Nikolas Polyzos - Meta-Analysis - II Simposio Reproducción Asistida Quirón

8/12/2019 Nikolas Polyzos - Meta-Analysis - II Simposio Reproducción Asistida Quirón

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Jnta-aeacysis0 wfy aeh wfne is sd

usnguc

Eikdcads R. Rdcyzds J.H. RfH



Ruocilatide typns ie DO/MYE aeh

_nprdhultivn Oidcdmy

Eujonr dg raehdjiznh

triacs

Eujonr dg jnta-aeacysns

aeh systnjatil rnvinws

\durln I\I ]no dg kedwcnhmn \narlf 1=/?/?218



]fy arn wn knne de ldehultiem aeh

allnptiem jnta-aeacysns4

Xfny prdvihn suostaetiac nvihneln td muihnlcieilac praltiln4

Xfny sdcvn uelcnar issuns4

It is sijpcy a way td mnt puocisfnh aeh

rnlnivn litatides4



Rrnsnetatide dutcien

]fy is jnta-aeacysis usnguc

]fne is jnta-aeacysis usnguc




1. Mrnatnr statistilac pdwnr

?. Mrnatnr aoicity td nxtrapdcatn rnsuct td tfn mnenracpdpucatide

<. Aoicity td nvacuatn tfn quacity dg tfn raehdjiznh triacs

8. Aoicity td nvacuatn tfn prnsneln dg puocilatide oias

>. Aoicity td nxajien rarn nvnets

7. Aoicity td pnrgdrj iehirnlt ldjparisdes



1. Mrnatnr statistilac pdwnr

\ajpcn sizn dg _LXs ie gnrticity ginch is sjacc n.m. pddr dvariae rnspdehnrs

Ajdem 8= raehdjiznh triacs decy 12 fah a sajpcn sizn 5122Rdcyzds aeh Hnvrdny, Gnrtic \tnric ?211

]fat is tfn pdwnr dg 122 patinets td hntnlt ahiggnrneln ie prnmeaely ratns grdj <2 td 82%

Decy 16%

Fdw jaey patinets hd wn ennh td favn 62% pdwnr=1? patinets



?. Mrnatnr aoicity td nxtrapdcatn rnsuct td tfn

mnenrac pdpucatide

Carmn spdesdrnh _LXs acways rngnr td tfn onst prdmedsis pdpucatide

\tuhins Ldjjde rnstriltides

Nurdpnae Rurnmde Ldccaodrativn Aedvucatide \tuhy Mrdup

_nldjoieaet fujae gdccilcn stijucatiem fdrjden

(r-fG\F; Mdeac-G®) vnrsus

fimfcy purifinh urieary G\F Jntrdhie FR®)

Nurdpnae Lntrdrncix \tuhy Mrdup

Xfn Nurdpnae Drmacutrae \tuhy Mrdup

JN_IX, JNMA\NX

NEMAMN, NE\^_N

1. Amn

?. Dvariae rnspdesn

(n.m. nxlcuhnh pddrrnspdehnrs dr RLD\)

<. OJI

8. Rrnvidus IWG attnjpts

>. Huratide dg iegnrticity

7. Xypn dg iegnrticity

=. Fimf risk gdr DF\\

•Is tfis rnaccy tfn pdpucatide wn trnat ie nvnryhay lcieilacpraltiln4

•]n hd ennh hata grdj dtfnr stuhins usiem pdpucatides

witf wdrsn prdmedsis

•Jnta-aeacysis lae syetfnsizn acc tfis hata



<. Aoicity td nvacuatn tfn quacity dg tfn raehdjiznh

triacs

Rdcyzds ER nt ac., OJ@ ?212



8. Aoicity td nvacuatn tfn prnsneln dg

puocilatide oias (1)

Hncaynh dr ed puocilatide dg triacs witf enmativn rnsucts

Rdcyzds ER nt ac., Fuj _nprdh ?211



8. Aoicity td nvacuatn tfn prnsneln dg

puocilatide oias (?)

Mrny citnraturn snarlf Xfn gueenc pcdt

Rdcyzds ER nt ac., OJ@ ?212



>. Aoicity td nxajien rarn nvnets

_arn nvnets- cnss tfae 1% dg tfn pdpucatide (n.m. sihnnggnlts, DF\\)

Nxajpcn0 \ihn nggnlts grdj rdsimcitazden

Eissne \N, ]dcski K EN@J ?229.



