S9 6è. Seminari internacional sobre imatge mèdica i tecnologies de la informació

4 de juliol

SABADELL

Imaging i aplicacions biomèdiques, una estació per a Alba

Manel Sabés, Centre d’Estudis en Biofísica CEB-UAB, Cerdanyola del Vallès

Patrocinador del seminari

Alba Imaging and Biomedical Applications

Manel Sabés Centre d’Estudis en Biofísica

WeWe visitvisit thethe ID17 ID17 stationstation andand wewereceivedreceived inmediatlyinmediatlythethe helphelp andand suportsuport of of

Alberto Alberto BravinBravin

ALBA BioMedical Beamline(ABME)

Manel Sabés (UAB), Jordi Sobrequés (IRHUVH), Ramon Noguera (UAB)Alberto Bravin (consultant)

Spatial distribution. Base floor (1)

Spatial distribution: First floor (2)

High and medium complexity Hospitals in the Barcelona area are

surrounding Alba

ABME project were not selected between the 7 first stations

•Not adequate on time •Low support of the medical institutions •No scientist working in this projects

SAC 2005

Probably we walked alone

CEB

Imaging BM station at a

70-80 m from the ring

ID Radiotherapy station at 30 m of ring

Irradiation at 4 Gy

Energies above and bellow K-edge of Pt (78,3 KeV)

MTT assay

Cell alive

Functional

MTT Formazan

MTT (5 mg/ml)4h reaction

DMSO

(Mosmann T, 1993.)

FORMAZAN

Purple crystals

540 nm and 620 nm

Blue colour is indicative of metabolic activity

Bellow

0

20

40

60

80

100

120

140

160

Control cis-Pt liposomes liposomescis-Pt

Control Cis-Pt Liposomes Liposomescis-Pt

% M

etab

olis

m

2 irradiations 1 irradiation

Above

020406080

100120140160

Contro

l

cis-P

t lip

osom

es

lipos

omes

cis-P

t Con

trol

Cis-Pt

Lipos

omes

Lipos

omes

cis-P

t

% M

etab

olis

m

2 irradiations 1 irradiation

• With the appropriated filtering, the proposed supercon-ducting wigglers can deliver up to 2100- 4400 Gy/s in the 50-150 KeV energy range.

• Spectral dose rate at 30 m from the source for the filtered spectrum:

1

10

10 100 1000E (keV)

Gy/

s/ke

V

100

1000 ESRFABME-W1ABME-W2

Radiation therapy programs

Imaging BM station at a

70-80 m from the ring

ID Radiotherapy station at 30 m of ring

The Imaging AIBA facility will address the interests of biomedical scientist in:

the diagnosis (breast tumours) and treatment of cancer (paediatric oncology), circulatory and respiratory disease (vascular diseases, asthma), neurological (brain and spinal cord injuries), andmuscle-skeletal disease and kinesiology(arthritis and injuries related with sport medicine).And also address to archaeological and paleontological research

Imaging BM station

• Annexed laboratories:– Animal facility– Cell laboratory– Molecular biology laboratory– Chemical laboratory

Infrastructure and laboratories

In the future• Following the events of ID17 .• The fact that the station will receive patients

makes it to take in consideration: – To have a kind facility next to the hutch to minimize

the impact that a visually ‘aggressive’ structure like the synchrotron can have on patients.

– A patient safety system, aside of the General safety system, with a fast acting/ responding mechanism has to be designed.

Alba Imaging and Biomedical Applications

AIBA

Research in new applications in Radiotherapy against resistant tumours

New strategies in imaging:in Biomedical applications for Paleontological users and heritage researchers

We will suggest complementary beam time allocation proposals together with ID17 In order to ensure immediately the presence of users in AIBA

When the adequate conditions will be done walk to the preclinical and clinical trials

Not adequate on time Low support of the medical institutions No scientist working in this projects

I would sincerely thanks the teams of ID17 and INSERM

And you for your attentionAnd you for your attention