ANALGÉSICOS ANTIINFLAMATORIOS PARA ENFERMERÍA

7/31/2019 ANALGSICOS ANTIINFLAMATORIOS PARA ENFERMERA

1/19

ANALGSICOS

ANTIINFLAMATORIOSPARA ENFERMERA

Prof. Luis Magaldi M


2/19

CONCEPTOS BSICOS

- TIPOS DE DOLOR:AGUDO Y CRNICO

- SUPERFICIAL- PROFUNDO- REFERIDO- VISCERAL

-DOLOR: SENSACIN DESAGRADABLE QUEINDICA DAO REAL O POTENCIAL DE UNTEJIDO


3/19

VAS DEL DOLOR


4/19

CONCEPTOS

.RUBOR

.TUMOR.CALOR

.DOLOR

.PRDIDA DE FUNCIN

INFLAMACIN: REACCIN DELORGANISMO CONTRA UN AGENTE

IRRITANTE O INFECCIOSO Y SECARACTERIZA POR
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5/19

INFLAMACIN AGUDA YCRNICA

Estmulo

Respuesta inmune innata Inflamacin aguda

Respuesta inmnune adaptativa

Estmulo no eliminado

Inflamacin crnica

Amplificacin


6/19

FIEBRE

TEMPERATURA CORPORAL

> 37,8 C ORAL O 38,2 C RECTAL

Estmulo Pirognico

Leucocitos, Monocitos, Macrfagos

Hipotlamo APOIL -1

Fiebre

Prostaglandinas


7/19

MEDIADORES DEL DOLOR, LAFIEBRE Y LA INFLAMACIN

- PROSTAGLANDINAS

- BRADIQUININAS- HISTAMINA- SEROTONINA

- CIDO LCTICO- SUSTANCIA P- PAF


8/19

ANALGSICOSANTIINFLAMATORIOS NOESTEROIDEOS (AINES

)- SON UN GRUPO DE FRMACOS

CON ESTRUCTURA QUMICA

DIFERENTE PERO CON EFECTOSFARMACOLGICOS COMUNES
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9/19

CLASIFICACINQUMICA DE LOS AINES

- SALICLICOS- ENLICOS:. PIRAZOLONAS. OXICANOS

- ACTICOS:. INDOLACTICO. PIRROLACTICO

. FENILACTCO

I- DERIVADOS CIDOS
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10/19

CLASIFICACINQUMICA DE LOS AINES(2)

- PROPINICO

- ANTRANLICOII- DERIVADOS NO CIDOS

- SULFOANILAMIDAS- PARAAMINOFENOLES

- BENCENOSULFONAMIDAS
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11/19

FARMACOCINTICA DELOS AINES

BIODISPONIB. 54 100 %

Vd. 0,15 2 L/KgB.H.E TODOS

U.P.P 49 99,9 %

METABOLISM. INTENSO-CEHt 1/2 0,5 48 H

EXCRECIN RENAL Y HB


12/19

FARMACODINAMIA DELOS AINES

FOSFOLPIDOS DE LAS MEMBRANAS

CIDO ARAQUIDNICO

FOSFOLIPASA A2

PROSTAGLANDINAS (PgI2-TxA2)

COX1, COX2, COX3


13/19

SELECTIVIDAD DE LOSAINES A LAS COXs

- COX1 - CONSTITUTIVA

- COX2 INDUCIDA

- COX3 CEREBRAL ?

- AINES NO SELECTIVOS (COX1,2)

- AINES SELECTIVOS (COX2,COX1)

- AINES ESPECFICOS (COX2)


14/19

REACCIONES ADVERSAS

. GASTRITIS

. LCERA

. DOLOR GSTRICO

. DIARREA

. ESTREIMIENTO

. DISPEPSIA

GASTROINTESTINALES
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15/19

REACCIONES ADVERSAS(2)

. AGRANULOCITOSIS. TROMBOCITOPENIA

. ANEMIA HEMOLTICA

- HEMATOLGICAS

- RENALES- OLIGURIA

. NEFROPATA

ANALGSICA
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16/19

REACCIONES ADVERSAS(3)

. RINITIS ALRGICA

. EDEMA ANGIONEURTICO

. ERUPCIONES

MACULOPAPULARES

. URTICARIA

. SHOCK ANAFILCTICO

- HIPERSENSIBILIDAD
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17/19

INTERACCIONESFARMACOLGICAS

- < ACCIN DIURTICA

- < ACCIN ANTIHIPERTENSIVA

- < ACCIN DE LAXANTES- > LA REABSORCIN DE Li

- DESPLAZAN FARM. UPP

- > GASTROLESIVIDAD+ALCOHOL

- > ACCIN ANTICOAGULANTE


18/19

USOS TERAPUTICOS

- FIEBRE

-DOLOR

-INFLAMACIN

-ANTIAGREGANTE

PLAQUETARIO (IM)
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19/19

ACCIONES DEENFERMERA

1- LOS 5 CORRECTOS2- PAC. CON ANTECEDENTES

DE LCERA GSTRICA3- PAC. ANTICOAGULADOS4- PREVENIR INTERACCIONES5- CONTROL DE RAMs

6- PAC. CON I.R Y/O I.H7- POR VA IV DILUIR LOS AINES8- CONTRAINDICACIONES DEL AAS
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ANALGÉSICOS ANTIINFLAMATORIOS PARA ENFERMERÍA

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