7. Aoicity td pnrgdrj iehirnlt ldjparisdes

Iehirnlt ldjparisdes

ontwnne trnatjnets

Ennhs carmn eujonr

dg _LXs

AlCH

Jl\H

Js\H

El

Es

E+Ojaol

E+cpeol

EXl

Dl

Ds

Xl

Al\HXs

X+tzjol

Xs+cpeol

AsCH

As\H

A+tzjol\H

AEl\H

AEXl\H

AXl\H

JlCH

Juctipcn trnatjnets jnta-aeacysis

<=2 ncimiocn raehdjiznh triacs

>8 169 patinets

Jauri H, Rdcyzds ER nt ac., @ELI ?226




Edt acc jnta-aeacysns arn tfn sajn

Quacity dg tfn triacs

Eujonr dg triacs aeh patinets ielcuhnh

Rdpucatide fntnrdmnenity



Eujonr dg triacs aeh patinets

Xfn amdeist-aetamdeist hnoatn

\ystnjatil _nvinws Ynar Ldelcuside

Cuhwim nt ac ?221 Ed higgnrneln ie lcieilac

prnmeaely ratn

Ac-Ieaey aeh Aoducmar ?22? Cdwnr lcieilac prnmeaely ratn

witf aetamdeists

Ac-Ieaey ?227 Cdwnr demdiem prnmeaely aeh

civn oirtf ratn witf aetamdeists

Kdcioiaeakis ?227 Ed higgnrneln ie civn oirtf ratn




Xfn amdeist-aetamdeist hnoatn

titnc16 ?8-?-?218

Ac-Ieaey F, nt ac.

Ldlfraen Hataoasn \yst _nv ?211




Hnlfartrns A nt ac., OJ@ ?21<

Carmn vnrsus sjacc triacs ie a jnta-aeacysis




71 systnjatil rnvinws puocisfnh huriem @ucy ?21? ieLdlfraen

1. 1>% dg tfn rnvinws ielcuhnh 1dr 2 triacs

?. Facg ielcuhnh gnwnr tfae 1,222 patinet raehdjiznh patinets

<. <1 wnrn uphatnh rnvinws

8. 11 dg tfnsn <1 uphatnh rnvinws ielcuhnh tfn sajn eujonrdg triacs aeh partilipaets as tfn prnvidus rnvinw tfnysdumft td oriem up td hatn.

Fujaihae & Rdcyzds Eat Jnh ?21?




8= raehdjiznh triacs usiem 81 hngieitides gdr pddrdvariae rnspdehnrs

Ed jdrn tfae < triacs usnh tfn sajn hngieitide

Nvne triacs grdj tfn sajn rnsnarlf mrdup usnh

higgnrnet hngieitide

Rdcyzds nt ac, Gnrtic \tnric ?211

R c ti f t it




Nstrahidc prn-trnatjnet gdr pddr rnspdehnrs

_nyedchs nt ac., Fuj _nprdh ?21<

Rdcyzds aeh Xdureayn ., Fuj _nprdh ?21<



Ldelcusides

Jnta-aeacysns lae on a pdwnrguc tddc tdijpcnjnet lfaemns ie lcieilac praltiln

It lae

1. Ielrnasn tfn statistilac pdwnr

?. Accdw nxtrapdcatide dg tfn rnsucts td tfn

mnenrac pdpucatide

<. Nvacuatn tfn quacity dg tfn raehdjiznh triacs

8. Nxajien rarn nvnets

>. Accdw pnrgdrjiem iehirnlt ldjparisdes



Ldelcusides

It sfduch on avdihnh wfne nvihneln isprnjaturn dr wfne hngieitides higgnr

Ievnstimatdrs, nhitdrs aeh rnvinwnrs sfduchrnacizn tfis aeh prnvnet allnptaeln,

puocilatide dr litatide dg sulf rnpdrts



Jnta-aeacysns ie rnprdhultivn jnhilien

Rrnsnet Guturn

Jaey

\jacc

Ieldelcusivn

Fntnrdmnendus

Cdw quacity _LXs

Gnwnr

Oimmnr

Ldelcusivn

Fdjdmnedus

Mddh quacity _LXs



]fat sfduch wn hd4

Eujonr dg raehdjiznh

triacs

Eujonr dg jnta-aeacysns

aeh systnjatil rnvinws

\durln I\I ]no dg kedwcnhmn \narlf 1=/?/?218



Lae wn4



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Nikolas Polyzos - Meta-Analysis - II Simposio Reproducción Asistida Quirón

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