.R and chaperones.

MOLECULAR MACHINE COULD HOLD KEY TO MORE EFFICIENT MANUFACTURING.

Jan. 10, 2013 — journal Science.

Their model: The ribosome. "The ribosome can put together 20 aminoacids in a second, we only can link together 4 blocks in 12 hours”. They said.

This innovatión is a micriscopic mecenic sistem that works, using an arm, which join together aa, making an enlongation section.

This posibility can be used to produce drugs like penicilin, in a more eficient way. And to

create newvaccin

e

Their advantage, is that the machines can work in parallel, now they have millions of this working together. The next level, is to build more complex molecules, and some type of proteins never seen. This is a very exciting possibility for the future.

 

IN MY OPINION…

I think, that this invent is a great advance for the molecular science, because it gives the possibility to really create new proteins ever seen, and in the same line, we could use them to produce cellular effects .

PROTEIN ORIGAMI: QUICK FOLDERS ARE THE BEST.

Jan. 31, 2013 — published inPLoS Computational Biology. 

Heidelberg Institute for Theoretical Studies (HITS) and the University of Illinois at Urbana Champaign: chaperones is an example of the intense machinary in the cell to well folding process, to repair and protect a protein.

 

Proteins are elementary building blocks of life, and all in the body Works, thanks to them. In order to be functionally the proteins have to fold into a tridimensional molecule.  

The damage in this process could cause

diseases like Alzheimer's or Creutzfeld-Jakob.

Whit a speed folding process, the protein is less susceptible to aggregation and has a fast conformational change.

This study helps in correct understanding of the protein properties, and a bigger knowledge in the form it work make possible, to design better investigative methods to make cellular interactions. Other advantage is the possibility to know the age of a protein, looking its folding speed, this could help the world of anthropology.

In my opinion…

MEDICAL UTILITY: 

Both news impact the pharmacological industry, because whit the synthetic protein machine, we can create a completely new protein, and studying the folding process we could improve the synthetic protein production.

Scientifics could in a few years, build a new receptor, or a new component that whit an specific structure, inactivate or activate a genome, a metabolic process or even induce apoptosis in tumor.

I through, the industrial production of drugs benefits with this contribution, in a long term.

In the case of folding process, is an incredible advance in understanding the protein kinetics, and these investigation could help to understand the importance of folding in interaction messenger-receptor, and in the protect function of chaperones.

B. Lewandowski, G. De Bo, J. W. Ward, M. Papmeyer, S. Kuschel, M. J. Aldegunde, P. M. E. Gramlich, D. Heckmann, S. M. Goldup, D. M. D'Souza, A. E. Fernandes, D. A. Leigh. Sequence-Specific Peptide Synthesis by an Artificial Small-Molecule Machine. Science, 2013.

DEBÈS Cédric, WANG Minglei, CAETANO-ANOLLÉS Gustavo, GRÄTER Frauke. Evolutionary Optimization of Protein Folding. PLoS Computational Biology, 2013; 9 (1)

Bibliography